NO950762L - Sulfaterte orer - Google Patents

Sulfaterte orer

Info

Publication number
NO950762L
NO950762L NO950762A NO950762A NO950762L NO 950762 L NO950762 L NO 950762L NO 950762 A NO950762 A NO 950762A NO 950762 A NO950762 A NO 950762A NO 950762 L NO950762 L NO 950762L
Authority
NO
Norway
Prior art keywords
sulfated
integer
ores
independently
selectin
Prior art date
Application number
NO950762A
Other languages
English (en)
Other versions
NO950762D0 (no
Inventor
Jacques Banville
Alain Martel
Alejandro A Aruffo
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO950762D0 publication Critical patent/NO950762D0/no
Publication of NO950762L publication Critical patent/NO950762L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Sulfaterte p-glykolipidforbindelser med formelen R40. OR« tfO NHR OR" hvor R er en acylrest av en fettsyre, R er -(CH=CH)m-(CH2)n-CH3, R2, R3, R4 og R6 er uavhengig av hverandre minst to -S03H, R2, R3, R4, R5 og R^ er hver uavhengig av hverandre hydrogen, usubstituert eller sub- stituert alkanoyl, arylalkyl eller arylkarbonyl hvor sub- stituenten er valgt blant halogen, Cj__4~alkyl, trifluor- metyl, hydroksy og C^-alkoksy, eller R4 og R6 er sammen benzyliden, eller R3 og R6 er sammen isopropyliden, m er et helt tall O eller l, n er et helt tall fra 5-14 inklusive, eller et ikke-toksisk, farmasøytisk akseptabelt salt, solvat eller hydrat derav som er inhibitorer av selectinforårsaket celleadhesjon og som er anvendelige til behandling eller hindring av betennelsessykdommer og andre patologiske tilstander i pattedyr.
NO950762A 1994-03-04 1995-02-28 Sulfaterte orer NO950762L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20606794A 1994-03-04 1994-03-04

Publications (2)

Publication Number Publication Date
NO950762D0 NO950762D0 (no) 1995-02-28
NO950762L true NO950762L (no) 1995-09-05

Family

ID=22764838

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950762A NO950762L (no) 1994-03-04 1995-02-28 Sulfaterte orer

Country Status (14)

Country Link
US (1) US5565433A (no)
EP (1) EP0671406A3 (no)
JP (1) JPH07285985A (no)
KR (1) KR950032259A (no)
CN (1) CN1111638A (no)
AU (1) AU1360495A (no)
CA (1) CA2142153A1 (no)
FI (1) FI951002A7 (no)
HU (1) HUT70433A (no)
IL (1) IL112734A0 (no)
NO (1) NO950762L (no)
PL (1) PL307523A1 (no)
RU (1) RU95103099A (no)
ZA (1) ZA951144B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048443A1 (en) * 1996-06-19 1997-12-24 Becton Dickinson And Company Iontophoretic delivery of cell adhesion inhibitors
DE19700774A1 (de) * 1997-01-13 1998-07-16 Hoechst Ag Antiadhäsive Sulfatid-Mimetika
CA2459482C (en) * 2001-08-16 2010-09-28 Daiichi Suntory Pharma Co., Ltd. Novel glycolipid and medicine for autoimmune disease containing the same as active ingredient
US7084122B2 (en) 2001-11-21 2006-08-01 Erik Larsen Use of glycosides of mono- and diacyglycerol as anti-inflammatory agents
WO2007038785A1 (en) * 2005-09-29 2007-04-05 Torrey Pines Institute For Molecular Studies Sulfatides for treatment of autoimmune disorders
US20110118197A1 (en) * 2005-09-29 2011-05-19 Vipin Kumar Chaturvedi Prevention of hepatic ischemic reperfusion injury by administration of sulfatides
BR112013017382B1 (pt) 2011-01-05 2021-03-16 National Taiwan University método de preparação de um composto de fórmula (5)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164388A (en) * 1966-06-14 1969-09-17 Shionogi & Co Crystalline Sulfur-Containing Glycolipid and the Production Thereof.
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
ATE71104T1 (de) * 1985-08-13 1992-01-15 Solco Basel Ag Neues verfahren zur herstellung von sphingosinderivaten.
JPH0317020A (ja) * 1989-06-14 1991-01-25 Nippon Koutai Kenkyusho:Kk 抗ｈｉｖ剤
ATE224911T1 (de) * 1990-07-17 2002-10-15 Univ Oklahoma Gmp-140 ligand
US5211937A (en) * 1990-07-30 1993-05-18 Glycomed Incorporated Method of determining a site of inflammation utilizing elam-1 ligands
DK84691D0 (da) * 1991-05-07 1991-05-07 Karsten Buschard Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater
WO1993005803A1 (en) * 1991-09-25 1993-04-01 Genetics Institute, Inc. Anti-inflammatory selectin inhibitors
US5326752A (en) * 1991-11-27 1994-07-05 Glycomed Incorporated Substituted lactose and lactosamine derivatives as cell adhesion inhibitors

Also Published As

Publication number Publication date
CA2142153A1 (en) 1995-09-05
RU95103099A (ru) 1997-03-20
ZA951144B (en) 1996-08-13
HU9500656D0 (en) 1995-04-28
KR950032259A (ko) 1995-12-20
PL307523A1 (en) 1995-09-18
US5565433A (en) 1996-10-15
FI951002L (fi) 1995-09-05
EP0671406A3 (en) 1995-11-08
EP0671406A2 (en) 1995-09-13
JPH07285985A (ja) 1995-10-31
CN1111638A (zh) 1995-11-15
IL112734A0 (en) 1995-05-26
NO950762D0 (no) 1995-02-28
FI951002A0 (fi) 1995-03-03
HUT70433A (en) 1995-10-30
AU1360495A (en) 1995-09-14
FI951002A7 (fi) 1995-09-05

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