NO965569L - Forbindelser og fremgangsmåter for behandling av kardiovaskulære, inflammatoriske og immunoforstyrrelser - Google Patents

Forbindelser og fremgangsmåter for behandling av kardiovaskulære, inflammatoriske og immunoforstyrrelser

Info

Publication number
NO965569L
NO965569L NO965569A NO965569A NO965569L NO 965569 L NO965569 L NO 965569L NO 965569 A NO965569 A NO 965569A NO 965569 A NO965569 A NO 965569A NO 965569 L NO965569 L NO 965569L
Authority
NO
Norway
Prior art keywords
lipoxygenase
compounds
inflammatory
activity
acting
Prior art date
Application number
NO965569A
Other languages
English (en)
Norwegian (no)
Other versions
NO965569D0 (no
Inventor
Xiong Cai
Gurmit Grewal
Sajjat Hussoin
Aberra Fura
Ralph Scannell
Tesfaye Biftu
Changgeng Qian
Original Assignee
Cytomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/265,656 external-priority patent/US5792776A/en
Priority claimed from US08/390,641 external-priority patent/US6201016B1/en
Priority claimed from US08/454,600 external-priority patent/US5750565A/en
Priority claimed from US08/454,748 external-priority patent/US5703093A/en
Application filed by Cytomed Inc filed Critical Cytomed Inc
Publication of NO965569D0 publication Critical patent/NO965569D0/no
Publication of NO965569L publication Critical patent/NO965569L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO965569A 1994-06-27 1996-12-23 Forbindelser og fremgangsmåter for behandling av kardiovaskulære, inflammatoriske og immunoforstyrrelser NO965569L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/265,656 US5792776A (en) 1994-06-27 1994-06-27 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US08/390,641 US6201016B1 (en) 1994-06-27 1995-02-17 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US08/454,600 US5750565A (en) 1995-05-25 1995-05-25 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US08/454,748 US5703093A (en) 1995-05-31 1995-05-31 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
PCT/US1995/008213 WO1996000212A1 (en) 1994-06-27 1995-06-27 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders

Publications (2)

Publication Number Publication Date
NO965569D0 NO965569D0 (no) 1996-12-23
NO965569L true NO965569L (no) 1997-02-17

Family

ID=27500861

Family Applications (1)

Application Number Title Priority Date Filing Date
NO965569A NO965569L (no) 1994-06-27 1996-12-23 Forbindelser og fremgangsmåter for behandling av kardiovaskulære, inflammatoriske og immunoforstyrrelser

Country Status (17)

Country Link
EP (1) EP0770064B1 (cs)
KR (1) KR100276570B1 (cs)
CN (1) CN1151125C (cs)
AT (1) ATE253564T1 (cs)
AU (1) AU703756B2 (cs)
BR (1) BR9508196A (cs)
CA (1) CA2194064C (cs)
CZ (1) CZ372096A3 (cs)
DE (1) DE69532077T2 (cs)
EE (1) EE9600184A (cs)
FI (1) FI965123A7 (cs)
HU (1) HUT77773A (cs)
MX (1) MX9606635A (cs)
NO (1) NO965569L (cs)
PL (1) PL317873A1 (cs)
RU (1) RU2190607C2 (cs)
WO (1) WO1996000212A1 (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT650485E (pt) 1992-07-13 2001-03-30 Millennium Pharm Inc 2,5-diaril-tetra-hidro-tiofenos -furanos e analogos para o tratamento de desordens inflamatorias e imunitarias
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
WO1999049865A1 (en) * 1998-03-31 1999-10-07 Mayo Foundation For Medical Education And Research Use of platelet activating factor (paf) inhibitors to inhibit il-5 induced eosinophil activation or degranulation
US6310221B1 (en) 1998-07-03 2001-10-30 Millennium Pharmaceuticals, Inc. Methods for synthesis of substituted tetrahydrofuran compound
CA2345919A1 (en) 1998-07-03 2000-01-13 Gangavaram Vasantha Madhava Sharma Substituted oxygen alicyclic compounds, including methods for synthesis thereof
US6255498B1 (en) 1998-10-16 2001-07-03 Millennium Pharmaceuticals, Inc. Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
CN100553636C (zh) 2000-08-04 2009-10-28 Dmi生物科学公司 二酮基哌嗪和包含它们的组合物的使用方法
WO2004030522A2 (en) 2002-10-02 2004-04-15 Dmi Biosciences, Inc. Diagnosis and monitoring of diseases
EP1560488B1 (en) 2002-11-05 2010-09-01 Glaxo Group Limited Antibacterial agents
RU2217141C1 (ru) * 2002-11-20 2003-11-27 Балавадзе Михаил Элизбарович Состав "витализин-1" для профилактики атеросклероза, сердечно-сосудистых заболеваний и поддерживающей терапии вирусных заболеваний
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
EP2517718B1 (en) 2003-05-15 2016-03-02 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
SG144925A1 (en) * 2003-08-04 2008-08-28 Bristol Myers Squibb Co Methods for treating cardiovascular disease using a soluble ctla4 molecule
RU2388756C2 (ru) * 2004-01-30 2010-05-10 Шеринг Корпорейшн Кристаллические полиморфные формы лиганда схс-хемокинового рецептора
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
EP2613786A4 (en) 2010-09-07 2013-10-23 Dmi Acquisition Corp TREATMENT OF DISEASES
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EA028343B1 (ru) 2011-10-10 2017-11-30 Ампио Фармасьютикалз, Инк. Лечение дегенеративного заболевания сустава
EP2771007B1 (en) 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
BR112015020469A2 (pt) 2013-03-15 2020-01-28 Ampio Pharmaceuticals Inc Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
KR101480674B1 (ko) * 2014-07-03 2015-01-09 주식회사 큐리언트 화합물 및 염증성 질환 치료용 약학적 조성물
KR101503647B1 (ko) 2014-07-03 2015-03-18 주식회사 큐리언트 염증성 질환 치료용 약학적 조성물
KR101496094B1 (ko) 2014-07-04 2015-02-25 주식회사 큐리언트 화합물 및 염증성 질환 치료용 약학적 조성물
KR101496095B1 (ko) * 2014-07-04 2015-03-03 주식회사 큐리언트 화합물 및 염증성 질환 치료용 약학적 조성물
KR101496096B1 (ko) * 2014-07-17 2015-03-02 주식회사 큐리언트 화합물 및 염증성 질환 치료용 약학적 조성물
RU2736513C2 (ru) 2014-08-18 2020-11-17 Ампио Фармасьютикалз, Инк. Лечение патологических состояний суставов
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757084A (en) * 1984-02-29 1988-07-12 Merck & Co., Inc. 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antagonists
NZ211146A (en) * 1984-02-29 1987-10-30 Merck & Co Inc 2,5-diaryl-tetrahydrothiophene derivatives and pharmaceutical compositions
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
DE3778248D1 (de) * 1986-08-21 1992-05-21 Merck & Co Inc 1,3-diarylcyclopentane und deren abkoemmlinge als paf-antagonisten.
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4996203A (en) * 1987-12-21 1991-02-26 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
EP0365089A3 (en) * 1988-10-18 1991-06-05 Merck & Co. Inc. 2-aryl-5(3-methoxy-5-(hydroxypropylsulfonyl)-4-propoxyphenyl) tetrahydrothiophen and analogs
US5175183A (en) * 1989-02-01 1992-12-29 Abbott Laboratories Lipoxygenase inhibiting compounds
US4977146A (en) * 1989-06-08 1990-12-11 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5037853A (en) * 1989-12-28 1991-08-06 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
GB9009469D0 (en) * 1990-04-27 1990-06-20 British Bio Technology Compounds
EP0465122A1 (en) * 1990-06-29 1992-01-08 Merck & Co. Inc. Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as paf antagonists
US5244896A (en) * 1990-09-14 1993-09-14 Marion Merrell Dow Inc. Carbocyclic adenosine analogs useful as immunosuppressants
US5110831A (en) * 1990-11-30 1992-05-05 Du Pont Merck Pharmaceutical Company Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors
JPH0730061B2 (ja) * 1991-02-07 1995-04-05 ファイザー製薬株式会社 ヒドロキサム酸誘導体および組成物
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
US5183818A (en) * 1991-08-27 1993-02-02 Abbott Laboratories Arylalkylether and arylalkylthioether inhibitors of lipoxygenase enzyme activity
US5169854A (en) * 1992-02-26 1992-12-08 Abbott Laboratories N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity
US5187192A (en) * 1992-03-13 1993-02-16 Abbott Laboratories Cyclobutyl derivatives having lipoxygenase inhibitory activity
US5326787A (en) * 1992-05-12 1994-07-05 Abbott Laboratories Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory activity
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
PT650485E (pt) * 1992-07-13 2001-03-30 Millennium Pharm Inc 2,5-diaril-tetra-hidro-tiofenos -furanos e analogos para o tratamento de desordens inflamatorias e imunitarias
US5288751A (en) * 1992-11-06 1994-02-22 Abbott Laboratories [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
TW448144B (en) * 1993-08-19 2001-08-01 Pfizer Phenoxyphenyl cyclopentenyl hydroxyureas

Also Published As

Publication number Publication date
CZ372096A3 (cs) 1998-04-15
EE9600184A (et) 1997-06-16
KR100276570B1 (ko) 2001-02-01
FI965123A7 (fi) 1997-02-26
WO1996000212A1 (en) 1996-01-04
CN1163610A (zh) 1997-10-29
NO965569D0 (no) 1996-12-23
BR9508196A (pt) 1997-09-02
HUT77773A (hu) 1998-08-28
MX9606635A (es) 1997-12-31
PL317873A1 (en) 1997-04-28
HK1004396A1 (en) 1998-11-27
CA2194064C (en) 2009-03-17
CA2194064A1 (en) 1996-01-04
EP0770064A4 (en) 1998-01-14
EP0770064B1 (en) 2003-11-05
CN1151125C (zh) 2004-05-26
FI965123A0 (fi) 1996-12-19
ATE253564T1 (de) 2003-11-15
DE69532077D1 (de) 2003-12-11
RU2190607C2 (ru) 2002-10-10
HU9603611D0 (en) 1997-02-28
EP0770064A1 (en) 1997-05-02
AU2914295A (en) 1996-01-19
DE69532077T2 (de) 2004-09-02
AU703756B2 (en) 1999-04-01

Similar Documents

Publication Publication Date Title
NO965569D0 (no) Forbindelser og fremgangsmåter for behandling av kardiovaskulære, inflammatoriske og immune forstyrrelser
IL114315A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same for inhibiting phosphodiesterase IV
MY133647A (en) Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
NO20060719L (no) Substituerte cykloalkylaminderivater som modulatorer av kemokin reseptor aktivitet
BR9808998A (pt) Imidazóis substituìdos úteis no tratamento de doenças inflamatórias
HUP0303363A2 (hu) Kináz-inhibitor hatású heterociklusos vegyületek alkalmazása gyógyszerkészítmények előállítására
NO971684D0 (no) Nye benzoxazoler
NO991732L (no) Nye heterocyklylmetylsubstituerte pyrazolderivater
HUP0001539A2 (hu) 2-(1-Imino-etil-amino)-etil-homocisztein, eljárás előállítására és az ezt tartalmazó gyógyszerkészítmények
WO2005000298A3 (en) 5-membered heterocycle-based p-38 inhibitors
FI20115753L (fi) Farmaseuttisia koostumuksia IL-6:n tuoton aiheuttamien sairauksien hoitoon
WO1993000330A3 (en) Azanorbornane derivatives
NO20051036L (no) 3,4-disubstituerte syklobuten-1,2-dioner som CXC-kjemokinreseptorligander
GB0222495D0 (en) Compounds
NO970161L (no) Triazolforbindelser og anvendelse derav
CA2234642A1 (en) 3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors
MXPA04006555A (es) Piridazinodionas-3,4-disustituidas como antagonistas de receptor de quimiocina cxc.
DK0650485T3 (da) 2,5-Diaryltetrahydrothiophener, -furaner og analoger til behandling af inflammatoriske forstyrrelser og immunforstyrrelser
CA2474511A1 (en) Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
NO974320L (no) Fucopeptider
DE60003911D1 (de) Heteroaryl-diazacycloalkane, ihre herstellung und verwendung
MX9708416A (es) Derivados de piperazino como antagonistas de neuroquininas.
AU4080097A (en) Piperazino derivatives as neurokinin antagonists
TR199700963T1 (xx) Kardiyovask�ler hastal�klar�n tedavisi i�in aminotetralin t�revi.
NO20060112L (no) Imidazolderivater III