NO964699L - Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike - Google Patents

Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike

Info

Publication number: NO964699L
Authority: NO; Norway
Prior art keywords: preparation; processes; tetrahydrofolic acid; stable crystalline; acid salts
Prior art date: 1995-11-07

Application number

NO964699A

Other languages

English (en)

Norwegian (no)

Other versions

NO964699D0 (no

Inventor

Hans Rudolf Mueller

Martin Ulmann

Rudolf Moser

Thomas Ammann

Original Assignee

Eprova Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-07

Filing date

1996-11-06

Publication date

1997-05-09

1996-11-06 Application filed by Eprova Ag filed Critical Eprova Ag

1996-11-06 Publication of NO964699D0 publication Critical patent/NO964699D0/no

1997-05-09 Publication of NO964699L publication Critical patent/NO964699L/no

Links

238000002360 preparation method Methods 0.000 title abstract 2
MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical class N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 abstract 1
MSTNYGQPCMXVAQ-NEPJUHHUSA-N 6R-Tetrahydrofolic acid Chemical compound C([C@@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-NEPJUHHUSA-N 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyridine Compounds (AREA)
Steroid Compounds (AREA)

NO964699A 1995-11-07 1996-11-06 Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike NO964699L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH03145/95A CH689831A5 (de)	1995-11-07	1995-11-07	Stabile kristalline Tetrahydrofolsaeure-Salze.

Publications (2)

Publication Number	Publication Date
NO964699D0 NO964699D0 (no)	1996-11-06
NO964699L true NO964699L (no)	1997-05-09

Family

ID=4249585

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO964699A NO964699L (no)	1995-11-07	1996-11-06	Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike

Country Status (19)

Country	Link
US (1)	US5817659A (fr)
EP (1)	EP0773221B1 (fr)
JP (1)	JP3382103B2 (fr)
KR (2)	KR100296162B1 (fr)
CN (1)	CN1067392C (fr)
AT (1)	ATE191482T1 (fr)
AU (1)	AU707443B2 (fr)
CA (1)	CA2187409C (fr)
CH (1)	CH689831A5 (fr)
DE (1)	DE59604878D1 (fr)
DK (1)	DK0773221T3 (fr)
ES (1)	ES2145360T3 (fr)
GR (1)	GR3033727T3 (fr)
HU (1)	HUP9603072A3 (fr)
NO (1)	NO964699L (fr)
PT (1)	PT773221E (fr)
RU (1)	RU2187508C2 (fr)
TW (1)	TW533214B (fr)
ZA (1)	ZA969284B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH693255A5 (de) *	1997-06-13	2003-05-15	Eprova Ag	Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels.
WO2000023448A1 (fr) *	1998-10-22	2000-04-27	Moheno Phillip B B	Nouveaux agents antineoplasiques de la pterine
CH693905A5 (de) *	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH694251A5 (de)	1999-07-14	2004-10-15	Eprova Ag	Herstellung von Tetrahydropterin und Derivaten.
FR2816944B1 (fr) *	2000-11-17	2005-10-21	Dospharma	Nouveaux sels de lithium, les compositions pharmaceutiques a base de ces sels de lithium et leurs applications comme medicament
DE602005026352D1 (de) *	2004-09-15	2011-03-31	Nipro Corp	Wässrige, stabile (6S)-Folinsäurelösung zur Injektion
PL2245032T3 (pl) *	2008-02-20	2015-08-31	Gnosis Spa	Foliany, ich kompozycje i zastosowania
US7947662B2 (en)	2008-02-20	2011-05-24	Gnosis S.P.A.	Folates, compositions and uses thereof
US9629846B1 (en)	2013-11-14	2017-04-25	Argent Development Group, Llc	Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
US9492421B1 (en)	2013-11-14	2016-11-15	Argent Development Group, Llc	Nutritional supplements for treatment of iron deficiency anemia
WO2016185413A1 (fr)	2015-05-20	2016-11-24	Nestec S.A.	Formulations à libération modifiée
HUE068578T2 (hu)	2017-03-31	2025-01-28	Merck Patent Gmbh	5-Metil-(6S)-tetrahidrofolsav kristályos nátriumsója
WO2018178144A1 (fr)	2017-03-31	2018-10-04	Merck Patent Gmbh	Sel de sodium cristallin d'acide 5-méthyl-(6s)-tétrahydrofolique
EP3461826A1 (fr)	2017-09-29	2019-04-03	Aprofol AG	Sels de folate multifonctionnel
CN108976232A (zh) *	2018-09-19	2018-12-11	江苏红豆杉药业有限公司	一种四氢叶酸钙的合成方法
EP3646873A1 (fr)	2018-10-31	2020-05-06	Aprofol AG	Sels de folate
CN109456330B (zh) *	2018-11-26	2021-05-14	连云港德洋化工有限公司	叶酸类稳定复合物及其制备方法
EP4501315A1 (fr)	2023-08-04	2025-02-05	Lesaffre et Compagnie	Formulations liquides de folates
IT202300027360A1 (it)	2023-12-20	2025-06-20	Lesaffre & Cie	Formulazioni solide di folati

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5124452A (en) *	1978-07-10	1992-06-23	Bioresearch S.P.A.	Process for producing d,1-5-methyltetrahydrofolic acid and its salts
DD274631A5 (de) *	1987-09-18	1989-12-27	Kk	Verfahren zur biologischen herstellung von amiden
DE3821875C1 (fr) *	1988-06-29	1990-02-15	Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH681303A5 (fr) *	1991-01-16	1993-02-26	Eprova Ag
CH684270A5 (de) *	1991-10-04	1994-08-15	Sapec Fine Chemicals	Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
CH686672A5 (de) *	1992-12-01	1996-05-31	Cerbios Pharma Sa	Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
GEP20012441B (en) *	1993-04-02	2001-05-25	Lonza Ag	Process for Preparing 3-Methylpiperidine and 3-Methylpyridine
CH686369A5 (de) *	1994-05-09	1996-03-15	Eprova Ag	Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
CZ338596A3 (en) *	1994-05-23	1997-07-16	Lonza Ag	Catalytic mixture for oxidative amonolysis of alkyl pyridines, process of its preparation and use

1995
- 1995-11-07 CH CH03145/95A patent/CH689831A5/de not_active IP Right Cessation
1996
- 1996-10-07 TW TW085112241A patent/TW533214B/zh not_active IP Right Cessation
- 1996-10-08 CA CA002187409A patent/CA2187409C/fr not_active Expired - Lifetime
- 1996-10-14 EP EP96116403A patent/EP0773221B1/fr not_active Expired - Lifetime
- 1996-10-14 AT AT96116403T patent/ATE191482T1/de not_active IP Right Cessation
- 1996-10-14 DE DE59604878T patent/DE59604878D1/de not_active Expired - Lifetime
- 1996-10-14 DK DK96116403T patent/DK0773221T3/da active
- 1996-10-14 PT PT96116403T patent/PT773221E/pt unknown
- 1996-10-14 ES ES96116403T patent/ES2145360T3/es not_active Expired - Lifetime
- 1996-10-30 KR KR1019960050318A patent/KR100296162B1/ko not_active Expired - Fee Related
- 1996-10-31 AU AU70533/96A patent/AU707443B2/en not_active Ceased
- 1996-11-05 CN CN96112040A patent/CN1067392C/zh not_active Expired - Fee Related
- 1996-11-05 ZA ZA969284A patent/ZA969284B/xx unknown
- 1996-11-06 NO NO964699A patent/NO964699L/no not_active Application Discontinuation
- 1996-11-06 KR KR1019960052354A patent/KR100702201B1/ko not_active Expired - Fee Related
- 1996-11-06 RU RU96121625/04A patent/RU2187508C2/ru active
- 1996-11-06 HU HU9603072A patent/HUP9603072A3/hu unknown
- 1996-11-06 JP JP29416096A patent/JP3382103B2/ja not_active Expired - Fee Related
- 1996-11-07 US US08/744,952 patent/US5817659A/en not_active Expired - Lifetime
2000
- 2000-06-20 GR GR20000401421T patent/GR3033727T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO964699D0 (no)	1996-11-06
US5817659A (en)	1998-10-06
ES2145360T3 (es)	2000-07-01
TW533214B (en)	2003-05-21
CA2187409C (fr)	2000-08-22
EP0773221B1 (fr)	2000-04-05
HUP9603072A3 (en)	1998-01-28
DK0773221T3 (da)	2000-07-10
AU7053396A (en)	1997-05-15
HU9603072D0 (en)	1996-12-30
KR970027048A (ko)	1997-06-24
GR3033727T3 (en)	2000-10-31
KR100702201B1 (ko)	2007-11-12
EP0773221A1 (fr)	1997-05-14
PT773221E (pt)	2000-09-29
AU707443B2 (en)	1999-07-08
JPH09169759A (ja)	1997-06-30
JP3382103B2 (ja)	2003-03-04
ZA969284B (en)	1997-05-07
CH689831A5 (de)	1999-12-15
CN1067392C (zh)	2001-06-20
DE59604878D1 (de)	2000-05-11
CN1153176A (zh)	1997-07-02
KR100296162B1 (ko)	2001-09-10
ATE191482T1 (de)	2000-04-15
RU2187508C2 (ru)	2002-08-20
KR970027056A (ko)	1997-06-24
CA2187409A1 (fr)	1997-05-08
HUP9603072A2 (en)	1997-08-28

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Legal Events

Date	Code	Title	Description
2003-08-11	FC2A	Withdrawal, rejection or dismissal of laid open patent application