NO955071L - abeo-Ergolin-derivater som 5HT1A-ligander - Google Patents
abeo-Ergolin-derivater som 5HT1A-liganderInfo
- Publication number
- NO955071L NO955071L NO955071A NO955071A NO955071L NO 955071 L NO955071 L NO 955071L NO 955071 A NO955071 A NO 955071A NO 955071 A NO955071 A NO 955071A NO 955071 L NO955071 L NO 955071L
- Authority
- NO
- Norway
- Prior art keywords
- group
- alkyl
- phenyl
- formula
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det tilveiebringes forbindelser med formel (I), hvor. Rer et hydrogen-, klor- eller bromatom eller en metyl-, metyltio-, hydroksy-, cyano-, karboksamido-eller nitrogruppe; Rer en C-C-alkyl eller allyl-gruppe; Rog Rer uavhengig et hydrogenatom, en lineær eller forgrenet C-C-alkylgruppe, en lineær eller forgrenet-C-alkenylgruppe, en C-Cg-sykloalkyl-C-C-alkylgruppe, en fenyl-C-Calkyl, en fenyl-C-C-alkenyl eller fenylgruppe: hvilke grupper eventu-. elt er substituert med en C^- C^ alkyl-, C-C-al-koksy-, trifluoremetyl-, hydroksy- eller amino-. I. gruppe: eller en gruppe av formelen (a) hvor Rer et hydrogenatom eller en C-C-alkylgruppe, og Rer en fenylgruppe, en substituert fenylgruppe som beskrevet ovenfor eller en hetrosyklisk ring med 5-6 ringatomer inklusive ett eller to hetroatomer uavhengig valgt fra oksygen, svovel og nitrogen; de stiplede linjer ved stillingene 2-3 og 9-10 repre-senterer uavhengig en enkelt- eller dobbeltbinding;. Rer et hydrogen-, brom-, fluor- eller jodatom. eller en metoksy-, cyano-, karboksamido-, nitro-, metyltio- eller trifluormetylgruppe eller en gruppe med formel NRRg, hvor Rog Rg uavhengig er et hydrogenatom eller en alkyl-, acetyl-, trifluor-acetyl- eller metansulfonulgruppe. R er et hydrogenatom, en lineær eller forgrenet C-alkylgruppe, en metansulfonulgruppe, en acetylgruppe eller en gruppe med formel -C(0)-NRRhvor Rog Rg er som definert ovenfor; eller et farmasøytisk akseptabel salt der-. av. En fremgangsmåte ved deres fremstilling og de farmasøytiske sammensetninger omfattende dem er også beskrevet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9407637A GB9407637D0 (en) | 1994-04-18 | 1994-04-18 | Serotoninergic abeo-ergoline derivatives |
| PCT/EP1995/001398 WO1995028403A1 (en) | 1994-04-18 | 1995-04-13 | Abeo-ergoline derivatives as 5ht1a ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO955071L true NO955071L (no) | 1995-12-14 |
| NO955071D0 NO955071D0 (no) | 1995-12-14 |
Family
ID=10753700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO955071A NO955071D0 (no) | 1994-04-18 | 1995-12-14 | abeo-Ergolin-derivater som 5HT1A-ligander |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6284896B1 (no) |
| EP (1) | EP0708777B1 (no) |
| JP (1) | JPH08512059A (no) |
| KR (1) | KR960703126A (no) |
| CN (1) | CN1126996A (no) |
| AT (1) | ATE255111T1 (no) |
| CA (1) | CA2163773A1 (no) |
| DE (1) | DE69532187T2 (no) |
| ES (1) | ES2211903T3 (no) |
| FI (1) | FI955933A7 (no) |
| GB (1) | GB9407637D0 (no) |
| HU (1) | HUT73430A (no) |
| NO (1) | NO955071D0 (no) |
| NZ (1) | NZ284472A (no) |
| PL (1) | PL312229A1 (no) |
| WO (1) | WO1995028403A1 (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000059909A1 (en) * | 1999-03-30 | 2000-10-12 | Shionogi & Co., Ltd. | Heterocyclic compounds having affinities for serotonin receptors |
| AU2001283393B2 (en) * | 2000-08-16 | 2005-09-22 | Pharmacia & Upjohn Company | Compounds for the treatment of addictive disorders |
| AU2001286259A1 (en) * | 2000-09-22 | 2002-04-02 | Shionogi And Co., Ltd. | Tricyclic indole compounds having affinity for serotonin receptor |
| JP2026525309A (ja) * | 2023-07-14 | 2026-07-29 | ２エイ バイオサイエンシズ、インコーポレイテッド | 置換されたエルゴリン |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1482871A (en) * | 1975-03-18 | 1977-08-17 | Farmaceutici Italia | Tetracyclic indole derivatives |
| IL59507A (en) | 1979-03-16 | 1984-01-31 | Erba Farmitalia | 5-(10-9)abeo-6-methylergoline derivatives,their preparation and pharmaceutical compositions containing them |
| GB8714767D0 (en) | 1987-06-24 | 1987-07-29 | Erba Farmitalia | Egoline derivatives |
| GB8612366D0 (en) | 1986-05-21 | 1986-06-25 | Erba Farmitalia | Ergoline esters |
| GB8702364D0 (en) | 1987-02-03 | 1987-03-11 | Erba Farmitalia | Ergolinyl heterocycles |
| ES2032570T3 (es) | 1987-11-20 | 1993-02-16 | Farmitalia Carlo Erba S.R.L. | Derivados antiparkinson de ergolina. (reserva del art. 167.2 cpe). |
| JPH04504582A (ja) | 1990-01-25 | 1992-08-13 | フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ | エルゴリン誘導体を製造する方法 |
| US5244911A (en) * | 1991-03-28 | 1993-09-14 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof |
| PT628042E (pt) | 1992-12-24 | 2002-01-30 | Pharmacia & Upjohn Spa | Derivados de ergolina serotoninergicos |
-
1994
- 1994-04-18 GB GB9407637A patent/GB9407637D0/en active Pending
-
1995
- 1995-04-03 HU HU9503718A patent/HUT73430A/hu unknown
- 1995-04-13 PL PL95312229A patent/PL312229A1/xx unknown
- 1995-04-13 CA CA002163773A patent/CA2163773A1/en not_active Abandoned
- 1995-04-13 CN CN95190309A patent/CN1126996A/zh active Pending
- 1995-04-13 EP EP95916653A patent/EP0708777B1/en not_active Expired - Lifetime
- 1995-04-13 WO PCT/EP1995/001398 patent/WO1995028403A1/en not_active Ceased
- 1995-04-13 JP JP7526720A patent/JPH08512059A/ja not_active Ceased
- 1995-04-13 AT AT95916653T patent/ATE255111T1/de not_active IP Right Cessation
- 1995-04-13 KR KR1019950705736A patent/KR960703126A/ko not_active Withdrawn
- 1995-04-13 NZ NZ284472A patent/NZ284472A/en unknown
- 1995-04-13 FI FI955933A patent/FI955933A7/fi unknown
- 1995-04-13 ES ES95916653T patent/ES2211903T3/es not_active Expired - Lifetime
- 1995-04-13 DE DE69532187T patent/DE69532187T2/de not_active Expired - Fee Related
- 1995-12-14 NO NO955071A patent/NO955071D0/no unknown
-
1997
- 1997-12-29 US US08/998,867 patent/US6284896B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2307395A (en) | 1995-11-10 |
| US6284896B1 (en) | 2001-09-04 |
| EP0708777A1 (en) | 1996-05-01 |
| DE69532187T2 (de) | 2004-09-02 |
| NZ284472A (en) | 1998-01-26 |
| KR960703126A (ko) | 1996-06-19 |
| PL312229A1 (en) | 1996-04-01 |
| DE69532187D1 (de) | 2004-01-08 |
| FI955933A0 (fi) | 1995-12-11 |
| FI955933L (fi) | 1995-12-11 |
| AU685268B2 (en) | 1998-01-15 |
| CN1126996A (zh) | 1996-07-17 |
| FI955933A7 (fi) | 1995-12-11 |
| WO1995028403A1 (en) | 1995-10-26 |
| ES2211903T3 (es) | 2004-07-16 |
| GB9407637D0 (en) | 1994-06-08 |
| HU9503718D0 (en) | 1996-03-28 |
| HUT73430A (en) | 1996-07-29 |
| EP0708777B1 (en) | 2003-11-26 |
| JPH08512059A (ja) | 1996-12-17 |
| ATE255111T1 (de) | 2003-12-15 |
| NO955071D0 (no) | 1995-12-14 |
| CA2163773A1 (en) | 1995-10-26 |
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