NO950758L - Fremgangsmåte for fremstilling og/eller rensing av clavulansyre - Google Patents

Fremgangsmåte for fremstilling og/eller rensing av clavulansyre

Info

Publication number
NO950758L
NO950758L NO950758A NO950758A NO950758L NO 950758 L NO950758 L NO 950758L NO 950758 A NO950758 A NO 950758A NO 950758 A NO950758 A NO 950758A NO 950758 L NO950758 L NO 950758L
Authority
NO
Norway
Prior art keywords
clavulanic acid
purification
preparation
oxylamine
tertiary
Prior art date
Application number
NO950758A
Other languages
English (en)
Other versions
NO950758D0 (no
Inventor
Michael Allen Cook
Robert Bennett Wilkins
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27450891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO950758(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB929212379A external-priority patent/GB9212379D0/en
Priority claimed from GB929222841A external-priority patent/GB9222841D0/en
Priority claimed from GB929226061A external-priority patent/GB9226061D0/en
Priority claimed from GB929226282A external-priority patent/GB9226282D0/en
Publication of NO950758L publication Critical patent/NO950758L/no
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to NO950758A priority Critical patent/NO950758D0/no
Publication of NO950758D0 publication Critical patent/NO950758D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60C—VEHICLE TYRES; TYRE INFLATION; TYRE CHANGING; CONNECTING VALVES TO INFLATABLE ELASTIC BODIES IN GENERAL; DEVICES OR ARRANGEMENTS RELATED TO TYRES
    • B60C27/00—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels
    • B60C27/006—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels provided with protective parts, e.g. rubber elements to protect the rim portion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60C—VEHICLE TYRES; TYRE INFLATION; TYRE CHANGING; CONNECTING VALVES TO INFLATABLE ELASTIC BODIES IN GENERAL; DEVICES OR ARRANGEMENTS RELATED TO TYRES
    • B60C27/00—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels
    • B60C27/06—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels extending over the complete circumference of the tread, e.g. made of chains or cables

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Det beskrives en fremgangsmåte for fremstilling og/eller rensing av clavulansyre eller dens farmasøytisk akseptable salter og estere. Isoleringen foregår over dannelse av et tertiært oksylaminsalt av clavulansyren.
NO950758A 1992-06-11 1995-02-27 Fremgangsmåte for fremstilling og/eller rensing av clavulansyre NO950758D0 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO950758A NO950758D0 (no) 1992-06-11 1995-02-27 Fremgangsmåte for fremstilling og/eller rensing av clavulansyre

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB929212379A GB9212379D0 (en) 1992-06-11 1992-06-11 Novel process
GB929222841A GB9222841D0 (en) 1992-10-31 1992-10-31 Novel process
GB929226061A GB9226061D0 (en) 1992-12-14 1992-12-14 Novel process
GB929226282A GB9226282D0 (en) 1992-12-17 1992-12-17 Novel process
PCT/GB1993/001206 WO1993025557A1 (en) 1992-06-11 1993-06-07 Process for the preparation of clavulanic acid
NO943093A NO943093L (no) 1992-06-11 1994-08-22 Fremgangsmåte for fremstilling av clavulansyre
NO950758A NO950758D0 (no) 1992-06-11 1995-02-27 Fremgangsmåte for fremstilling og/eller rensing av clavulansyre

Publications (2)

Publication Number Publication Date
NO950758L true NO950758L (no) 1994-12-09
NO950758D0 NO950758D0 (no) 1995-02-27

Family

ID=27450891

Family Applications (3)

Application Number Title Priority Date Filing Date
NO943093A NO943093L (no) 1992-06-11 1994-08-22 Fremgangsmåte for fremstilling av clavulansyre
NO950758A NO950758D0 (no) 1992-06-11 1995-02-27 Fremgangsmåte for fremstilling og/eller rensing av clavulansyre
NO951725A NO178499C (no) 1992-06-11 1995-05-03 Fremgangsmåte for fremstilling og/eller rensing av clavulansyre og diaminosalter av clavulansyre

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO943093A NO943093L (no) 1992-06-11 1994-08-22 Fremgangsmåte for fremstilling av clavulansyre

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO951725A NO178499C (no) 1992-06-11 1995-05-03 Fremgangsmåte for fremstilling og/eller rensing av clavulansyre og diaminosalter av clavulansyre

Country Status (35)

Country Link
EP (7) EP0699682A1 (no)
JP (3) JPH07507324A (no)
KR (1) KR0162264B1 (no)
CN (3) CN1037967C (no)
AP (3) AP473A (no)
AT (3) ATE146180T1 (no)
AU (3) AU4342793A (no)
BG (3) BG60999B1 (no)
CA (2) CA2160768A1 (no)
CS (1) CS202194A3 (no)
CY (1) CY1895A (no)
CZ (5) CZ267594A3 (no)
DE (6) DE69301571T2 (no)
DK (5) DK0672669T3 (no)
ES (3) ES2095059T3 (no)
FI (7) FI944031A7 (no)
GB (2) GB2287025B (no)
GR (4) GR950300070T1 (no)
HK (2) HK6996A (no)
HU (3) HUT69374A (no)
IL (1) IL105966A (no)
LU (1) LU88567A1 (no)
MA (1) MA22907A1 (no)
MX (1) MX9303441A (no)
MY (1) MY131501A (no)
NL (1) NL9320037A (no)
NO (3) NO943093L (no)
PT (2) PT101710A (no)
RO (3) RO111193B1 (no)
RU (1) RU2081121C1 (no)
SE (5) SE9404290L (no)
SI (1) SI9300296B (no)
SK (3) SK278561B6 (no)
UY (1) UY24154A1 (no)
WO (1) WO1993025557A1 (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
CZ284855B6 (cs) * 1993-03-26 1999-03-17 Dsm N.V. Soli klavulanové kyseliny s diaminy, způsob jejich výroby, farmaceutické přípravky na jejich bázi, použití těchto solí pro výrobu kyseliny klavulanové nebo jejích farmaceuticky vhodných solí nebo esterů a způsob čištění posledně uvedených látek
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
RU2135502C1 (ru) 1993-03-26 1999-08-27 Гист-Брокейдс Н.В. Диаминовые соли клавулановой кислоты, способ их получения (варианты), способ получения клавулановой кислоты или ее фармацевтически приемлемой соли, способ очистки клавулановой кислоты или ее соли
EP0658558B1 (en) 1993-11-17 2001-01-24 Biochemie Gesellschaft M.B.H. Separation of cephalosporin isomers
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
CZ266697A3 (en) * 1995-02-25 1997-11-12 Spurcourt Ltd Salts of clavulanic acid
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
WO1998021212A1 (en) * 1996-11-11 1998-05-22 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
WO2000004028A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
US6440708B1 (en) * 1998-09-29 2002-08-27 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
DE19917428A1 (de) * 1999-04-19 2000-10-26 Clariant Gmbh Flammwidrige phosphormodifizierte Epoxidharze
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
BRPI0110774B8 (pt) 2000-05-13 2021-05-25 Smithkline Beecham Plc processo para purificação de um sal de ácido clavulânico
ITMI20011764A1 (it) 2001-08-10 2003-02-10 Dinamite Dipharma Spa Metodo per l'ottenimento del pemirolast ad elevata purezza
GB201010439D0 (en) * 2010-06-21 2010-08-04 Arch Timber Protection Ltd A method
CN103304583B (zh) * 2013-07-09 2016-01-20 山东新时代药业有限公司 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
US11603582B2 (en) 2017-04-19 2023-03-14 Nippon Light Metal Company, Ltd. Al—Si—Fe-based aluminum alloy casting material and method for producing the same
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法
CN116283498B (zh) * 2023-03-07 2025-02-28 国药集团威奇达药业有限公司 从克拉维酸钾生产废液中回收有机溶剂的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1507978A (en) 1974-03-28 1978-04-19 Dunlop Ltd Pneumatic tyre and wheel rim assemblies
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1508978A (en) 1975-04-11 1978-04-26 Beecham Group Ltd Esters of clavulanic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
DE2861607D1 (en) * 1977-11-26 1982-03-11 Beecham Group Plc Derivatives of clavulanic acid and pharmaceutical compositions containing them
BE862211A (fr) 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
JPS5562993A (en) 1978-11-07 1980-05-12 Idemitsu Petrochem Co Ltd Operation of olefin manufacturing equipment
JPS55162993A (en) 1979-06-07 1980-12-18 Sanraku Inc Preparation of culavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AU600655B2 (en) * 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
FR2644543A1 (no) 1989-03-17 1990-09-21 Renault
PT94908B (pt) 1990-08-03 1998-05-29 Portela & Ca Lda Processo para a preparacao de derivados carboxilicos beta-lactamicos altamente purificados estaveis e hipoalergenicos
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
CZ284855B6 (cs) * 1993-03-26 1999-03-17 Dsm N.V. Soli klavulanové kyseliny s diaminy, způsob jejich výroby, farmaceutické přípravky na jejich bázi, použití těchto solí pro výrobu kyseliny klavulanové nebo jejích farmaceuticky vhodných solí nebo esterů a způsob čištění posledně uvedených látek
EP0887178A1 (de) 1997-06-27 1998-12-30 Pamag Ag Verfahren zum Bündeln von Seitenfaltbeuteln und Vorrichtung zur Durchführung des Verfahrens

Also Published As

Publication number Publication date
RU2081121C1 (ru) 1997-06-10
CN1041934C (zh) 1999-02-03
CN1037967C (zh) 1998-04-08
DK68595A (da) 1995-06-15
FI96952B (fi) 1996-06-14
SI9300296B (sl) 1998-06-30
HUT69374A (en) 1995-09-28
CZ125495A3 (en) 1996-06-12
JPH08157480A (ja) 1996-06-18
FI96952C (fi) 1998-05-20
EP0747383A3 (en) 1996-12-18
FI980630A0 (fi) 1998-03-20
EP0672670A1 (en) 1995-09-20
FI944031L (fi) 1994-10-24
CN1036592C (zh) 1997-12-03
CN1095069A (zh) 1994-11-16
AP474A (en) 1996-03-06
DE69313869D1 (de) 1997-10-16
SE9600797D0 (sv) 1996-02-29
RO111191B1 (ro) 1996-07-30
FI961739L (fi) 1996-04-22
GB9508496D0 (en) 1995-06-14
DE69301571T2 (de) 1996-07-18
CZ267694A3 (en) 1997-08-13
SK278520B6 (en) 1997-08-06
SE9600797L (sv) 1996-02-29
DK170569B1 (da) 1995-10-23
PT101710A (pt) 1995-12-29
CY1895A (en) 1996-09-27
WO1993025557A1 (en) 1993-12-23
FI982790A7 (fi) 1998-12-23
AP471A (en) 1996-03-06
SE9404290L (sv) 1995-01-16
MY131501A (en) 2007-08-30
CS202194A3 (cs) 1994-12-15
SE9501544L (sv) 1995-04-26
SE503077C2 (sv) 1996-03-18
DE69306574T2 (de) 1997-04-30
DE69301571D1 (de) 1996-03-28
HU212583B (en) 1996-08-29
EP0644887A1 (en) 1995-03-29
HUT68775A (en) 1995-07-28
FI980630A7 (fi) 1998-03-20
ES2095059T3 (es) 1997-02-01
CZ267594A3 (en) 1997-08-13
NO178499C (no) 1997-04-01
ATE146180T1 (de) 1996-12-15
SE9501544D0 (sv) 1995-04-26
NO951725D0 (no) 1995-05-03
FI952820L (fi) 1995-06-08
SE9704244D0 (sv) 1997-11-19
CZ19396A3 (en) 1997-08-13
KR950700914A (ko) 1995-02-20
BG99639A (bg) 1996-02-28
JPH07507324A (ja) 1995-08-10
DK0672670T3 (da) 1996-03-25
MX9303441A (es) 1994-03-31
NO943093L (no) 1994-12-09
SK278367B6 (en) 1997-01-08
FI982790L (fi) 1998-12-23
AU680099B2 (en) 1997-07-17
SE504220C2 (sv) 1996-12-09
CA2160768A1 (en) 1993-12-12
IL105966A (en) 1997-09-30
BG99131A (bg) 1995-08-28
SK153294A3 (en) 1995-05-10
LU88567A1 (fr) 1995-06-01
SE9500718L (sv) 1995-02-27
EP0672669A1 (en) 1995-09-20
GR3024666T3 (en) 1997-12-31
AU1471697A (en) 1997-05-22
PT101711A (pt) 1995-12-29
KR0162264B1 (ko) 1998-12-01
BG99640A (bg) 1996-02-28
BG61190B1 (bg) 1997-02-28
NO951725L (no) 1994-12-09
GB2287025B (en) 1997-02-26
DE69306574D1 (de) 1997-01-23
EP0801069A1 (en) 1997-10-15
FI944031A0 (fi) 1994-09-02
UY24154A1 (es) 1996-07-23
EP0672669B1 (en) 1997-09-10
ES2106615T3 (es) 1997-11-01
FI980630L (fi) 1998-03-20
EP0644887B1 (en) 1996-12-11
AP9300537A0 (en) 1993-07-31
EP0747383A2 (en) 1996-12-11
HK1003245A1 (en) 1998-10-16
EP0672670B1 (en) 1996-02-14
AU1473795A (en) 1995-06-22
IL105966A0 (en) 1993-10-20
FI104488B (fi) 2000-02-15
SK153394A3 (en) 1995-05-10
DK0672669T3 (da) 1997-12-22
SK99494A3 (en) 1995-04-12
AU681569B3 (en) 1997-08-28
AU665159B2 (en) 1995-12-14
ATE134192T1 (de) 1996-02-15
FI952820A0 (fi) 1995-06-08
GR3022006T3 (en) 1997-03-31
FI103973B (fi) 1999-10-29
HK1003222A1 (en) 1998-10-16
ES2080710T3 (es) 1996-05-16
FI982790A0 (fi) 1998-12-23
CN1112928A (zh) 1995-12-06
SE9404290D0 (sv) 1994-12-09
CZ54495A3 (en) 1997-08-13
NO950758D0 (no) 1995-02-27
CA2117538A1 (en) 1993-12-23
FI951414L (fi) 1995-03-24
CN1113244A (zh) 1995-12-13
RU95112522A (ru) 1997-02-10
RO111192B1 (ro) 1996-07-30
BG61306B1 (en) 1997-05-30
HU9501214D0 (en) 1995-06-28
JPH08134072A (ja) 1996-05-28
HU9500610D0 (en) 1995-04-28
HK1007311A1 (en) 1999-04-09
SK278561B6 (en) 1997-10-08
BG60999B1 (en) 1996-08-30
AU1786595A (en) 1995-07-06
HK6996A (en) 1996-01-19
ES2080710T1 (es) 1996-02-16
HU9402405D0 (en) 1994-10-28
FI944031A7 (fi) 1994-10-24
DE69313869T2 (de) 1998-01-29
FI980631L (fi) 1998-03-20
EP0699682A1 (en) 1996-03-06
GB2287026A (en) 1995-09-06
GB2287025A (en) 1995-09-06
DK0644887T3 (da) 1997-06-02
DE4392664T1 (de) 1995-06-01
FI980631A0 (fi) 1998-03-20
GB2287026B (en) 1995-11-01
FI980631A7 (fi) 1998-03-20
GB9508497D0 (en) 1995-06-14
DE4345286A1 (de) 1995-09-21
FI951414A0 (fi) 1995-03-24
MA22907A1 (fr) 1993-12-31
SE9500718D0 (sv) 1995-02-27
RO111193B1 (ro) 1996-07-30
CZ281102B6 (cs) 1996-06-12
AU4342793A (en) 1994-01-04
GR3019006T3 (en) 1996-05-31
FI961739A0 (fi) 1996-04-22
AP473A (en) 1996-03-06
SI9300296A (en) 1993-12-31
FI103973B1 (fi) 1999-10-29
EP0806426A1 (en) 1997-11-12
GR950300070T1 (en) 1996-01-31
DE4345311C1 (de) 1996-02-01
NO943093D0 (no) 1994-08-22
DK140694A (da) 1994-12-08
NO178499B (no) 1996-01-02
ATE157981T1 (de) 1997-09-15
NL9320037A (nl) 1995-06-01

Similar Documents

Publication Publication Date Title
NO943093L (no) Fremgangsmåte for fremstilling av clavulansyre
FI862878L (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten hyaluronihapon täydellisten ja osittaisten esterien sekä näiden suolojen valmistamiseksi
GB2219795B (en) Method of producing optically active beta-lactam derivatives
AU1397892A (en) New crystallised microporous gallium phosphate and its substituted derivatives and a method of preparing them
DE69319296D1 (de) Verfahren zur Reinigung von roher Clavulansäure
DE3566404D1 (en) Substituted benzopyrans, process for their preparation and their use in medicines
NO301372B1 (no) Fremgangsmåte for fremstilling av et farmasöytisk tålbart salt av klavulansyre
HUT45060A (en) Process for producing new 4-pindone derivatives and physiologically tolerable salts and esters thereof
NO932722D0 (no) Salter av et 4-amino-3acyl-kinolinderivat og deres anvendelse som inhibatorer for gastrisk syresekresjon
SI0811689T1 (en) Process for the production of clavulanic acid and/or salts thereof
AU3072889A (en) Process for the preparation of optically active 4-oxo-1- benzopyran-2-carboxylic acid derivatives and intermediates thereof
AU2706788A (en) Method of inhibiting virus
NO165393C (no) Fremgansmaate for fremstilling av aryloksypropanolaminer og salter av disse med difenyleddiksyre.
PL324855A1 (en) Isolation of clavulanic acid from fermentation broth by ultrafiltration
HU9201412D0 (en) Process for the enzymatic hydrolysis of carbonic acid derivatives
FI935712L (fi) Menetelmä optisesti aktiivisten transglysidihappoestereiden entsyaattiseksi valmistamiseksi
NO944336L (no) Enzymatisk fremgangsmåte for fremstilling av S-6-metoksy- -metyl-2-naftaleneddiksyre
AU8051891A (en) Means for treatment of diseases caused by microorganisms which is a solution of sodium thiosulphate and a weak acid and method of preparing it
CA2105861A1 (en) Fish Production
AU9008091A (en) Process for the preparation of optically active esters of quinoxalinyloxyphenoxypropionic acid
HUT47232A (en) Process for the racemization of optically active chrysanthemic acid derivatives
MY107389A (en) Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
IE39474L (en) PHENYL-BENZ[f] ISOINDOLINES
NO179207C (no) Analogifremgangsmåte til fremstilling av en terapeutisk aktiv forbindelse
NO173828C (no) Fremgangsmaate for fremstilling av 1,2-dihydro-3H-pyrrolo-(1,2-a)-pyrrol-1,7-dicarboxylsyre og dennes lavere dialkylestere