NO953352D0 - Ortosubstituerte benzosyrederivater - Google Patents

Ortosubstituerte benzosyrederivater

Info

Publication number: NO953352D0
Authority: NO; Norway
Prior art keywords: benzoic acid; halogen; ortho; acid derivatives; substituted benzoic
Prior art date: 1994-08-28

Application number

NO953352A

Other languages

English (en)

Other versions

NO953352L (no

NO305794B1 (no

Inventor

Rolf Gericke

Dieter Dorsch

Manfred Baumgarth

Klaus-Otto Minck

Norbert Beier

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-28

Filing date

1995-08-25

Publication date

1995-08-25

1995-08-25 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1995-08-25 Publication of NO953352D0 publication Critical patent/NO953352D0/no

1996-02-29 Publication of NO953352L publication Critical patent/NO953352L/no

1999-07-26 Publication of NO305794B1 publication Critical patent/NO305794B1/no

Links

150000001558 benzoic acid derivatives Chemical class 0.000 title 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 2
108010081348 HRT1 protein Hairy Proteins 0.000 abstract 2
102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 2
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
239000005711 Benzoic acid Substances 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
241000972349 Ocoa Species 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
235000010233 benzoic acid Nutrition 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO953352A 1994-08-28 1995-08-25 Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler NO305794B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4430212A DE4430212A1 (de)	1994-08-28	1994-08-28	Ortho-substituierte Benzoesäure-Derivate

Publications (3)

Publication Number	Publication Date
NO953352D0 true NO953352D0 (no)	1995-08-25
NO953352L NO953352L (no)	1996-02-29
NO305794B1 NO305794B1 (no)	1999-07-26

Family

ID=6526569

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO953352A NO305794B1 (no)	1994-08-28	1995-08-25	Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler

Country Status (23)

Country	Link
US (1)	US5849796A (no)
EP (1)	EP0704431B1 (no)
JP (1)	JPH0859602A (no)
KR (1)	KR100406686B1 (no)
CN (1)	CN1068587C (no)
AT (1)	ATE193282T1 (no)
AU (1)	AU703633B2 (no)
BR (1)	BR9503817A (no)
CA (1)	CA2156959A1 (no)
CZ (1)	CZ289492B6 (no)
DE (2)	DE4430212A1 (no)
DK (1)	DK0704431T3 (no)
ES (1)	ES2147810T3 (no)
GR (1)	GR3033989T3 (no)
HU (1)	HUT74946A (no)
NO (1)	NO305794B1 (no)
PL (1)	PL181183B1 (no)
PT (1)	PT704431E (no)
RU (1)	RU2125981C1 (no)
SK (1)	SK282202B6 (no)
TW (1)	TW406067B (no)
UA (1)	UA44238C2 (no)
ZA (1)	ZA957161B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19713427A1 (de) *	1997-04-01	1998-10-08	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19919349A1 (de) *	1999-04-28	2000-11-02	Merck Patent Gmbh	Verfahren zur Herstellung eines Benzoylguanidinderivates
AU2001293555A1 (en) *	2000-09-21	2002-04-02	Novation Pharmaceuticals Inc.	Benzoic acid derivatives and uses thereof
CN101284773A (zh) *	2001-08-09	2008-10-15	小野药品工业株式会社	羧酸衍生物及以它为活性成分的药剂
US8980952B2 (en) *	2002-03-20	2015-03-17	University Of Maryland, Baltimore	Methods for treating brain swelling with a compound that blocks a non-selective cation channel
EP2438913B1 (en) *	2002-03-20	2020-05-06	University of Maryland, Baltimore	A non-selective cation channel in neural cells and compounds that block the channel for use in treating brain swelling
EP1802313B1 (en) *	2004-09-18	2010-11-03	University of Maryland, Baltimore	Therapeutic agents trageting the ncca-atp channel and methods of use thereof
JP5085326B2 (ja) *	2004-09-18	2012-11-28	ユニバーシティオブメリーランド，ボルチモア	ＮＣＣａ−ＡＴＰチャネルを標的とする処置剤およびその使用方法
UA95244C2 (ru) *	2005-06-22	2011-07-25	Плексикон, Инк.	Соединения и способ модулирования активности киназ, и показания для их применения
US9511075B2 (en) *	2007-01-12	2016-12-06	The University Of Maryland, Baltimore	Targeting NCCA-ATP channel for organ protection following ischemic episode
EP2114160B1 (en) *	2007-02-09	2016-11-16	University of Maryland, Baltimore	Antagonists of a non-selective cation channel in neural cells
CA2691199C (en)	2007-06-22	2017-09-12	Marc J. Simard	Inhibitors of ncca-atp channels for therapy
LT6401B (lt) *	2015-07-28	2017-06-12	Vilniaus Universitetas	Karboanhidrazės selektyvūs inhibitoriai
CN105732357A (zh) *	2016-03-23	2016-07-06	叶芳	2-氯-4氟苯甲酸及其制备方法
CN106892852B (zh) *	2017-03-21	2019-07-09	重庆医科大学	具有抗流感病毒活性的胍基类似物及其制备方法
CN111116395B (zh) *	2019-12-27	2023-04-07	湖北工业大学	多碘代芳香酸类化合物及其在抗腺病毒7型中的应用
WO2025215115A1 (en) *	2024-04-09	2025-10-16	B&A Oncomedical	Compounds for use the treatment of cancer, neurodegenerative diseases, psychiatric disorders, inflammation, epilepsy and seizures

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DK0556674T3 (da) *	1992-02-15	1996-10-14	Hoechst Ag	3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation
EP0556673B1 (de) *	1992-02-15	1997-09-17	Hoechst Aktiengesellschaft	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DK0577024T3 (no) *	1992-07-01	1997-02-24	Hoechst Ag
EP0589336B1 (de) *	1992-09-22	1997-01-08	Hoechst Aktiengesellschaft	Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
TW250479B (no) *	1992-12-15	1995-07-01	Hoechst Ag
DE4404183A1 (de) *	1994-02-10	1995-08-17	Merck Patent Gmbh	4-Amino-1-piperidylbenzoylguanidine
DE4422685A1 (de) *	1994-06-29	1996-01-04	Hoechst Ag	Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

1994
- 1994-08-28 DE DE4430212A patent/DE4430212A1/de not_active Withdrawn
1995
- 1995-07-25 TW TW084107705A patent/TW406067B/zh not_active IP Right Cessation
- 1995-08-18 PT PT95112998T patent/PT704431E/pt unknown
- 1995-08-18 EP EP95112998A patent/EP0704431B1/de not_active Expired - Lifetime
- 1995-08-18 AT AT95112998T patent/ATE193282T1/de not_active IP Right Cessation
- 1995-08-18 DE DE59508383T patent/DE59508383D1/de not_active Expired - Fee Related
- 1995-08-18 ES ES95112998T patent/ES2147810T3/es not_active Expired - Lifetime
- 1995-08-18 DK DK95112998T patent/DK0704431T3/da active
- 1995-08-21 AU AU30145/95A patent/AU703633B2/en not_active Ceased
- 1995-08-23 UA UA95083919A patent/UA44238C2/uk unknown
- 1995-08-25 NO NO953352A patent/NO305794B1/no not_active IP Right Cessation
- 1995-08-25 CA CA002156959A patent/CA2156959A1/en not_active Abandoned
- 1995-08-25 CN CN95116623A patent/CN1068587C/zh not_active Expired - Fee Related
- 1995-08-25 RU RU95114389/04A patent/RU2125981C1/ru not_active IP Right Cessation
- 1995-08-25 HU HU9502500A patent/HUT74946A/hu unknown
- 1995-08-25 PL PL95310192A patent/PL181183B1/pl not_active IP Right Cessation
- 1995-08-25 CZ CZ19952181A patent/CZ289492B6/cs not_active IP Right Cessation
- 1995-08-25 ZA ZA957161A patent/ZA957161B/xx unknown
- 1995-08-25 SK SK1054-95A patent/SK282202B6/sk unknown
- 1995-08-28 BR BR9503817A patent/BR9503817A/pt not_active IP Right Cessation
- 1995-08-28 US US08/520,340 patent/US5849796A/en not_active Expired - Fee Related
- 1995-08-28 KR KR1019950026798A patent/KR100406686B1/ko not_active Expired - Fee Related
- 1995-08-28 JP JP7240500A patent/JPH0859602A/ja active Pending
2000
- 2000-07-21 GR GR20000401675T patent/GR3033989T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR3033989T3 (en)	2000-11-30
HUT74946A (en)	1997-03-28
JPH0859602A (ja)	1996-03-05
DE59508383D1 (de)	2000-06-29
AU3014595A (en)	1996-03-14
PT704431E (pt)	2000-10-31
US5849796A (en)	1998-12-15
KR960007539A (ko)	1996-03-22
UA44238C2 (uk)	2002-02-15
CN1125722A (zh)	1996-07-03
HU9502500D0 (en)	1995-10-30
PL181183B1 (pl)	2001-06-29
CZ289492B6 (cs)	2002-02-13
RU2125981C1 (ru)	1999-02-10
NO953352L (no)	1996-02-29
SK282202B6 (sk)	2001-12-03
DK0704431T3 (da)	2000-09-11
DE4430212A1 (de)	1996-02-29
ZA957161B (en)	1996-04-17
TW406067B (en)	2000-09-21
CZ218195A3 (en)	1996-03-13
AU703633B2 (en)	1999-03-25
ES2147810T3 (es)	2000-10-01
SK105495A3 (en)	1996-03-06
NO305794B1 (no)	1999-07-26
BR9503817A (pt)	1996-04-16
CA2156959A1 (en)	1996-03-01
ATE193282T1 (de)	2000-06-15
KR100406686B1 (ko)	2004-07-19
EP0704431A3 (de)	1997-01-29
EP0704431A2 (de)	1996-04-03
EP0704431B1 (de)	2000-05-24
PL310192A1 (en)	1996-03-04
CN1068587C (zh)	2001-07-18

Legal Events

Date	Code	Title	Description
2005-05-02	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
DK0704431T3 (da)	2000-09-11	Ortho-substituerede benzoesyrederivater
FI955024A0 (fi)	1995-10-20	Uudet piperidiiniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
BR9505039A (pt)	1997-10-21	Derivados de oxazolidinona enantiômeros ou diastereômeros dos compostos processo para sua preparação processo para a produção de uma preparação farmacêutica e uso
ATE172716T1 (de)	1998-11-15	Arylbenzoylguanidine
BR9505008A (pt)	1997-10-14	Derivados de benzilpiperidina processo para sua preparação processo para a produção de preparações farmacêuticas preparação farmacêutica e uso
DE3865112D1 (de)	1991-10-31	Azolylmethyl-cyclopropyl-derivate.
CO4480021A1 (es)	1997-07-09	Derivados de amino(tio)eter
GR3004789T3 (no)	1993-04-28
NO950360D0 (no)	1995-01-31	Nytt legemiddel som inneholder 3-fenylsulfonyl-3,7-diazabisyklo[3,3,1Ånonan-forbindelser
NO306991B1 (no)	2000-01-24	Alkenylbenzoylguanidinderivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler
BR9504489A (pt)	1997-05-20	Derivados de benzoilguanidinas processo para sua preparaçao processo para a produçao de preparados farmacêuticos preparado farmacêutico e uso
DE3782141D1 (de)	1992-11-12	N-arylsulfonyl-n'-pyrimidyl-(triazinyl)-harnstoffe.
FR2043463A1 (en)	1971-02-19	Benzoxazines and benzothiazines having c n s and
ES8601960A1 (es)	1985-11-16	Un procedimiento para la preparacion de nuevas 6h-dibenzo(b,e)(1,4)-oxatiepinas.
DK597487A (da)	1987-11-13	Hyaluronsyre-tungmetalsalte til anvendelse som mikrobielle midler