ATE335748T1 - Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen - Google Patents

Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen

Info

Publication number
ATE335748T1
ATE335748T1 AT04702477T AT04702477T ATE335748T1 AT E335748 T1 ATE335748 T1 AT E335748T1 AT 04702477 T AT04702477 T AT 04702477T AT 04702477 T AT04702477 T AT 04702477T AT E335748 T1 ATE335748 T1 AT E335748T1
Authority
AT
Austria
Prior art keywords
thienopyrimidiindiones
sup
autoimmune diseases
modulating autoimmune
compounds
Prior art date
Application number
AT04702477T
Other languages
English (en)
Inventor
Simon David Guile
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE335748T1 publication Critical patent/ATE335748T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04702477T 2003-01-17 2004-01-15 Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen ATE335748T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0300119A SE0300119D0 (sv) 2003-01-17 2003-01-17 Novel compounds

Publications (1)

Publication Number Publication Date
ATE335748T1 true ATE335748T1 (de) 2006-09-15

Family

ID=20290154

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04702477T ATE335748T1 (de) 2003-01-17 2004-01-15 Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen

Country Status (23)

Country Link
US (2) US7384951B2 (de)
EP (1) EP1587812B1 (de)
JP (1) JP4519121B2 (de)
KR (2) KR101107486B1 (de)
CN (1) CN100334093C (de)
AT (1) ATE335748T1 (de)
AU (1) AU2004206012B2 (de)
BR (1) BRPI0406801B8 (de)
CA (1) CA2512441C (de)
DE (1) DE602004001857T2 (de)
EG (1) EG25613A (de)
ES (1) ES2270337T3 (de)
IL (1) IL169370A (de)
IS (1) IS2376B (de)
MX (1) MXPA05007496A (de)
NO (1) NO333702B1 (de)
NZ (1) NZ541217A (de)
PL (1) PL214682B1 (de)
RU (1) RU2331647C2 (de)
SE (1) SE0300119D0 (de)
UA (1) UA81788C2 (de)
WO (1) WO2004065394A1 (de)
ZA (1) ZA200505364B (de)

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GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
SE0300120D0 (sv) 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
WO2004065395A1 (en) * 2003-01-17 2004-08-05 Astrazeneca Ab Thienopyridazinones and their use in modulation of autoimmune disease
PL1696920T3 (pl) 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
CA2608733A1 (en) 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
DK2395004T3 (en) 2005-06-22 2016-03-21 Plexxikon Inc Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
WO2008080015A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20081581A1 (es) 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
GB0713479D0 (en) * 2007-07-11 2007-08-22 Syngenta Participations Ag Substituted aromatic heterocyclic compounds as fungicides
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2010089580A1 (en) 2009-02-06 2010-08-12 Astrazeneca Ab Use of a mct1 inhibitor in the treatment of cancers expressing mct1 over mct4
SG174398A1 (en) * 2009-03-23 2011-10-28 Glenmark Pharmaceuticals Sa Furopyrimidinedione derivatives as trpa1 modulators
BRPI1009372A2 (pt) * 2009-03-23 2016-05-31 Glenmark Pharmaceuticals Sa compostos, composição farmacêutica e respectivos usos
HUE027598T2 (en) 2009-04-03 2016-10-28 Hoffmann La Roche Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
MA34948B1 (fr) 2011-02-07 2014-03-01 Plexxikon Inc Composes et procedes de modulation de kinase, et leurs indications
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
EP2804852A2 (de) 2012-01-20 2014-11-26 Regents Of The University Of Minnesota Therapeutische verbindungen
US10085987B2 (en) 2012-01-27 2018-10-02 Thomas Jefferson University MCT protein inhibitor-related prognostic and therapeutic methods
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP2986290A4 (de) 2013-04-19 2017-01-04 Thomas Jefferson University Caveolin-1-verwandte verfahren zur behandlung von glioblastom mit temozolomid
NZ718576A (en) * 2013-10-21 2019-11-29 Genosco Substituted pyrimidine compounds and their use as syk inhibitors
JP6725519B2 (ja) * 2015-01-22 2020-07-22 ザ スクリプス リサーチ インスティテュート 複素環式のモノカルボン酸トランスポータ阻害薬
UY36586A (es) * 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
KR101712836B1 (ko) * 2016-03-17 2017-03-22 주식회사 골프존 가상 골프 시뮬레이션 장치, 가상 골프를 위한 영상 구현 방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록 매체
KR101712838B1 (ko) * 2016-03-17 2017-03-07 주식회사 골프존 가상 골프 시뮬레이션 장치, 가상 골프를 위한 영상 구현 방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록 매체
KR101730536B1 (ko) * 2016-03-17 2017-05-02 주식회사 골프존 스크린 골프 시스템에서 구현되는 컨텐츠 전송 서비스 방법, 컨텐츠 전송 서비스를 위한 모바일 단말기의 제어방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록매체
TWI823932B (zh) * 2018-05-11 2023-12-01 中國大陸商迪哲（江蘇）醫藥有限公司 三唑并嘧啶化合物及其在治療癌症中之用途
CN119080799B (zh) * 2024-09-27 2025-12-05 山东大学 一种n-羟基噻吩并嘧啶二酮类衍生物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US738495A (en) * 1902-12-26 1903-09-08 William E Sherwood Thill-coupling.
SE9702001D0 (sv) * 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
US6469014B1 (en) * 1997-05-28 2002-10-22 Astrazeneca Ab Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
SK8402000A3 (en) 1997-12-05 2001-03-12 Astrazeneca Uk Ltd Novel compounds
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
CA2339664A1 (en) * 1998-08-28 2000-03-09 Astrazeneca Ab Thieno{2,3,-d}pyrimidinedione derivatives and their use as immunosuppressants
ATE272642T1 (de) * 2000-05-04 2004-08-15 Astrazeneca Ab Thieno(2,3-d)pyrimidindione und ihre verwendung als pharmazeutische mittel
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
WO2004065395A1 (en) 2003-01-17 2004-08-05 Astrazeneca Ab Thienopyridazinones and their use in modulation of autoimmune disease
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
BRPI0406801B8 (pt) 2021-05-25
HK1081959A1 (en) 2006-05-26
AU2004206012A1 (en) 2004-08-05
AU2004206012B2 (en) 2007-06-14
BRPI0406801A (pt) 2006-01-17
SE0300119D0 (sv) 2003-01-17
UA81788C2 (uk) 2008-02-11
JP4519121B2 (ja) 2010-08-04
DE602004001857D1 (de) 2006-09-21
JP2006516974A (ja) 2006-07-13
US7384951B2 (en) 2008-06-10
CA2512441C (en) 2012-01-03
PL378222A1 (pl) 2006-03-20
RU2005121494A (ru) 2006-02-10
CN1761672A (zh) 2006-04-19
NO333702B1 (no) 2013-08-26
NZ541217A (en) 2008-05-30
RU2331647C2 (ru) 2008-08-20
BRPI0406801B1 (pt) 2018-04-03
US20060052400A1 (en) 2006-03-09
NO20053826D0 (no) 2005-08-15
WO2004065394A1 (en) 2004-08-05
CA2512441A1 (en) 2004-08-05
ZA200505364B (en) 2006-09-27
KR20050092760A (ko) 2005-09-22
MXPA05007496A (es) 2005-09-21
KR20110125256A (ko) 2011-11-18
EP1587812B1 (de) 2006-08-09
EP1587812A1 (de) 2005-10-26
NO20053826L (no) 2005-10-17
KR101107486B1 (ko) 2012-01-19
IL169370A (en) 2011-05-31
IS2376B (is) 2008-07-15
EG25613A (en) 2012-03-22
DE602004001857T2 (de) 2007-05-24
PL214682B1 (pl) 2013-09-30
IL169370A0 (en) 2007-07-04
ES2270337T3 (es) 2007-04-01
US20080214579A1 (en) 2008-09-04
CN100334093C (zh) 2007-08-29
IS7965A (is) 2005-07-29

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