UA41353C2 - Похідні алкілбензоїлгуанідинів, спосіб їх одержання, фармацевтична композиція, що має аритмічну активність - Google Patents

Похідні алкілбензоїлгуанідинів, спосіб їх одержання, фармацевтична композиція, що має аритмічну активність

Info

Publication number
UA41353C2
UA41353C2 UA95083917A UA95083917A UA41353C2 UA 41353 C2 UA41353 C2 UA 41353C2 UA 95083917 A UA95083917 A UA 95083917A UA 95083917 A UA95083917 A UA 95083917A UA 41353 C2 UA41353 C2 UA 41353C2
Authority
UA
Ukraine
Prior art keywords
derivatives
alkylbenzoylguanidines
producing
pharmaceutical composition
arrhythmic activity
Prior art date
Application number
UA95083917A
Other languages
English (en)
Russian (ru)
Inventor
Рольф ГЕРІКЕ
Рольф Герике
Дітер Дорш
Дитер Дорш
Манфред БАУМГАРТ
Клаус-Отто МІНК
Клаус-Отто Минк
Норберт Байєр
Норберт Байер
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of UA41353C2 publication Critical patent/UA41353C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)

Abstract

Винахід належить до орто-заміщених похідних бензоілгуанідину формули: Похідні алкілбензоілгуанідинів загальної формули (1) де R1 означає А або Hal; Alk означає C1-C8-алкіл з розгалуженим або не розгалуженим ланцюгом, Сз-С8-циклоалкіл, А означає C1-С6-алкіл, Наl-FCl,Вr або J, а також їх фармацевтично прийнятні солі.
UA95083917A 1994-08-31 1995-08-23 Похідні алкілбензоїлгуанідинів, спосіб їх одержання, фармацевтична композиція, що має аритмічну активність UA41353C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4430916A DE4430916A1 (de) 1994-08-31 1994-08-31 Alkyl-benzoylguanidin-Derivate

Publications (1)

Publication Number Publication Date
UA41353C2 true UA41353C2 (uk) 2001-09-17

Family

ID=6527018

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95083917A UA41353C2 (uk) 1994-08-31 1995-08-23 Похідні алкілбензоїлгуанідинів, спосіб їх одержання, фармацевтична композиція, що має аритмічну активність

Country Status (20)

Country Link
US (1) US5840761A (uk)
EP (1) EP0699663B1 (uk)
JP (1) JP3732873B2 (uk)
KR (1) KR100406687B1 (uk)
CN (1) CN1055920C (uk)
AT (1) ATE172962T1 (uk)
AU (1) AU701558B2 (uk)
BR (1) BR9503854A (uk)
CA (1) CA2157143C (uk)
CZ (1) CZ288015B6 (uk)
DE (2) DE4430916A1 (uk)
ES (1) ES2126190T3 (uk)
HU (1) HU222401B1 (uk)
NO (1) NO305901B1 (uk)
PL (1) PL180902B1 (uk)
RU (1) RU2142940C1 (uk)
SK (1) SK281051B6 (uk)
TW (1) TW397814B (uk)
UA (1) UA41353C2 (uk)
ZA (1) ZA957283B (uk)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate
DE19531138A1 (de) * 1995-08-24 1997-02-27 Merck Patent Gmbh Alkenyl-benzoylguanidin-Derivate
CA2195697A1 (en) * 1996-02-02 1997-08-03 Masahumi Kitano Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
DE19624178A1 (de) * 1996-06-18 1998-01-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ID29523A (id) * 1998-11-26 2001-09-06 Marck Patent Gmbh Penggunaan benzoilgunidin-benzoilguanidin untuk pengobatan diabetes melitus yang tidak bergantung pada insulin
DE10001879A1 (de) * 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATE440827T1 (de) * 2002-12-04 2009-09-15 Ore Pharmaceuticals Inc Melanocortin-rezeptormodulatoren
EP1620394B1 (de) * 2003-05-06 2008-08-13 MERCK PATENT GmbH Verfahren zur kristallisation von guanidinium-salzen
USD781236S1 (en) 2016-01-14 2017-03-14 Premier Accessory Group LLC Charging device
WO2018058109A1 (en) 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0556674B1 (de) * 1992-02-15 1996-06-19 Hoechst Aktiengesellschaft 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
ATE158278T1 (de) * 1992-02-15 1997-10-15 Hoechst Ag Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
DK0577024T3 (uk) * 1992-07-01 1997-02-24 Hoechst Ag
EP0589336B1 (de) * 1992-09-22 1997-01-08 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
TW250479B (uk) * 1992-12-15 1995-07-01 Hoechst Ag
ES2100435T3 (es) * 1992-12-16 1997-06-16 Hoechst Ag Aminobenzoilguanidinas 3,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
DE59403818D1 (de) * 1993-02-20 1997-10-02 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
MY128187A (en) * 1993-06-23 2007-01-31 Icn Switzerland Ag Preparation for skin and mucous membrane
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) * 1994-05-13 1995-11-16 Hoechst Ag Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
NO953405L (no) 1996-03-01
CA2157143C (en) 2009-02-17
AU701558B2 (en) 1999-01-28
EP0699663B1 (de) 1998-11-04
KR100406687B1 (ko) 2004-07-19
EP0699663A1 (de) 1996-03-06
JPH08188568A (ja) 1996-07-23
CN1128753A (zh) 1996-08-14
BR9503854A (pt) 1996-09-17
HUT75094A (en) 1997-04-28
ATE172962T1 (de) 1998-11-15
HU222401B1 (hu) 2003-06-28
DE59504122D1 (de) 1998-12-10
ES2126190T3 (es) 1999-03-16
HU9502501D0 (en) 1995-10-30
AU3025195A (en) 1996-02-15
CA2157143A1 (en) 1996-03-01
ZA957283B (en) 1996-04-02
JP3732873B2 (ja) 2006-01-11
SK105595A3 (en) 1996-03-06
NO953405D0 (no) 1995-08-30
CZ220395A3 (en) 1996-03-13
CN1055920C (zh) 2000-08-30
SK281051B6 (sk) 2000-11-07
RU2142940C1 (ru) 1999-12-20
CZ288015B6 (cs) 2001-04-11
US5840761A (en) 1998-11-24
DE4430916A1 (de) 1996-03-07
PL310225A1 (en) 1996-03-04
TW397814B (en) 2000-07-11
NO305901B1 (no) 1999-08-16
KR960007538A (ko) 1996-03-22
PL180902B1 (pl) 2001-04-30

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