ES2141383T3 - Derivados de benzoatos biciclicos de piperidinilo sustituido en n. - Google Patents

Derivados de benzoatos biciclicos de piperidinilo sustituido en n.

Info

Publication number
ES2141383T3
ES2141383T3 ES95933400T ES95933400T ES2141383T3 ES 2141383 T3 ES2141383 T3 ES 2141383T3 ES 95933400 T ES95933400 T ES 95933400T ES 95933400 T ES95933400 T ES 95933400T ES 2141383 T3 ES2141383 T3 ES 2141383T3
Authority
ES
Spain
Prior art keywords
sub
alkyl
sup
substituted
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95933400T
Other languages
English (en)
Inventor
Daele Georges Henri Paul Van
Jean-Paul Rene Marie A Bosmans
Den Keybus Frans Maria Alf Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2141383T3 publication Critical patent/ES2141383T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE BENZOATO QUE TIENEN LA FORMULA (I), LAS FORMAS N-OXIDAS, LAS SALES Y LAS FORMAS ESTEREOQUIMICAMENTE ISOMERICAS DE LOS MISMOS, EN DONDE: R{SUP,1} ES HALO O C{SUB,1-6}ALQUILSULFONILAMINO; A REPRESENTA UN RADICAL BIVALENTE DE FORMULA -CH{SUB,2}-CH{SUB,2}- (A), CH{SUB,2}-CH{SUB,2}-CH{SUB,2}- (B), O -CH=CH- (C), EN LOS RADICALES BIVALENTES (A), (B) Y (C) UNO O DOS ATOMOS DE HIDROGENO PUEDEN SER SUSTITUIDOS POR C{SUB,1-6}ALQUILO; R{SUP,2} ES HIDROGENO O C{SUB,1-6}ALQUILOXI; L ES UN RADICAL DE FORMULA: ALQ-R{SUP,4} (D), -ALQ-O-R{SUP,5} (E), -ALQ-NR{SUP,6}R{SUP,7} (F), ALQ ES C{SUB,1-12}ALCANEDIILO; R{SUP,4} ES HIDROGENO; CIANO; C{SUB,1-6}ALQUILCARBONILO; C{SUB,1-6}ALQUILOXICARBONILO; C{SUB,37}CICLOALQUILO; C{SUB,1-6}ALQUILSULFINILO; C{SUB,16}ALQUILSULFONILO; FENILO O FENILO SUSTITUIDO CON HALO C{SUB,16}ALQUILO O C{SUB,1-6}ALQUILOXI; TETRAHIDROFURANO; DIOXOLANO; DIOXOLANO SUSTITUIDO CON C{SUB,1-6}ALQUILO; DIOXANO; DIOXANO SUSTITUIDO CON C{SUB,1-6}ALQUILO; PIRIDINA; PIRIDINA SUSTITUIDA CON HALO O C{SUB,1-6}ALQUILO; PIRIDAZINA; PIRIDAZINA SUSTITUIDA CON UNO O DOS SUSTITUYENTES SELECCIONADOS DE HALO, C{SUB,16}ALQUILO, HIDROXI O UNA BENCIMIDAZOLONA OPCIONALMENTE SUSTITUIDA O UNA IMIDAZOLONA OPCIONALMENTE SUSTITUIDA; R{SUP,5} ES HIDROGENO; C{SUB,1-6}ALQUILO; HIDROXIC{SUB,1-6}ALQUILO; C{SUB,16}ALQUILCARBONILO; FENILO O FENILO SUSTITUIDO CON HASTA TRES SUSTITUYENTES SELECCIONADOS DE HALO, C{SUB,1-6}ALQUILO, C{SUB,16}ALQUILOXI; R{SUP,6} ES HIDROGENO O C{SUB,1-6}ALQUILO; R{SUP,7} ES HIDROGENO; C{SUB,1-6}ALQUILO; C{SUB,1-6}ALQUILCARBONILO; C{SUB,1-6}ALQUILOXICARBONILO; PIRIDAZINA; PIRIDAZINA SUSTITUIDA CON UNO O DOS SUSTITUYENTES SELECCIONADOS DE HALO, ALQUILO C{SUB,1-6}, HIDROXI; PIRAZINA; PIRAZINA SUSTITUIDA CON UNO O DOS SUSTITUYENTES SELECCIONADOS DE HALO, C{SUB,1-6}ALQUILO, HIDROXI. SE DESCRIBEN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS, PROCEDIMIENTOS PARA PREPARAR COMPUESTOS Y COMPOSICIONES ASI COMO EL USO COMO UNAMEDICINA, EN PARTICULAR PARA EL TRATAMIENTO DE TRASTORNOS GASTROINTESTINALES INCLUYENDO UNA REDUCIDA MOVILIDAD DEL COLON.
ES95933400T 1994-09-27 1995-09-19 Derivados de benzoatos biciclicos de piperidinilo sustituido en n. Expired - Lifetime ES2141383T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31

Publications (1)

Publication Number Publication Date
ES2141383T3 true ES2141383T3 (es) 2000-03-16

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95933400T Expired - Lifetime ES2141383T3 (es) 1994-09-27 1995-09-19 Derivados de benzoatos biciclicos de piperidinilo sustituido en n.

Country Status (23)

Country Link
EP (1) EP0784620B1 (es)
JP (1) JP3953097B2 (es)
CN (1) CN1068880C (es)
AT (1) ATE187453T1 (es)
AU (1) AU699152B2 (es)
BR (1) BR9509036A (es)
CA (1) CA2200578C (es)
CZ (1) CZ289031B6 (es)
DE (1) DE69513846T2 (es)
DK (1) DK0784620T3 (es)
ES (1) ES2141383T3 (es)
FI (1) FI119640B (es)
GR (1) GR3032646T3 (es)
HU (1) HU218698B (es)
IL (1) IL115413A (es)
MY (1) MY113202A (es)
NO (1) NO313238B1 (es)
NZ (1) NZ293605A (es)
PL (1) PL182502B1 (es)
PT (1) PT784620E (es)
RU (1) RU2154064C2 (es)
WO (1) WO1996010027A1 (es)
ZA (1) ZA958081B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20000750A2 (en) * 1998-05-14 2001-06-30 Egyt Gyogyszervegyeszeti Gyar Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
RU2301806C2 (ru) * 2002-01-16 2007-06-27 Янссен Фармацевтика Н.В. Прукалоприд-n-оксид
DE602004025508D1 (de) * 2003-12-23 2010-03-25 Serodus As Modulatoren von peripheren 5-ht-rezeptoren
EA200700117A1 (ru) 2004-06-24 2007-06-29 Инсайт Корпорейшн N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
EP2774925B1 (en) 2005-11-08 2016-12-28 Vertex Pharmaceuticals Incorporated Heterocyclic modulators of ATP-binding cassette transporters
WO2008141119A2 (en) 2007-05-09 2008-11-20 Vertex Pharmaceuticals Incorporated Modulators of cftr
PL2231606T3 (pl) 2007-12-07 2013-07-31 Vertex Pharma Sposoby wytwarzania kwasów cykloalkilokarboksyamidopirydynobenzoesowych
HUE031913T2 (en) 2007-12-07 2017-08-28 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
JP5523352B2 (ja) 2008-02-28 2014-06-18 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒ修飾因子としてのへテロアリール誘導体
NZ602795A (en) * 2010-04-07 2015-01-30 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
RS62767B1 (sr) 2010-04-07 2022-01-31 Vertex Pharma Farmaceutski sastavi 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiriodin-2-il)benzojeve kiseline i njihova primena
MX355183B (es) 2012-01-25 2018-04-09 Vertex Pharma Formulaciones de acido 3- (6- (1- (2.2- difluorobenzo [d] [1,3] dioxol-5-il) ciclopropancarboxamido) -3- metilpiridin-2-il) benzoico.
HRP20210516T2 (hr) 2013-11-12 2021-10-01 Vertex Pharmaceuticals Incorporated Postupak proizvodnje farmaceutskih pripravaka za liječenje bolesti koje su posredovane putem cftr
KR102576006B1 (ko) 2014-11-18 2023-09-06 버텍스 파마슈티칼스 인코포레이티드 고처리량 시험 고성능 액체 크로마토그래피의 수행 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1593569A3 (ru) * 1982-07-30 1990-09-15 Janssen Pharmaceutica Nv Cпocoб пoлучehия пpoизboдhыx n-(3-гидpokcи-4-пипepидиhил)бehзamидa или иx kиcлotho-aддиtиbhыx coлeй
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
NZ243993A (en) * 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
DK0784620T3 (da) 2000-05-22
PT784620E (pt) 2000-05-31
CN1166171A (zh) 1997-11-26
FI971274A0 (fi) 1997-03-26
BR9509036A (pt) 1997-10-14
NO971376L (no) 1997-05-05
PL182502B1 (pl) 2002-01-31
HUT77173A (hu) 1998-03-02
ZA958081B (en) 1997-03-26
IL115413A (en) 2000-02-17
EP0784620A1 (en) 1997-07-23
FI119640B (fi) 2009-01-30
NO971376D0 (no) 1997-03-24
NO313238B1 (no) 2002-09-02
FI971274A7 (fi) 1997-03-26
AU699152B2 (en) 1998-11-26
CZ289031B6 (cs) 2001-10-17
JP3953097B2 (ja) 2007-08-01
PL319997A1 (en) 1997-09-01
ATE187453T1 (de) 1999-12-15
RU2154064C2 (ru) 2000-08-10
CZ91897A3 (en) 1997-12-17
IL115413A0 (en) 1995-12-31
DE69513846T2 (de) 2000-07-06
EP0784620B1 (en) 1999-12-08
HU218698B (hu) 2000-11-28
DE69513846D1 (de) 2000-01-13
GR3032646T3 (en) 2000-06-30
MY113202A (en) 2001-12-31
NZ293605A (en) 1998-07-28
AU3608195A (en) 1996-04-19
CA2200578C (en) 2006-11-07
CA2200578A1 (en) 1996-04-04
WO1996010027A1 (en) 1996-04-04
MX9702363A (es) 1997-10-31
CN1068880C (zh) 2001-07-25
JPH10506118A (ja) 1998-06-16

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