NO950757L - Antitussiv - Google Patents

Antitussiv

Info

Publication number
NO950757L
NO950757L NO950757A NO950757A NO950757L NO 950757 L NO950757 L NO 950757L NO 950757 A NO950757 A NO 950757A NO 950757 A NO950757 A NO 950757A NO 950757 L NO950757 L NO 950757L
Authority
NO
Norway
Prior art keywords
antitussives
salts
derivatives
useful
compound
Prior art date
Application number
NO950757A
Other languages
English (en)
Other versions
NO950757D0 (no
Inventor
Hiroshi Nagase
Koji Kawai
Takashi Endoh
Shinya Ueno
Yuji Negishi
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO950757D0 publication Critical patent/NO950757D0/no
Publication of NO950757L publication Critical patent/NO950757L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det tilveiebringes nye antitussiver som er forskjellig fra eksisterende antitussiver eller dem som er under utvik- ling. Antitussiver inneholder morfinanderivater representert ved forbindelse 6: OH O Me eller farmakologisk akseptable syreaddisjonssalter derav og disses derivater eller salter som aktive bestanddeler. Antitussivene i henhold til foreliggende oppfinnelse har sterk antitussiv virkning som sterkt selektive K-opioid-ago- nister, og kan således benyttes som nyttige antitussiver.
NO950757A 1993-06-30 1995-02-27 Antitussiv NO950757L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16162693 1993-06-30
PCT/JP1994/001047 WO1995001178A1 (en) 1993-06-30 1994-06-28 Antitussive

Publications (2)

Publication Number Publication Date
NO950757D0 NO950757D0 (no) 1995-02-27
NO950757L true NO950757L (no) 1995-04-27

Family

ID=15738765

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950757A NO950757L (no) 1993-06-30 1995-02-27 Antitussiv

Country Status (11)

Country Link
US (1) US5739145A (no)
EP (1) EP0657163B1 (no)
KR (1) KR950702833A (no)
CN (1) CN1111900A (no)
AU (1) AU683664B2 (no)
CA (1) CA2143318A1 (no)
DE (1) DE69413933T2 (no)
FI (1) FI950908L (no)
NO (1) NO950757L (no)
TW (1) TW329386B (no)
WO (1) WO1995001178A1 (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323212B1 (en) 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
EP0661283B1 (en) * 1993-07-19 1998-10-21 Toray Industries, Inc. Brain cell protective
EP0663401B1 (en) 1993-07-23 2000-06-07 Toray Industries, Inc. Morphinan derivative and medicinal use
EP0829481A1 (en) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan hydroxamic acid compounds
ATE359076T1 (de) 1996-11-25 2007-05-15 Toray Industries Mittel gegen juckreiz
US6440987B1 (en) 1996-11-25 2002-08-27 Toray Industries, Inc. Antipruritic
US6403602B1 (en) * 1997-02-20 2002-06-11 The University Of Kentucky Research Foundation Morphine-6-sulfate analogues and their use for the treatment of pain
DE60039444D1 (de) * 1999-08-24 2008-08-21 Toray Industries Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes
WO2002080918A1 (en) * 2001-04-02 2002-10-17 Toray Industries, Inc. Remedial or prophylactic agent for frequent urination or urinary incontinence
BRPI0608671B1 (pt) * 2005-04-06 2022-07-19 Toray Industries, Inc Processos para produzir um cristal de forma a de cloridrato de 17-ciclopropilmetil-3,14 b-diidróxi-4,5a-epóxi-6b-[n-metil-trans-3-(3-furil)-acril amido]-morfinano
WO2008133297A1 (ja) 2007-04-24 2008-11-06 Toray Industries, Inc. ジスキネジアの治療または予防剤
EP2168580B1 (en) * 2007-06-22 2015-12-02 Toray Industries, Inc. Remedy or preventive for schizophrenia
EP2252150B1 (en) 2008-02-14 2018-04-11 Alkermes, Inc. Selective opioid compounds
WO2010096790A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
MX362830B (es) 2010-01-29 2019-02-14 Toray Industries Agente terapeutico o profilactico para enfermedades del tracto biliar.
WO2012054566A2 (en) * 2010-10-19 2012-04-26 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
ES2586655T3 (es) 2011-01-31 2016-10-18 Toray Industries, Inc. (-)-17-(ciclopropilmetil)-3,14beta-dihidroxi-4,5alfa-epoxi-6beta-[N-metil-trans-3-(3-furil)acrilamido]morfinano para su utilización en el tratamiento o prevención de la caquexia por cáncer
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
WO2016176657A1 (en) 2015-04-30 2016-11-03 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
CN105461727A (zh) * 2015-12-01 2016-04-06 吕涛 一种纳呋拉啡的精制方法
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN114736210A (zh) * 2022-03-29 2022-07-12 伊诺药物研究(南京)有限公司 吗啡喃衍生物的一种晶型的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB843908A (en) * 1957-12-20 1960-08-10 Hoffmann La Roche Novel morphinan derivatives and the manufacture thereof
FR1503524A (fr) * 1964-10-17 1967-12-01 Tanabe Seiyaku Co Morphine à noyaux b/c condensés en configuration trans, et son procédé de préparation
US3865943A (en) * 1971-02-19 1975-02-11 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(furyl-methyl)-3-oxy-morphinan and method of use
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3880863A (en) * 1973-08-31 1975-04-29 Warner Lambert Co 17-Aralkyl-6 beta-azido-4,5 alpha-epox-ymorphinan-3-01{hu s
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4730048A (en) * 1985-12-12 1988-03-08 Regents Of The University Of Minnesota Gut-selective opiates
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives
EP0415693A1 (en) * 1989-08-28 1991-03-06 Arizona Technology Development Corporation Composition and method for selective enhancement of opiate activity and reduction of opiate tolerance and dependence
US6323212B1 (en) * 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications

Also Published As

Publication number Publication date
TW329386B (en) 1998-04-11
EP0657163A1 (en) 1995-06-14
FI950908A0 (fi) 1995-02-28
CA2143318A1 (en) 1995-01-12
AU6984494A (en) 1995-01-24
DE69413933D1 (de) 1998-11-19
WO1995001178A1 (en) 1995-01-12
KR950702833A (ko) 1995-08-23
CN1111900A (zh) 1995-11-15
AU683664B2 (en) 1997-11-20
FI950908A7 (fi) 1995-04-28
EP0657163B1 (en) 1998-10-14
FI950908L (fi) 1995-04-28
US5739145A (en) 1998-04-14
EP0657163A4 (en) 1995-12-13
NO950757D0 (no) 1995-02-27
DE69413933T2 (de) 1999-04-08

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