NO953405L - Alkylbenzoylguanidinderivater - Google Patents

Alkylbenzoylguanidinderivater

Info

Publication number: NO953405L
Authority: NO; Norway
Prior art keywords: opt; ch2f; substd; chf2; halo
Prior art date: 1994-08-31

Application number

NO953405A

Other languages

English (en)

Other versions

NO953405D0 (no

NO305901B1 (no

Inventor

Rolf Gericke

Dieter Dorsch

Manfred Baumgarth

Klaus-Otto Minck

Norbert Beier

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-31

Filing date

1995-08-30

Publication date

1996-03-01

1995-08-30 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1995-08-30 Publication of NO953405D0 publication Critical patent/NO953405D0/no

1996-03-01 Publication of NO953405L publication Critical patent/NO953405L/no

1999-08-16 Publication of NO305901B1 publication Critical patent/NO305901B1/no

Links

JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 3
108010081348 HRT1 protein Hairy Proteins 0.000 abstract 3
102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 3
VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 2
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicinal Preparation (AREA)

NO953405A 1994-08-31 1995-08-30 Alkylbenzoylguanidiner, farmasöytiske preparater som inneholder minst en slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler NO305901B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4430916A DE4430916A1 (de)	1994-08-31	1994-08-31	Alkyl-benzoylguanidin-Derivate

Publications (3)

Publication Number	Publication Date
NO953405D0 NO953405D0 (no)	1995-08-30
NO953405L true NO953405L (no)	1996-03-01
NO305901B1 NO305901B1 (no)	1999-08-16

Family

ID=6527018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO953405A NO305901B1 (no)	1994-08-31	1995-08-30	Alkylbenzoylguanidiner, farmasöytiske preparater som inneholder minst en slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler

Country Status (20)

Country	Link
US (1)	US5840761A (no)
EP (1)	EP0699663B1 (no)
JP (1)	JP3732873B2 (no)
KR (1)	KR100406687B1 (no)
CN (1)	CN1055920C (no)
AT (1)	ATE172962T1 (no)
AU (1)	AU701558B2 (no)
BR (1)	BR9503854A (no)
CA (1)	CA2157143C (no)
CZ (1)	CZ288015B6 (no)
DE (2)	DE4430916A1 (no)
ES (1)	ES2126190T3 (no)
HU (1)	HU222401B1 (no)
NO (1)	NO305901B1 (no)
PL (1)	PL180902B1 (no)
RU (1)	RU2142940C1 (no)
SK (1)	SK281051B6 (no)
TW (1)	TW397814B (no)
UA (1)	UA41353C2 (no)
ZA (1)	ZA957283B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4328352A1 (de)	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19517848A1 (de) *	1995-05-16	1996-11-21	Merck Patent Gmbh	Fluorhaltige Benzoylguanidine
DE19529612A1 (de) *	1995-08-11	1997-02-13	Merck Patent Gmbh	Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate
DE19531138A1 (de) *	1995-08-24	1997-02-27	Merck Patent Gmbh	Alkenyl-benzoylguanidin-Derivate
CA2195697A1 (en) *	1996-02-02	1997-08-03	Masahumi Kitano	Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
DE19624178A1 (de) *	1996-06-18	1998-01-08	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ID29523A (id) *	1998-11-26	2001-09-06	Marck Patent Gmbh	Penggunaan benzoilgunidin-benzoilguanidin untuk pengobatan diabetes melitus yang tidak bergantung pada insulin
DE10001879A1 (de) *	2000-01-19	2001-07-19	Aventis Pharma Gmbh	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATE440827T1 (de) *	2002-12-04	2009-09-15	Ore Pharmaceuticals Inc	Melanocortin-rezeptormodulatoren
EP1620394B1 (de) *	2003-05-06	2008-08-13	MERCK PATENT GmbH	Verfahren zur kristallisation von guanidinium-salzen
USD781236S1 (en)	2016-01-14	2017-03-14	Premier Accessory Group LLC	Charging device
WO2018058109A1 (en)	2016-09-26	2018-03-29	Nusirt Sciences, Inc.	Compositions and methods for treating metabolic disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3929582A1 (de)	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0556674B1 (de) *	1992-02-15	1996-06-19	Hoechst Aktiengesellschaft	3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
ATE158278T1 (de) *	1992-02-15	1997-10-15	Hoechst Ag	Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
DK0577024T3 (no) *	1992-07-01	1997-02-24	Hoechst Ag
EP0589336B1 (de) *	1992-09-22	1997-01-08	Hoechst Aktiengesellschaft	Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
TW250479B (no) *	1992-12-15	1995-07-01	Hoechst Ag
ES2100435T3 (es) *	1992-12-16	1997-06-16	Hoechst Ag	Aminobenzoilguanidinas 3,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
DE59403818D1 (de) *	1993-02-20	1997-10-02	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
MY128187A (en) *	1993-06-23	2007-01-31	Icn Switzerland Ag	Preparation for skin and mucous membrane
DE4328869A1 (de) *	1993-08-27	1995-03-02	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) *	1994-05-13	1995-11-16	Hoechst Ag	Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

1994
- 1994-08-31 DE DE4430916A patent/DE4430916A1/de not_active Withdrawn
1995
- 1995-07-25 TW TW084107704A patent/TW397814B/zh active
- 1995-08-21 ES ES95113104T patent/ES2126190T3/es not_active Expired - Lifetime
- 1995-08-21 DE DE59504122T patent/DE59504122D1/de not_active Expired - Lifetime
- 1995-08-21 EP EP95113104A patent/EP0699663B1/de not_active Expired - Lifetime
- 1995-08-21 AT AT95113104T patent/ATE172962T1/de not_active IP Right Cessation
- 1995-08-23 UA UA95083917A patent/UA41353C2/uk unknown
- 1995-08-24 AU AU30251/95A patent/AU701558B2/en not_active Ceased
- 1995-08-25 HU HU9502501A patent/HU222401B1/hu not_active IP Right Cessation
- 1995-08-25 SK SK1055-95A patent/SK281051B6/sk unknown
- 1995-08-29 CZ CZ19952203A patent/CZ288015B6/cs not_active IP Right Cessation
- 1995-08-29 CA CA002157143A patent/CA2157143C/en not_active Expired - Fee Related
- 1995-08-30 CN CN95116672A patent/CN1055920C/zh not_active Expired - Fee Related
- 1995-08-30 NO NO953405A patent/NO305901B1/no not_active IP Right Cessation
- 1995-08-30 BR BR9503854A patent/BR9503854A/pt active Search and Examination
- 1995-08-30 ZA ZA957283A patent/ZA957283B/xx unknown
- 1995-08-30 RU RU95114673A patent/RU2142940C1/ru not_active IP Right Cessation
- 1995-08-30 PL PL95310225A patent/PL180902B1/pl not_active IP Right Cessation
- 1995-08-30 US US08/520,767 patent/US5840761A/en not_active Expired - Lifetime
- 1995-08-31 JP JP24515295A patent/JP3732873B2/ja not_active Expired - Fee Related
- 1995-08-31 KR KR1019950027958A patent/KR100406687B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2157143C (en)	2009-02-17
AU701558B2 (en)	1999-01-28
EP0699663B1 (de)	1998-11-04
KR100406687B1 (ko)	2004-07-19
EP0699663A1 (de)	1996-03-06
JPH08188568A (ja)	1996-07-23
CN1128753A (zh)	1996-08-14
BR9503854A (pt)	1996-09-17
HUT75094A (en)	1997-04-28
ATE172962T1 (de)	1998-11-15
HU222401B1 (hu)	2003-06-28
DE59504122D1 (de)	1998-12-10
ES2126190T3 (es)	1999-03-16
HU9502501D0 (en)	1995-10-30
AU3025195A (en)	1996-02-15
CA2157143A1 (en)	1996-03-01
ZA957283B (en)	1996-04-02
JP3732873B2 (ja)	2006-01-11
SK105595A3 (en)	1996-03-06
NO953405D0 (no)	1995-08-30
CZ220395A3 (en)	1996-03-13
CN1055920C (zh)	2000-08-30
UA41353C2 (uk)	2001-09-17
SK281051B6 (sk)	2000-11-07
RU2142940C1 (ru)	1999-12-20
CZ288015B6 (cs)	2001-04-11
US5840761A (en)	1998-11-24
DE4430916A1 (de)	1996-03-07
PL310225A1 (en)	1996-03-04
TW397814B (en)	2000-07-11
NO305901B1 (no)	1999-08-16
KR960007538A (ko)	1996-03-22
PL180902B1 (pl)	2001-04-30

Legal Events

Date	Code	Title	Description
2005-05-02	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO953405D0 (no)	1995-08-30	Alkylbenzoylguanidinderivater
PL310224A1 (en)	1996-03-04	Novel derivatives of heterocyclyl-benzoyl guanidine, method of obtaining them and pharmaceutic preparation and method of preparing same
NO307515B1 (no)	2000-04-17	Nye piperidinforbindelser og farmasøytiske preparater inneholdende dem
DE3879264D1 (de)	1993-04-22	N-substituierte azole.
NO306777B1 (no)	1999-12-20	4-(anilinometylen)-2,4-dihydropyrazol-3-on-forbindelser, legemidler som består av en slik forbindelse, farmasöytiske preparater som inneholder minst én slik forbindelse, og anvendelser av forbindelsene og legemidlene til fremstilling av legemidd
TR199600319A2 (tr)	1996-11-21	Heteroatom-ihtiva-eden benzosiklopentanoksazolidinonlar.
HRP20020298B1 (hr)	2007-02-28	Farmaceutske otopine levosimendana
ATE172716T1 (de)	1998-11-15	Arylbenzoylguanidine
DK0694537T3 (da)	2001-12-03	Heterocyclyloxy-benzoylguanidinderivater, fremstilling deraf og anvendelse deraf som inhibitorer for den cellulære Na+/H+-antiporter
NO306991B1 (no)	2000-01-24	Alkenylbenzoylguanidinderivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler
DE59505429D1 (de)	1999-04-29	Alkyl-5-methylsulfonyl-benzoyl-guanidin-Derivate
DK0439796T3 (da)	1996-02-12	Indolylpropanoler, fremgangsmåde til fremstilling deraf, deres anvendelse og præparater indeholdende disse forbindelser