NO962015L - Pyron derivatives such as protease inhibitors and antivirus agents - Google Patents

Pyron derivatives such as protease inhibitors and antivirus agents

Info

Publication number
NO962015L
NO962015L NO962015A NO962015A NO962015L NO 962015 L NO962015 L NO 962015L NO 962015 A NO962015 A NO 962015A NO 962015 A NO962015 A NO 962015A NO 962015 L NO962015 L NO 962015L
Authority
NO
Norway
Prior art keywords
protease inhibitors
pyron
derivatives
pyron derivatives
antivirus agents
Prior art date
Application number
NO962015A
Other languages
Norwegian (no)
Other versions
NO962015D0 (en
Inventor
John Michael Domagala
Edmund L Ellsworth
Elizabeth Lunney
Daniel Fred Ortwine
Kimberly Suzanne Para
Josyula Venkata Nagendr Prasad
Tomi Sawyer
Bradley Dean Tait
Original Assignee
Parke Davis & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,768 external-priority patent/US5808062A/en
Application filed by Parke Davis & Co filed Critical Parke Davis & Co
Publication of NO962015D0 publication Critical patent/NO962015D0/en
Publication of NO962015L publication Critical patent/NO962015L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Chemical Vapour Deposition (AREA)

Abstract

Foreliggende oppfinnelse vedrører nye tri- og tetra- substituerte pyroner og relaterte strukturer som potent inhiberer den HIV-aspartylprotease som blokkerer HIV- infeksiøsitet. Pyron-derivatene er anvendelige ved utviklingen av terapier for behandling av bakterielle og virale infeksjoner og sykdommer, inklusivt AIDS. Foreliggende opp- finnelse er også rettet mot fremgangsmåter for syntese av multifunksjonaliserte pyroner og av relaterte strukturer.The present invention relates to novel tri- and tetra-substituted pyrons and related structures that potently inhibit the HIV aspartyl protease that blocks HIV infectivity. The pyron derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods for the synthesis of multifunctional pyrones and of related structures.

NO962015A 1993-11-19 1996-05-15 Pyron derivatives such as protease inhibitors and antivirus agents NO962015L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15502893A 1993-11-19 1993-11-19
US08/319,768 US5808062A (en) 1993-11-19 1994-10-12 Pyrone derivatives as protease inhibitors and antiviral agents
PCT/US1994/012367 WO1995014014A2 (en) 1993-11-19 1994-10-26 Pyrone derivatives as protease inhibitors and antiviral agents

Publications (2)

Publication Number Publication Date
NO962015D0 NO962015D0 (en) 1996-05-15
NO962015L true NO962015L (en) 1996-05-15

Family

ID=26851948

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962015A NO962015L (en) 1993-11-19 1996-05-15 Pyron derivatives such as protease inhibitors and antivirus agents

Country Status (16)

Country Link
EP (1) EP0729466A1 (en)
JP (1) JPH09505295A (en)
AU (1) AU682417B2 (en)
BG (1) BG62770B1 (en)
CA (1) CA2174124A1 (en)
CZ (1) CZ134396A3 (en)
EE (1) EE9600044A (en)
FI (1) FI962019L (en)
HR (1) HRP940938A2 (en)
HU (1) HUT74888A (en)
IL (1) IL111671A0 (en)
NO (1) NO962015L (en)
PL (1) PL314484A1 (en)
RU (1) RU2153497C2 (en)
SK (1) SK63996A3 (en)
WO (1) WO1995014014A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW587079B (en) * 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
ES2154561B1 (en) * 1998-09-25 2001-12-01 Almirall Prodesfarma Sa DERIVATIVES OF 2-FENILPIRAN-4-ONA.
ES2168895A1 (en) * 1999-03-26 2002-06-16 Almirall Prodesfarma Sa 2-Phenylpyran-4-one derivatives as cyclooxygenase-2 (COX-2) inhibitors useful e.g. for treating pain, fever or inflammation, preventing colorectal cancer or neurodegenerative diseases
PE20011333A1 (en) * 2000-03-16 2002-01-16 Almirall Prodesfarma Ag DERIVATIVES OF 2-FENYLPYRAN-4-ONA AS INHIBITORS OF CYCLOOXYGENASE 2
KR102384668B1 (en) * 2016-06-14 2022-04-07 브리스톨-마이어스 스큅 컴퍼니 6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1H)-one as APJ agonist
EP3468952B1 (en) * 2016-06-14 2020-11-25 Bristol-Myers Squibb Company 4-hydroxy-3-sulfonylpyridin-2(1h)-ones as apj receptor agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3724M (en) * 1963-12-04 1965-12-06 Marcel Perrault Medicinal product based on anisoyl-3 hydroxy-4 p. methoxy-phenyl-6α-pyrone.
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
DE4308451A1 (en) * 1992-09-10 1994-04-14 Bayer Ag 3-aryl-pyrone derivatives
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
JP3372338B2 (en) * 1994-02-14 2003-02-04 オリンパス光学工業株式会社 Distance measuring device

Also Published As

Publication number Publication date
FI962019A7 (en) 1996-05-20
HUT74888A (en) 1997-02-28
CZ134396A3 (en) 1996-08-14
JPH09505295A (en) 1997-05-27
BG62770B1 (en) 2000-07-31
HRP940938A2 (en) 1997-06-30
EP0729466A1 (en) 1996-09-04
IL111671A0 (en) 1995-01-24
FI962019A0 (en) 1996-05-13
AU682417B2 (en) 1997-10-02
FI962019L (en) 1996-05-20
PL314484A1 (en) 1996-09-16
HU9601347D0 (en) 1996-07-29
NO962015D0 (en) 1996-05-15
WO1995014014A3 (en) 1995-06-15
RU2153497C2 (en) 2000-07-27
WO1995014014A2 (en) 1995-05-26
EE9600044A (en) 1996-10-15
CA2174124A1 (en) 1995-05-26
SK63996A3 (en) 1996-11-06
AU8127694A (en) 1995-06-06
BG100564A (en) 1996-12-31

Similar Documents

Publication Publication Date Title
NO962017D0 (en) 5,6-Dihydropyrone - derivatives such as protease inhibitors and antivirals
MD960171A (en) Pyrone derivatives as protease inhibitors and antiviral agents
NO962018L (en) 5,6-dihydropyrone derivatives such as protease inhibitors and antivirals
MY138860A (en) Hiv protease inhibitors.
FI915819A0 (en) HIV PROTEAS INHIBITOR.
NO20075806L (en) Amino acid hydroxyethylaminosulfonamide retroviral protease inhibitors
DE69518840D1 (en) N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren
ATE157988T1 (en) NOVEL PROLYL ENDOPEPTIDASE INHIBITORS SNA-115 AND SNA-115T, THEIR PREPARATION, AND STRAINS USED THEREIN
NO962015L (en) Pyron derivatives such as protease inhibitors and antivirus agents
NO962016D0 (en) Pyron derivatives such as protease inhibitors and antivirus agents
UA41338C2 (en) METHOD OF INHIBITION OF RETROVIRUS INFECTION CAUSED BY HUMAN IMMUNODEFICIENCY VIRUS (HIV), METHOD OF IMMUNIDUF IMMUNODE VIRUS INHIBITION

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application