NO952959L - Aza-alifatiske broinneholdende chinolin-2,3-dion - Google Patents
Aza-alifatiske broinneholdende chinolin-2,3-dionInfo
- Publication number
- NO952959L NO952959L NO952959A NO952959A NO952959L NO 952959 L NO952959 L NO 952959L NO 952959 A NO952959 A NO 952959A NO 952959 A NO952959 A NO 952959A NO 952959 L NO952959 L NO 952959L
- Authority
- NO
- Norway
- Prior art keywords
- optionally
- stands
- esterified
- hydroxy
- formula
- Prior art date
Links
- ADXCEOBGDCQCKM-UHFFFAOYSA-N quinoline-2,3-dione Chemical compound C1=CC=CC2=NC(=O)C(=O)C=C21 ADXCEOBGDCQCKM-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 carboxy, carbamoyl Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003257 excitatory amino acid Substances 0.000 abstract 1
- 230000002461 excitatory amino acid Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Aza-allfatlske broinneholdende chlnoksalln-2,3-dloner ! med formel I, (I) hvor -AI står for laverealkyllden eller en gruppe med formelen >CH-A4-R4 (la), A2 står for laverealkyliden eller en gruppe med formlene >CH-A4-R4 (la) eller >C-0 (lb) eller >CH(OH)-A5-R4 (Ic), A3 står for en ! gruppe med formelen ZN-A^-R5 (Id), A4 står for lavere- !, alkylen, A$ og A£ står uavhengig av hverandre for lave- realkylen eller en direkte binding, n står for O eller l, Rj og R£ står uavhengig av hverandre for hydrogen, 1 i eventuelt med laverealkyl og/eller laverealkanoylsubs- i. tltuert amlno, nltro, laverealkanoyl, eventuelt foret- ret hydroksy, eventuelt forestret karboksy, karbamoyl, 1 cyano, eventuelt halogenert laverealkyl eller halogen, || R3 står for hydrogen eller hydroksy, R4 står eventuelt for forestret eller amldert karboksy, eventuelt for- estret fosfono eller 5-tetrazolyl og RS står for hydro- gen, laverealkyl, laverealkenyl, laverealklnyl, aryl, laverealkanoyl, eventuelt forestret eller amidert kar- boksy, cyano, 5-tetrazolyl, eventuelt foretret eller forestret hydroksy eller dlhydroksylaverealkyl og deres salter, har antagonistiske egenskaper og overfor eksi- tatoriske aminosyre, og kan bil anvendt som antlkonvul- slv og antl-neurodegeneratlve legemiddelvlrkestoffer. Det blir dessuten beskrevet fremgangsmåter for frem- tilllng av disse forbindelsene, farmasøytiske prepa- rater Inneholdende dem samt deres anvendelse som lege- middelvirkestoff .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH236694 | 1994-07-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO952959D0 NO952959D0 (no) | 1995-07-26 |
| NO952959L true NO952959L (no) | 1996-01-29 |
Family
ID=4232111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO952959A NO952959L (no) | 1994-07-27 | 1995-07-26 | Aza-alifatiske broinneholdende chinolin-2,3-dion |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0705834A1 (no) |
| JP (1) | JPH0873465A (no) |
| KR (1) | KR960004346A (no) |
| CN (1) | CN1117493A (no) |
| AU (1) | AU2711695A (no) |
| BR (1) | BR9503458A (no) |
| CA (1) | CA2154624A1 (no) |
| FI (1) | FI953549A7 (no) |
| HU (1) | HUT73438A (no) |
| IL (1) | IL114729A0 (no) |
| NO (1) | NO952959L (no) |
| NZ (1) | NZ272639A (no) |
| ZA (1) | ZA956209B (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9711274B (en) * | 1996-12-16 | 1998-06-23 | Warner Lambert Co | Tricyclic quinoxaline derivatives as neuroprotective agents. |
| AU9651198A (en) | 1997-11-11 | 1999-05-31 | Ono Pharmaceutical Co. Ltd. | Fused pyrazine compounds |
| CN102630227B (zh) | 2009-10-26 | 2016-03-23 | 沃纳奇尔科特有限责任公司 | 用于治疗骨代谢紊乱的双膦酸盐化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK715888D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| DK716188D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| ES2067744T3 (es) * | 1989-06-09 | 1995-04-01 | Upjohn Co | Aminas heterociclicas con actividad sobre el sistema nervioso central. |
| JPH05117276A (ja) * | 1991-10-23 | 1993-05-14 | Sumitomo Pharmaceut Co Ltd | 新規な３環性キノキサリンジオン誘導体 |
| WO1994000124A1 (en) * | 1992-06-22 | 1994-01-06 | Eckard Weber | Glycine receptor antagonists and the use thereof |
| ATE157977T1 (de) * | 1992-10-13 | 1997-09-15 | Warner Lambert Co | Chinoxalinderivate als eaa antagonisten |
| US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
-
1995
- 1995-07-18 EP EP95810470A patent/EP0705834A1/de not_active Withdrawn
- 1995-07-20 AU AU27116/95A patent/AU2711695A/en not_active Abandoned
- 1995-07-24 FI FI953549A patent/FI953549A7/fi not_active Application Discontinuation
- 1995-07-25 CA CA002154624A patent/CA2154624A1/en not_active Abandoned
- 1995-07-25 NZ NZ272639A patent/NZ272639A/en unknown
- 1995-07-25 JP JP7189177A patent/JPH0873465A/ja active Pending
- 1995-07-25 IL IL11472995A patent/IL114729A0/xx unknown
- 1995-07-26 HU HU9502240A patent/HUT73438A/hu unknown
- 1995-07-26 BR BR9503458A patent/BR9503458A/pt not_active Application Discontinuation
- 1995-07-26 CN CN95108718A patent/CN1117493A/zh active Pending
- 1995-07-26 KR KR1019950022224A patent/KR960004346A/ko not_active Withdrawn
- 1995-07-26 ZA ZA956209A patent/ZA956209B/xx unknown
- 1995-07-26 NO NO952959A patent/NO952959L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2711695A (en) | 1996-02-08 |
| BR9503458A (pt) | 1996-02-27 |
| JPH0873465A (ja) | 1996-03-19 |
| HU9502240D0 (en) | 1995-09-28 |
| NZ272639A (en) | 1997-05-26 |
| ZA956209B (en) | 1996-01-29 |
| KR960004346A (ko) | 1996-02-23 |
| FI953549A0 (fi) | 1995-07-24 |
| CN1117493A (zh) | 1996-02-28 |
| NO952959D0 (no) | 1995-07-26 |
| FI953549A7 (fi) | 1996-01-28 |
| EP0705834A1 (de) | 1996-04-10 |
| IL114729A0 (en) | 1995-11-27 |
| CA2154624A1 (en) | 1996-01-28 |
| HUT73438A (en) | 1996-07-29 |
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