NO950682L - Syntese av N-substituerte oligomerer - Google Patents

Syntese av N-substituerte oligomerer

Info

Publication number
NO950682L
NO950682L NO950682A NO950682A NO950682L NO 950682 L NO950682 L NO 950682L NO 950682 A NO950682 A NO 950682A NO 950682 A NO950682 A NO 950682A NO 950682 L NO950682 L NO 950682L
Authority
NO
Norway
Prior art keywords
oligomers
poly
substituted
synthesis
acylation
Prior art date
Application number
NO950682A
Other languages
English (en)
Other versions
NO950682D0 (no
Inventor
Ronald N Zuckermann
Janice M Kerr
Stephen Brian Henry Kent
Walter H Moos
Reyna J Simon
Dane A Goff
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of NO950682D0 publication Critical patent/NO950682D0/no
Publication of NO950682L publication Critical patent/NO950682L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polymers & Plastics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Fast fase metod for syntese av N-substltuerte oligo- merer, så som poly (N-substltuerte glyclner) (angitt heri som poly NSG) blir anvendt for å oppnå oligomerer, så som poly NSG med potensiell terapeutisk Interesse. Disse poly NSG kan ha mange forskjellige slde-kjede substltuente. Hver N-substltuerte glyclnmonomer blir oppstilt fra to "sub-monomerer" direkte på den faste bæreren. Hver syklus med monomer tilsetning består av to trinn: (1) acylerlng av et andre amln bundet til bæreren med et acylerlngsmlddel omfattende en avspalt- bar gruppe med evne til nukleofllforflytnlng av -NH2, så som en haloeddlksyre, og (2) innføring av slde- kjeden ved nukleofll forflytning av den avspaltbare gruppen, så som halogen (som et harplks-bundet a- haloacetamld) med en tilstrekkelig mengde av en annen sub-monomer omfattende en -NH2 gruppe, så som et primært amin, alkoskyamin, semikarbazid, acylhydrazld, karbazat eller lignende. Repetering av to trinns syklusen som omfatter acylering og forflytning tilvelebrlnger de ønskede ollgomerene. Den effektive syntesen av forskjellige ollgomerlske NSG ved an- vendelse av automatisert synteseteknologl Ifølge foreliggende oppfinnelse gjør disse ollgomerene til attraktive kandidater for dannelse og hurtig screening av diverse peptidomimetiske biblioteker. Ollgomerene, så N-substituerte glyciner (dvs. poly NSG) tilveie- brlnger en ny klasse peptld-llgnende forbindelse som ikke finnes l naturen, men som er syntetisk oppnåelige og som har vist å ha betydelig biologisk aktivitet og proteolytlsk stabilitet.
NO950682A 1992-09-24 1995-02-23 Syntese av N-substituerte oligomerer NO950682L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95085392A 1992-09-24 1992-09-24
PCT/US1993/009117 WO1994006451A1 (en) 1992-09-24 1993-09-24 Synthesis of n-substituted oligomers

Publications (2)

Publication Number Publication Date
NO950682D0 NO950682D0 (no) 1995-02-23
NO950682L true NO950682L (no) 1995-04-18

Family

ID=25490930

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950682A NO950682L (no) 1992-09-24 1995-02-23 Syntese av N-substituerte oligomerer

Country Status (17)

Country Link
US (1) US20020115612A1 (no)
EP (2) EP1258492A1 (no)
JP (3) JP3461505B2 (no)
KR (1) KR0168709B1 (no)
AT (1) ATE228532T1 (no)
AU (1) AU679945B2 (no)
BG (1) BG99521A (no)
BR (1) BR9307092A (no)
CA (1) CA2144067A1 (no)
DE (1) DE69332524T2 (no)
FI (1) FI951356A7 (no)
HK (1) HK1049173A1 (no)
HU (1) HUT72614A (no)
NO (1) NO950682L (no)
NZ (1) NZ256952A (no)
PL (1) PL308204A1 (no)
WO (1) WO1994006451A1 (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5536853A (en) * 1994-04-11 1996-07-16 Chiron Corporation Opiate receptor ligands
US5939268A (en) * 1994-07-26 1999-08-17 The Scripps Research Institute Combinatorial libraries of molecules and methods for producing same
DE69530119T2 (de) * 1994-12-30 2003-09-25 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Verfahren zur kontrollierten synthese von beliebigen peptidmischungen kodierende polynukleotidmischungen
US5481020A (en) * 1994-12-30 1996-01-02 Chiron Corporation Opiate receptor ligands
US5891742A (en) * 1995-01-19 1999-04-06 Chiron Corporation Affinity selection of ligands by mass spectroscopy
US5627210A (en) * 1995-02-06 1997-05-06 Chiron Corporation Branched combinatorial libraries
US5747458A (en) * 1995-06-07 1998-05-05 Chiron Corporation Urokinase receptor ligands
US5958792A (en) * 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
US6277583B1 (en) 1996-02-07 2001-08-21 Conjuchem, Inc. Affinity labeling libraries and applications thereof
US6251433B1 (en) 1996-08-13 2001-06-26 Chiron Corporation Polycationic polymers
US6045755A (en) * 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
ES2329955T3 (es) * 1997-04-28 2009-12-02 Novartis Vaccines And Diagnostics, Inc. Aparato para la sintesis de oligomeros, especialmente peptoides, con reciclado de reactivos.
US6197332B1 (en) 1997-08-13 2001-03-06 Chiron Corporation Lipid-conjugated polyamide compounds and related compositions and methods thereof
AU1519699A (en) 1997-11-07 1999-05-31 Conjuchem, Inc. Affinity markers for human serum albumin
WO1999045026A1 (en) 1998-03-05 1999-09-10 Chiron Corporation Method for increasing the serum half-life of a biologically active molecule
WO2000043547A1 (en) 1999-01-20 2000-07-27 Northwestern University Dna mobility modifier
ES2300379T3 (es) 2000-12-23 2008-06-16 Novartis Vaccines And Diagnostics, Inc. Procedimiento de deteccion selectiva de transfeccion de oligonucleotidos.
US7664553B2 (en) * 2005-04-27 2010-02-16 Cardiac Pacemakers, Inc. System and method for enabling communications with implantable medical devices
EP1931695B1 (en) * 2005-09-09 2013-04-10 Novartis AG Prion-specific peptoid reagents
JP2009525269A (ja) * 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． カルシウムチャネルブロッカーとしての環状尿素化合物
DE102006039615A1 (de) * 2006-08-24 2008-03-13 Leibniz-Institut Für Pflanzenbiochemie Esterelongationsverfahren zum sequenzgesteuerten Aufbau alternierender Peptid-Peptoid-Polymere (Peptid-Peptoid-Polymere)
WO2008091632A2 (en) 2007-01-22 2008-07-31 Acologix, Inc. A peptide composition and a method of promoting cartilage formation
JP4997038B2 (ja) * 2007-07-27 2012-08-08 株式会社ブリヂストン 更生タイヤ用トレッド及び更生タイヤ
CA2714853A1 (en) * 2008-02-08 2009-08-27 Northwestern University Selective poly-n-substituted glycine antibiotics
WO2011115687A2 (en) * 2010-03-19 2011-09-22 Northwestern University Alkylated sp-b peptoid compounds and related lung surfactant compositions
US9764953B2 (en) 2013-03-20 2017-09-19 The Regents Of The University Of California Peptoids useful for the mineralization of apatite
CA3001065A1 (en) 2015-10-14 2017-04-20 Xiaoxi WEI Compositions and methods for reducing ice crystal formation
WO2017139329A1 (en) 2016-02-09 2017-08-17 Alexander Krantz Site-selective functionalization of proteins using traceless affinity lables
US11021514B2 (en) 2016-06-01 2021-06-01 Athira Pharma, Inc. Compounds
EP3681900A4 (en) 2017-09-11 2021-09-08 Protagonist Therapeutics, Inc. OPIOID AGONIST PEPTIDES AND THEIR USES
US11400165B2 (en) 2017-11-04 2022-08-02 Advanced Proteome Therapeutics Inc. Composition and method for modifying polypeptides
KR20240007491A (ko) 2022-07-08 2024-01-16 문정현 수평유지하는 유모차

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1037474A (en) * 1964-04-21 1966-07-27 British Nylon Spinners Ltd N-substituted polyamides and filaments therefrom
US3634364A (en) * 1969-09-26 1972-01-11 Grace W R & Co Polyminodiacetic acid and polysarcosine homopolymers
DE2447305C3 (de) * 1973-10-05 1979-09-13 Miyoshi Yushi K.K., Tokio Verfahren zur Herstellung chelatbildender Polymerisate
WO1986005519A1 (en) * 1985-03-15 1986-09-25 James Summerton Polynucleotide assay reagent and method
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
IE66205B1 (en) * 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
WO1992013018A1 (en) 1991-01-25 1992-08-06 Kodak Limited Polymers and products derived therefrom

Also Published As

Publication number Publication date
NZ256952A (en) 1997-07-27
EP0671928A1 (en) 1995-09-20
JP2003012622A (ja) 2003-01-15
DE69332524T2 (de) 2003-04-24
FI951356A0 (fi) 1995-03-22
FI951356A7 (fi) 1995-04-26
HU9500855D0 (en) 1995-05-29
HUT72614A (en) 1996-05-28
JP2000239242A (ja) 2000-09-05
PL308204A1 (en) 1995-07-24
AU679945B2 (en) 1997-07-17
BG99521A (en) 1996-01-31
BR9307092A (pt) 1999-03-30
US20020115612A1 (en) 2002-08-22
JP3461505B2 (ja) 2003-10-27
EP0671928A4 (en) 1997-04-23
DE69332524D1 (de) 2003-01-16
NO950682D0 (no) 1995-02-23
CA2144067A1 (en) 1994-03-31
EP1258492A1 (en) 2002-11-20
JP3596752B2 (ja) 2004-12-02
JPH08501565A (ja) 1996-02-20
EP0671928B1 (en) 2002-11-27
HK1049173A1 (en) 2003-05-02
KR0168709B1 (ko) 1999-01-15
KR950703349A (ko) 1995-09-20
WO1994006451A1 (en) 1994-03-31
ATE228532T1 (de) 2002-12-15
AU5292093A (en) 1994-04-12

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