NO970165L - Kortikotropin frigivningsfaktor-bindingsprotein inhibitorer og deres anvendelse - Google Patents
Kortikotropin frigivningsfaktor-bindingsprotein inhibitorer og deres anvendelseInfo
- Publication number
- NO970165L NO970165L NO970165A NO970165A NO970165L NO 970165 L NO970165 L NO 970165L NO 970165 A NO970165 A NO 970165A NO 970165 A NO970165 A NO 970165A NO 970165 L NO970165 L NO 970165L
- Authority
- NO
- Norway
- Prior art keywords
- crf
- binding protein
- ligand inhibitor
- brain
- protein inhibitors
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 102400000739 Corticotropin Human genes 0.000 title 1
- 101800000414 Corticotropin Proteins 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title 1
- 229960000258 corticotropin Drugs 0.000 title 1
- 229940121649 protein inhibitor Drugs 0.000 title 1
- 239000012268 protein inhibitor Substances 0.000 title 1
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 abstract 7
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 abstract 7
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 7
- 239000003112 inhibitor Substances 0.000 abstract 4
- 239000003446 ligand Substances 0.000 abstract 4
- 210000004556 brain Anatomy 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102100032165 Corticotropin-releasing factor-binding protein Human genes 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 108010083720 corticotropin releasing factor-binding protein Proteins 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 235000018823 dietary intake Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nivåer av fri kortikotropin-frigjørende faktor (CRF) i hjernen økes ved at pasienten administreres en ligand-inhibitor av et CRF/GRF-bindende protein- kompleks. Ligand-inhibitoren binder seg til CRF-bindende protein og forårsaker frigjøring av CRF. Ligand-inhibitoren kan være et peptid som skriver seg fra CRF eller et beslektet protein eller et ikke-peptid. Administrering av ligand-inhibitoren kan bevirke forbedring av læring og hukommelse, resultere i nedsatt næringsinntak eller bevirke behandling av sykdommer assosiert med lave nivåer av CRF i hjernen, særlig Alzheimers sykdom. Det tilveiebringes også en fremgangsmåte for screening av forbindelser for seleksjon av særiig effektive CRF-antagonister for in vivo administrering til pattedyr.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27624094A | 1994-07-15 | 1994-07-15 | |
| US48477695A | 1995-06-07 | 1995-06-07 | |
| PCT/US1995/008867 WO1996002569A1 (en) | 1994-07-15 | 1995-07-14 | Corticotropin-releasing factor-binding-protein inhibitors and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO970165D0 NO970165D0 (no) | 1997-01-14 |
| NO970165L true NO970165L (no) | 1997-03-14 |
Family
ID=26957870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO970165A NO970165L (no) | 1994-07-15 | 1997-01-14 | Kortikotropin frigivningsfaktor-bindingsprotein inhibitorer og deres anvendelse |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0771323A1 (no) |
| JP (2) | JPH10503187A (no) |
| CN (1) | CN1157620A (no) |
| AU (1) | AU705984B2 (no) |
| CA (1) | CA2195197A1 (no) |
| MX (1) | MX9700413A (no) |
| NO (1) | NO970165L (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107058237A (zh) * | 2016-12-07 | 2017-08-18 | 陈锋 | 杂交瘤细胞株及基于杂交瘤细胞株的抗crh抗体c‑d17及其检测方面的应用 |
| CN107043752A (zh) * | 2016-12-07 | 2017-08-15 | 陈锋 | 杂交瘤细胞株及基于杂交瘤细胞株的抗crh抗体n‑d19及其检测方面的应用 |
| KR20240023691A (ko) * | 2020-08-12 | 2024-02-22 | 스프루스 바이오사이언시스 인코포레이티드 | 다낭성 난소 증후군을 치료하기 위한 방법 및 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4908352A (en) * | 1987-09-28 | 1990-03-13 | The Salk Institute For Biological Studies | Urotensin peptides |
| US5464757A (en) * | 1991-01-15 | 1995-11-07 | The Salk Institute For Biological Studies | DNA encoding CRF binding protein |
-
1995
- 1995-07-14 CA CA002195197A patent/CA2195197A1/en not_active Abandoned
- 1995-07-14 EP EP95927176A patent/EP0771323A1/en not_active Withdrawn
- 1995-07-14 AU AU31283/95A patent/AU705984B2/en not_active Ceased
- 1995-07-14 JP JP8505177A patent/JPH10503187A/ja active Pending
- 1995-07-14 MX MX9700413A patent/MX9700413A/es unknown
- 1995-07-14 CN CN95194716A patent/CN1157620A/zh active Pending
-
1997
- 1997-01-14 NO NO970165A patent/NO970165L/no not_active Application Discontinuation
-
2001
- 2001-04-18 JP JP2001120416A patent/JP2001348400A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO970165D0 (no) | 1997-01-14 |
| EP0771323A1 (en) | 1997-05-07 |
| MX9700413A (es) | 1998-05-31 |
| CN1157620A (zh) | 1997-08-20 |
| CA2195197A1 (en) | 1996-02-01 |
| AU3128395A (en) | 1996-02-16 |
| JPH10503187A (ja) | 1998-03-24 |
| JP2001348400A (ja) | 2001-12-18 |
| AU705984B2 (en) | 1999-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |