ATE234268T1 - Synthese von n-substituierten oligomeren - Google Patents

Synthese von n-substituierten oligomeren

Info

Publication number: ATE234268T1
Authority: AT; Austria
Prior art keywords: compounds; oligomers; substituted; nsgs; poly
Prior art date: 1995-06-07

Application number

AT96921278T

Other languages

English (en)

Inventor

Ronald N Zuckermann

Dane A Goff

Simon Ng

Kerry Spear

Barbara O Scott

Aaron C Sigmund

Richard A Goldsmith

Charles K Marlowe

Yazhong Pei

Lutz Richter

Reyna Simon

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-04

Publication date

2003-03-15

1996-06-04 Application filed by Chiron Corp filed Critical Chiron Corp

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE234268T1 publication Critical patent/ATE234268T1/de

Links

230000015572 biosynthetic process Effects 0.000 title abstract 4
238000003786 synthesis reaction Methods 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 abstract 5
239000000178 monomer Substances 0.000 abstract 4
108010049175 N-substituted Glycines Proteins 0.000 abstract 3
238000006073 displacement reaction Methods 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
230000010933 acylation Effects 0.000 abstract 2
238000005917 acylation reaction Methods 0.000 abstract 2
150000001923 cyclic compounds Chemical class 0.000 abstract 2
230000000269 nucleophilic effect Effects 0.000 abstract 2
238000012216 screening Methods 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
108010043958 Peptoids Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000005262 alkoxyamine group Chemical group 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
-1 cyclic organic compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
OWIUPIRUAQMTTK-UHFFFAOYSA-M n-aminocarbamate Chemical compound NNC([O-])=O OWIUPIRUAQMTTK-UHFFFAOYSA-M 0.000 abstract 1
239000000816 peptidomimetic Substances 0.000 abstract 1
125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
230000002797 proteolythic effect Effects 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1
125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Structural Engineering (AREA)
Gastroenterology & Hepatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Polyamides (AREA)
Furan Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT96921278T 1995-06-07 1996-06-04 Synthese von n-substituierten oligomeren ATE234268T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/487,282 US5877278A (en)	1992-09-24	1995-06-07	Synthesis of N-substituted oligomers
PCT/US1996/008832 WO1996040202A1 (en)	1995-06-07	1996-06-04	Synthesis of n-substituted oligomers

Publications (1)

Publication Number	Publication Date
ATE234268T1 true ATE234268T1 (de)	2003-03-15

Family

ID=23935100

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96921278T ATE234268T1 (de)	1995-06-07	1996-06-04	Synthese von n-substituierten oligomeren

Country Status (8)

Country	Link
US (1)	US5877278A (de)
EP (1)	EP0789577B1 (de)
JP (2)	JP3943593B2 (de)
AT (1)	ATE234268T1 (de)
AU (1)	AU6253496A (de)
CA (1)	CA2221517C (de)
DE (1)	DE69626621T2 (de)
WO (1)	WO1996040202A1 (de)

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US5288514A (en) *	1992-09-14	1994-02-22	The Regents Of The University Of California	Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
WO1994006451A1 (en) *	1992-09-24	1994-03-31	Chiron Corporation	Synthesis of n-substituted oligomers
US5539083A (en) *	1994-02-23	1996-07-23	Isis Pharmaceuticals, Inc.	Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE19910988A1 (de) *	1999-03-11	2000-09-14	Bosch Gmbh Robert	Elektronisches Gerät, insbesondere Fernmeldevermittlungsanlage

1995
- 1995-06-07 US US08/487,282 patent/US5877278A/en not_active Expired - Lifetime
1996
- 1996-06-04 AT AT96921278T patent/ATE234268T1/de not_active IP Right Cessation
- 1996-06-04 EP EP96921278A patent/EP0789577B1/de not_active Expired - Lifetime
- 1996-06-04 DE DE69626621T patent/DE69626621T2/de not_active Expired - Lifetime
- 1996-06-04 WO PCT/US1996/008832 patent/WO1996040202A1/en not_active Ceased
- 1996-06-04 CA CA002221517A patent/CA2221517C/en not_active Expired - Fee Related
- 1996-06-04 JP JP50131797A patent/JP3943593B2/ja not_active Expired - Fee Related
- 1996-06-04 AU AU62534/96A patent/AU6253496A/en not_active Abandoned
2005
- 2005-12-19 JP JP2005365635A patent/JP2006182780A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO1996040202A1 (en)	1996-12-19
CA2221517A1 (en)	1996-12-19
DE69626621D1 (de)	2003-04-24
US5877278A (en)	1999-03-02
CA2221517C (en)	2008-11-18
JP2006182780A (ja)	2006-07-13
DE69626621T2 (de)	2004-03-04
EP0789577A4 (de)	1998-07-22
EP0789577B1 (de)	2003-03-12
EP0789577A1 (de)	1997-08-20
JP3943593B2 (ja)	2007-07-11
JPH11507049A (ja)	1999-06-22
AU6253496A (en)	1996-12-30

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2003-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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