NO962239L - Benzimidazolderivater, deres fremstilling og terapeutiske anvendelse - Google Patents

Benzimidazolderivater, deres fremstilling og terapeutiske anvendelse

Info

Publication number
NO962239L
NO962239L NO962239A NO962239A NO962239L NO 962239 L NO962239 L NO 962239L NO 962239 A NO962239 A NO 962239A NO 962239 A NO962239 A NO 962239A NO 962239 L NO962239 L NO 962239L
Authority
NO
Norway
Prior art keywords
ylmethyl
preparation
dioxothiazolidin
therapeutic use
benzimidazole derivatives
Prior art date
Application number
NO962239A
Other languages
English (en)
Other versions
NO962239D0 (no
NO308744B1 (no
Inventor
Takashi Fujita
Kunio Wada
Minoru Oguchi
Hiroaki Yanagisawa
Koichi Fujimoto
Toshihiko Fujiwara
Hiroyoshi Horikoshi
Takao Yoshioka
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26385935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO962239(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO962239D0 publication Critical patent/NO962239D0/no
Publication of NO962239L publication Critical patent/NO962239L/no
Publication of NO308744B1 publication Critical patent/NO308744B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO962239A 1995-06-01 1996-05-31 Benzimidazolderivater, deres anvendelse, og farmasøytisk preparat inneholdende disse NO308744B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13509795 1995-06-01
JP4584596 1996-03-04

Publications (3)

Publication Number Publication Date
NO962239D0 NO962239D0 (no) 1996-05-31
NO962239L true NO962239L (no) 1996-12-02
NO308744B1 NO308744B1 (no) 2000-10-23

Family

ID=26385935

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962239A NO308744B1 (no) 1995-06-01 1996-05-31 Benzimidazolderivater, deres anvendelse, og farmasøytisk preparat inneholdende disse

Country Status (20)

Country Link
US (1) US5886014A (no)
EP (1) EP0745600B1 (no)
JP (2) JP2976885B2 (no)
KR (2) KR100485425B1 (no)
CN (1) CN1066729C (no)
AT (1) ATE207489T1 (no)
AU (1) AU712390B2 (no)
CA (1) CA2177858C (no)
CZ (1) CZ293016B6 (no)
DE (1) DE69616151T2 (no)
DK (1) DK0745600T3 (no)
ES (1) ES2164841T3 (no)
HU (1) HU225778B1 (no)
IL (1) IL118474A (no)
MX (1) MX9602122A (no)
NO (1) NO308744B1 (no)
NZ (1) NZ286716A (no)
PT (1) PT745600E (no)
RU (1) RU2125048C1 (no)
TW (1) TW449594B (no)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
EP0783888A1 (en) * 1995-12-26 1997-07-16 Sankyo Company Limited Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis
IL120264A0 (en) * 1996-02-29 1997-06-10 Pfizer Method of reducing tissue damage associated with non-cardiac ischemia
ZA972152B (en) * 1996-03-18 1997-09-17 Sankyo Co Treatment and prophylaxis of pancreatitis.
IL120443A (en) * 1996-03-18 2000-07-16 Sankyo Co Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
HUP9903292A3 (en) * 1996-05-31 2000-08-28 Sankyo Co Use of substances improving insulin resistance for production of remedies for autoimmune diseases
CA2257284C (en) * 1996-05-31 2005-10-04 Sankyo Company Limited Remedy for autoimmune diseases
USRE39266E1 (en) 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
BR9711098B1 (pt) 1996-07-01 2011-10-04 compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
US6011036A (en) * 1997-04-15 2000-01-04 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them
WO1997041121A1 (en) * 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
KR100666887B1 (ko) * 1997-10-08 2007-01-10 상꾜 가부시키가이샤 치환 축합 복소환 화합물
HUP9902721A2 (hu) 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
AU1507799A (en) * 1997-12-16 1999-07-05 Sankyo Company Limited Leukemia remedy
WO2000028991A1 (en) * 1998-11-13 2000-05-25 Fujisawa Pharmaceutical Co., Ltd. Remedies for polycystic ovary syndrome
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
WO2000043007A1 (en) * 1999-01-19 2000-07-27 Sankyo Company, Limited Troglitazone-containing medicinal compositions for inhibiting apoptosis
CZ20013593A3 (cs) * 1999-04-06 2002-03-13 Sankyo Company, Limited Alfa-Substituované deriváty karboxylových kyselin
PL351878A1 (en) * 1999-04-07 2003-06-30 Sankyo Co Amino compound derivatives
WO2000061582A1 (en) * 1999-04-08 2000-10-19 Sankyo Company, Limited Substituted fused imidazole derivatives
TWI284533B (en) * 1999-05-24 2007-08-01 Sankyo Co Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant
JP2001072671A (ja) * 1999-06-28 2001-03-21 Sankyo Co Ltd ベンズイミダゾール化合物の合成中間体およびその製造方法
AU5570000A (en) * 1999-06-28 2001-01-31 Sankyo Company Limited Intermediates for the synthesis of benzimidazole compounds and process for the preparation thereof
BR0012591A (pt) * 1999-07-19 2002-04-09 Sankyo Co Agente profilático ou terapêutico para câncer
WO2001027094A1 (en) * 1999-10-12 2001-04-19 Japan Tobacco Inc. Hypertriglyceridemia remedies and antiobestics
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
JP2002088048A (ja) * 2000-07-13 2002-03-27 Sumitomo Chem Co Ltd Ｎ−ｔ−ブトキシカルボニルニトロアニリン誘導体の製造法
US6630598B2 (en) 2000-07-13 2003-10-07 Sumitomo Chemical Company, Limited Process for producing N-acylnitroaniline derivative
RU2205826C2 (ru) * 2000-12-21 2003-06-10 Национальная фармацевтическая академия Украины (±)-цис-3-(2'-бензимидазолил)-1,2,2-триметилциклопентанкарбоновая кислота, проявляющая сахароснижающее и антидиабетогенное действие
US6452014B1 (en) * 2000-12-22 2002-09-17 Geron Corporation Telomerase inhibitors and methods of their use
ATE341343T1 (de) 2000-12-26 2006-10-15 Sankyo Co Medizinische zusammensetzungen mit diuretischem und die insulinresistenz verbesserndem mittel
GB0112363D0 (en) 2001-05-21 2001-07-11 Allied Therapeutics Ltd Method and apparatus for treating biological fluids
FR2829765A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique
EP1448794A4 (en) 2001-10-24 2005-06-01 Univ California IDENTIFICATION OF 5-LIPOXYGENASE AS ONE OF THE GENES THAT CONTRIBUTE MAINLY TO ATHEROSCLEROSIS
JP2004002365A (ja) * 2002-04-05 2004-01-08 Sankyo Co Ltd Ａｃａｔ阻害剤とインシュリン抵抗性改善剤とからなる医薬組成物
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
KR20040099394A (ko) * 2002-04-05 2004-11-26 상꾜 가부시키가이샤 Ａｃａｔ 저해제 및 인슐린 저항성 개선제를 함유하는의약 조성물
WO2004000356A1 (ja) * 2002-06-25 2003-12-31 Sankyo Company, Limited 利尿剤及びペルオキシソーム増殖因子活性化受容体（PPAR)γ活性化剤を含有する医薬組成物
JP2004083574A (ja) * 2002-06-25 2004-03-18 Sankyo Co Ltd 利尿剤及びペルオキシソーム増殖因子活性化受容体（ＰＰＡＲ）γ活性化剤を含有する医薬組成物
WO2004013109A1 (ja) * 2002-08-02 2004-02-12 Sankyo Company, Limited レゾルシノール誘導体
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
WO2004035830A1 (ja) * 2002-10-18 2004-04-29 Sankyo Company,Limited β細胞機能不全改善剤の評価方法
US20040198800A1 (en) * 2002-12-19 2004-10-07 Geoffrey Allan Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
US6794401B2 (en) * 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
WO2005039574A1 (ja) * 2003-10-24 2005-05-06 Santen Pharmaceutical Co., Ltd. 角結膜障害の治療剤
CA2543555A1 (en) 2003-10-29 2005-05-06 Santen Pharmaceutical Co., Ltd. Therapeutic agent for keratoconjunctival disorder
BRPI0509305A (pt) * 2004-03-29 2007-09-04 Sankyo Co uso de um sensibilizador insulìnico, composição farmecêutica, e , kit
RU2246945C1 (ru) * 2004-05-11 2005-02-27 Аверин Константин Михайлович Суппозитории притововоспалительного, антисептического и регенерационного действия
TW200608967A (en) * 2004-07-29 2006-03-16 Sankyo Co Pharmaceutical compositions containing with diabetic agent
WO2006022450A1 (ja) * 2004-08-26 2006-03-02 Santen Pharmaceutical Co., Ltd. 皮膚疾患治療剤
JP4789180B2 (ja) * 2004-09-28 2011-10-12 第一三共株式会社 ６−置換−１−メチル−１−ｈ−ベンズイミダゾール誘導体の製造方法及びその製造中間体
CN101068770B (zh) 2004-09-28 2012-01-04 三共株式会社 制备6-取代的-1-甲基-1-h-苯并咪唑衍生物的方法及其合成中间体
WO2006044556A2 (en) * 2004-10-14 2006-04-27 Galileo Pharmaceuticals, Inc. Dual inhibitors of lipoxygenase for treating diabetes
AU2005298986A1 (en) * 2004-10-27 2006-05-04 F. Hoffmann-La Roche Ag New indole or benzimidazole derivatives
BRPI0519015A2 (pt) * 2004-12-15 2008-12-23 Daiichi Sankyo Co Ltd composiÇço farmacÊutica, agente profilÁtico ou agente terapÊutico, agentes para melhorar a funÇço das cÉlulas b no pÂncreas, e para a reduÇço da razço da hemoglobina glicosilada, e, usos da 5-[4-(6-metàxi-1-metil-1h-benzimidazol-2-ilmetàxi)benzi l] tiazolidina-2,4-diona ou de um sal farmacologicamente aceitÁvel da mesma e de um inibidor de fbpase, e do 2-amino-5-isobutil-4-[2-[5-(n,n'-bis((s)-1etoxicarbonil)eti l) fosfonamido] furanil} tiazol ou de um sal farmacologicamente aceitÁvel do mesmo
JP2006225382A (ja) * 2005-01-24 2006-08-31 Sankyo Co Ltd チアゾリジンジオン化合物の製造方法及びその製造中間体
TW200637856A (en) * 2005-01-24 2006-11-01 Sankyo Co Process for producing thiazolidinedion compound and intermediate thereof
EP1889618A4 (en) * 2005-05-27 2010-11-24 Daiichi Sankyo Co Ltd Combined drug for treating diabetes
TWI418350B (zh) * 2005-06-24 2013-12-11 Sankyo Co 含有ｐｐａｒ調節劑之醫藥組成物的用途
TW200740802A (en) * 2005-07-08 2007-11-01 Sankyo Co Pharmaceutical composition containing thiazolidinedione compound
TW200740460A (en) * 2005-07-12 2007-11-01 Sankyo Co Pharmaceutical composition containing PPAR γ agonist
TW200738266A (en) * 2005-09-29 2007-10-16 Sankyo Co Pharmaceutical agent containing insulin resistance improving agent
TW200730173A (en) * 2005-12-16 2007-08-16 Sankyo Co Pharmaceutical composition enhancing production of adiponectin
JP2008044932A (ja) * 2006-07-21 2008-02-28 Daiichi Sankyo Co Ltd チアゾリジンジオン化合物を含有する組成物
UA100497C2 (ru) 2006-09-07 2013-01-10 Никомед Гмбх Комбинированное лечение сахарного диабета
KR100811100B1 (ko) * 2006-09-27 2008-03-06 한국생명공학연구원 벤즈아졸 유도체를 유효성분으로 함유하는 대사성 질환예방 및 치료용 약학적 조성물
BRPI0809643A2 (pt) * 2007-04-05 2014-11-11 Daiichi Sankyo Co Ltd Derivados de heteroarila bicíclica fundida
KR101560844B1 (ko) 2007-06-04 2015-10-15 벤-구리온 유니버시티 오브 더 네게브 리서치 앤드 디벨럽먼트 어쏘러티 트라이-아릴계 화합물 및 이를 포함하는 조성물
CN101959531A (zh) 2008-02-25 2011-01-26 参天制药株式会社 角膜上皮屏障功能增强剂
EP2505587A1 (en) 2009-11-26 2012-10-03 Daiichi Sankyo Company, Limited Method for manufacturing a 6-substituted-1-methyl-1h-benzimidazole derivative, and manufacturing intermediate from said method
EP2809656A2 (en) 2011-12-28 2014-12-10 Allergan, Inc. Benzimidazole derivatives as selective blockers of persistent sodium current
EA201690938A1 (ru) 2013-11-05 2016-11-30 Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити Соединения для лечения диабета и осложнений, возникающих из-за этого заболевания
CN104086541B (zh) * 2014-07-18 2016-01-20 高中设 一种治疗小儿呼吸道感染的药物组合物
CN104083364B (zh) * 2014-07-18 2015-12-09 泰山医学院附属医院 一种治疗阴沟肠杆菌引起的小儿呼吸道感染的药物组合物

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
JPS60226873A (ja) * 1984-03-28 1985-11-12 Sankyo Co Ltd １，３−ベンゾオキサチオ−ル誘導体及びその製法
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
US4681940A (en) * 1985-11-19 1987-07-21 American Home Products Corporation 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles
US4873255A (en) * 1987-02-04 1989-10-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
JP2826379B2 (ja) * 1990-01-22 1998-11-18 三共株式会社 チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
EP0839812A1 (en) * 1990-04-27 1998-05-06 Sankyo Company Limited Preparation of benzylthiazolidine derivatives
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
US5334604A (en) * 1990-08-23 1994-08-02 Pfizer Inc. Hypoglycemic hydroxyurea derivatives
GB9023584D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023585D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
RU2066322C1 (ru) * 1991-06-28 1996-09-10 Киевский Государственный Университет Им.Т.Г.Шевченко 3-(4-метил-2-тиазолил)-6-пропил-7-(1-метил-1-этоксикарбонил)метоксихромон, обладающий гипогликемическим, гиполипидемическим действием и аналептическим действием
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO302519B1 (no) * 1991-12-26 1998-03-16 Sankyo Co Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
TW363959B (en) * 1994-03-23 1999-07-11 Sankyo Co Thiazolidine and oxazolidine derivatives, their preparation and their medical use
CZ289317B6 (cs) * 1994-04-11 2002-01-16 Sankyo Company Limited Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití
US5420146A (en) * 1994-05-10 1995-05-30 American Home Products Corporation Di-oxadiazolidine derivatives as antihyperglycemic agents
JPH08143556A (ja) * 1994-11-15 1996-06-04 Terumo Corp ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物
JPH08143568A (ja) * 1994-11-22 1996-06-04 Terumo Corp ピリドピリミジン誘導体及びそれを含有する医薬組成物
JPH08143566A (ja) * 1994-11-25 1996-06-04 Terumo Corp キナゾリン誘導体及びそれを含有する医薬組成物
JP3929512B2 (ja) * 1995-06-02 2007-06-13 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
JP3144624B2 (ja) * 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法

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AU5462796A (en) 1996-12-12
ATE207489T1 (de) 2001-11-15
JP3249490B2 (ja) 2002-01-21
HU225778B1 (en) 2007-08-28
HUP9601492A3 (en) 1998-10-28
DE69616151T2 (de) 2002-07-11
KR100493772B1 (ko) 2005-06-08
CA2177858A1 (en) 1996-12-02
JPH09295970A (ja) 1997-11-18
KR970001349A (ko) 1997-01-24
HK1011683A1 (en) 1999-07-16
EP0745600B1 (en) 2001-10-24
EP0745600A1 (en) 1996-12-04
US5886014A (en) 1999-03-23
KR100485425B1 (ko) 2005-10-27
AU712390B2 (en) 1999-11-04
CZ156796A3 (en) 1996-12-11
DE69616151D1 (de) 2001-11-29
NO962239D0 (no) 1996-05-31
IL118474A0 (en) 1996-09-12
HK1002280A1 (en) 1998-08-14
CN1157288A (zh) 1997-08-20
PT745600E (pt) 2002-02-28
CZ293016B6 (cs) 2004-01-14
JP2976885B2 (ja) 1999-11-10
JP2000001487A (ja) 2000-01-07
IL118474A (en) 2001-08-08
TW449594B (en) 2001-08-11
MX9602122A (es) 1997-06-28
ES2164841T3 (es) 2002-03-01
CN1066729C (zh) 2001-06-06
NO308744B1 (no) 2000-10-23
HUP9601492A2 (hu) 1998-08-28
RU2125048C1 (ru) 1999-01-20
DK0745600T3 (da) 2001-11-12
NZ286716A (en) 1997-08-22
HU9601492D0 (en) 1996-07-29

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