NO971104L - Terapeutisk kvalitet trombin, fremstilling og produkter - Google Patents

Terapeutisk kvalitet trombin, fremstilling og produkter

Info

Publication number
NO971104L
NO971104L NO971104A NO971104A NO971104L NO 971104 L NO971104 L NO 971104L NO 971104 A NO971104 A NO 971104A NO 971104 A NO971104 A NO 971104A NO 971104 L NO971104 L NO 971104L
Authority
NO
Norway
Prior art keywords
thrombin
viral
phosphate buffer
manufacture
products
Prior art date
Application number
NO971104A
Other languages
English (en)
Other versions
NO323460B1 (no
NO971104D0 (no
Inventor
Zbigniew Proba
Nicolas Dupuis
Teresa Brodniewics
Trung Bui-Khac
Original Assignee
Haemacure Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haemacure Corp filed Critical Haemacure Corp
Publication of NO971104D0 publication Critical patent/NO971104D0/no
Publication of NO971104L publication Critical patent/NO971104L/no
Publication of NO323460B1 publication Critical patent/NO323460B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
NO19971104A 1994-09-21 1997-03-11 Fremgangsmate til fremstilling i stor skala av en lagringsstabil trombinsammensetning med terapeutisk kvalitet som hovedsakelig er fri for virus NO323460B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/309,583 US5506127A (en) 1994-09-21 1994-09-21 Therapeutic grade thrombin produced by chromatography
PCT/CA1995/000541 WO1996009376A1 (en) 1994-09-21 1995-09-21 Therapeutic grade thrombin production and products

Publications (3)

Publication Number Publication Date
NO971104D0 NO971104D0 (no) 1997-03-11
NO971104L true NO971104L (no) 1997-04-24
NO323460B1 NO323460B1 (no) 2007-05-14

Family

ID=23198815

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19971104A NO323460B1 (no) 1994-09-21 1997-03-11 Fremgangsmate til fremstilling i stor skala av en lagringsstabil trombinsammensetning med terapeutisk kvalitet som hovedsakelig er fri for virus

Country Status (12)

Country Link
US (1) US5506127A (no)
EP (1) EP0782616B1 (no)
JP (1) JP3628703B2 (no)
AT (1) ATE315641T1 (no)
AU (1) AU711298B2 (no)
DE (1) DE69534749T2 (no)
DK (1) DK0782616T3 (no)
ES (1) ES2258264T3 (no)
NO (1) NO323460B1 (no)
PT (1) PT782616E (no)
RU (1) RU2144081C1 (no)
WO (1) WO1996009376A1 (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4137996A1 (de) * 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
FI952196A0 (fi) * 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Framstaellning av immunoglobulin
US5702715A (en) * 1995-10-27 1997-12-30 Drying Technology Reinforced biological sealants
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
US5981254A (en) * 1997-10-30 1999-11-09 Haemacure Corporation Process for producing thrombin from plasma
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
ATE313068T1 (de) * 1998-10-07 2005-12-15 Trinity Biotech Mfg Ltd Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
ATE346145T1 (de) * 1999-09-27 2006-12-15 Sysmex Corp Verfahren zur stabilisierung von thrombin
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
ES2214967B1 (es) * 2003-03-06 2005-06-16 Probitas Pharma, S.A Procedimiento para la eliminacion de virus en soluciones de fibrinogeno y fibrinogeno obtenido por dicho procedimiento.
ES2226587B1 (es) * 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US20060270014A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
ES2775974T3 (es) * 2006-06-26 2020-07-28 Omrix Biopharmaceuticals Inc Eliminación de virus por nanofiltración
RU2457248C2 (ru) * 2010-06-09 2012-07-27 Общество с ограниченной ответственностью фирма "Технология-Стандарт" Способ промышленного получения тромбина
WO2012051147A1 (en) * 2010-10-11 2012-04-19 Abbott Laboratories Processes for purification of proteins
WO2013091895A1 (en) * 2011-12-23 2013-06-27 Merz Pharma Gmbh & Co. Kgaa Novel method for the manufacturing of di-chain proteins for use in humans
CN107406840B (zh) 2015-02-25 2021-05-28 奥姆里克斯生物药品有限公司 用于纯化和定量凝血酶及其降解多肽的方法
JP2021513913A (ja) * 2018-02-19 2021-06-03 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 修正フィルタ膜及び方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4083957A (en) * 1974-07-26 1978-04-11 Lang John L Process for the alteration of the sex-ratio of mammals
NL7602423A (nl) * 1976-03-08 1977-09-12 Leuven Res & Dev Vzw Bepaling van heparine in bloedplasma.
US4380511A (en) * 1981-08-12 1983-04-19 Miles Laboratories, Inc. Purification of bovine thrombin
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
JPS63243032A (ja) * 1987-03-27 1988-10-07 Green Cross Corp:The トロンビンの加熱処理方法
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
SU1527261A1 (ru) * 1988-03-21 1989-12-07 Институт Химической И Биологической Физики Ан Эсср Способ получени тромбина
JP2832835B2 (ja) * 1988-12-21 1998-12-09 旭化成工業株式会社 ウイルス除去方法
DE3843126C3 (de) * 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
CA2007545A1 (en) * 1989-01-13 1990-07-13 Yahiro Uemura Production method for protein-containing composition
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
EP0443724B1 (en) * 1990-02-20 1999-03-17 Baxter International Inc. Viral-safe purified human thrombin
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
JP3127232B2 (ja) * 1990-03-08 2001-01-22 ウェルファイド株式会社 蛋白質製剤の製造法
JP3093821B2 (ja) * 1991-06-19 2000-10-03 旭化成工業株式会社 銅アンモニア法再生セルロース多孔性中空糸膜の製造方法
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
US5331092A (en) * 1992-11-06 1994-07-19 Coletica Process of preparation of collagen containing in major proportion insoluble collagen and collagen having high mechanical resistance and thermal stability obtained thereby
US5229172A (en) * 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization
JP2003318980A (ja) * 2002-04-24 2003-11-07 Mitsubishi Electric Corp ショートパケット用伝送フォーマット並びにゲートウェイシステム

Also Published As

Publication number Publication date
NO323460B1 (no) 2007-05-14
DE69534749T2 (de) 2006-11-02
RU2144081C1 (ru) 2000-01-10
ES2258264T3 (es) 2006-08-16
EP0782616B1 (en) 2006-01-11
DK0782616T3 (da) 2006-05-22
US5506127A (en) 1996-04-09
JPH10505753A (ja) 1998-06-09
AU3515195A (en) 1996-04-09
EP0782616A1 (en) 1997-07-09
WO1996009376A1 (en) 1996-03-28
NO971104D0 (no) 1997-03-11
ATE315641T1 (de) 2006-02-15
DE69534749D1 (de) 2006-04-06
JP3628703B2 (ja) 2005-03-16
AU711298B2 (en) 1999-10-07
PT782616E (pt) 2006-05-31

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Legal Events

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