NO972433L - Substituerte 2-naftoylguanidiner, fremgangsmåter for deres fremstilling, deres anvendelse som medikament eller diagnostikum samt medikamenter inneholdende forbindelsene - Google Patents

Substituerte 2-naftoylguanidiner, fremgangsmåter for deres fremstilling, deres anvendelse som medikament eller diagnostikum samt medikamenter inneholdende forbindelsene

Info

Publication number: NO972433L
Authority: NO; Norway
Prior art keywords: naphthoylguanidines; diagnostic; drug; substituted; compounds
Prior art date: 1996-05-29

Application number

NO972433A

Other languages

English (en)

Other versions

NO972433D0 (no

NO308527B1 (no

Inventor

Joachim Brendel

Heinz-Werner Kleemann

Heinrich Christian Englert

Hans Jochen Lang

Jan-Robert Schwark

Andreas Weichert

Bansi Lal

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-29

Filing date

1997-05-28

Publication date

1997-12-01

1997-05-28 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-05-28 Publication of NO972433D0 publication Critical patent/NO972433D0/no

1997-12-01 Publication of NO972433L publication Critical patent/NO972433L/no

2000-09-25 Publication of NO308527B1 publication Critical patent/NO308527B1/no

Links

239000003814 drug Substances 0.000 title 2
150000001875 compounds Chemical class 0.000 title 1
229940079593 drug Drugs 0.000 title 1
OECMIBNCPUMKFU-UHFFFAOYSA-N n-(diaminomethylidene)naphthalene-2-carboxamide Chemical class C1=CC=CC2=CC(C(=O)N=C(N)N)=CC=C21 OECMIBNCPUMKFU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Surgery (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyridine Compounds (AREA)

NO972433A 1996-05-29 1997-05-28 Substituerte 2-naftoylguanidiner, deres anvendelse for fremstilling av et medikament samt legemidler og preparater inneholdende forbindelsene NO308527B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19621483A DE19621483A1 (de)	1996-05-29	1996-05-29	Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (3)

Publication Number	Publication Date
NO972433D0 NO972433D0 (no)	1997-05-28
NO972433L true NO972433L (no)	1997-12-01
NO308527B1 NO308527B1 (no)	2000-09-25

Family

ID=7795549

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO972433A NO308527B1 (no)	1996-05-29	1997-05-28	Substituerte 2-naftoylguanidiner, deres anvendelse for fremstilling av et medikament samt legemidler og preparater inneholdende forbindelsene

Country Status (29)

Country	Link
US (1)	US6087304A (no)
EP (1)	EP0810206B1 (no)
JP (1)	JP4039588B2 (no)
KR (1)	KR970074776A (no)
CN (1)	CN1167759A (no)
AR (1)	AR008373A1 (no)
AT (1)	ATE198320T1 (no)
AU (1)	AU710065B2 (no)
BR (1)	BR9703338A (no)
CA (1)	CA2206366C (no)
CZ (1)	CZ163097A3 (no)
DE (2)	DE19621483A1 (no)
DK (1)	DK0810206T3 (no)
ES (1)	ES2154002T3 (no)
GR (1)	GR3035126T3 (no)
HR (1)	HRP970292B1 (no)
HU (1)	HUP9700955A3 (no)
ID (1)	ID16989A (no)
IL (1)	IL120924A (no)
NO (1)	NO308527B1 (no)
NZ (1)	NZ314915A (no)
PL (1)	PL185754B1 (no)
PT (1)	PT810206E (no)
RU (1)	RU2190600C2 (no)
SI (1)	SI0810206T1 (no)
SK (1)	SK282020B6 (no)
TR (1)	TR199700428A2 (no)
TW (1)	TW416944B (no)
ZA (1)	ZA974665B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19621482A1 (de)	1996-05-29	1997-12-04	Hoechst Ag	Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO2000051998A1 (en)	1999-03-02	2000-09-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en)	1999-09-13	2002-07-16	Boehringer Ingelheim Pharmaceuticals, Inc.	Compound useful as reversible inhibitors of cysteine proteases
AR039156A1 (es) *	2002-03-28	2005-02-09	Novartis Ag	Amidas del acido piperidinilamino sulfamico o piperazinil sulfamico y su uso para la manufactura de un medicamento en enfermedades mediadas por la accion de la sulfatasa esteroide
CA2566526C (en) *	2004-06-02	2012-10-23	F. Hoffmann-La Roche Ag	Naphthaline derivatives useful as histamine-3-receptor ligands
TW200614995A (en) *	2004-11-10	2006-05-16	Nicholas Piramal India Ltd	Tricyclic guanidine derivatives as sodium-proton exchange inhibitors
AU2013205388B2 (en) *	2005-06-24	2016-05-05	Biotron Limited	Antiviral compounds and methods
PT2826770T (pt) *	2005-06-24	2018-12-18	Biotron Ltd	Compostos acilguanidinas com atividade antiviral
EP2069302B1 (en) *	2006-09-15	2010-08-25	Pfizer Inc.	Substituted pyridylmethyl bicyclocarboxyamide compounds
EP2394987A4 (en) *	2009-02-09	2012-09-05	Astellas Pharma Inc	ACYLGUANIDINDERIVAT
JPWO2010090305A1 (ja) *	2009-02-09	2012-08-09	アステラス製薬株式会社	置換アシルグアニジン誘導体
TW201116281A (en) *	2009-08-06	2011-05-16	Astellas Pharma Inc	N atom containing ring acylguanidine derivatives
PL2671869T3 (pl)	2011-02-02	2016-09-30		Pochodna tetrahydroizochinoliny
WO2026008867A1 (en) *	2024-07-04	2026-01-08	Institut National de la Santé et de la Recherche Médicale	Novel inhibitors of acsl4 and their use as medicines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4251545A (en) *	1979-09-19	1981-02-17	Gaf Corporation	Fungicidal process using 1-(alkoxyaroyl)guanidines
IT1238227B (it) *	1989-12-01	1993-07-12		Modulo di smistamento per impianti di convogliamento a nastro e simili
DE4035961A1 (de) *	1990-11-02	1992-05-07	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL109570A0 (en) *	1993-05-17	1994-08-26	Fujisawa Pharmaceutical Co	Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4318658A1 (de) *	1993-06-04	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4415873A1 (de) *	1994-05-05	1995-11-09	Hoechst Ag	Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
JPH08225513A (ja) *	1994-12-21	1996-09-03	Kanebo Ltd	ナフトイルグアニジン誘導体
DE19621482A1 (de) *	1996-05-29	1997-12-04	Hoechst Ag	Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

1996
- 1996-05-29 DE DE19621483A patent/DE19621483A1/de not_active Withdrawn
1997
- 1997-02-28 PL PL97318723A patent/PL185754B1/pl not_active IP Right Cessation
- 1997-05-16 AT AT97108013T patent/ATE198320T1/de not_active IP Right Cessation
- 1997-05-16 PT PT97108013T patent/PT810206E/pt unknown
- 1997-05-16 US US08/857,631 patent/US6087304A/en not_active Expired - Lifetime
- 1997-05-16 DK DK97108013T patent/DK0810206T3/da active
- 1997-05-16 EP EP97108013A patent/EP0810206B1/de not_active Expired - Lifetime
- 1997-05-16 SI SI9730102T patent/SI0810206T1/xx unknown
- 1997-05-16 DE DE59702802T patent/DE59702802D1/de not_active Expired - Lifetime
- 1997-05-16 ES ES97108013T patent/ES2154002T3/es not_active Expired - Lifetime
- 1997-05-27 HR HR970292A patent/HRP970292B1/xx not_active IP Right Cessation
- 1997-05-27 CZ CZ971630A patent/CZ163097A3/cs unknown
- 1997-05-27 TW TW086107120A patent/TW416944B/zh not_active IP Right Cessation
- 1997-05-27 TR TR97/00428A patent/TR199700428A2/xx unknown
- 1997-05-27 AR ARP970102253A patent/AR008373A1/es unknown
- 1997-05-27 NZ NZ314915A patent/NZ314915A/en unknown
- 1997-05-27 HU HU9700955A patent/HUP9700955A3/hu unknown
- 1997-05-27 CN CN97113187A patent/CN1167759A/zh active Pending
- 1997-05-27 IL IL12092497A patent/IL120924A/en not_active IP Right Cessation
- 1997-05-27 SK SK670-97A patent/SK282020B6/sk unknown
- 1997-05-27 AU AU23645/97A patent/AU710065B2/en not_active Ceased
- 1997-05-28 NO NO972433A patent/NO308527B1/no not_active IP Right Cessation
- 1997-05-28 JP JP13822797A patent/JP4039588B2/ja not_active Expired - Fee Related
- 1997-05-28 RU RU97109003/04A patent/RU2190600C2/ru not_active IP Right Cessation
- 1997-05-28 ZA ZA9704665A patent/ZA974665B/xx unknown
- 1997-05-28 CA CA002206366A patent/CA2206366C/en not_active Expired - Fee Related
- 1997-05-28 KR KR1019970021107A patent/KR970074776A/ko not_active Ceased
- 1997-05-28 ID IDP971814A patent/ID16989A/id unknown
- 1997-05-30 BR BR9703338A patent/BR9703338A/pt not_active IP Right Cessation
2000
- 2000-12-28 GR GR20000402772T patent/GR3035126T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
TR199700428A2 (xx)	1997-12-21
AU2364597A (en)	1997-12-04
NZ314915A (en)	1998-02-26
DE19621483A1 (de)	1997-12-04
KR970074776A (ko)	1997-12-10
AU710065B2 (en)	1999-09-16
US6087304A (en)	2000-07-11
EP0810206B1 (de)	2000-12-27
IL120924A0 (en)	1997-09-30
SK282020B6 (sk)	2001-10-08
HRP970292B1 (en)	2001-08-31
PT810206E (pt)	2001-06-29
ATE198320T1 (de)	2001-01-15
NO972433D0 (no)	1997-05-28
ZA974665B (en)	1997-12-01
HRP970292A2 (en)	1998-04-30
GR3035126T3 (en)	2001-03-30
DK0810206T3 (da)	2001-02-26
BR9703338A (pt)	1998-08-18
PL185754B1 (pl)	2003-07-31
CA2206366C (en)	2008-02-19
CA2206366A1 (en)	1997-11-29
MX9703922A (es)	1997-11-29
HU9700955D0 (en)	1997-07-28
EP0810206A1 (de)	1997-12-03
SI0810206T1 (en)	2001-04-30
HUP9700955A3 (en)	1998-04-28
IL120924A (en)	2002-03-10
SK67097A3 (en)	1997-12-10
RU2190600C2 (ru)	2002-10-10
JPH1081664A (ja)	1998-03-31
ES2154002T3 (es)	2001-03-16
ID16989A (id)	1997-11-27
HUP9700955A2 (hu)	1998-03-02
JP4039588B2 (ja)	2008-01-30
CN1167759A (zh)	1997-12-17
PL318723A1 (en)	1997-12-08
TW416944B (en)	2001-01-01
NO308527B1 (no)	2000-09-25
AR008373A1 (es)	2000-01-19
CZ163097A3 (cs)	1998-06-17
DE59702802D1 (de)	2001-02-01

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