NO951133L - Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivater - Google Patents
Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivaterInfo
- Publication number
- NO951133L NO951133L NO951133A NO951133A NO951133L NO 951133 L NO951133 L NO 951133L NO 951133 A NO951133 A NO 951133A NO 951133 A NO951133 A NO 951133A NO 951133 L NO951133 L NO 951133L
- Authority
- NO
- Norway
- Prior art keywords
- amino
- renin
- oxoethyl
- inhibiting
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Beskrevet heri er forbindelser med formelen: CCOJCHjCHR^fOJ-B, hvori A er R3R*NC(O)CH2 hvori, f.eks., R3 er hydrogen eller alkyl og R* er hydrogen, alkyl eller en substituert alkyl slik som 2-(2-pyridinyl)etyl, eller R3 og R* sammen med det nitrogenatom som de er bundet til, danner en pyrrolidino, piperidino, morfolino eller tiomorfolino; R1 er f.eks. benzyl, alkyl eller en substituert alkyl slik som cykloheksylmetyl; R2 er f.eks. alkyl, cykloalkylmetyl, 1H- imidazol-4-ylmetyl, 4-tiazolylmetyl eller (2-amino-4-tia- zolyl)metyl; og B er en reninsubstrat-overgangstilstands- analog, f.eks. [l(S)-(cykloheksylmetyl)-2(R),3(S)-dihydroksy- 5-metylheksyl]amino. Forbindelsene inhiberer reninaktivitet og er egnet for behandling av hypertensjon og kongestiv hjer- tesvikt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95147892A | 1992-09-25 | 1992-09-25 | |
| PCT/CA1993/000380 WO1994007846A1 (en) | 1992-09-25 | 1993-09-15 | Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO951133D0 NO951133D0 (no) | 1995-03-24 |
| NO951133L true NO951133L (no) | 1995-05-24 |
Family
ID=25491725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO951133A NO951133L (no) | 1992-09-25 | 1995-03-24 | Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivater |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5541163A (no) |
| EP (1) | EP0589445B1 (no) |
| JP (1) | JP3490442B2 (no) |
| KR (1) | KR950703520A (no) |
| CN (1) | CN1090278A (no) |
| AT (1) | ATE147720T1 (no) |
| AU (1) | AU680829B2 (no) |
| BG (1) | BG99542A (no) |
| BR (1) | BR9307110A (no) |
| CA (1) | CA2143300C (no) |
| CO (1) | CO4560549A1 (no) |
| CZ (1) | CZ74895A3 (no) |
| DE (1) | DE69307446T2 (no) |
| EE (1) | EE03083B1 (no) |
| FI (1) | FI951398A7 (no) |
| HU (2) | HUT70432A (no) |
| IL (1) | IL107092A (no) |
| LT (1) | LT3072B (no) |
| LV (1) | LV10945B (no) |
| MX (1) | MX9305918A (no) |
| NO (1) | NO951133L (no) |
| NZ (1) | NZ255301A (no) |
| PH (1) | PH30881A (no) |
| PL (1) | PL174454B1 (no) |
| RU (1) | RU95113586A (no) |
| SK (1) | SK37695A3 (no) |
| TW (1) | TW239117B (no) |
| WO (1) | WO1994007846A1 (no) |
| ZA (1) | ZA937079B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3490441B2 (ja) * | 1992-09-25 | 2004-01-26 | ベーリンガー インゲルハイム （カナダ） リミテッド | レニン阻害剤としてのｎ−（ヒドロキシエチル）ブタンジアミド誘導体 |
| CA2165996C (en) * | 1995-12-22 | 2002-01-29 | Murray Douglas Bailey | Stereoselective preparation of 2-substituted succinic derivatives |
| US6096759A (en) | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| US20050209141A1 (en) * | 2003-10-17 | 2005-09-22 | Silver Randi B | Mast cell-derived renin |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5006511A (en) * | 1981-10-14 | 1991-04-09 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa |
| EP0278158A3 (en) | 1986-11-12 | 1990-05-23 | Merck & Co. Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| US4839357A (en) | 1987-10-02 | 1989-06-13 | Merck & Co., Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| EP0312283A3 (en) * | 1987-10-14 | 1990-05-09 | Merck & Co. Inc. | Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa |
| US5001113A (en) | 1987-10-14 | 1991-03-19 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA |
| CA1329680C (en) * | 1987-11-23 | 1994-05-17 | Harold Norris Weller, Iii | N-heterocyclic alcohol derivatives |
| US5055466A (en) * | 1987-11-23 | 1991-10-08 | E. R. Squibb & Sons, Inc. | N-morpholino derivatives and their use as anti-hypertensive agents |
| NO892728L (no) * | 1988-07-01 | 1990-01-02 | Searle & Co | Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler. |
| IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
| US5063208A (en) * | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
| ATE135368T1 (de) * | 1989-09-12 | 1996-03-15 | Hoechst Ag | Aminosäurederivate mit reninhemmenden eigenschaften, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| JPH0532602A (ja) * | 1991-07-26 | 1993-02-09 | Terumo Corp | ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤 |
-
1993
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Withdrawn
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 CA CA002143300A patent/CA2143300C/en not_active Expired - Fee Related
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/en not_active Ceased
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-15 FI FI951398A patent/FI951398A7/fi not_active Application Discontinuation
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-23 EP EP93115326A patent/EP0589445B1/en not_active Expired - Lifetime
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
-
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/xx unknown
-
1995
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
-
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO986055D0 (no) | Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat | |
| IL193244A0 (en) | Amine derivatives useul for the synthesis of ceramide-like compounds and methods utilizing the same | |
| AU6216686A (en) | Heterocyclic-substituted indole | |
| AU7607791A (en) | 4-(Piperazinyl, morpholinyl, or thiomorpholinyl) sulphonyl derivatives used as renin inhibitors, compositions and processes for their production | |
| MX9800718A (es) | Derivados de 2-(4-substituidos)-bencilamino-2-metil- propanamida. | |
| EP0749966A4 (en) | 5-HT 3-RECEPTOR AGONISTS, NEW THIAZOLE DERIVATIVES AND INTERMEDIATE PRODUCTS | |
| NO951133D0 (no) | Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivater | |
| NO982927L (no) | Biologisk aktive benzotiazolon etanaminer | |
| DK491089D0 (da) | Benzoxazepinon og fremgangsmaade til fremstilling deraf samt mellemprodukt til brug i fremgangsmaaden | |
| HU9500872D0 (en) | N-(hydroxyethyl)butanediamide derivatives as renin inhibitors | |
| NO941073L (no) | Fenylglycinamid av heterocykliske, substituerte fenyleddiksyrederivater | |
| CA2257322C (en) | Thiazole derivatives | |
| DK0681584T3 (da) | Kondenserede, heterocykliske glutaminsyrederivater som antiproliferative midler | |
| DE3788955D1 (de) | Pyridinyl-Derivate von 2-Aminoacetamid. | |
| MX9703363A (es) | Nuevos derivados de pirimidiniloxi- y pirimidinilamino etilfenil-dioxolano. | |
| NO930776L (no) | Tetrahydropyrimidin-derivater |