ATE212036T1 - Lactol-derivate, als cathepsin l inhibitoren - Google Patents

Lactol-derivate, als cathepsin l inhibitoren

Info

Publication number: ATE212036T1
Authority: AT; Austria
Prior art keywords: group; substituted; cathepsin; acyl group; esterified
Prior art date: 1993-09-03

Application number

AT94113669T

Other languages

English (en)

Inventor

Takashi Sohda

Yukio Fujisawa

Satoru Oi

Junji Mizoguchi

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-03

Filing date

1994-09-01

Publication date

2002-02-15

1994-09-01 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE212036T1 publication Critical patent/ATE212036T1/de

Links

102000005600 Cathepsins Human genes 0.000 title 1
108010084457 Cathepsins Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000002252 acyl group Chemical group 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
208000006386 Bone Resorption Diseases 0.000 abstract 1
102000004172 Cathepsin L Human genes 0.000 abstract 1
108090000624 Cathepsin L Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
230000024279 bone resorption Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Pyrane Compounds (AREA)
Saccharide Compounds (AREA)

AT94113669T 1993-09-03 1994-09-01 Lactol-derivate, als cathepsin l inhibitoren ATE212036T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP21965593		1993-09-03
JP16850194		1994-07-20
JP19038594		1994-08-12

Publications (1)

Publication Number	Publication Date
ATE212036T1 true ATE212036T1 (de)	2002-02-15

Family

ID=27323012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94113669T ATE212036T1 (de)	1993-09-03	1994-09-01	Lactol-derivate, als cathepsin l inhibitoren

Country Status (12)

Country	Link
US (1)	US5496834A (de)
EP (1)	EP0641800B1 (de)
KR (1)	KR950008497A (de)
CN (1)	CN1106001A (de)
AT (1)	ATE212036T1 (de)
AU (1)	AU678493B2 (de)
CA (1)	CA2131397A1 (de)
DE (1)	DE69429642T2 (de)
FI (1)	FI944040A7 (de)
HU (1)	HUT68717A (de)
NO (1)	NO943210L (de)
NZ (1)	NZ264376A (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW394764B (en) *	1995-02-14	2000-06-21	Mitsubishi Chemcal Corp	Oxygen-containing heterocyclic derivatives
US20030096760A1 (en) *	1997-03-10	2003-05-22	Smithklinebeecham Corporation	Method of antagonizing the human SRC SH2 domain
FR2800737B1 (fr) *	1999-11-05	2006-06-30	Sod Conseils Rech Applic	Nouveaux composes heterocycliques et leur application a titre de medicaments
BR0015315A (pt) *	1999-11-05	2002-06-25	Sod Conseils Rech Applic	Compostos, medicamentos, composições farmacêuticas, utilização de compostos e produtos industriais
US6720327B2 (en) *	2000-09-27	2004-04-13	Pharmacia Corporation	Lactone integrin antagonists
DE10124041A1 (de) *	2001-05-16	2002-11-21	Graffinity Pharm Design Gmbh	Protease Inhibitoren
JPWO2003078415A1 (ja) *	2002-03-15	2005-07-14	千寿製薬株式会社	環状ヘミアセタール誘導体およびその用途
WO2005033068A1 (en) *	2003-10-06	2005-04-14	Oy Juvantia Pharma Ltd	Somatostatin receptor 1 and/or 4 selective agonists and antagonists
WO2008045017A2 (en) *	2005-06-22	2008-04-17	Diamond Scott L	Sars and ebola inhibitors and use thereof, and methods for their discovery
AU2022306289A1 (en)	2021-07-09	2024-01-18	Aligos Therapeutics, Inc.	Anti-viral compounds
WO2023043816A1 (en)	2021-09-17	2023-03-23	Aligos Therapeutics, Inc.	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0504938A3 (en) *	1991-03-22	1993-04-14	Suntory Limited	Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient
DE69226820T2 (de) *	1991-06-21	1999-05-12	Merck & Co., Inc., Rahway, N.J.	Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen

1994
- 1994-08-30 NO NO943210A patent/NO943210L/no unknown
- 1994-09-01 AT AT94113669T patent/ATE212036T1/de not_active IP Right Cessation
- 1994-09-01 EP EP94113669A patent/EP0641800B1/de not_active Expired - Lifetime
- 1994-09-01 DE DE69429642T patent/DE69429642T2/de not_active Expired - Fee Related
- 1994-09-02 NZ NZ264376A patent/NZ264376A/en unknown
- 1994-09-02 US US08/300,738 patent/US5496834A/en not_active Expired - Fee Related
- 1994-09-02 AU AU71682/94A patent/AU678493B2/en not_active Expired - Fee Related
- 1994-09-02 CN CN94115669A patent/CN1106001A/zh active Pending
- 1994-09-02 CA CA002131397A patent/CA2131397A1/en not_active Abandoned
- 1994-09-02 FI FI944040A patent/FI944040A7/fi not_active Application Discontinuation
- 1994-09-02 HU HU9402536A patent/HUT68717A/hu unknown
- 1994-09-03 KR KR1019940022180A patent/KR950008497A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
AU678493B2 (en)	1997-05-29
FI944040A7 (fi)	1995-03-04
HU9402536D0 (en)	1994-10-28
NZ264376A (en)	1996-03-26
CA2131397A1 (en)	1995-03-04
CN1106001A (zh)	1995-08-02
NO943210L (no)	1995-03-06
EP0641800A1 (de)	1995-03-08
US5496834A (en)	1996-03-05
KR950008497A (ko)	1995-04-17
NO943210D0 (no)	1994-08-30
FI944040A0 (fi)	1994-09-02
EP0641800B1 (de)	2002-01-16
DE69429642D1 (de)	2002-02-21
DE69429642T2 (de)	2002-09-12
HUT68717A (en)	1995-07-28
AU7168294A (en)	1995-03-16

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Legal Events

Date	Code	Title	Description
2002-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties