NO954323L - Heterocykliske derivater - Google Patents

Heterocykliske derivater

Info

Publication number: NO954323L
Authority: NO; Norway
Prior art keywords: alkyl; alkylcarbamoyl; carbamoyl; alkoxycarbonyl; alkoxy
Prior art date: 1993-04-29

Application number

NO954323A

Other languages

English (en)

Norwegian (no)

Other versions

NO954323D0 (no

Inventor

George Robert Brown

Paul Robert Owen Whittamore

David Robert Brittain

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-29

Filing date

1995-10-27

Publication date

1995-12-21

1993-04-29 Priority claimed from GB939308842A external-priority patent/GB9308842D0/en

1993-12-03 Priority claimed from GB939324813A external-priority patent/GB9324813D0/en

1994-02-04 Priority claimed from GB9402127A external-priority patent/GB9402127D0/en

1995-10-27 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1995-10-27 Publication of NO954323D0 publication Critical patent/NO954323D0/no

1995-12-21 Publication of NO954323L publication Critical patent/NO954323L/no

Links

125000000623 heterocyclic group Chemical group 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 8
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
150000002923 oximes Chemical class 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
150000005215 alkyl ethers Chemical class 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
-1 amino, carbamoyl Chemical group 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 abstract 1
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940031439 squalene Drugs 0.000 abstract 1
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 abstract 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO954323A 1993-04-29 1995-10-27 Heterocykliske derivater NO954323L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB939308842A GB9308842D0 (en)	1993-04-29	1993-04-29	Heterocyclic derivatives
GB939324813A GB9324813D0 (en)	1993-12-03	1993-12-03	Heterocyclic compounds
GB9402127A GB9402127D0 (en)	1994-02-04	1994-02-04	Heterocyclic derivatives
PCT/GB1994/000910 WO1994025459A1 (en)	1993-04-29	1994-04-28	Heterocyclic derivatives

Publications (2)

Publication Number	Publication Date
NO954323D0 NO954323D0 (no)	1995-10-27
NO954323L true NO954323L (no)	1995-12-21

Family

ID=27266674

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO954323A NO954323L (no)	1993-04-29	1995-10-27	Heterocykliske derivater

Country Status (11)

Country	Link
US (1)	US5919793A (ja)
EP (1)	EP0696284A1 (ja)
JP (1)	JPH08509488A (ja)
CN (1)	CN1121718A (ja)
AU (1)	AU6576494A (ja)
CA (1)	CA2160795A1 (ja)
FI (1)	FI955164A0 (ja)
GB (1)	GB9408473D0 (ja)
IL (1)	IL109451A0 (ja)
NO (1)	NO954323L (ja)
WO (1)	WO1994025459A1 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2737721B1 (fr) *	1995-08-08	1997-09-05	Roussel Uclaf	Nouveaux composes biphenyles, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicament et les compositions pharmaceutiques les contenant
NZ517788A (en)	1999-09-28	2003-11-28	Eisai Co Ltd	Quinuclidine compounds and drugs containing the same as the active ingredient
WO2002016357A2 (en)	2000-08-18	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
US6479510B2 (en)	2000-08-18	2002-11-12	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
DE60220997T2 (de)	2001-03-27	2008-03-13	Eisai R&D Management Co., Ltd.	N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
JP2005504059A (ja) *	2001-08-24	2005-02-10	ファルマシアアンドアップジョンカンパニーリミティドライアビリティーカンパニー	疾患を処置するための置換アリール７−アザ［２．２．１］ビシクロヘプタン
EP1480977A2 (en)	2002-02-15	2004-12-01	PHARMACIA & UPJOHN COMPANY	Substituted aryl compounds for treatment of disease
TW200305636A (en) *	2002-04-18	2003-11-01	Merck Patent Gmbh	Polymerisable compounds comprising a cinnamic acid group and an acetylene group
US7129268B2 (en) *	2002-10-28	2006-10-31	Novo Nordisk A/S	Peroxisome proliferator activated receptor-active arylene acetic acid derivatives
WO2005105736A1 (en) *	2004-05-05	2005-11-10	Novo Nordisk A/S	Novel compounds, their preparation and use
ATE475642T1 (de) *	2004-05-05	2010-08-15	High Point Pharmaceuticals Llc	Phenoxyessigsäurederivate als ppar-agonisten
BRPI0620468A2 (pt)	2005-12-22	2011-11-08	Transtech Pharma, Inc.	ácidos fenóxi acéticos como ativadores de ppar delta
SA08290475B1 (ar) *	2007-08-02	2013-06-22	Targacept Inc	(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
US11267795B2 (en)	2020-07-22	2022-03-08	Reneo Pharmaceuticals, Inc.	Crystalline PPAR-delta agonist
WO2023147309A1 (en)	2022-01-25	2023-08-03	Reneo Pharmaceuticals, Inc.	Use of ppar-delta agonists in the treatment of disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0597821A1 (en) *	1988-04-01	1994-05-18	Sankyo Company Limited	2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics
YU84791A (sh) *	1990-05-19	1994-06-10	Boehringer Ingelheim Kg.	Biciklicni 1-aza-cikloalkalni
US5385912A (en) *	1991-03-08	1995-01-31	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
AU1752792A (en) *	1991-03-08	1992-10-06	Rhone-Poulenc Rorer International (Holdings) Inc.	Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
GB9127279D0 (en) *	1991-12-23	1992-02-19	Ici Plc	Heterocyclic derivatives
GB9201749D0 (en) *	1992-01-28	1992-03-11	Smithkline Beecham Plc	Medicaments
AU3901393A (en) *	1992-04-10	1993-11-18	Zeneca Limited	Biphenylylquinuclidine derivatives as squalene synthase inhibitors
GB9216721D0 (en) *	1992-08-06	1992-09-23	Ici Plc	Therapeutic heterocyclic derivatives
GB9218334D0 (en) *	1992-08-28	1992-10-14	Ici Plc	Heterocyclic compounds

1994
- 1994-04-27 IL IL10945194A patent/IL109451A0/xx unknown
- 1994-04-28 WO PCT/GB1994/000910 patent/WO1994025459A1/en not_active Ceased
- 1994-04-28 AU AU65764/94A patent/AU6576494A/en not_active Abandoned
- 1994-04-28 JP JP6524035A patent/JPH08509488A/ja active Pending
- 1994-04-28 CN CN94191933A patent/CN1121718A/zh active Pending
- 1994-04-28 GB GB9408473A patent/GB9408473D0/en active Pending
- 1994-04-28 CA CA002160795A patent/CA2160795A1/en not_active Abandoned
- 1994-04-28 EP EP94913724A patent/EP0696284A1/en not_active Withdrawn
- 1994-04-28 US US08/537,827 patent/US5919793A/en not_active Expired - Fee Related
1995
- 1995-10-27 NO NO954323A patent/NO954323L/no not_active Application Discontinuation
- 1995-10-27 FI FI955164A patent/FI955164A0/fi unknown

Also Published As

Publication number	Publication date
CA2160795A1 (en)	1994-11-10
FI955164A7 (fi)	1995-10-27
IL109451A0 (en)	1994-07-31
US5919793A (en)	1999-07-06
CN1121718A (zh)	1996-05-01
NO954323D0 (no)	1995-10-27
JPH08509488A (ja)	1996-10-08
FI955164A0 (fi)	1995-10-27
EP0696284A1 (en)	1996-02-14
AU6576494A (en)	1994-11-21
GB9408473D0 (en)	1994-06-22
WO1994025459A1 (en)	1994-11-10

Legal Events

Date	Code	Title	Description
2001-10-01	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO954323L (no)	1995-12-21	Heterocykliske derivater
DE60003001D1 (en)	2003-07-03	Pyrimidinverbindungen
GB0206860D0 (en)	2002-05-01	Compounds
EP1550662A4 (en)	2007-03-07	NEW ADENINE COMPOUND AND ITS USE
AU6307290A (en)	1991-04-18	Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
AU617918B2 (en)	1991-12-05	2-aminopyrimidinone derivatives
AU4257901A (en)	2001-10-08	Triarylimidazole derivatives as cytokine inhibitors
EP1400529A4 (en)	2007-12-19	GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL AND INTERMEDIARY USE THEREOF
AU624405B2 (en)	1992-06-11	Heterocyclic bisphosphonic acid derivatives
MXPA03008215A (es)	2004-01-29	Inhibidores de integrina alfa v beta 6.
RU2027435C1 (ru)	1995-01-27	Вещество, снижающее внутриглазное давление
AU622509B2 (en)	1992-04-09	2-aminopyrimidinone derivatives
NZ516100A (en)	2004-01-30	Streptogramin derivatives, preparation and compositions containing them
TNSN05080A1 (en)	2007-05-14	NOVEL ANTIMYCOBACTERIAL COMPOUNDS (as filed) AND PYRROLE DERIVATIVES AS ANTIMYCOBACTERIAL COMPOUNDS (as published)
KR880012586A (ko)	1988-11-28	새로운 피리딜 및 피리미딜 유도체
DK561487D0 (da)	1987-10-27	4-phenylsulfonyl-3,4-dihydro-2(1h)-quinoxalinon-1-alkansyre-forbindelser og farmaceutiske praeparater indeholdende disse
EP0654032A1 (en)	1995-05-24	Quinuclidine derivatives as squalene synthase inhibitors.
EP1136488A4 (en)	2002-06-12	SF2809-I, II, III. VI, V AND VI COMPOUNDS WITH CHYMASE INHIBITING EFFECT
CA2140781A1 (en)	1994-02-03	Pharmocologically active .alpha.-¬tertiary-aminomethyl\|- benzenemethanol derivatives
ATE285771T1 (de)	2005-01-15	Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung
EP1132085A4 (en)	2003-04-23	MEDICINAL PRODUCTS AND REAGENTS CONTAIN THE N-ACYLOXYLATED CYCLOALKYL COMPOUNDS AS ACTIVE INGREDIENTS
NZ512891A (en)	2003-01-31	S-oxide lipid lowering compounds
DE69320911D1 (de)	1998-10-15	Chinuclidine derivate als squalen synthase inhibitore
EP1219619A4 (en)	2002-10-23	piperidine
US5273976A (en)	1993-12-28	Ocular hypotensive agents