NO964965L - Fremgangsmåte ved fremstilling av proteiner - Google Patents

Fremgangsmåte ved fremstilling av proteiner

Info

Publication number: NO964965L
Authority: NO; Norway
Prior art keywords: protein; pro; solid support; proteins; above process
Prior art date: 1995-11-24

Application number

NO964965A

Other languages

English (en)

Other versions

NO319266B1 (no

NO964965D0 (no

Inventor

Bernhard Fischer

Artur Mitterer

Friedrich Dorner

Johann Eibl

Original Assignee

Immuno Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-24

Filing date

1996-11-22

Publication date

1997-05-26

1996-11-22 Application filed by Immuno Ag filed Critical Immuno Ag

1996-11-22 Publication of NO964965D0 publication Critical patent/NO964965D0/no

1997-05-26 Publication of NO964965L publication Critical patent/NO964965L/no

2005-07-11 Publication of NO319266B1 publication Critical patent/NO319266B1/no

Links

102000004169 proteins and genes Human genes 0.000 title abstract 9
108090000623 proteins and genes Proteins 0.000 title abstract 9
238000000034 method Methods 0.000 title abstract 3
239000007787 solid Substances 0.000 abstract 5
108091005804 Peptidases Proteins 0.000 abstract 2
239000004365 Protease Substances 0.000 abstract 2
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 2
102000007625 Hirudins Human genes 0.000 abstract 1
108010007267 Hirudins Proteins 0.000 abstract 1
239000007857 degradation product Substances 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1
239000012460 protein solution Substances 0.000 abstract 1
238000001179 sorption measurement Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

NO19964965A 1995-11-24 1996-11-22 Fremgangsmate ved fremstilling og utvinning av proteiner fra pro-proteiner i ett fremgangsmatetrinn samt anvendelse av fremgangsmaten til fremstilling av proteiner. NO319266B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0192795A AT404597B (de)	1995-11-24	1995-11-24	Verfahren zur herstellung von proteinen

Publications (3)

Publication Number	Publication Date
NO964965D0 NO964965D0 (no)	1996-11-22
NO964965L true NO964965L (no)	1997-05-26
NO319266B1 NO319266B1 (no)	2005-07-11

Family

ID=3524033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19964965A NO319266B1 (no)	1995-11-24	1996-11-22	Fremgangsmate ved fremstilling og utvinning av proteiner fra pro-proteiner i ett fremgangsmatetrinn samt anvendelse av fremgangsmaten til fremstilling av proteiner.

Country Status (7)

Country	Link
US (1)	US6010844A (no)
EP (1)	EP0776969B1 (no)
JP (1)	JP4180671B2 (no)
AT (2)	AT404597B (no)
CA (1)	CA2190802C (no)
DE (1)	DE59611093D1 (no)
NO (1)	NO319266B1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATA159597A (de) *	1997-09-19	2000-09-15	Immuno Ag	Präparat zur behandlung von blutgerinnungsstörungen
US7560622B2 (en) *	2000-10-06	2009-07-14	Pioneer Hi-Bred International, Inc.	Methods and compositions relating to the generation of partially transgenic organisms
US6830917B2 (en)	2001-12-10	2004-12-14	Baxter Healthcare S.A.	Method of isolation and purification of trypsin from pronase protease and use thereof
US7235655B2 (en) *	2002-03-22	2007-06-26	Pharmacia & Upjohn Company	Processes to prepare eplerenone
ATE517914T1 (de)	2004-03-08	2011-08-15	Zymogenetics Inc	Dimere fusionsproteine und materialien und verfahren zu deren herstellung
JP2012050387A (ja) *	2010-09-01	2012-03-15	Kaneka Corp	２種類以上の分子を多孔質担体に固定化する方法
JP2012050386A (ja) *	2010-09-01	2012-03-15	Kaneka Corp	２種類以上の多孔質充填剤を充填するカラム

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2000887A1 (en) *	1988-11-01	1990-05-01	Cecilia S.L. Ku	Thromboresistant materials and methods for making same
US5053453A (en) *	1988-11-01	1991-10-01	Baxter International Inc.	Thromboresistant materials and methods for making same
DE3843126C3 (de) *	1988-12-22	1994-10-06	Octapharma Ag	Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
CA2024598A1 (en) *	1989-09-05	1991-03-06	Sau-Chi B. Yan	Method for activating protein c
US5296352A (en) *	1990-10-02	1994-03-22	Ciba-Geigy Corporation	Monoclonal antibodies directed against complexes formed by thrombin and hirudin
AT398079B (de)	1991-11-04	1994-09-26	Immuno Ag	Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
AT397390B (de) *	1992-04-06	1994-03-25	Immuno Ag	Verfahren zur spaltung von proteinen
AT396937B (de)	1992-04-06	1993-12-27	Immuno Ag	Verfahren zur aktivierung von blutgerinnungsfaktoren

1995
- 1995-11-24 AT AT0192795A patent/AT404597B/de not_active IP Right Cessation
1996
- 1996-11-19 EP EP96890172A patent/EP0776969B1/de not_active Expired - Lifetime
- 1996-11-19 DE DE59611093T patent/DE59611093D1/de not_active Expired - Lifetime
- 1996-11-19 AT AT96890172T patent/ATE277169T1/de active
- 1996-11-20 US US08/752,892 patent/US6010844A/en not_active Expired - Lifetime
- 1996-11-20 CA CA002190802A patent/CA2190802C/en not_active Expired - Fee Related
- 1996-11-22 NO NO19964965A patent/NO319266B1/no not_active IP Right Cessation
- 1996-11-25 JP JP33027896A patent/JP4180671B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4180671B2 (ja)	2008-11-12
CA2190802C (en)	2008-02-12
US6010844A (en)	2000-01-04
NO319266B1 (no)	2005-07-11
ATE277169T1 (de)	2004-10-15
EP0776969B1 (de)	2004-09-22
CA2190802A1 (en)	1997-05-25
EP0776969A3 (de)	1999-06-02
AT404597B (de)	1998-12-28
EP0776969A2 (de)	1997-06-04
ATA192795A (de)	1998-05-15
NO964965D0 (no)	1996-11-22
DE59611093D1 (de)	2004-10-28
JPH09183794A (ja)	1997-07-15

Legal Events

Date	Code	Title	Description
2015-10-26	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: BAXALTA INCORPORATED, CH
2016-11-28	MK1K	Patent expired

Publication	Publication Date	Title
AU7832991A (en)	1991-12-12	Ribosome inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
EP0322687A3 (en)	1990-04-11	Method for the manufacture of a product having at least one substance embedded in a carrier
DE69111917D1 (de)	1995-09-14	Druckwechsel-Adsorptionsverfahren zur Trennung von Gasgemischen.
NO913186D0 (no)	1991-08-15	Fremgangsmaate for anvendelse og syntese av peptider.
KR970009949B1 (en)	1997-06-19	Novel serine proteolytic enzyme and its process
NO964965D0 (no)	1996-11-22	Fremgangsmåte ved fremstilling av proteiner
SE8302638D0 (sv)	1983-05-09	Forfarande och anordning for utvinning av en forening
HU9200225D0 (en)	1992-04-28	Complex process containing anti-coagulant ix-factor
DE58908866D1 (de)	1995-02-23	Verfahren zur Herstellung von feinteiligen und porösen Celluloseteilchen.
EA200000024A1 (ru)	2000-06-26	Способ получения гранулированных моющих средств
WO1996009547A3 (de)	1996-05-30	Verfahren zur untersuchung der wechselwirkung von biomolekülen mittels oberflächen-plasmon-resonanz
DE69433875D1 (de)	2004-08-05	Verfahren zur präparation von humanem aktiviertem protein c
CA2213577A1 (en)	1996-09-06	A process for the preparation of factor ix from biological sources
DE3855002D1 (de)	1996-03-21	Verfahren zur Herstellung von Dodecahydro-3a,6,6,9a-tetramethylnaphto(2,1-b)furan
ATE216778T1 (de)	2002-05-15	Verfahren zur herstellung von konjugaten aus einem spezifischen bindungspartner und einem kohlenhydrathaltigen protein
DE3668185D1 (de)	1990-02-15	Verfahren zur reinigung von plasminogenaktivatoren (pa).
AU9075682A (en)	1983-05-26	Immobilised protease
DK0379887T3 (da)	1995-01-16	Immunobestemmelse til cellulære proteiner
FI854373A0 (fi)	1985-11-06	Anordning foer behandling av roekgaser som en produkt i form av pulver.
EP0345812A3 (en)	1990-05-16	Process utilizing alcohol oxidase
AU1062588A (en)	1988-07-28	Immunoassay utilizing microparticle neutralization
EP0276008A3 (en)	1989-09-06	Fibrin-specific antibody, method for its production and its use
DK0846166T3 (da)	2008-02-04	Fremgangsmåde til thrombinfremstilling
ES2133867T3 (es)	1999-09-16	Procedimiento para la separacion de aminoacidos y acidos aminosulfonicos mediante adsorcion a zeolitas.
ATE60345T1 (de)	1991-02-15	Verfahren zur herstellung von heteropolysaccharidteilchen.