ES2141330T3 - Monohidrato de (e)-2'-desoxi-2'-(fluorometileno)citidina. - Google Patents

Monohidrato de (e)-2'-desoxi-2'-(fluorometileno)citidina.

Info

Publication number
ES2141330T3
ES2141330T3 ES95907232T ES95907232T ES2141330T3 ES 2141330 T3 ES2141330 T3 ES 2141330T3 ES 95907232 T ES95907232 T ES 95907232T ES 95907232 T ES95907232 T ES 95907232T ES 2141330 T3 ES2141330 T3 ES 2141330T3
Authority
ES
Spain
Prior art keywords
fluorometilene
citidina
monohydrate
desoxi
ribonucleotida
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95907232T
Other languages
English (en)
Inventor
Richard E Donaldson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2141330T3 publication Critical patent/ES2141330T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO MONOHIDRATO O (E)2''-DEOXI-2''-(FLUOROMETILENO)CITIDINA UTIL COMO INHIBIDOR DE REDUCTASA RIBONUCLEOTIDA EN EL TRATAMIENTO DE PACIENTES AQUEJADOS DE ESTADOS NEOPLASTICOS O ENFERMEDADES VIRALES.
ES95907232T 1994-01-07 1994-12-13 Monohidrato de (e)-2'-desoxi-2'-(fluorometileno)citidina. Expired - Lifetime ES2141330T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17895294A 1994-01-07 1994-01-07

Publications (1)

Publication Number Publication Date
ES2141330T3 true ES2141330T3 (es) 2000-03-16

Family

ID=22654587

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95907232T Expired - Lifetime ES2141330T3 (es) 1994-01-07 1994-12-13 Monohidrato de (e)-2'-desoxi-2'-(fluorometileno)citidina.

Country Status (20)

Country Link
EP (1) EP0738273B1 (es)
JP (1) JPH09511227A (es)
KR (1) KR100330328B1 (es)
CN (1) CN1043231C (es)
AT (1) ATE186732T1 (es)
AU (1) AU684604B2 (es)
CA (1) CA2179987C (es)
DE (1) DE69421721T2 (es)
DK (1) DK0738273T3 (es)
ES (1) ES2141330T3 (es)
FI (1) FI114396B (es)
GR (1) GR3032614T3 (es)
HU (1) HU217849B (es)
IL (1) IL112242A (es)
MX (1) MX9500363A (es)
NO (1) NO306409B1 (es)
NZ (1) NZ279030A (es)
TW (1) TW397838B (es)
WO (1) WO1995018815A1 (es)
ZA (1) ZA9512B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2309350C (en) 1997-11-12 2007-04-03 Mitsubishi Chemical Corporation Purine derivatives and medicaments comprising the same as active ingredient
CN1160355C (zh) 1999-05-11 2004-08-04 三菱化学株式会社 嘌呤衍生物二水合物、含有该化合物作为有效成分的药物及其制备中间体
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer
WO2026090116A2 (en) 2024-10-21 2026-04-30 Revolution Medicines, Inc. Ras inhibitors
US20260108528A1 (en) 2024-10-22 2026-04-23 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2026090245A1 (en) 2024-10-22 2026-04-30 Revolution Medicines, Inc. Use of ras inhibitors for treating cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002648C (en) * 1988-11-15 2000-02-29 James R. Mccarthy 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
EP0640092B1 (en) * 1992-05-12 1996-12-11 Merrell Pharmaceuticals Inc. A process for the preparation of ribonucleotide reductase inhibitors

Also Published As

Publication number Publication date
AU684604B2 (en) 1997-12-18
AU1553295A (en) 1995-08-01
NO962848D0 (no) 1996-07-05
CN1043231C (zh) 1999-05-05
CA2179987A1 (en) 1995-07-13
HU217849B (hu) 2000-04-28
CN1141045A (zh) 1997-01-22
FI962769A0 (fi) 1996-07-05
WO1995018815A1 (en) 1995-07-13
HUT75055A (en) 1997-03-28
HU9601848D0 (en) 1996-09-30
NO306409B1 (no) 1999-11-01
IL112242A0 (en) 1995-03-30
ATE186732T1 (de) 1999-12-15
EP0738273A1 (en) 1996-10-23
TW397838B (en) 2000-07-11
CA2179987C (en) 1999-01-19
IL112242A (en) 2000-08-31
DE69421721D1 (de) 1999-12-23
NZ279030A (en) 1997-05-26
DE69421721T2 (de) 2000-04-27
FI114396B (fi) 2004-10-15
ZA9512B (en) 1995-09-11
FI962769L (fi) 1996-07-05
KR100330328B1 (ko) 2002-12-05
JPH09511227A (ja) 1997-11-11
DK0738273T3 (da) 2000-04-17
EP0738273B1 (en) 1999-11-17
MX9500363A (es) 1998-04-30
NO962848L (no) 1996-09-06
GR3032614T3 (en) 2000-05-31

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