NO950757L - Antitussiv - Google Patents

Antitussiv

Info

Publication number
NO950757L
NO950757L NO950757A NO950757A NO950757L NO 950757 L NO950757 L NO 950757L NO 950757 A NO950757 A NO 950757A NO 950757 A NO950757 A NO 950757A NO 950757 L NO950757 L NO 950757L
Authority
NO
Norway
Prior art keywords
antitussives
salts
derivatives
useful
compound
Prior art date
Application number
NO950757A
Other languages
English (en)
Norwegian (no)
Other versions
NO950757D0 (no
Inventor
Hiroshi Nagase
Koji Kawai
Takashi Endoh
Shinya Ueno
Yuji Negishi
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO950757D0 publication Critical patent/NO950757D0/no
Publication of NO950757L publication Critical patent/NO950757L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO950757A 1993-06-30 1995-02-27 Antitussiv NO950757L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16162693 1993-06-30
PCT/JP1994/001047 WO1995001178A1 (en) 1993-06-30 1994-06-28 Antitussive

Publications (2)

Publication Number Publication Date
NO950757D0 NO950757D0 (no) 1995-02-27
NO950757L true NO950757L (no) 1995-04-27

Family

ID=15738765

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950757A NO950757L (no) 1993-06-30 1995-02-27 Antitussiv

Country Status (11)

Country Link
US (1) US5739145A (zh)
EP (1) EP0657163B1 (zh)
KR (1) KR950702833A (zh)
CN (1) CN1111900A (zh)
AU (1) AU683664B2 (zh)
CA (1) CA2143318A1 (zh)
DE (1) DE69413933T2 (zh)
FI (1) FI950908L (zh)
NO (1) NO950757L (zh)
TW (1) TW329386B (zh)
WO (1) WO1995001178A1 (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2121988T3 (es) 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
KR100341950B1 (ko) * 1993-07-19 2002-11-29 도레이 가부시끼가이샤 뇌세포보호제
NZ268969A (en) * 1993-07-23 1997-06-24 Toray Industries Morphinan derivatives and pharmaceutical compositions
EP0829481A1 (en) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan hydroxamic acid compounds
US6440987B1 (en) 1996-11-25 2002-08-27 Toray Industries, Inc. Antipruritic
DE69732868T2 (de) * 1996-11-25 2006-04-13 Toray Industries, Inc. Mittel gegen Juckreiz
US6403602B1 (en) * 1997-02-20 2002-06-11 The University Of Kentucky Research Foundation Morphine-6-sulfate analogues and their use for the treatment of pain
CN1204139C (zh) * 1999-08-24 2005-06-01 东丽株式会社 神经性疼痛治疗剂
WO2002080918A1 (en) * 2001-04-02 2002-10-17 Toray Industries, Inc. Remedial or prophylactic agent for frequent urination or urinary incontinence
WO2006109671A1 (ja) * 2005-04-06 2006-10-19 Toray Industries, Inc. モルヒナン誘導体の結晶及びその製造法
PL2151240T3 (pl) 2007-04-24 2014-01-31 Toray Industries Środek terapeutyczny lub profilaktyczny przeciw dyskinezie
EP2168580B1 (en) * 2007-06-22 2015-12-02 Toray Industries, Inc. Remedy or preventive for schizophrenia
ES2671897T3 (es) 2008-02-14 2018-06-11 Alkermes, Inc. Compuestos opioides selectivos
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398806A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
US8563724B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-吗啡喃*季盐及其制备方法
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
PH12012501552A1 (en) 2010-01-29 2017-04-26 Toray Industries Therapeutic or prophylactic agent for biliary diseases
WO2012054566A2 (en) * 2010-10-19 2012-04-26 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
CA2825165C (en) 2011-01-31 2018-07-03 Toray Industries, Inc. Therapeutic or prophylactic agent for cachexia
MX2014002630A (es) 2011-09-08 2014-04-14 Mallinckrodt Llc Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
EP4212532A3 (en) 2015-04-30 2023-09-27 Memorial Sloan Kettering Cancer Center Mitragynine analogs and uses thereof
CN105461727A (zh) * 2015-12-01 2016-04-06 吕涛 一种纳呋拉啡的精制方法
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN114736210A (zh) * 2022-03-29 2022-07-12 伊诺药物研究(南京)有限公司 吗啡喃衍生物的一种晶型的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB843908A (en) * 1957-12-20 1960-08-10 Hoffmann La Roche Novel morphinan derivatives and the manufacture thereof
FR1503524A (fr) * 1964-10-17 1967-12-01 Tanabe Seiyaku Co Morphine à noyaux b/c condensés en configuration trans, et son procédé de préparation
US3865943A (en) * 1971-02-19 1975-02-11 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(furyl-methyl)-3-oxy-morphinan and method of use
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3880863A (en) * 1973-08-31 1975-04-29 Warner Lambert Co 17-Aralkyl-6 beta-azido-4,5 alpha-epox-ymorphinan-3-01{hu s
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4730048A (en) * 1985-12-12 1988-03-08 Regents Of The University Of Minnesota Gut-selective opiates
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives
DE415693T1 (de) * 1989-08-28 1991-10-17 Arizona Technology Development Corp., Tucson, Ariz. Zusammensetzung und verfahren zur selektiven verstaerkung der opiat-wirkung und verminderung von opiat-toleranz und abhaengigkeit.
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.

Also Published As

Publication number Publication date
CA2143318A1 (en) 1995-01-12
WO1995001178A1 (en) 1995-01-12
EP0657163A4 (en) 1995-12-13
TW329386B (en) 1998-04-11
NO950757D0 (no) 1995-02-27
US5739145A (en) 1998-04-14
FI950908A0 (fi) 1995-02-28
EP0657163A1 (en) 1995-06-14
EP0657163B1 (en) 1998-10-14
FI950908A7 (fi) 1995-04-28
AU6984494A (en) 1995-01-24
DE69413933D1 (de) 1998-11-19
AU683664B2 (en) 1997-11-20
DE69413933T2 (de) 1999-04-08
KR950702833A (ko) 1995-08-23
FI950908L (fi) 1995-04-28
CN1111900A (zh) 1995-11-15

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