NO962848L - Monohydrat av (E)-2'-deoksy-2'-(fluormetylen)cytidin - Google Patents

Monohydrat av (E)-2'-deoksy-2'-(fluormetylen)cytidin

Info

Publication number: NO962848L
Authority: NO; Norway
Prior art keywords: fluoromethylene; cytidine; deoxy; monohydrate; neoplastic
Prior art date: 1994-01-07

Application number

NO962848A

Other languages

English (en)

Other versions

NO306409B1 (no

NO962848D0 (no

Inventor

Richard E Donaldson

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-07

Filing date

1996-07-05

Publication date

1996-09-06

1996-07-05 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-07-05 Publication of NO962848D0 publication Critical patent/NO962848D0/no

1996-09-06 Publication of NO962848L publication Critical patent/NO962848L/no

1999-11-01 Publication of NO306409B1 publication Critical patent/NO306409B1/no

Links

150000004682 monohydrates Chemical class 0.000 title abstract 2
XPYQFIISZQCINN-QVXDJYSKSA-N 4-amino-1-[(2r,3e,4s,5r)-3-(fluoromethylidene)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrate Chemical compound O.O=C1N=C(N)C=CN1[C@H]1C(=C/F)/[C@H](O)[C@@H](CO)O1 XPYQFIISZQCINN-QVXDJYSKSA-N 0.000 title 1
229940123934 Reductase inhibitor Drugs 0.000 abstract 1
102000000505 Ribonucleotide Reductases Human genes 0.000 abstract 1
108010041388 Ribonucleotide Reductases Proteins 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001613 neoplastic effect Effects 0.000 abstract 1
GFFXZLZWLOBBLO-ASKVSEFXSA-N tezacitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(=C/F)/[C@H](O)[C@@H](CO)O1 GFFXZLZWLOBBLO-ASKVSEFXSA-N 0.000 abstract 1
230000003612 virological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO962848A 1994-01-07 1996-07-05 Monohydrat av (E)-2'-deoxy-2'-(fluormethylen)cytidin NO306409B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17895294A	1994-01-07	1994-01-07
PCT/US1994/014648 WO1995018815A1 (en)	1994-01-07	1994-12-13	Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine

Publications (3)

Publication Number	Publication Date
NO962848D0 NO962848D0 (no)	1996-07-05
NO962848L true NO962848L (no)	1996-09-06
NO306409B1 NO306409B1 (no)	1999-11-01

Family

ID=22654587

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO962848A NO306409B1 (no)	1994-01-07	1996-07-05	Monohydrat av (E)-2'-deoxy-2'-(fluormethylen)cytidin

Country Status (20)

Country	Link
EP (1)	EP0738273B1 (no)
JP (1)	JPH09511227A (no)
KR (1)	KR100330328B1 (no)
CN (1)	CN1043231C (no)
AT (1)	ATE186732T1 (no)
AU (1)	AU684604B2 (no)
CA (1)	CA2179987C (no)
DE (1)	DE69421721T2 (no)
DK (1)	DK0738273T3 (no)
ES (1)	ES2141330T3 (no)
FI (1)	FI114396B (no)
GR (1)	GR3032614T3 (no)
HU (1)	HU217849B (no)
IL (1)	IL112242A (no)
MX (1)	MX9500363A (no)
NO (1)	NO306409B1 (no)
NZ (1)	NZ279030A (no)
TW (1)	TW397838B (no)
WO (1)	WO1995018815A1 (no)
ZA (1)	ZA9512B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1130363C (zh)	1997-11-12	2003-12-10	三菱化学株式会社	嘌呤衍生物以及含有其作为有效成分的药物
WO2000068231A1 (en)	1999-05-11	2000-11-16	Mitsubishi Chemical Corporation	Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof
TW202547461A (zh)	2024-05-17	2025-12-16	美商銳新醫藥公司	Ｒａｓ抑制劑
WO2025255438A1 (en)	2024-06-07	2025-12-11	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en)	2024-06-21	2025-12-26	Revolution Medicines, Inc.	Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en)	2024-06-28	2026-01-02	Revolution Medicines, Inc.	Ras inhibitors
WO2026015790A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015801A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015796A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015825A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en)	2024-08-29	2026-03-05	Revolution Medicines, Inc.	Ras inhibitors
WO2026072904A2 (en)	2024-09-26	2026-04-02	Revolution Medicines, Inc.	Compositions and methods for treating lung cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA898567B (en) *	1988-11-15	1990-08-29	Merrell Dow Pharma	Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
FI95269C (fi) *	1989-05-15	1996-01-10	Squibb Bristol Myers Co	2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
JPH0615557B2 (ja) *	1990-02-19	1994-03-02	ヤマサ醤油株式会社	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
JP3265548B2 (ja) *	1992-05-12	2002-03-11	メレルファーマス−ティカルズインコーポレイテッド	リボヌクレオチド還元酵素阻害剤の製法

1994
- 1994-12-13 AT AT95907232T patent/ATE186732T1/de not_active IP Right Cessation
- 1994-12-13 CN CN94194779A patent/CN1043231C/zh not_active Expired - Fee Related
- 1994-12-13 EP EP95907232A patent/EP0738273B1/en not_active Expired - Lifetime
- 1994-12-13 WO PCT/US1994/014648 patent/WO1995018815A1/en not_active Ceased
- 1994-12-13 DE DE69421721T patent/DE69421721T2/de not_active Expired - Fee Related
- 1994-12-13 HU HU9601848A patent/HU217849B/hu not_active IP Right Cessation
- 1994-12-13 NZ NZ279030A patent/NZ279030A/en unknown
- 1994-12-13 ES ES95907232T patent/ES2141330T3/es not_active Expired - Lifetime
- 1994-12-13 AU AU15532/95A patent/AU684604B2/en not_active Ceased
- 1994-12-13 JP JP7518503A patent/JPH09511227A/ja active Pending
- 1994-12-13 CA CA002179987A patent/CA2179987C/en not_active Expired - Fee Related
- 1994-12-13 KR KR1019960703658A patent/KR100330328B1/ko not_active Expired - Fee Related
- 1994-12-13 DK DK95907232T patent/DK0738273T3/da active
1995
- 1995-01-03 ZA ZA9512A patent/ZA9512B/xx unknown
- 1995-01-04 IL IL11224295A patent/IL112242A/xx not_active IP Right Cessation
- 1995-01-04 TW TW084100012A patent/TW397838B/zh not_active IP Right Cessation
- 1995-01-06 MX MX9500363A patent/MX9500363A/es unknown
1996
- 1996-07-05 FI FI962769A patent/FI114396B/fi active IP Right Grant
- 1996-07-05 NO NO962848A patent/NO306409B1/no unknown
2000
- 2000-02-09 GR GR20000400313T patent/GR3032614T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI962769L (fi)	1996-07-05
HU217849B (hu)	2000-04-28
CN1141045A (zh)	1997-01-22
DE69421721T2 (de)	2000-04-27
AU684604B2 (en)	1997-12-18
ATE186732T1 (de)	1999-12-15
WO1995018815A1 (en)	1995-07-13
TW397838B (en)	2000-07-11
DK0738273T3 (da)	2000-04-17
IL112242A0 (en)	1995-03-30
FI962769A0 (fi)	1996-07-05
GR3032614T3 (en)	2000-05-31
AU1553295A (en)	1995-08-01
HU9601848D0 (en)	1996-09-30
CA2179987C (en)	1999-01-19
NZ279030A (en)	1997-05-26
ES2141330T3 (es)	2000-03-16
NO306409B1 (no)	1999-11-01
EP0738273B1 (en)	1999-11-17
DE69421721D1 (de)	1999-12-23
IL112242A (en)	2000-08-31
CA2179987A1 (en)	1995-07-13
JPH09511227A (ja)	1997-11-11
EP0738273A1 (en)	1996-10-23
HUT75055A (en)	1997-03-28
NO962848D0 (no)	1996-07-05
KR100330328B1 (ko)	2002-12-05
MX9500363A (es)	1998-04-30
CN1043231C (zh)	1999-05-05
ZA9512B (en)	1995-09-11
FI114396B (fi)	2004-10-15

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