NO954756L - Fremgangsmåte og apparatur for fremstilling av liposomer - Google Patents

Fremgangsmåte og apparatur for fremstilling av liposomer

Info

Publication number
NO954756L
NO954756L NO954756A NO954756A NO954756L NO 954756 L NO954756 L NO 954756L NO 954756 A NO954756 A NO 954756A NO 954756 A NO954756 A NO 954756A NO 954756 L NO954756 L NO 954756L
Authority
NO
Norway
Prior art keywords
liposomes
critical
preparation
supercritical
methods
Prior art date
Application number
NO954756A
Other languages
English (en)
Other versions
NO954756D0 (no
Inventor
Trevor P Castor
Original Assignee
Aphios Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aphios Corp filed Critical Aphios Corp
Publication of NO954756D0 publication Critical patent/NO954756D0/no
Publication of NO954756L publication Critical patent/NO954756L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Saccharide Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen vedrører fremgangsmåter og apparat for fremstilling av liposomer med kritiske, overkritiske eller nesten kritiske fluider. Fremgangsmåter og apparat kombinerer et fosfolipid og en vandig fase, eller multilamellære vesikler, med et kritisk, overkritisk eller nesten kritisk fluid. Ved trykkreduksjon dannes liposomer.
NO954756A 1993-05-28 1995-11-24 Fremgangsmåte og apparatur for fremstilling av liposomer NO954756L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/069,134 US5554382A (en) 1993-05-28 1993-05-28 Methods and apparatus for making liposomes
PCT/US1994/005933 WO1994027581A1 (en) 1993-05-28 1994-05-26 Methods and apparatus for making liposomes

Publications (2)

Publication Number Publication Date
NO954756D0 NO954756D0 (no) 1995-11-24
NO954756L true NO954756L (no) 1996-01-26

Family

ID=22086969

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954756A NO954756L (no) 1993-05-28 1995-11-24 Fremgangsmåte og apparatur for fremstilling av liposomer

Country Status (11)

Country Link
US (1) US5554382A (no)
EP (1) EP0703778B1 (no)
JP (1) JP3742427B2 (no)
KR (1) KR960702748A (no)
AT (1) ATE152615T1 (no)
AU (1) AU6919094A (no)
CA (1) CA2163903A1 (no)
DE (1) DE69403077T2 (no)
FI (1) FI115115B (no)
NO (1) NO954756L (no)
WO (1) WO1994027581A1 (no)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
DE69528062T2 (de) * 1994-06-20 2003-04-30 Nippon Shinyaku Co., Ltd. Verfahren zum herstellen von emulsionen aus einem emulgator
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
DE69528077T2 (de) * 1994-11-18 2003-04-17 Aphios Corp., Woburn Verfahren zur Herstellung von Liposomen, die hydrophobische Artzneistoffe enthalten
DE4445341A1 (de) * 1994-12-19 1996-06-20 Basf Ag Verfahren und Vorrichtung zur Herstellung wirkstoffhaltiger Dispersionen
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6008202A (en) * 1995-01-23 1999-12-28 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
US6740335B1 (en) * 1997-09-16 2004-05-25 Osi Pharmaceuticals, Inc. Liposomal camptothecin formulations
BR9812316A (pt) * 1997-09-16 2001-03-20 Nexstar Pharmaceuticals Inc Formulações de camptotecina lipossÈmica
ES2343767T3 (es) 1997-09-18 2010-08-09 Pacira Pharmaceuticals, Inc. Composiciones anestesicas liposomicas de liberacion sostenida.
JP4575592B2 (ja) * 1997-11-14 2010-11-04 パシラ ファーマシューティカルズ インコーポレーテッド 多小胞リポソームの製造
US5994855A (en) 1998-05-07 1999-11-30 Optiva Corporation Automatic power adjustment system for introductory use of a vibrating device on a human body
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6461637B1 (en) * 2000-09-01 2002-10-08 Neopharm, Inc. Method of administering liposomal encapsulated taxane
ATE397488T1 (de) * 1998-11-13 2008-06-15 Heriot William A Vorrichtung zur herstellung von liposomen
US6855296B1 (en) 1998-11-13 2005-02-15 Optime Therapeutics, Inc. Method and apparatus for liposome production
US6040330A (en) * 1999-01-08 2000-03-21 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of taxanes
GB9915975D0 (en) 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
US6521258B1 (en) * 2000-09-08 2003-02-18 Ferro Corporation Polymer matrices prepared by supercritical fluid processing techniques
EP1334765B1 (en) * 2000-10-13 2010-06-30 National Institute of Advanced Industrial Science and Technology Process for producing liposome
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
US20020130430A1 (en) * 2000-12-29 2002-09-19 Castor Trevor Percival Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
US7708915B2 (en) * 2004-05-06 2010-05-04 Castor Trevor P Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
AU2002256398A2 (en) * 2001-04-30 2002-11-11 Targeted Genetics Corporation Lipid-comprising drug delivery complexes and methods for their production
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
US7029707B2 (en) * 2001-10-03 2006-04-18 Herbalscience, Llc Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
US7001620B2 (en) 2001-10-03 2006-02-21 Herbal Science, Llc Kavalactone product
US7037524B2 (en) * 2001-10-03 2006-05-02 Herbalscience, Llc Oral delivery of a botanical
US7105185B2 (en) 2001-10-03 2006-09-12 Herbalscience, Llc Kavalactone profile
US7291352B2 (en) 2001-10-03 2007-11-06 Herbalscience Llc Methods and compositions for oral delivery of Areca and mate' or theobromine
US20050069596A1 (en) * 2001-10-03 2005-03-31 Gow Robert T. Compositions and methods comprising kava and anti-anxiety compounds
DE10205130A1 (de) * 2002-02-07 2003-08-28 Air Liquide Gmbh Verfahren zum unterbrechungsfreien Bereitstellen von flüssigem, unterkühltem Kohlendioxid bei konstantem Druck oberhalb von 40 bar sowie Versorgungssystem
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US6966990B2 (en) 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
CN1700906A (zh) * 2003-02-03 2005-11-23 新药物公司 稳定的无菌过滤性脂质体包封的紫杉烷和其他抗肿瘤药物
US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
US6931888B2 (en) 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
WO2004098561A2 (en) * 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
US20060008531A1 (en) * 2003-05-08 2006-01-12 Ferro Corporation Method for producing solid-lipid composite drug particles
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
CN1917892A (zh) * 2003-10-24 2007-02-21 草本制药科学有限责任公司 包含冬青的方法和组合物
US7294353B2 (en) * 2003-10-24 2007-11-13 Herbalscience, Llc Methods and compositions comprising ilex
JP4595319B2 (ja) * 2003-12-03 2010-12-08 コニカミノルタエムジー株式会社 リポソーム用脂質、リポソームおよびそれらの製造方法
JP2005162702A (ja) * 2003-12-04 2005-06-23 Konica Minolta Medical & Graphic Inc リポソーム製剤の製造方法、リポソーム製剤およびその製造装置
JP4649841B2 (ja) * 2004-02-18 2011-03-16 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法、およびリポソーム含有製剤
US7588751B2 (en) * 2004-07-21 2009-09-15 Konica Minolta Medical & Graphic, Inc. Liposome-containing radiographic contrast medium and preparation method thereof
WO2006016468A1 (ja) * 2004-08-11 2006-02-16 Konica Minolta Medical & Graphic, Inc. リポソーム含有製剤の製造方法
JP2006056807A (ja) * 2004-08-18 2006-03-02 Konica Minolta Medical & Graphic Inc 光線力学療法製剤
JP4715133B2 (ja) * 2004-08-26 2011-07-06 コニカミノルタエムジー株式会社 抗腫瘍リポソーム製剤およびその製造方法
JP2006069929A (ja) * 2004-08-31 2006-03-16 Konica Minolta Medical & Graphic Inc 真菌症治療製剤およびその製造方法
ES2265262B1 (es) * 2005-01-31 2008-03-01 Activery Biotech, S.L.(Titular Al 50%) Procedimiento para la obtencion de sistemas micro- y nanodispersos.
US20060239925A1 (en) * 2005-04-21 2006-10-26 Konica Minolta Medical & Graphic, Inc. Method of manufacturing pharmaceutical preparation containing liposomes
JP5846711B2 (ja) * 2005-06-09 2016-01-20 メダ アーベー 炎症性疾患の治療のための方法及び組成物
ES2292300B1 (es) * 2005-07-19 2009-02-16 Sociedad Española De Carburos Metalicos, S.A.(Titular Al 50%) Procedimiento para la obtencion de un material compuesto.
EP1920765A1 (en) * 2006-11-07 2008-05-14 Medigene AG Liposome preparation by single-pass process
KR100811447B1 (ko) * 2006-12-05 2008-03-11 재단법인서울대학교산학협력재단 초임계 유체를 이용한 세라마이드 나노입자 제조방법
EP3494964B1 (en) * 2007-05-14 2021-04-07 Konica Minolta Holdings, Inc. Liposome and method for producing liposome
PL2229233T3 (pl) * 2007-12-07 2020-03-31 Xspray Pharma Ab (Publ) Sposób wytwarzania cząstek
US8637074B2 (en) * 2009-03-31 2014-01-28 Aphios Corporation Methods for co-encapsulation of combination drugs and co-encapsulated combination drug product
KR101102834B1 (ko) * 2010-02-24 2012-01-05 충남대학교산학협력단 신규한 리포좀 제조 방법 및 장치
WO2011127456A2 (en) * 2010-04-09 2011-10-13 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
KR101795019B1 (ko) * 2010-06-16 2017-12-01 초임계연구소 주식회사 봉입물질의 열변성을 방지하는 저온 리포좀 제조방법
KR101047873B1 (ko) * 2010-06-23 2011-07-08 주식회사 에프씨비투웰브 인체유래 줄기세포 배양액 추출물을 포접시킨 리포좀을 함유하는 화장료 조성물
US9981238B2 (en) * 2010-08-25 2018-05-29 Aphios Corporation Apparatus and methods for making nanosomes loaded with nucleic acid
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
WO2013004234A2 (en) 2011-07-04 2013-01-10 Statens Serum Institut Methods for producing liposomes
US20150297725A1 (en) 2012-07-30 2015-10-22 Rutgers, The State University Of New Jersey Cochleates made with soy phosphatidylserine
JP6373749B2 (ja) 2014-12-19 2018-08-15 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
CN109291298B (zh) * 2018-09-30 2024-03-29 苏州艾特森制药设备有限公司 一种微量脂质体高压挤出装置
US20230139328A1 (en) * 2020-03-12 2023-05-04 Aphios Corporation Dosage forms for improving organ transplantation, graft versus host disease and stem cells transplants
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
GB2627096A (en) 2021-10-14 2024-08-14 Pacira Pharmaceuticals Inc Bupivacaine multivesicular liposome formulations and uses thereof
DE102021130372A1 (de) 2021-11-19 2023-05-25 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren und Anordnung zur Herstellung eines Treibstoffgemisches
US12246092B1 (en) 2024-05-20 2025-03-11 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251468B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
FR2543018B1 (fr) * 1983-03-22 1985-07-26 Oreal Procede de preparation de vesicules lipidiques par vaporisation de solvants
US5141674A (en) * 1984-03-08 1992-08-25 Phares Pharmaceutical Research N.V. Methods of preparing pro-liposome dispersions and aerosols
GB8613811D0 (en) * 1986-06-06 1986-07-09 Phares Pharm Res Nv Composition & method
GB8423436D0 (en) * 1984-09-17 1984-10-24 Riker Laboratories Inc Preparation of liposomes
GB8502892D0 (en) * 1985-02-05 1985-03-06 Sterwin Ag Aerosol composition
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
WO1988001864A1 (en) * 1986-09-18 1988-03-24 Liposome Technology, Inc. High-concentration liposome processing method
US4752425A (en) * 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method
DE3812816A1 (de) * 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents

Also Published As

Publication number Publication date
JP3742427B2 (ja) 2006-02-01
FI115115B (fi) 2005-03-15
KR960702748A (ko) 1996-05-23
NO954756D0 (no) 1995-11-24
DE69403077D1 (de) 1997-06-12
AU6919094A (en) 1994-12-20
WO1994027581A1 (en) 1994-12-08
US5554382A (en) 1996-09-10
EP0703778B1 (en) 1997-05-07
ATE152615T1 (de) 1997-05-15
FI955727L (fi) 1996-01-26
FI955727A0 (fi) 1995-11-28
CA2163903A1 (en) 1994-12-08
DE69403077T2 (de) 1997-11-13
JPH09502644A (ja) 1997-03-18
EP0703778A1 (en) 1996-04-03

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