NO943210L - Laktolderivater, deres fremstilling og anvendelse - Google Patents
Laktolderivater, deres fremstilling og anvendelseInfo
- Publication number
- NO943210L NO943210L NO943210A NO943210A NO943210L NO 943210 L NO943210 L NO 943210L NO 943210 A NO943210 A NO 943210A NO 943210 A NO943210 A NO 943210A NO 943210 L NO943210 L NO 943210L
- Authority
- NO
- Norway
- Prior art keywords
- group
- substituted
- acyl group
- esterified
- salt
- Prior art date
Links
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000004172 Cathepsin L Human genes 0.000 abstract 1
- 108090000624 Cathepsin L Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Det blir beskrevet en ny forbindelse med formel (la) eller (I): A¿O R3¿o¿NH-CH-CH-0-B (la) hvor O er en eller to aminosyrerester som kan være substituert; R3 er en karboksylgruppe som kan være esterifisert eller en acylgruppe; A er en alkylen- gruppe; B er hydrogen eller en alkylgruppe som kan være substituert eller acylgruppe: eller et salt av dette; R2 Ri A¿O l l II R3---(NH-CH-CO)m---(NH-CH-CO)n---NH-CH-CH-0-B hvor R1 og R2 hver er like eller forskjellige og hver er hydrogen eller en hydrokarbonrest som kan være substituert; R3, A og B har samme definisjonen som vist ovenfor; m og n er hver lik O eller 1; forutsatt at når både m og n er lik O, står R3 for en karboksylgruppe som kan være esterifisert eller en acylgruppe som ikke har færre enn 7 karbonatomer; eller et salt av dette. Forbindelsene (la) eller (I) viser cathepsin L hemmende og beresorpsjonshemmende aktivitet og er nyttig som profylaktisk/terapeutisk middel for osteoporose.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21965593 | 1993-09-03 | ||
| JP16850194 | 1994-07-20 | ||
| JP19038594 | 1994-08-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO943210D0 NO943210D0 (no) | 1994-08-30 |
| NO943210L true NO943210L (no) | 1995-03-06 |
Family
ID=27323012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO943210A NO943210L (no) | 1993-09-03 | 1994-08-30 | Laktolderivater, deres fremstilling og anvendelse |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5496834A (no) |
| EP (1) | EP0641800B1 (no) |
| KR (1) | KR950008497A (no) |
| CN (1) | CN1106001A (no) |
| AT (1) | ATE212036T1 (no) |
| AU (1) | AU678493B2 (no) |
| CA (1) | CA2131397A1 (no) |
| DE (1) | DE69429642T2 (no) |
| FI (1) | FI944040A7 (no) |
| HU (1) | HUT68717A (no) |
| NO (1) | NO943210L (no) |
| NZ (1) | NZ264376A (no) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW394764B (en) * | 1995-02-14 | 2000-06-21 | Mitsubishi Chemcal Corp | Oxygen-containing heterocyclic derivatives |
| US20030096760A1 (en) * | 1997-03-10 | 2003-05-22 | Smithklinebeecham Corporation | Method of antagonizing the human SRC SH2 domain |
| FR2800737B1 (fr) * | 1999-11-05 | 2006-06-30 | Sod Conseils Rech Applic | Nouveaux composes heterocycliques et leur application a titre de medicaments |
| DE60026348T2 (de) * | 1999-11-05 | 2006-10-19 | Societe De Conseils De Recherches Et D`Applications Scientifiques (S.C.R.A.S.) | Heterocyclische verbindungen und ihre verwendung als medikamente |
| US6720327B2 (en) * | 2000-09-27 | 2004-04-13 | Pharmacia Corporation | Lactone integrin antagonists |
| DE10124041A1 (de) * | 2001-05-16 | 2002-11-21 | Graffinity Pharm Design Gmbh | Protease Inhibitoren |
| KR101016593B1 (ko) * | 2002-03-15 | 2011-02-22 | 센주 세이야꾸 가부시키가이샤 | 환식 반아세탈 유도체 및 이의 용도 |
| WO2005033068A1 (en) * | 2003-10-06 | 2005-04-14 | Oy Juvantia Pharma Ltd | Somatostatin receptor 1 and/or 4 selective agonists and antagonists |
| WO2008045017A2 (en) * | 2005-06-22 | 2008-04-17 | Diamond Scott L | Sars and ebola inhibitors and use thereof, and methods for their discovery |
| JP2024525589A (ja) | 2021-07-09 | 2024-07-12 | アリゴス セラピューティクス インコーポレイテッド | 抗ウイルス化合物 |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0504938A3 (en) * | 1991-03-22 | 1993-04-14 | Suntory Limited | Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient |
| DE69226820T2 (de) * | 1991-06-21 | 1999-05-12 | Merck & Co., Inc., Rahway, N.J. | Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen |
-
1994
- 1994-08-30 NO NO943210A patent/NO943210L/no unknown
- 1994-09-01 EP EP94113669A patent/EP0641800B1/en not_active Expired - Lifetime
- 1994-09-01 DE DE69429642T patent/DE69429642T2/de not_active Expired - Fee Related
- 1994-09-01 AT AT94113669T patent/ATE212036T1/de not_active IP Right Cessation
- 1994-09-02 CA CA002131397A patent/CA2131397A1/en not_active Abandoned
- 1994-09-02 CN CN94115669A patent/CN1106001A/zh active Pending
- 1994-09-02 HU HU9402536A patent/HUT68717A/hu unknown
- 1994-09-02 FI FI944040A patent/FI944040A7/fi not_active Application Discontinuation
- 1994-09-02 NZ NZ264376A patent/NZ264376A/en unknown
- 1994-09-02 US US08/300,738 patent/US5496834A/en not_active Expired - Fee Related
- 1994-09-02 AU AU71682/94A patent/AU678493B2/en not_active Expired - Fee Related
- 1994-09-03 KR KR1019940022180A patent/KR950008497A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NO943210D0 (no) | 1994-08-30 |
| DE69429642D1 (de) | 2002-02-21 |
| FI944040A7 (fi) | 1995-03-04 |
| CN1106001A (zh) | 1995-08-02 |
| EP0641800A1 (en) | 1995-03-08 |
| FI944040A0 (fi) | 1994-09-02 |
| EP0641800B1 (en) | 2002-01-16 |
| DE69429642T2 (de) | 2002-09-12 |
| HU9402536D0 (en) | 1994-10-28 |
| NZ264376A (en) | 1996-03-26 |
| US5496834A (en) | 1996-03-05 |
| HUT68717A (en) | 1995-07-28 |
| KR950008497A (ko) | 1995-04-17 |
| CA2131397A1 (en) | 1995-03-04 |
| AU7168294A (en) | 1995-03-16 |
| AU678493B2 (en) | 1997-05-29 |
| ATE212036T1 (de) | 2002-02-15 |
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