NO955352L - Metylfosforsyreester, fremgangsmåte for fremstilling samt anvendelse - Google Patents

Metylfosforsyreester, fremgangsmåte for fremstilling samt anvendelse

Info

Publication number
NO955352L
NO955352L NO955352A NO955352A NO955352L NO 955352 L NO955352 L NO 955352L NO 955352 A NO955352 A NO 955352A NO 955352 A NO955352 A NO 955352A NO 955352 L NO955352 L NO 955352L
Authority
NO
Norway
Prior art keywords
preparation
pct
acid ester
phosphoric acid
methyl phosphoric
Prior art date
Application number
NO955352A
Other languages
English (en)
Other versions
NO319860B1 (no
NO955352D0 (no
Inventor
Eugen Uhlmann
Chris Meier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO955352D0 publication Critical patent/NO955352D0/no
Publication of NO955352L publication Critical patent/NO955352L/no
Publication of NO319860B1 publication Critical patent/NO319860B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO19955352A 1993-07-01 1995-12-29 Metylfosfonsyre-ester, fremgangsmate for fremstilling, legemiddel samt anvendelse NO319860B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4321946A DE4321946A1 (de) 1993-07-01 1993-07-01 Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung
PCT/EP1994/002121 WO1995001363A1 (de) 1993-07-01 1994-06-29 Methylphosphonsäureester, verfahren zu deren herstellung und deren verwendung

Publications (3)

Publication Number Publication Date
NO955352D0 NO955352D0 (no) 1995-12-29
NO955352L true NO955352L (no) 1996-02-14
NO319860B1 NO319860B1 (no) 2005-09-26

Family

ID=6491730

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19955352A NO319860B1 (no) 1993-07-01 1995-12-29 Metylfosfonsyre-ester, fremgangsmate for fremstilling, legemiddel samt anvendelse

Country Status (13)

Country Link
US (1) US6028182A (no)
EP (1) EP0707591B1 (no)
JP (1) JP3831407B2 (no)
AT (1) ATE206130T1 (no)
AU (1) AU698928B2 (no)
CA (1) CA2165971C (no)
DE (2) DE4321946A1 (no)
DK (1) DK0707591T3 (no)
ES (1) ES2165391T3 (no)
FI (1) FI115399B (no)
NO (1) NO319860B1 (no)
PT (1) PT707591E (no)
WO (1) WO1995001363A1 (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
DE4331670A1 (de) * 1993-09-17 1995-03-23 Hoechst Ag Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung
DE4338704A1 (de) 1993-11-12 1995-05-18 Hoechst Ag Stabilisierte Oligonucleotide und deren Verwendung
DE19502912A1 (de) * 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilisierte Oligonucleotide
DE59607750D1 (de) * 1995-03-13 2001-10-31 Aventis Pharma Gmbh Phosphonomonoesternnukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
US5821354A (en) * 1996-11-26 1998-10-13 Angiogene Inc. Radiolabeled DNA oligonucleotide and method of preparation
EP0948511B1 (en) * 1996-12-24 2006-10-18 Sirna Therapeutics, Inc. Chemical synthesis of nucleosides analogs and their incorporation into polynucleotides
US6248878B1 (en) 1996-12-24 2001-06-19 Ribozyme Pharmaceuticals, Inc. Nucleoside analogs
ES2572834T3 (es) 1999-02-17 2016-06-02 Csl Limited Complejos inmunogénicos y métodos relacionados con los mismos
DE19935303A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
WO2002066092A2 (en) * 2001-02-23 2002-08-29 Angiogene Inc. Drug eluting device for treating vascular diseases
GB0110732D0 (en) * 2001-05-02 2001-06-27 Psl Technology Ltd Apparatus and method
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
CA2503693A1 (en) 2002-10-29 2004-05-13 Coley Pharmaceutical Group, Ltd. Use of cpg oligonucleotides in the treatment of hepatitis c virus infection
EP1720568A2 (en) 2004-02-19 2006-11-15 Coley Pharmaceutical Group, Inc. Immunostimulatory viral rna oligonucleotides
CA2572427A1 (en) 2004-07-18 2006-01-18 Heather L. Davis Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses
PT1991678E (pt) 2006-02-15 2015-11-25 Adiutide Pharmaceuticals Gmbh Composições e métodos para formulações de oligonucleótidos
CN101517082B (zh) 2006-09-27 2014-01-22 科勒制药有限责任公司 具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物
AU2008252577A1 (en) * 2007-05-17 2008-11-27 Coley Pharmaceutical Gmbh Class A oligonucleotides with immunostimulatory potency
KR20100068422A (ko) 2007-10-09 2010-06-23 콜리 파마슈티칼 게엠베하 변경된 당 잔기를 함유하는 면역자극성 올리고뉴클레오티드 유사체
WO2009158668A1 (en) * 2008-06-26 2009-12-30 Prolynx Llc Prodrugs and drug-macromolecule conjugates having controlled drug release rates
MX337723B (es) 2008-12-09 2016-03-15 Pfizer Vaccines Llc Vacuna de peptido ch3 de ige.
WO2010067262A1 (en) 2008-12-09 2010-06-17 Pfizer Inc. Immunostimulatory oligonucleotides
CA2768346A1 (en) 2009-07-30 2011-02-03 Pfizer Vaccines Llc Antigenic tau peptides and uses thereof
EP2575878B1 (en) 2010-05-28 2018-06-13 Zoetis Belgium S.A. Vaccines comprising cholesterol and cpg as sole adjuvant-carrier molecules
EP2942061A3 (en) 2010-06-07 2016-01-13 Pfizer Vaccines LLC Ige ch3 peptide vaccine
RU2737765C2 (ru) 2012-05-04 2020-12-02 Пфайзер Инк. Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин
SI3240801T1 (sl) 2014-12-31 2021-04-30 Checkmate Pharmaceuticals, Inc. Kombinirana imunoterapija tumorja
EP3752194A4 (en) 2018-02-13 2022-03-16 Checkmate Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
SG11202009647VA (en) 2018-04-09 2020-10-29 Checkmate Pharmaceuticals Packaging oligonucleotides into virus-like particles
TW202438104A (zh) 2022-12-13 2024-10-01 美商輝瑞股份有限公司 誘發針對困難梭狀芽孢桿菌之免疫反應的免疫原性組成物和方法
TW202602467A (zh) 2024-03-11 2026-01-16 美商輝瑞股份有限公司 包含經共軛之大腸桿菌糖的免疫原性組成物及其用途
WO2025238502A1 (en) 2024-05-14 2025-11-20 Pfizer Inc. Aluminum adjuvant nanoparticles, methods of manufacture, and uses thereof
WO2025257712A1 (en) 2024-06-12 2025-12-18 Pfizer Inc. Immunogenic compositions and methods for eliciting an immune response against clostridioides (clostridium) difficile

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010140A1 (en) * 1991-11-21 1993-05-27 Pharmagenics, Inc. Oligonucleotides having modified anionic moieties

Also Published As

Publication number Publication date
CA2165971A1 (en) 1995-01-12
NO319860B1 (no) 2005-09-26
FI956341A0 (fi) 1995-12-29
JPH08512039A (ja) 1996-12-17
PT707591E (pt) 2002-03-28
JP3831407B2 (ja) 2006-10-11
EP0707591A1 (de) 1996-04-24
DK0707591T3 (da) 2002-01-21
US6028182A (en) 2000-02-22
AU7073594A (en) 1995-01-24
EP0707591B1 (de) 2001-09-26
WO1995001363A1 (de) 1995-01-12
ES2165391T3 (es) 2002-03-16
NO955352D0 (no) 1995-12-29
FI956341L (fi) 1996-02-19
ATE206130T1 (de) 2001-10-15
AU698928B2 (en) 1998-11-12
CA2165971C (en) 2006-05-30
FI115399B (fi) 2005-04-29
DE59409880D1 (de) 2001-10-31
DE4321946A1 (de) 1995-01-12

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