NO971765L - Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene - Google Patents

Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene

Info

Publication number
NO971765L
NO971765L NO971765A NO971765A NO971765L NO 971765 L NO971765 L NO 971765L NO 971765 A NO971765 A NO 971765A NO 971765 A NO971765 A NO 971765A NO 971765 L NO971765 L NO 971765L
Authority
NO
Norway
Prior art keywords
alkynyl
cycloalkyl
alkenyl
compounds
preparation
Prior art date
Application number
NO971765A
Other languages
English (en)
Other versions
NO971765D0 (no
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Corinne Terrier
Martine Zucco
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO971765D0 publication Critical patent/NO971765D0/no
Publication of NO971765L publication Critical patent/NO971765L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Arrangement And Driving Of Transmission Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Nfe taxoider med den generelle formel: 1-Q der R|NH O Ra betyr hydrogen, hydroksy, alkoksy, ^^yioksy, alkoksy- acetoksy og Rj^ betyr hydrogen, eller også R^ og R^, saimicn med karbonatomet hvor til de er bundet danner en ketonfunksjon, 2 betyr et hydrogenatom eller en rest med den generelle formel (II), der Rj^ betyr en eventuelt substituert benzoyl- rest, tenoyl eller furoyl eller en rest R2~0-C0-, der Rg betyr alkyl, alkenyl, alkynyl, cykloalkyl, cykloalkenyl, blcykloalkyl, eventuelt substituert fenyl eller heterocyklyl, R3 betyr alkyl, alkenyl, alkynyl, cykloalkyl, fenyl, naftyl eller en aromatiske heterocyklyl, B) ibetyr alkyl, alkenyl, alkynyl, cykloalkyl, cykloalkenyl, blcykloalkyl, aryl eller heterocyklyl, og % toetyr alkyl, alkenyl, alkynyl, cykloalkyl eller eventuelt substituert cykloalkenyl. OH (II) rorbindelsenes fremstilling beskrives. ié .iM,ye rorbiiiuelser itied den generelle fonriel (1) der Z sante antitumorale og antileukemiske egenskaper.
NO971765A 1994-10-26 1997-04-17 Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene NO971765L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9412795A FR2726272B1 (fr) 1994-10-26 1994-10-26 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1995/001393 WO1996013494A1 (fr) 1994-10-26 1995-10-23 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
NO971765D0 NO971765D0 (no) 1997-04-17
NO971765L true NO971765L (no) 1997-04-17

Family

ID=9468223

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971765A NO971765L (no) 1994-10-26 1997-04-17 Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene

Country Status (26)

Country Link
US (1) US5840931A (no)
EP (1) EP0788492B1 (no)
JP (1) JPH10508015A (no)
KR (1) KR970707113A (no)
CN (1) CN1166170A (no)
AT (1) ATE178326T1 (no)
AU (1) AU704719B2 (no)
BG (1) BG62697B1 (no)
BR (1) BR9510235A (no)
CA (1) CA2202682A1 (no)
CZ (1) CZ287649B6 (no)
DE (1) DE69508781T2 (no)
DK (1) DK0788492T3 (no)
ES (1) ES2131864T3 (no)
FR (1) FR2726272B1 (no)
GR (1) GR3029838T3 (no)
HU (1) HUT77930A (no)
NO (1) NO971765L (no)
NZ (1) NZ294880A (no)
OA (1) OA10417A (no)
PL (1) PL319834A1 (no)
RO (1) RO115876B1 (no)
RU (1) RU2153496C2 (no)
SK (1) SK281556B6 (no)
WO (1) WO1996013494A1 (no)
ZA (1) ZA958997B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6433187B1 (en) 1998-12-17 2002-08-13 Tularik Inc. Certain polycyclic compounds useful as tubulin-binding agents
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) * 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
IT1319168B1 (it) * 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
JP2004525860A (ja) 2000-09-22 2004-08-26 ブリストル−マイヤーズ スクイブ カンパニー 併用化学療法剤の毒性を低下させる方法
US6956124B2 (en) 2003-04-14 2005-10-18 Aventis Pharma S.A. Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
EP1663153A4 (en) * 2003-05-20 2011-01-05 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH A LIPOSOMAL PLATINUM COMPLEX

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2710642B1 (fr) * 1993-09-29 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
KR970707113A (ko) 1997-12-01
US5840931A (en) 1998-11-24
RO115876B1 (ro) 2000-07-28
CZ125797A3 (en) 1997-08-13
CZ287649B6 (en) 2001-01-17
NO971765D0 (no) 1997-04-17
OA10417A (fr) 2001-12-05
JPH10508015A (ja) 1998-08-04
ES2131864T3 (es) 1999-08-01
FR2726272A1 (fr) 1996-05-03
ZA958997B (en) 1996-05-15
AU704719B2 (en) 1999-04-29
DE69508781T2 (de) 1999-09-02
CN1166170A (zh) 1997-11-26
CA2202682A1 (fr) 1996-05-09
NZ294880A (en) 1999-02-25
PL319834A1 (en) 1997-09-01
DK0788492T3 (da) 1999-10-11
MX9702742A (es) 1997-09-30
GR3029838T3 (en) 1999-07-30
RU2153496C2 (ru) 2000-07-27
AU3809195A (en) 1996-05-23
WO1996013494A1 (fr) 1996-05-09
EP0788492B1 (fr) 1999-03-31
HUT77930A (hu) 1998-11-30
DE69508781D1 (de) 1999-05-06
SK281556B6 (sk) 2001-05-10
FR2726272B1 (fr) 1996-12-06
SK51997A3 (en) 1997-10-08
EP0788492A1 (fr) 1997-08-13
BR9510235A (pt) 1997-11-04
ATE178326T1 (de) 1999-04-15
BG101442A (en) 1998-03-31
BG62697B1 (bg) 2000-05-31

Similar Documents

Publication Publication Date Title
AU631743B2 (en) New chalcones, process for preparing these and pharmaceutical compositions containing them
RO115877B1 (ro) Taxoide, procedee pentru prepararea acestora şi compoziţie farmaceutică care le conţine
EA199800588A1 (ru) Новые таксоиды, их получение и содержащие их фармацевтические композиции
BR9307613A (pt) Novos taxóides processo de preparação de um taxóide e composição farmacêutica
NO951772L (no) Fremgangsmåte for fremstilling av taxanderivater, de således oppnådde nye taxaner samt antitumor- og antileukemipreparater inneholdende taxanene
NO885096L (no) Substituerte benzazepiner, deres fremstilling og farmasoeytiske preparater inneholdende disse.
BG101402A (en) Apoliprotein-b synthesis inhibitors
FI954111A0 (fi) Uudet taksoidit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet
AU6798190A (en) Serotonin antagonists, their preparation and compositions containing them
NO974563L (no) Nye taxoider, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
YU38398A (sh) Novi taksoidi, njihovo dobivanje i farmaceutske smeše koje ih sadrže
PL319834A1 (en) Novel taxoides, method of obtaining and pharmaceutic compositions containing them
NO960441L (no) Benzopyraner og farmasöytiske forbindelser inneholdende dem
AU2713897A (en) Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
FI964899A0 (fi) Uusia taksoideja, niiden valmistus ja niitä sisältäviä koostumuksia
DE60222244D1 (de) Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga
HUT49122A (en) Process for producing pharmaceutical compositions containing pyridyl-ethanol-amine as active component and the active component
AU2309795A (en) Process for the preparation of 7-hydroxy taxanes
IL92280A0 (en) Oxime ether derivatives,their preparation and fungicidal compositions containing them
AU639079B2 (en) N-phenyl n-alkoxycarbonylalkyl glycinamides, preparation method and drugs containing them
AU8329782A (en) Cyclic sulphenamide derivatives
ATE70050T1 (de) 1-benzoyl-2-oxo-5-alkoxy-pyrrolidin-derivate, ihre herstellung und verwendung als heilmittel und zubereitungen, die sie enthalten.
MX9606227A (es) Taxoides novedosos su preparacion y las composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application