ATE335748T1 - Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen - Google Patents

Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen

Info

Publication number
ATE335748T1
ATE335748T1 AT04702477T AT04702477T ATE335748T1 AT E335748 T1 ATE335748 T1 AT E335748T1 AT 04702477 T AT04702477 T AT 04702477T AT 04702477 T AT04702477 T AT 04702477T AT E335748 T1 ATE335748 T1 AT E335748T1
Authority
AT
Austria
Prior art keywords
thienopyrimidiindiones
sup
autoimmune diseases
modulating autoimmune
compounds
Prior art date
Application number
AT04702477T
Other languages
English (en)
Inventor
Simon David Guile
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE335748T1 publication Critical patent/ATE335748T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04702477T 2003-01-17 2004-01-15 Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen ATE335748T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0300119A SE0300119D0 (sv) 2003-01-17 2003-01-17 Novel compounds

Publications (1)

Publication Number Publication Date
ATE335748T1 true ATE335748T1 (de) 2006-09-15

Family

ID=20290154

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04702477T ATE335748T1 (de) 2003-01-17 2004-01-15 Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen

Country Status (23)

Country Link
US (2) US7384951B2 (de)
EP (1) EP1587812B1 (de)
JP (1) JP4519121B2 (de)
KR (2) KR101107486B1 (de)
CN (1) CN100334093C (de)
AT (1) ATE335748T1 (de)
AU (1) AU2004206012B2 (de)
BR (1) BRPI0406801B8 (de)
CA (1) CA2512441C (de)
DE (1) DE602004001857T2 (de)
EG (1) EG25613A (de)
ES (1) ES2270337T3 (de)
IL (1) IL169370A (de)
IS (1) IS2376B (de)
MX (1) MXPA05007496A (de)
NO (1) NO333702B1 (de)
NZ (1) NZ541217A (de)
PL (1) PL214682B1 (de)
RU (1) RU2331647C2 (de)
SE (1) SE0300119D0 (de)
UA (1) UA81788C2 (de)
WO (1) WO2004065394A1 (de)
ZA (1) ZA200505364B (de)

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GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
PL378221A1 (pl) * 2003-01-17 2006-03-20 Astrazeneca Ab Tienopirydazynony i ich zastosowanie w modulacji choroby autoimmunologicznej
CN1925855B (zh) 2003-12-19 2010-06-16 普莱希科公司 开发Ret调节剂的化合物和方法
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
MX2007014377A (es) 2005-05-17 2008-02-06 Plexxikon Inc Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
PL2395004T3 (pl) 2005-06-22 2016-08-31 Plexxikon Inc Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US7872018B2 (en) 2006-12-21 2011-01-18 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20081581A1 (es) 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
GB0713479D0 (en) * 2007-07-11 2007-08-22 Syngenta Participations Ag Substituted aromatic heterocyclic compounds as fungicides
MX2010000617A (es) 2007-07-17 2010-05-17 Plexxikon Inc Compuestos y metodos para modulacion de cinasa, e indicaciones de estos.
WO2010089580A1 (en) 2009-02-06 2010-08-12 Astrazeneca Ab Use of a mct1 inhibitor in the treatment of cancers expressing mct1 over mct4
EP2411395B1 (de) * 2009-03-23 2013-05-29 Glenmark Pharmaceuticals S.A. Furopyrimidindionderivate als trpa1-modulatoren
DK2411397T3 (da) * 2009-03-23 2013-08-05 Glenmark Pharmaceuticals Sa Isothiazol-pyrimidindionderivater som modulatorer af TRPA1
EA031116B1 (ru) 2009-04-03 2018-11-30 Ф. Хоффманн-Ля Рош Аг КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
UA105813C2 (uk) 2009-11-06 2014-06-25 Плексікон, Інк. Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти)
PL2672967T3 (pl) 2011-02-07 2019-04-30 Plexxikon Inc Związki i sposoby modulacji kinaz i wskazania ku temu
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
WO2013109972A2 (en) 2012-01-20 2013-07-25 Regents Of The University Of Minnesota Therapeutic compounds
GB2523211B (en) 2012-01-27 2020-03-18 Univ Jefferson MCT protein inhibitor-related prognostic and therapeutic methods
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
WO2014172627A1 (en) 2013-04-19 2014-10-23 Thomas Jefferson University Caveolin-1 related methods for treating glioblastoma with temozolomide
KR102228034B1 (ko) * 2013-10-21 2021-03-16 제노스코 치환된 피리미딘 화합물 및 syk 억제제로서의 이의 용도
EP3247360B1 (de) 2015-01-22 2021-08-25 The Scripps Research Institute Heterocyclische inhibitoren von monocarboxylat-transportern
UY36586A (es) * 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
KR101712838B1 (ko) * 2016-03-17 2017-03-07 주식회사 골프존 가상 골프 시뮬레이션 장치, 가상 골프를 위한 영상 구현 방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록 매체
KR101712836B1 (ko) * 2016-03-17 2017-03-22 주식회사 골프존 가상 골프 시뮬레이션 장치, 가상 골프를 위한 영상 구현 방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록 매체
KR101730536B1 (ko) * 2016-03-17 2017-05-02 주식회사 골프존 스크린 골프 시스템에서 구현되는 컨텐츠 전송 서비스 방법, 컨텐츠 전송 서비스를 위한 모바일 단말기의 제어방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록매체
TWI823932B (zh) 2018-05-11 2023-12-01 中國大陸商迪哲（江蘇）醫藥有限公司 三唑并嘧啶化合物及其在治療癌症中之用途
CN119080799B (zh) * 2024-09-27 2025-12-05 山东大学 一种n-羟基噻吩并嘧啶二酮类衍生物及其制备方法与应用

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US738495A (en) * 1902-12-26 1903-09-08 William E Sherwood Thill-coupling.
WO1999029695A1 (en) 1997-12-05 1999-06-17 Astrazeneca Uk Limited Novel compounds
US6469014B1 (en) * 1997-05-28 2002-10-22 Astrazeneca Ab Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
SE9702001D0 (sv) 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
PT1107973E (pt) 1998-08-28 2004-03-31 Astrazeneca Ab Novas tieno¬2,3-d| pirimidinodionas processo para a sua preparacao e sua utilizacao em terapia
AU2001252825A1 (en) * 2000-05-04 2001-11-12 Astrazeneca Ab Thieno(2,3-d)pyrimidinediones and their use as pharmaceuticals
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
PL378221A1 (pl) * 2003-01-17 2006-03-20 Astrazeneca Ab Tienopirydazynony i ich zastosowanie w modulacji choroby autoimmunologicznej
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
EG25613A (en) 2012-03-22
CA2512441C (en) 2012-01-03
IS7965A (is) 2005-07-29
CA2512441A1 (en) 2004-08-05
KR20050092760A (ko) 2005-09-22
NO20053826L (no) 2005-10-17
US7384951B2 (en) 2008-06-10
JP4519121B2 (ja) 2010-08-04
US20080214579A1 (en) 2008-09-04
MXPA05007496A (es) 2005-09-21
SE0300119D0 (sv) 2003-01-17
US20060052400A1 (en) 2006-03-09
IL169370A0 (en) 2007-07-04
JP2006516974A (ja) 2006-07-13
BRPI0406801B8 (pt) 2021-05-25
KR101107486B1 (ko) 2012-01-19
CN100334093C (zh) 2007-08-29
NZ541217A (en) 2008-05-30
RU2005121494A (ru) 2006-02-10
AU2004206012A1 (en) 2004-08-05
HK1081959A1 (en) 2006-05-26
EP1587812B1 (de) 2006-08-09
DE602004001857T2 (de) 2007-05-24
BRPI0406801A (pt) 2006-01-17
PL214682B1 (pl) 2013-09-30
WO2004065394A1 (en) 2004-08-05
CN1761672A (zh) 2006-04-19
EP1587812A1 (de) 2005-10-26
NO20053826D0 (no) 2005-08-15
NO333702B1 (no) 2013-08-26
RU2331647C2 (ru) 2008-08-20
IS2376B (is) 2008-07-15
DE602004001857D1 (de) 2006-09-21
PL378222A1 (pl) 2006-03-20
UA81788C2 (uk) 2008-02-11
ZA200505364B (en) 2006-09-27
KR20110125256A (ko) 2011-11-18
ES2270337T3 (es) 2007-04-01
IL169370A (en) 2011-05-31
BRPI0406801B1 (pt) 2018-04-03
AU2004206012B2 (en) 2007-06-14

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