NO953913L - Perhydroisoindolderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene - Google Patents

Perhydroisoindolderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene

Info

Publication number
NO953913L
NO953913L NO953913A NO953913A NO953913L NO 953913 L NO953913 L NO 953913L NO 953913 A NO953913 A NO 953913A NO 953913 A NO953913 A NO 953913A NO 953913 L NO953913 L NO 953913L
Authority
NO
Norway
Prior art keywords
derivatives
preparation
optionally substituted
well
phenyl
Prior art date
Application number
NO953913A
Other languages
English (en)
Other versions
NO953913D0 (no
Inventor
Andre Crespo
Veronique Fardin
Jean-Marc Guillaume
Jean-Luc Malleron
Jean-Francois Peyronel
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO953913D0 publication Critical patent/NO953913D0/no
Publication of NO953913L publication Critical patent/NO953913L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Perhydrolsolndolderlvater med den generelle formel (I): der R er fenylrester som kan være substituert med et halogenaton eller en metylrest l 2- eller 3-posisJon, R! er eventuelt substituert fenyl, cykloheksadlenyl, naftyl, Indenyl eller eventuelt substituert heterocyklyl, R2 er E. halogen. CB, alkyl, aminoalkyl, alkylamlnoalkyl, dlalkylsmlnoalkyl, alkyloksy, alkyltlo, acyloksy, karboksy, eventuelt substituert alkyloksykarbonyl, ben?yloksyltarbonyl, amlno eller acylamlno og R3 er fenyl som kan være substituert l 2-poslsJon. samt eventuelt deres salter hvis de eksisterer. Derivatene Ifølge oppfinnelsen er spesielt Interessante son neuroklnln-A-antagonlster. Forblndelsenes fremstilling beskrives.
NO953913A 1993-04-05 1995-10-02 Perhydroisoindolderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene NO953913L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9303965A FR2703679B1 (fr) 1993-04-05 1993-04-05 Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1994/000371 WO1994022822A1 (fr) 1993-04-05 1994-04-01 Derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
NO953913D0 NO953913D0 (no) 1995-10-02
NO953913L true NO953913L (no) 1995-10-02

Family

ID=9445733

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953913A NO953913L (no) 1993-04-05 1995-10-02 Perhydroisoindolderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene

Country Status (21)

Country Link
US (1) US5631279A (no)
EP (1) EP0693059B1 (no)
JP (1) JPH08508283A (no)
KR (1) KR960701842A (no)
AT (1) ATE150014T1 (no)
AU (1) AU6506894A (no)
CA (1) CA2158663A1 (no)
CZ (1) CZ258495A3 (no)
DE (1) DE69402058T2 (no)
DK (1) DK0693059T3 (no)
ES (1) ES2099601T3 (no)
FI (1) FI954730L (no)
FR (1) FR2703679B1 (no)
GR (1) GR3022798T3 (no)
HU (1) HUT74089A (no)
IL (1) IL109217A0 (no)
NO (1) NO953913L (no)
PL (1) PL310948A1 (no)
SK (1) SK123595A3 (no)
TW (1) TW333525B (no)
WO (1) WO1994022822A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW432061B (en) * 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
FR2737495B1 (fr) * 1995-08-02 1997-08-29 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
GB9816897D0 (en) * 1998-08-04 1998-09-30 Merck Sharp & Dohme Therapeutic use
DE102006007882A1 (de) 2006-02-21 2007-08-30 Bayer Cropscience Ag Cycloalkyl-phenylsubstituierte cyclische Ketoenole
SG11201403268QA (en) * 2011-12-22 2014-07-30 Connexios Life Sciences Pvt Ltd Cyclic amide derivatives as inhibitors of 11 - beta - hydroxysteroid dehydrogenase and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6372689A (ja) * 1986-09-16 1988-04-02 Taisho Pharmaceut Co Ltd （−）−α−カイニン酸の中間体およびその製造方法
FR2654726B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone et leur preparation.
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676443B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole et leur preparation.
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689888B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.

Also Published As

Publication number Publication date
CZ258495A3 (en) 1996-01-17
FR2703679A1 (fr) 1994-10-14
DK0693059T3 (da) 1997-09-15
HUT74089A (en) 1996-11-28
TW333525B (en) 1998-06-11
ES2099601T3 (es) 1997-05-16
NO953913D0 (no) 1995-10-02
CA2158663A1 (fr) 1994-10-13
DE69402058D1 (de) 1997-04-17
FI954730A0 (fi) 1995-10-04
ATE150014T1 (de) 1997-03-15
GR3022798T3 (en) 1997-06-30
DE69402058T2 (de) 1997-09-18
JPH08508283A (ja) 1996-09-03
WO1994022822A1 (fr) 1994-10-13
HU9502902D0 (en) 1995-11-28
FI954730A7 (fi) 1995-11-17
FI954730L (fi) 1995-11-17
KR960701842A (ko) 1996-03-28
US5631279A (en) 1997-05-20
EP0693059A1 (fr) 1996-01-24
SK123595A3 (en) 1996-06-05
FR2703679B1 (fr) 1995-06-23
AU6506894A (en) 1994-10-24
PL310948A1 (en) 1996-01-08
EP0693059B1 (fr) 1997-03-12
IL109217A0 (en) 1994-07-31

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