NO961906L - Fremgangsmåte ved fremstilling av et klodronatpreparat - Google Patents

Fremgangsmåte ved fremstilling av et klodronatpreparat

Info

Publication number: NO961906L
Authority: NO; Norway
Prior art keywords: clodronate; pct; preparation; tetrahydrate; disodium
Prior art date: 1993-11-12

Application number

NO961906A

Other languages

English (en)

Other versions

NO312938B1 (no

NO961906D0 (no

Inventor

Esko Pohjala

Heikki Nupponen

Kari Lehmussaari

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-12

Filing date

1996-05-10

Publication date

1996-05-23

1996-05-10 Application filed by Leiras Oy filed Critical Leiras Oy

1996-05-10 Publication of NO961906D0 publication Critical patent/NO961906D0/no

1996-05-23 Publication of NO961906L publication Critical patent/NO961906L/no

2002-07-22 Publication of NO312938B1 publication Critical patent/NO312938B1/no

Links

ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 title abstract 3
229960002286 clodronic acid Drugs 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
XWHPUCFOTRBMGS-UHFFFAOYSA-L disodium clodronate tetrahydrate Chemical compound O.O.O.O.[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O XWHPUCFOTRBMGS-UHFFFAOYSA-L 0.000 abstract 4
239000007864 aqueous solution Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
HJKBJIYDJLVSAO-UHFFFAOYSA-L clodronic acid disodium salt Chemical compound [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O HJKBJIYDJLVSAO-UHFFFAOYSA-L 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
239000007884 disintegrant Substances 0.000 abstract 1
239000000945 filler Substances 0.000 abstract 1
239000008187 granular material Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Medicinal Preparation (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Ceramic Products (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Glass Compositions (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Peptides Or Proteins (AREA)
Glanulating (AREA)
Seasonings (AREA)
Detergent Compositions (AREA)

NO19961906A 1993-11-12 1996-05-10 Fremgangsmåte ved fremstilling av et klodronatpreparat NO312938B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI935019A FI94926C (fi)	1993-11-12	1993-11-12	Menetelmä klodronaattivalmisteen valmistamiseksi
PCT/FI1994/000509 WO1995013054A1 (en)	1993-11-12	1994-11-11	Process for preparing a clodronate preparation

Publications (3)

Publication Number	Publication Date
NO961906D0 NO961906D0 (no)	1996-05-10
NO961906L true NO961906L (no)	1996-05-23
NO312938B1 NO312938B1 (no)	2002-07-22

Family

ID=8538945

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19961906A NO312938B1 (no)	1993-11-12	1996-05-10	Fremgangsmåte ved fremstilling av et klodronatpreparat

Country Status (25)

Country	Link
US (1)	US5776499A (no)
EP (1)	EP0727983B1 (no)
JP (1)	JPH09504800A (no)
KR (1)	KR100352155B1 (no)
CN (1)	CN1040945C (no)
AT (1)	ATE202700T1 (no)
AU (1)	AU679586B2 (no)
CA (1)	CA2175994A1 (no)
CZ (1)	CZ286132B6 (no)
DE (1)	DE69427648T2 (no)
DK (1)	DK0727983T3 (no)
ES (1)	ES2160688T3 (no)
FI (1)	FI94926C (no)
GR (1)	GR3036470T3 (no)
HU (1)	HU220633B1 (no)
IL (1)	IL111596A (no)
NO (1)	NO312938B1 (no)
NZ (1)	NZ275833A (no)
PL (1)	PL176658B1 (no)
PT (1)	PT727983E (no)
RU (1)	RU2141323C1 (no)
SK (1)	SK280552B6 (no)
TW (1)	TW436297B (no)
WO (1)	WO1995013054A1 (no)
ZA (1)	ZA948974B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI109088B (fi) *	1997-09-19	2002-05-31	Leiras Oy	Tabletti ja menetelmä sen valmistamiseksi
DE19808634A1 (de) *	1998-02-24	1999-08-26	Schering Ag	Mantel für eine pharmazeutische Zusammensetzung
AR021347A1 (es)	1999-10-20	2002-07-17	Cipla Ltd	Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
RO121891B1 (ro)	2001-07-04	2008-07-30	Sindan S.R.L.	Compoziţie farmaceutică pentru profilaxia şi tratamentul dereglărilor metabolismului calciului şi procedeu de preparare
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
GB0616794D0 (en)	2006-08-24	2006-10-04	Arrow Int Ltd	Solid dosage form
JP6864955B2 (ja) *	2015-12-22	2021-04-28	ストックカンパニー“チェペトスキーメカニカルプラント”	チタン合金から棒材を製造する方法
MX2020005182A (es)	2017-11-22	2020-08-17	Inbiomotion Sl	Tratamiento terapeutico del cancer de mama basado en el estado del c-maf.
TWI806467B (zh)	2022-03-03	2023-06-21	金兆豐數位科技股份有限公司	金融商品提昇報酬率多維度決策方法
IT202300007269A1 (it)	2023-04-14	2024-10-14	Univ Degli Studi Magna Graecia Di Catanzaro	Formulazione farmaceutica composta da Peptide-C associato a un bisfosfonato in forma unica e suo uso nel trattamento dell’osteosarcopenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE60711T1 (de) *	1986-12-20	1991-02-15	Boehringer Mannheim Gmbh	Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
SE501389C2 (sv) *	1992-04-24	1995-01-30	Leiras Oy	Farmaceutiskt preparat och förfarande för dess framställning
NZ254765A (en)	1993-05-15	1997-02-24	Boehringer Mannheim Gmbh	Tablet medicament; comprises dichloromethylene diphosphonic acid (clodronic acid) or a pharmaceutically acceptable salt thereof as active ingredient and microcrystalline cellulose as auxiliary

1993
- 1993-11-12 FI FI935019A patent/FI94926C/fi not_active IP Right Cessation
1994
- 1994-11-10 IL IL11159694A patent/IL111596A/en active IP Right Grant
- 1994-11-11 AU AU81087/94A patent/AU679586B2/en not_active Ceased
- 1994-11-11 CZ CZ19961327A patent/CZ286132B6/cs not_active IP Right Cessation
- 1994-11-11 PL PL94314299A patent/PL176658B1/pl unknown
- 1994-11-11 US US08/646,359 patent/US5776499A/en not_active Expired - Lifetime
- 1994-11-11 PT PT95900155T patent/PT727983E/pt unknown
- 1994-11-11 DK DK95900155T patent/DK0727983T3/da active
- 1994-11-11 SK SK606-96A patent/SK280552B6/sk unknown
- 1994-11-11 AT AT95900155T patent/ATE202700T1/de not_active IP Right Cessation
- 1994-11-11 ES ES95900155T patent/ES2160688T3/es not_active Expired - Lifetime
- 1994-11-11 HU HU9601257A patent/HU220633B1/hu not_active IP Right Cessation
- 1994-11-11 NZ NZ275833A patent/NZ275833A/en unknown
- 1994-11-11 CN CN94194083A patent/CN1040945C/zh not_active Expired - Fee Related
- 1994-11-11 ZA ZA948974A patent/ZA948974B/xx unknown
- 1994-11-11 CA CA002175994A patent/CA2175994A1/en not_active Abandoned
- 1994-11-11 RU RU96113106A patent/RU2141323C1/ru not_active IP Right Cessation
- 1994-11-11 EP EP95900155A patent/EP0727983B1/en not_active Expired - Lifetime
- 1994-11-11 JP JP7513620A patent/JPH09504800A/ja not_active Ceased
- 1994-11-11 KR KR1019960702481A patent/KR100352155B1/ko not_active Expired - Fee Related
- 1994-11-11 WO PCT/FI1994/000509 patent/WO1995013054A1/en not_active Ceased
- 1994-11-11 DE DE69427648T patent/DE69427648T2/de not_active Expired - Fee Related
- 1994-11-17 TW TW083110664A patent/TW436297B/zh not_active IP Right Cessation
1996
- 1996-05-10 NO NO19961906A patent/NO312938B1/no unknown
2001
- 2001-08-30 GR GR20010401329T patent/GR3036470T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL314299A1 (en)	1996-09-02
HU220633B1 (hu)	2002-03-28
FI935019A0 (fi)	1993-11-12
JPH09504800A (ja)	1997-05-13
AU679586B2 (en)	1997-07-03
IL111596A (en)	1998-12-06
RU2141323C1 (ru)	1999-11-20
IL111596A0 (en)	1995-01-24
EP0727983A1 (en)	1996-08-28
PL176658B1 (pl)	1999-07-30
CZ286132B6 (cs)	2000-01-12
SK280552B6 (sk)	2000-03-13
NO312938B1 (no)	2002-07-22
PT727983E (pt)	2001-11-30
CZ132796A3 (en)	1996-10-16
DE69427648T2 (de)	2002-04-18
CA2175994A1 (en)	1995-05-18
FI94926C (fi)	1995-11-27
KR960705548A (ko)	1996-11-08
SK60696A3 (en)	1997-02-05
HU9601257D0 (en)	1996-07-29
HUT75228A (en)	1997-04-28
EP0727983B1 (en)	2001-07-04
KR100352155B1 (ko)	2002-12-31
ZA948974B (en)	1995-11-21
DK0727983T3 (da)	2001-09-24
NZ275833A (en)	1997-10-24
FI935019L (fi)	1995-05-13
ES2160688T3 (es)	2001-11-16
NO961906D0 (no)	1996-05-10
ATE202700T1 (de)	2001-07-15
FI94926B (fi)	1995-08-15
CN1040945C (zh)	1998-12-02
DE69427648D1 (de)	2001-08-09
WO1995013054A1 (en)	1995-05-18
US5776499A (en)	1998-07-07
AU8108794A (en)	1995-05-29
TW436297B (en)	2001-05-28
CN1134664A (zh)	1996-10-30
GR3036470T3 (en)	2001-11-30

Publication	Publication Date	Title
GR3031936T3 (en)	2000-03-31	Process for preparing controlled release pharmaceutical forms and the forms thus obtained.
DK0777964T3 (da)	2002-03-11	Fremgangsmåde til fremstilling af et doseringssystem
MY104772A (en)	1994-05-31	Dispersible granules of fungicidal products.
ZA957670B (en)	1997-03-13	Pharmaceutical preparation containing metformin and processes for the production thereof
DK0789559T3 (da)	1999-11-15	Farmaceutisk præparat indeholdende en smeltelig bærer og en fremgangsmåde til fremstilling deraf
HUT47376A (en)	1989-03-28	Insecticide compositions containing /p-phenoxy-phenoxy/-methyl-heteroaromatic compounds as active components and process for producing the active components
MY136231A (en)	2008-08-29	Slow release compositions
NO961906D0 (no)	1996-05-10	Fremgangsmåte ved fremstilling av et klodronatpreparat
HUT44128A (en)	1988-02-29	Process for producing substituted pyrimidines and pesticide compositions containing them as active components
HUT50141A (en)	1989-12-28	Herbicide compositions containing isoxazoline derivatives as active components and process for producing isoxazoline derivatives
MY113718A (en)	2002-05-31	Pharmaceutical formulation containing a hydrophobic active substance and an effervescent system, and process for the preparation of the formulation
ATE59960T1 (de)	1991-02-15	Theophyllintabletten mit verzoegerter freigabe.
GB2124078B (en)	1985-11-27	Processes for preparing tablets by a modified wet-granulation technique
JPS5296729A (en)	1977-08-13	Mixed vaccin for cyanomycosis
ES2113408T3 (es)	1998-05-01	Procedimiento para preparar una composicion detergente granular.
JPS57170165A (en)	1982-10-20	Active calcium fortifier
ES2122837A1 (es)	1998-12-16	Mezcla gaseosa y procedimiento para prepararla.
HUT52485A (en)	1990-07-28	Herbicide compositions containing benzo(f)indazol-4,9-quinones as active components and process for producing the active components
JPS53122679A (en)	1978-10-26	Process for preparing forming tablets
DK260387D0 (da)	1987-05-22	Soenderdelingsapparat til tilvejebringelse af pastaagtige masser, isaer poelsemasse
JPS53103441A (en)	1978-09-08	Preparation of optical active phenylglycines
RU94018502A (ru)	1995-11-10	Способ получения гербицидных гранулированных продуктов
JPS55105881A (en)	1980-08-13	Buffer memory system
UA11627A1 (uk)	1996-12-25	Спосіб отримаhhя модифіковаhого кремhезема
JPS51122022A (en)	1976-10-25	Process for preparing 3-methyl-3- pentenenitrile