NO971376L - N-substituerte piperidinyl bisykliske benzoatderivater - Google Patents

N-substituerte piperidinyl bisykliske benzoatderivater

Info

Publication number: NO971376L
Authority: NO; Norway
Prior art keywords: 6alkyl; substituted; halo; hydrogen; alk
Prior art date: 1994-09-27

Application number

NO971376A

Other languages

English (en)

Other versions

NO971376D0 (no

NO313238B1 (no

Inventor

Georges Henri Paul Van Daele

Jean-Paul Rene Marie A Bosmans

Frans Maria Alfons Van Keybus

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-27

Filing date

1997-03-24

Publication date

1997-05-05

1997-03-24 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1997-03-24 Publication of NO971376D0 publication Critical patent/NO971376D0/no

1997-05-05 Publication of NO971376L publication Critical patent/NO971376L/no

2002-09-02 Publication of NO313238B1 publication Critical patent/NO313238B1/no

Links

150000001558 benzoic acid derivatives Chemical class 0.000 title abstract 2
-1 N-substituted piperidinyl Chemical group 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
125000001475 halogen functional group Chemical group 0.000 abstract 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 3
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical group C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 2
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical group C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical group C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
CAAMSDWKXXPUJR-UHFFFAOYSA-N 3,5-dihydro-4H-imidazol-4-one Chemical class O=C1CNC=N1 CAAMSDWKXXPUJR-UHFFFAOYSA-N 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
125000000815 N-oxide group Chemical group 0.000 abstract 1
150000008641 benzimidazolones Chemical class 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
150000002012 dioxanes Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000004899 motility Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003216 pyrazines Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19971376A 1994-09-27 1997-03-24 N-substituerte piperidinyl bisykliske benzoatderivater NO313238B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94202792		1994-09-27
US45548695A	1995-05-31	1995-05-31
PCT/EP1995/003691 WO1996010027A1 (en)	1994-09-27	1995-09-19	N-substituted piperidinyl bicyclic benzoate derivatives

Publications (3)

Publication Number	Publication Date
NO971376D0 NO971376D0 (no)	1997-03-24
NO971376L true NO971376L (no)	1997-05-05
NO313238B1 NO313238B1 (no)	2002-09-02

Family

ID=26136613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19971376A NO313238B1 (no)	1994-09-27	1997-03-24	N-substituerte piperidinyl bisykliske benzoatderivater

Country Status (23)

Country	Link
EP (1)	EP0784620B1 (no)
JP (1)	JP3953097B2 (no)
CN (1)	CN1068880C (no)
AT (1)	ATE187453T1 (no)
AU (1)	AU699152B2 (no)
BR (1)	BR9509036A (no)
CA (1)	CA2200578C (no)
CZ (1)	CZ289031B6 (no)
DE (1)	DE69513846T2 (no)
DK (1)	DK0784620T3 (no)
ES (1)	ES2141383T3 (no)
FI (1)	FI119640B (no)
GR (1)	GR3032646T3 (no)
HU (1)	HU218698B (no)
IL (1)	IL115413A (no)
MY (1)	MY113202A (no)
NO (1)	NO313238B1 (no)
NZ (1)	NZ293605A (no)
PL (1)	PL182502B1 (no)
PT (1)	PT784620E (no)
RU (1)	RU2154064C2 (no)
WO (1)	WO1996010027A1 (no)
ZA (1)	ZA958081B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2332275A1 (en) *	1998-05-14	1999-11-18	Zoltan Tamas Nagy	Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
DE60300683T2 (de) *	2002-01-16	2006-04-27	Janssen Pharmaceutica N.V.	Prucaloprid-n-oxid
JP4740152B2 (ja)	2003-12-23	2011-08-03	セロドスアクスイェセルスカブ	末梢性５−ｈｔ受容体の修飾因子
US8071624B2 (en)	2004-06-24	2011-12-06	Incyte Corporation	N-substituted piperidines and their use as pharmaceuticals
CN102775396B (zh)	2005-11-08	2014-10-08	沃泰克斯药物股份有限公司	Atp-结合弹夹转运蛋白的杂环调控剂
CN104447716A (zh)	2007-05-09	2015-03-25	沃泰克斯药物股份有限公司	Cftr调节剂
MX365732B (es)	2007-12-07	2019-06-12	Vertex Pharma	Procesos para producir acidos cicloalquilcarboxamido-piridin benzoicos.
EP3683218B1 (en)	2007-12-07	2024-09-18	Vertex Pharmaceuticals Incorporated	Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
NZ720282A (en)	2008-02-28	2017-12-22	Vertex Pharma	Heteroaryl derivatives as cftr modulators
MX2012011655A (es) *	2010-04-07	2012-11-23	Vertex Pharma	Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo [d][1-3]dioxol-5-il]ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico.
JP2013523833A (ja)	2010-04-07	2013-06-17	バーテックスファーマシューティカルズインコーポレイテッド	３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与
NZ727015A (en)	2012-01-25	2017-12-22	Vertex Pharma	Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
AU2014349010C1 (en)	2013-11-12	2020-08-06	Vertex Pharmaceuticals Incorporated	Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases
RU2691136C2 (ru)	2014-11-18	2019-06-11	Вертекс Фармасьютикалз Инкорпорейтед	Способ проведения высокопроизводительной тестовой высокоэффективной жидкостной хроматографии

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1593569A3 (ru) *	1982-07-30	1990-09-15	Janssen Pharmaceutica Nv	Cпocoб пoлучehия пpoизboдhыx n-(3-гидpokcи-4-пипepидиhил)бehзamидa или иx kиcлotho-aддиtиbhыx coлeй
CA1317940C (en) *	1987-09-25	1993-05-18	Georges H. P. Van Daele	Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) *	1988-03-29	1989-10-19	Sandoz Ag	Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) *	1990-03-06	1990-05-02	Janssen Pharmaceutica Nv	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
CA2116024A1 (en) *	1991-08-20	1993-03-04	Francis David King	5-ht4 receptor antagonists
MX9306311A (es) *	1992-10-13	1994-04-29	Smithkline Beecham Plc	Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

1995
- 1995-09-19 WO PCT/EP1995/003691 patent/WO1996010027A1/en not_active Ceased
- 1995-09-19 JP JP51133896A patent/JP3953097B2/ja not_active Expired - Fee Related
- 1995-09-19 AU AU36081/95A patent/AU699152B2/en not_active Ceased
- 1995-09-19 AT AT95933400T patent/ATE187453T1/de not_active IP Right Cessation
- 1995-09-19 RU RU97107464/04A patent/RU2154064C2/ru not_active IP Right Cessation
- 1995-09-19 BR BR9509036A patent/BR9509036A/pt not_active IP Right Cessation
- 1995-09-19 DK DK95933400T patent/DK0784620T3/da active
- 1995-09-19 NZ NZ293605A patent/NZ293605A/en not_active IP Right Cessation
- 1995-09-19 HU HU9701944A patent/HU218698B/hu not_active IP Right Cessation
- 1995-09-19 ES ES95933400T patent/ES2141383T3/es not_active Expired - Lifetime
- 1995-09-19 EP EP95933400A patent/EP0784620B1/en not_active Expired - Lifetime
- 1995-09-19 PL PL95319997A patent/PL182502B1/pl not_active IP Right Cessation
- 1995-09-19 CZ CZ1997918A patent/CZ289031B6/cs not_active IP Right Cessation
- 1995-09-19 DE DE69513846T patent/DE69513846T2/de not_active Expired - Lifetime
- 1995-09-19 CN CN95195300A patent/CN1068880C/zh not_active Expired - Fee Related
- 1995-09-19 CA CA002200578A patent/CA2200578C/en not_active Expired - Lifetime
- 1995-09-19 PT PT95933400T patent/PT784620E/pt unknown
- 1995-09-22 IL IL11541395A patent/IL115413A/xx not_active IP Right Cessation
- 1995-09-26 ZA ZA958081A patent/ZA958081B/xx unknown
- 1995-09-26 MY MYPI95002870A patent/MY113202A/en unknown
1997
- 1997-03-24 NO NO19971376A patent/NO313238B1/no not_active IP Right Cessation
- 1997-03-26 FI FI971274A patent/FI119640B/fi active
2000
- 2000-02-11 GR GR20000400344T patent/GR3032646T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU699152B2 (en)	1998-11-26
AU3608195A (en)	1996-04-19
FI119640B (fi)	2009-01-30
RU2154064C2 (ru)	2000-08-10
HUT77173A (hu)	1998-03-02
JPH10506118A (ja)	1998-06-16
CZ289031B6 (cs)	2001-10-17
CA2200578A1 (en)	1996-04-04
MX9702363A (es)	1997-10-31
NZ293605A (en)	1998-07-28
ATE187453T1 (de)	1999-12-15
DK0784620T3 (da)	2000-05-22
NO971376D0 (no)	1997-03-24
CA2200578C (en)	2006-11-07
CN1068880C (zh)	2001-07-25
IL115413A (en)	2000-02-17
GR3032646T3 (en)	2000-06-30
IL115413A0 (en)	1995-12-31
FI971274A7 (fi)	1997-03-26
HU218698B (hu)	2000-11-28
PL319997A1 (en)	1997-09-01
PL182502B1 (pl)	2002-01-31
EP0784620B1 (en)	1999-12-08
WO1996010027A1 (en)	1996-04-04
MY113202A (en)	2001-12-31
FI971274A0 (fi)	1997-03-26
DE69513846D1 (de)	2000-01-13
ZA958081B (en)	1997-03-26
EP0784620A1 (en)	1997-07-23
CN1166171A (zh)	1997-11-26
DE69513846T2 (de)	2000-07-06
CZ91897A3 (en)	1997-12-17
JP3953097B2 (ja)	2007-08-01
ES2141383T3 (es)	2000-03-16
PT784620E (pt)	2000-05-31
NO313238B1 (no)	2002-09-02
BR9509036A (pt)	1997-10-14

Legal Events

Date	Code	Title	Description
2010-04-26	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO971376D0 (no)	1997-03-24	N-substituerte piperidinyl bisykliske benzoatderivater
ES449191A1 (es)	1977-12-01	Un procedimiento de preparacion de derivados de 4,5,6,7-te- trahidro-tieno-(2,3-c)-piridina.
TW369526B (en)	1999-09-11	Diazabicyclic neurokinin antagonists
DE60040901D1 (de)	2009-01-08	Polyhydroxyalkanoat
DK0447285T3 (da)	1993-08-16	Nephtalenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
MY101359A (en)	1991-09-05	7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, their starting compounds and their preparation
DE60139639D1 (de)	2009-10-01	Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung
DK0479546T3 (da)	1996-11-25	Piperazinderivater
ATE282610T1 (de)	2004-12-15	Heterozyklische verbindungen mit faktor xa hemmender wirkung
MY120248A (en)	2005-09-30	Water soluble azoles as broad-spectrum antifungals
ATE171943T1 (de)	1998-10-15	Piperidin-verbindungen, ihre darstellung und ihre verwendung
PL322872A1 (en)	1998-03-02	Novel triazolones - inhibitors of b apolipoprotein synthesis
TW360653B (en)	1999-06-11	A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
ATE212996T1 (de)	2002-02-15	Anthracyclin-derivate
DK1150974T3 (da)	2002-12-02	Heterocykliske derivater som inhibitor af faktor Xa
AP1396A (en)	2005-04-19	1-Trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives.
HUP9900895A2 (hu)	1999-07-28	Simaizom sejtburjánzást gátló 2-szubsztituált benzimidazolszármazékok
JO1648B1 (en)	1991-11-27	Nitrogen compounds
JO1697B1 (en)	1992-12-15	Pyridine derivatives