NO970731L - 2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner - Google Patents

2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner

Info

Publication number
NO970731L
NO970731L NO970731A NO970731A NO970731L NO 970731 L NO970731 L NO 970731L NO 970731 A NO970731 A NO 970731A NO 970731 A NO970731 A NO 970731A NO 970731 L NO970731 L NO 970731L
Authority
NO
Norway
Prior art keywords
benzodiazepine
trifluoroethyl
dihydro
oxo
phenyl
Prior art date
Application number
NO970731A
Other languages
English (en)
Other versions
NO970731D0 (no
Inventor
David A Claremon
Nigel Liverton
Harold G Selnick
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO970731L publication Critical patent/NO970731L/no
Publication of NO970731D0 publication Critical patent/NO970731D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Oppfinnelsen angår nye for-bindelser representert ved struktur-formel (I). hvor X og Y uavhengig er hydrogen, klor, fluor, brom, jod eller trifluormetyl, og n er 0, 1 eller 2; R er hydrogen, fluor, klor, brom, jod eller trifluormetyl, metyl eller metoksy; og racemater, blandinger av enantiomerer,. individuelle diastereomerer eller individuelle enantiomerer, med alle isomere former og farmasøytisk akseptable sal-ter, hydrater eller krystallformer der-av, som er antiarytmiske midler.
NO970731A 1994-08-18 1997-02-17 2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner NO970731D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29244794A 1994-08-18 1994-08-18
PCT/US1995/010500 WO1996005839A1 (en) 1994-08-18 1995-08-17 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines

Publications (2)

Publication Number Publication Date
NO970731L true NO970731L (no) 1997-02-17
NO970731D0 NO970731D0 (no) 1997-02-17

Family

ID=23124712

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970731A NO970731D0 (no) 1994-08-18 1997-02-17 2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner

Country Status (24)

Country Link
US (1) US5658901A (no)
EP (1) EP0776208B1 (no)
JP (1) JPH10504570A (no)
KR (1) KR970705395A (no)
CN (1) CN1158568A (no)
AT (1) ATE186463T1 (no)
AU (1) AU692300B2 (no)
BG (1) BG63032B1 (no)
BR (1) BR9508608A (no)
CA (1) CA2195974C (no)
CZ (1) CZ285008B6 (no)
DE (1) DE69513295T2 (no)
DK (1) DK0776208T3 (no)
ES (1) ES2139933T3 (no)
FI (1) FI970668A7 (no)
GR (1) GR3032592T3 (no)
HU (1) HU220635B1 (no)
MX (1) MX9701195A (no)
NO (1) NO970731D0 (no)
NZ (1) NZ291988A (no)
PL (1) PL319104A1 (no)
RU (1) RU2149161C1 (no)
SK (1) SK282019B6 (no)
WO (1) WO1996005839A1 (no)

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US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JP4410328B2 (ja) * 1998-12-14 2010-02-03 久光製薬株式会社 オキソクアゼパムの製造方法
GB0221923D0 (en) * 2002-09-20 2002-10-30 Arrow Therapeutics Ltd Chemical compounds
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
RU2239419C1 (ru) * 2003-06-06 2004-11-10 Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское" Лекарственная форма, обладающая антиаритмическим и антиангинальным действием, и способ ее изготовления
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular

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Also Published As

Publication number Publication date
CA2195974A1 (en) 1996-02-29
BG101227A (bg) 1998-03-31
HUT76811A (en) 1997-11-28
SK282019B6 (sk) 2001-10-08
DK0776208T3 (da) 2000-05-01
CZ48597A3 (en) 1997-09-17
US5658901A (en) 1997-08-19
FI970668L (fi) 1997-02-17
CZ285008B6 (cs) 1999-04-14
HU220635B1 (hu) 2002-03-28
ATE186463T1 (de) 1999-11-15
AU692300B2 (en) 1998-06-04
BR9508608A (pt) 1997-12-30
AU3366795A (en) 1996-03-14
EP0776208A1 (en) 1997-06-04
NZ291988A (en) 1998-11-25
FI970668A0 (fi) 1997-02-17
RU2149161C1 (ru) 2000-05-20
FI970668A7 (fi) 1997-02-17
EP0776208A4 (en) 1997-12-29
EP0776208B1 (en) 1999-11-10
JPH10504570A (ja) 1998-05-06
WO1996005839A1 (en) 1996-02-29
SK22297A3 (en) 1997-09-10
PL319104A1 (en) 1997-07-21
BG63032B1 (bg) 2001-02-28
NO970731D0 (no) 1997-02-17
ES2139933T3 (es) 2000-02-16
DE69513295T2 (de) 2000-06-08
MX9701195A (es) 1997-05-31
GR3032592T3 (en) 2000-05-31
CA2195974C (en) 2000-12-05
KR970705395A (ko) 1997-10-09
DE69513295D1 (de) 1999-12-16
CN1158568A (zh) 1997-09-03

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