NO971453L - Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske og akutte leversykdommer - Google Patents

Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske og akutte leversykdommer

Info

Publication number
NO971453L
NO971453L NO971453A NO971453A NO971453L NO 971453 L NO971453 L NO 971453L NO 971453 A NO971453 A NO 971453A NO 971453 A NO971453 A NO 971453A NO 971453 L NO971453 L NO 971453L
Authority
NO
Norway
Prior art keywords
treatment
drugs
manufacture
liver diseases
chronic
Prior art date
Application number
NO971453A
Other languages
English (en)
Other versions
NO971453D0 (no
Inventor
Gerhard Breipohl
Stephan Henke
Jochen Knolle
Klaus Wirth
Max Hropot
Martin Bickel
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO971453D0 publication Critical patent/NO971453D0/no
Publication of NO971453L publication Critical patent/NO971453L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske leversykdommer (leverzirrhose og leverfibrose) og akutte leversykdommer, og for forhindring av komplikasjoner, spesielt for proiylakse henholdsvis behandling av portal hypertoni, dekompensasjonsfiemkomster som aszites, ødemdannelse, hepatorenaJt syndrom, hypertensiv gastro- og cholopati, splenomegali samt blødningskomplikasjoner i mage-tarm-kanalen ved portal hypertoni, kollateralt kretsløp og hyperemi og en kardiopati som følge av en kronisk hyperdynam kretsløp- situasjon og fialger derav, er beskrevet.
NO971453A 1996-03-27 1997-03-26 Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske og akutte leversykdommer NO971453L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19612067A DE19612067A1 (de) 1996-03-27 1996-03-27 Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen

Publications (2)

Publication Number Publication Date
NO971453D0 NO971453D0 (no) 1997-03-26
NO971453L true NO971453L (no) 1997-09-29

Family

ID=7789557

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971453A NO971453L (no) 1996-03-27 1997-03-26 Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske og akutte leversykdommer

Country Status (24)

Country Link
US (1) US5863901A (no)
EP (1) EP0797997B1 (no)
JP (1) JP4185169B2 (no)
KR (1) KR100453394B1 (no)
CN (1) CN1164421A (no)
AT (1) ATE297749T1 (no)
AU (1) AU1651697A (no)
BR (1) BR9701455A (no)
CA (1) CA2200040A1 (no)
CZ (1) CZ90797A3 (no)
DE (2) DE19612067A1 (no)
DK (1) DK0797997T3 (no)
ES (1) ES2242973T3 (no)
HR (1) HRP970171A2 (no)
HU (1) HUP9700642A3 (no)
ID (1) ID16413A (no)
IL (1) IL120521A0 (no)
NO (1) NO971453L (no)
PL (1) PL319193A1 (no)
PT (1) PT797997E (no)
SI (1) SI0797997T1 (no)
SK (1) SK39297A3 (no)
TR (1) TR199700228A2 (no)
ZA (1) ZA972599B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
TWI407960B (zh) 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
CN102159211A (zh) * 2008-06-20 2011-08-17 金尼医疗公司 用于治疗纤维化疾病或病症的组合物
IL274883B2 (en) 2017-11-24 2023-11-01 Pharvaris Netherlands B V BRADYKININ B2 receptor antagonists
AR118982A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
UY38707A (es) 2019-05-23 2020-12-31 Pharvaris Gmbh Nuevos antagonistas cíclicos del receptor b2 de bradiquinina

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4693993A (en) * 1985-06-13 1987-09-15 Stewart John M Bradykinin antagonist peptides
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
AU3428089A (en) * 1988-03-25 1989-10-16 The Administrators Of The Tulane Eductional Fund Therapeutic peptides
DE3926822A1 (de) * 1989-08-14 1991-02-21 Hoechst Ag Peptide mit bradykinin-antagonistischer wirkung
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
DE4013270A1 (de) * 1990-04-26 1991-10-31 Hoechst Ag Peptide mit bradykinin-antagonistischer wirkung
DE69012142D1 (de) * 1989-12-08 1994-10-06 Univ Boston Acylierte bradykininantagonisten und deren verwendung.
MX9100717A (es) * 1990-08-24 1992-04-01 Syntex Inc Antagonistas de la bradiquinina
CZ203693A3 (en) * 1991-04-01 1994-07-13 Cortech Bradykinin antagonists
WO1992018156A1 (en) * 1991-04-19 1992-10-29 Nova Technology Limited Partnership Bradykinin antagonist peptides
ES2123556T3 (es) * 1991-04-19 1999-01-16 Scios Nova Inc Peptidos de tipo bradiquinina.
WO1993011789A1 (en) * 1991-12-12 1993-06-24 Scios Nova Inc. Modified position (7) bradykinin antagonist peptides
FR2686343B1 (fr) * 1992-01-17 1994-03-11 Adir Cie Nouveaux derives pseudopeptidiques a activite antagoniste de la bradykinine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
TW258739B (no) * 1992-04-04 1995-10-01 Hoechst Ag
FR2692581B1 (fr) * 1992-06-18 1994-08-19 Adir Nouveaux dérivés peptidiques à activité antagoniste de la bradykinine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
AU5098593A (en) * 1992-09-11 1994-04-12 Lajos Gera Bradykinin antagonists containing aliphatic amino acids in the 5-position
US5521158A (en) * 1992-10-08 1996-05-28 Scios Nova Inc. Pseudopeptide bradykinin receptor antagonists
IL107400A0 (en) * 1992-11-10 1994-01-25 Cortech Inc Bradykinin antagonists
WO1994019372A1 (en) * 1993-02-17 1994-09-01 Scios Nova Inc. Cyclic bradykinin antagonist peptides
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
CA2171446C (en) * 1993-09-09 2004-11-23 Donald James Kyle Pseudo- and non-peptide bradykinin receptor antagonists
DE4345062A1 (de) * 1993-12-31 1995-07-13 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen
CA2184824A1 (en) * 1994-03-09 1995-09-14 Val S. Goodfellow Bradykinin antagonist peptides incorporating n-substituted glycines

Also Published As

Publication number Publication date
KR100453394B1 (ko) 2004-12-30
PL319193A1 (en) 1997-09-29
JPH1017491A (ja) 1998-01-20
CZ90797A3 (en) 1997-10-15
NO971453D0 (no) 1997-03-26
HRP970171A2 (en) 1998-04-30
PT797997E (pt) 2005-09-30
MX9702292A (es) 1997-09-30
BR9701455A (pt) 1998-08-18
ATE297749T1 (de) 2005-07-15
KR970064622A (ko) 1997-10-13
EP0797997A3 (de) 2000-05-31
DE59712344D1 (de) 2005-07-21
EP0797997A2 (de) 1997-10-01
ZA972599B (en) 1997-09-29
DE19612067A1 (de) 1997-10-02
TR199700228A2 (xx) 1997-10-21
ES2242973T3 (es) 2005-11-16
SI0797997T1 (en) 2005-10-31
CN1164421A (zh) 1997-11-12
SK39297A3 (en) 1997-10-08
HUP9700642A3 (en) 1998-03-02
HUP9700642A2 (hu) 1998-01-28
CA2200040A1 (en) 1997-09-27
US5863901A (en) 1999-01-26
AU1651697A (en) 1997-10-02
IL120521A0 (en) 1997-07-13
DK0797997T3 (da) 2005-10-17
ID16413A (id) 1997-09-25
HU9700642D0 (en) 1997-05-28
JP4185169B2 (ja) 2008-11-26
EP0797997B1 (de) 2005-06-15

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