NO964699L - Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike - Google Patents
Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slikeInfo
- Publication number
- NO964699L NO964699L NO964699A NO964699A NO964699L NO 964699 L NO964699 L NO 964699L NO 964699 A NO964699 A NO 964699A NO 964699 A NO964699 A NO 964699A NO 964699 L NO964699 L NO 964699L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- processes
- tetrahydrofolic acid
- stable crystalline
- acid salts
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical class N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 abstract 1
- MSTNYGQPCMXVAQ-NEPJUHHUSA-N 6R-Tetrahydrofolic acid Chemical compound C([C@@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-NEPJUHHUSA-N 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH03145/95A CH689831A5 (de) | 1995-11-07 | 1995-11-07 | Stabile kristalline Tetrahydrofolsaeure-Salze. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO964699D0 NO964699D0 (no) | 1996-11-06 |
| NO964699L true NO964699L (no) | 1997-05-09 |
Family
ID=4249585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO964699A NO964699L (no) | 1995-11-07 | 1996-11-06 | Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5817659A (fr) |
| EP (1) | EP0773221B1 (fr) |
| JP (1) | JP3382103B2 (fr) |
| KR (2) | KR100296162B1 (fr) |
| CN (1) | CN1067392C (fr) |
| AT (1) | ATE191482T1 (fr) |
| AU (1) | AU707443B2 (fr) |
| CA (1) | CA2187409C (fr) |
| CH (1) | CH689831A5 (fr) |
| DE (1) | DE59604878D1 (fr) |
| DK (1) | DK0773221T3 (fr) |
| ES (1) | ES2145360T3 (fr) |
| GR (1) | GR3033727T3 (fr) |
| HU (1) | HUP9603072A3 (fr) |
| NO (1) | NO964699L (fr) |
| PT (1) | PT773221E (fr) |
| RU (1) | RU2187508C2 (fr) |
| TW (1) | TW533214B (fr) |
| ZA (1) | ZA969284B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH693255A5 (de) * | 1997-06-13 | 2003-05-15 | Eprova Ag | Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels. |
| JP4780834B2 (ja) * | 1998-10-22 | 2011-09-28 | フィリップ・ビー・ビー・モヘノ | 新規なプテリン抗新生物薬 |
| CH693905A5 (de) * | 1999-04-15 | 2004-04-15 | Eprova Ag | Stabile kristalline Salze von 5-Methyltetrahydrofolsäure. |
| CH694251A5 (de) * | 1999-07-14 | 2004-10-15 | Eprova Ag | Herstellung von Tetrahydropterin und Derivaten. |
| FR2816944B1 (fr) * | 2000-11-17 | 2005-10-21 | Dospharma | Nouveaux sels de lithium, les compositions pharmaceutiques a base de ces sels de lithium et leurs applications comme medicament |
| KR20060051135A (ko) * | 2004-09-15 | 2006-05-19 | 니프로 가부시키가이샤 | 안정화된 주사용 수용액 제재 |
| US7947662B2 (en) | 2008-02-20 | 2011-05-24 | Gnosis S.P.A. | Folates, compositions and uses thereof |
| JP5856372B2 (ja) * | 2008-02-20 | 2016-02-09 | グノーシス・エツセ・ピー・アー | 葉酸塩、これらの組成物および使用 |
| US9492421B1 (en) | 2013-11-14 | 2016-11-15 | Argent Development Group, Llc | Nutritional supplements for treatment of iron deficiency anemia |
| US9629846B1 (en) | 2013-11-14 | 2017-04-25 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
| WO2016185413A1 (fr) | 2015-05-20 | 2016-11-24 | Nestec S.A. | Formulations à libération modifiée |
| CN110461845B (zh) | 2017-03-31 | 2023-05-12 | 默克专利股份有限公司 | 5-甲基-（6s）-四氢叶酸的结晶钠盐 |
| ES2989869T3 (es) | 2017-03-31 | 2024-11-28 | Merck Patent Gmbh | Sal sódica cristalina de ácido 5-metil-(6S)-tetrahidrofólico |
| EP3461826A1 (fr) | 2017-09-29 | 2019-04-03 | Aprofol AG | Sels de folate multifonctionnel |
| CN108976232A (zh) * | 2018-09-19 | 2018-12-11 | 江苏红豆杉药业有限公司 | 一种四氢叶酸钙的合成方法 |
| EP3646873A1 (fr) | 2018-10-31 | 2020-05-06 | Aprofol AG | Sels de folate |
| CN109456330B (zh) * | 2018-11-26 | 2021-05-14 | 连云港德洋化工有限公司 | 叶酸类稳定复合物及其制备方法 |
| EP4501315A1 (fr) | 2023-08-04 | 2025-02-05 | Lesaffre et Compagnie | Formulations liquides de folates |
| IT202300027360A1 (it) | 2023-12-20 | 2025-06-20 | Lesaffre & Cie | Formulazioni solide di folati |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124452A (en) * | 1978-07-10 | 1992-06-23 | Bioresearch S.P.A. | Process for producing d,1-5-methyltetrahydrofolic acid and its salts |
| MX169933B (es) * | 1987-09-18 | 1993-08-02 | Hideaki Yamada | Procedimiento para la produccion biologica de amidas |
| DE3821875C1 (fr) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
| CH681303A5 (fr) * | 1991-01-16 | 1993-02-26 | Eprova Ag | |
| CH684270A5 (de) * | 1991-10-04 | 1994-08-15 | Sapec Fine Chemicals | Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure. |
| CH686672A5 (de) * | 1992-12-01 | 1996-05-31 | Cerbios Pharma Sa | Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure. |
| GEP20012441B (en) * | 1993-04-02 | 2001-05-25 | Lonza Ag | Process for Preparing 3-Methylpiperidine and 3-Methylpyridine |
| CH686369A5 (de) * | 1994-05-09 | 1996-03-15 | Eprova Ag | Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure. |
| CN1086311C (zh) * | 1994-05-23 | 2002-06-19 | 隆萨股份公司 | 烷基吡啶的氧化氨解 |
-
1995
- 1995-11-07 CH CH03145/95A patent/CH689831A5/de not_active IP Right Cessation
-
1996
- 1996-10-07 TW TW085112241A patent/TW533214B/zh not_active IP Right Cessation
- 1996-10-08 CA CA002187409A patent/CA2187409C/fr not_active Expired - Lifetime
- 1996-10-14 DK DK96116403T patent/DK0773221T3/da active
- 1996-10-14 ES ES96116403T patent/ES2145360T3/es not_active Expired - Lifetime
- 1996-10-14 AT AT96116403T patent/ATE191482T1/de not_active IP Right Cessation
- 1996-10-14 DE DE59604878T patent/DE59604878D1/de not_active Expired - Lifetime
- 1996-10-14 EP EP96116403A patent/EP0773221B1/fr not_active Expired - Lifetime
- 1996-10-14 PT PT96116403T patent/PT773221E/pt unknown
- 1996-10-30 KR KR1019960050318A patent/KR100296162B1/ko not_active Expired - Fee Related
- 1996-10-31 AU AU70533/96A patent/AU707443B2/en not_active Ceased
- 1996-11-05 CN CN96112040A patent/CN1067392C/zh not_active Expired - Fee Related
- 1996-11-05 ZA ZA969284A patent/ZA969284B/xx unknown
- 1996-11-06 JP JP29416096A patent/JP3382103B2/ja not_active Expired - Fee Related
- 1996-11-06 RU RU96121625/04A patent/RU2187508C2/ru active
- 1996-11-06 KR KR1019960052354A patent/KR100702201B1/ko not_active Expired - Fee Related
- 1996-11-06 NO NO964699A patent/NO964699L/no not_active Application Discontinuation
- 1996-11-06 HU HU9603072A patent/HUP9603072A3/hu unknown
- 1996-11-07 US US08/744,952 patent/US5817659A/en not_active Expired - Lifetime
-
2000
- 2000-06-20 GR GR20000401421T patent/GR3033727T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP3382103B2 (ja) | 2003-03-04 |
| DK0773221T3 (da) | 2000-07-10 |
| ZA969284B (en) | 1997-05-07 |
| EP0773221A1 (fr) | 1997-05-14 |
| ES2145360T3 (es) | 2000-07-01 |
| CN1067392C (zh) | 2001-06-20 |
| CN1153176A (zh) | 1997-07-02 |
| CA2187409C (fr) | 2000-08-22 |
| KR970027056A (ko) | 1997-06-24 |
| CH689831A5 (de) | 1999-12-15 |
| TW533214B (en) | 2003-05-21 |
| DE59604878D1 (de) | 2000-05-11 |
| GR3033727T3 (en) | 2000-10-31 |
| RU2187508C2 (ru) | 2002-08-20 |
| CA2187409A1 (fr) | 1997-05-08 |
| US5817659A (en) | 1998-10-06 |
| KR970027048A (ko) | 1997-06-24 |
| NO964699D0 (no) | 1996-11-06 |
| HUP9603072A2 (en) | 1997-08-28 |
| EP0773221B1 (fr) | 2000-04-05 |
| HU9603072D0 (en) | 1996-12-30 |
| KR100702201B1 (ko) | 2007-11-12 |
| PT773221E (pt) | 2000-09-29 |
| HUP9603072A3 (en) | 1998-01-28 |
| ATE191482T1 (de) | 2000-04-15 |
| AU707443B2 (en) | 1999-07-08 |
| AU7053396A (en) | 1997-05-15 |
| JPH09169759A (ja) | 1997-06-30 |
| KR100296162B1 (ko) | 2001-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |