NO964231L - Stabil vandig folinatopplösning - Google Patents

Stabil vandig folinatopplösning

Info

Publication number: NO964231L
Authority: NO; Norway
Prior art keywords: stable aqueous; folinate solution; aqueous folinate; solution; aqueous solution
Prior art date: 1994-04-05

Application number

NO964231A

Other languages

English (en)

Other versions

NO964231D0 (no

NO314039B1 (no

Inventor

Alfred James Nijkerk

Johanna Maria Pieterne Vermeer

Original Assignee

Pharmachemie Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-05

Filing date

1996-10-04

Publication date

1996-10-04

1996-10-04 Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv

1996-10-04 Publication of NO964231L publication Critical patent/NO964231L/no

1996-10-04 Publication of NO964231D0 publication Critical patent/NO964231D0/no

2003-01-20 Publication of NO314039B1 publication Critical patent/NO314039B1/no

Links

VVIAGPKUTFNRDU-STQMWFEESA-N (6S)-5-formyltetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C=O)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-STQMWFEESA-N 0.000 title 1
239000007864 aqueous solution Substances 0.000 abstract 2
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 abstract 1
MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 abstract 1
235000008191 folinic acid Nutrition 0.000 abstract 1
239000011672 folinic acid Substances 0.000 abstract 1
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 abstract 1
229960001691 leucovorin Drugs 0.000 abstract 1
235000008190 sodium folinate Nutrition 0.000 abstract 1
239000011673 sodium folinate Substances 0.000 abstract 1
229940055334 sodium folinate Drugs 0.000 abstract 1
UDDUKFYJPZYIPC-ZEDZUCNESA-M sodium folinate Chemical compound [Na+].C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC([O-])=O)C(O)=O)C=C1 UDDUKFYJPZYIPC-ZEDZUCNESA-M 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Obesity (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Nutrition Science (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO19964231A 1994-04-05 1996-10-04 Stabil vandig folinatopplösning NO314039B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL9400530A NL9400530A (nl)	1994-04-05	1994-04-05	Stabiele waterige folinaatoplossing.
PCT/NL1995/000126 WO1995026963A1 (en)	1994-04-05	1995-04-04	Stable aqueous folinate solution

Publications (3)

Publication Number	Publication Date
NO964231L true NO964231L (no)	1996-10-04
NO964231D0 NO964231D0 (no)	1996-10-04
NO314039B1 NO314039B1 (no)	2003-01-20

Family

ID=19864026

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19964231A NO314039B1 (no)	1994-04-05	1996-10-04	Stabil vandig folinatopplösning

Country Status (15)

Country	Link
US (1)	US6613767B1 (no)
EP (1)	EP0755396B1 (no)
JP (1)	JPH09510989A (no)
AT (1)	ATE194346T1 (no)
AU (1)	AU684350B2 (no)
DE (1)	DE69517806T2 (no)
DK (1)	DK0755396T3 (no)
ES (1)	ES2149354T3 (no)
FI (1)	FI120039B (no)
GR (1)	GR3033863T3 (no)
NL (1)	NL9400530A (no)
NO (1)	NO314039B1 (no)
PT (1)	PT755396E (no)
WO (1)	WO1995026963A1 (no)
ZA (1)	ZA952805B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH687062A5 (de) *	1994-02-14	1996-09-13	Cerbios Pharma Sa	Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl)	1994-04-05	1995-11-01	Pharmachemie Bv	Stabiele waterige folinaatoplossing.
CH697021A5 (de) *	2003-06-26	2008-03-31	Merck Eprova Ag	Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat.
CH696717A5 (de) *	2004-02-20	2007-10-31	Cerbios Pharma Sa	Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
CN102258463A (zh) *	2011-07-18	2011-11-30	重庆煜澍丰医药有限公司	一种稳定的亚叶酸钠注射液
ES2414557B1 (es) *	2012-01-16	2014-06-10	Novocat Farma, S.A.	Composición acuosa de paracetamol para inyección
US9713616B2 (en)	2012-08-06	2017-07-25	Spectrum Pharmaceuticals, Inc.	Pharmaceutical compositions comprising L-leucovorin
US10059710B2 (en)	2016-02-17	2018-08-28	Merck & Cie	Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2695860A (en) *	1952-04-29	1954-11-30	American Cyanamid Co	Stabilized pteroyl solutions
CH673459A5 (no)	1987-05-15	1990-03-15	Eprova Ag
DE69027598T2 (de)	1989-03-13	1996-10-31	Kenneth N Matsumura	Zusammensetzung zur herabsetzung der nebenwirkungen eines arzneimittels
NL8901432A (nl) *	1989-06-06	1991-01-02	Pharmachemie Bv	Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.
US5173488A (en) *	1989-08-21	1992-12-22	American Cyanamid Company	Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
CH687062A5 (de)	1994-02-14	1996-09-13	Cerbios Pharma Sa	Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl)	1994-04-05	1995-11-01	Pharmachemie Bv	Stabiele waterige folinaatoplossing.

1994
- 1994-04-05 NL NL9400530A patent/NL9400530A/nl not_active Application Discontinuation
1995
- 1995-04-04 AT AT95913428T patent/ATE194346T1/de active
- 1995-04-04 DE DE69517806T patent/DE69517806T2/de not_active Expired - Lifetime
- 1995-04-04 ES ES95913428T patent/ES2149354T3/es not_active Expired - Lifetime
- 1995-04-04 AU AU20862/95A patent/AU684350B2/en not_active Expired
- 1995-04-04 EP EP95913428A patent/EP0755396B1/en not_active Expired - Lifetime
- 1995-04-04 JP JP7525589A patent/JPH09510989A/ja active Pending
- 1995-04-04 PT PT95913428T patent/PT755396E/pt unknown
- 1995-04-04 WO PCT/NL1995/000126 patent/WO1995026963A1/en not_active Ceased
- 1995-04-04 DK DK95913428T patent/DK0755396T3/da active
- 1995-04-05 ZA ZA952805A patent/ZA952805B/xx unknown
1996
- 1996-10-03 FI FI963972A patent/FI120039B/fi not_active IP Right Cessation
- 1996-10-04 NO NO19964231A patent/NO314039B1/no not_active IP Right Cessation
- 1996-10-07 US US08/726,803 patent/US6613767B1/en not_active Expired - Lifetime
2000
- 2000-07-06 GR GR20000401477T patent/GR3033863T3/el unknown

Also Published As

Publication number	Publication date
EP0755396B1 (en)	2000-07-05
DE69517806T2 (de)	2001-11-08
AU2086295A (en)	1995-10-23
FI963972A0 (fi)	1996-10-03
ZA952805B (en)	1995-12-19
WO1995026963A1 (en)	1995-10-12
DE69517806D1 (de)	2000-08-10
NL9400530A (nl)	1995-11-01
EP0755396A1 (en)	1997-01-29
NO964231D0 (no)	1996-10-04
GR3033863T3 (en)	2000-10-31
ATE194346T1 (de)	2000-07-15
NO314039B1 (no)	2003-01-20
FI120039B (fi)	2009-06-15
JPH09510989A (ja)	1997-11-04
FI963972L (fi)	1996-10-03
US6613767B1 (en)	2003-09-02
PT755396E (pt)	2000-10-31
DK0755396T3 (da)	2000-11-13
AU684350B2 (en)	1997-12-11
ES2149354T3 (es)	2000-11-01

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Legal Events

Date	Code	Title	Description
2015-04-13	MK1K	Patent expired