NO972461L - Fremstilling av cefem- og isooxacefemderivater - Google Patents

Fremstilling av cefem- og isooxacefemderivater

Info

Publication number
NO972461L
NO972461L NO972461A NO972461A NO972461L NO 972461 L NO972461 L NO 972461L NO 972461 A NO972461 A NO 972461A NO 972461 A NO972461 A NO 972461A NO 972461 L NO972461 L NO 972461L
Authority
NO
Norway
Prior art keywords
lower alkyl
aryl
formula
heterocyclyl
cycloalkyl
Prior art date
Application number
NO972461A
Other languages
English (en)
Other versions
NO972461D0 (no
Inventor
Thomas Oberhauser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO972461D0 publication Critical patent/NO972461D0/no
Publication of NO972461L publication Critical patent/NO972461L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Oppfinnelsen vedrører en ny fremgangsmåte ved fremstilling av forbindelser med formel OR. hvor COOH wer trityl, acetyl, tetrahydropyranyl eller syklopentyl,er hydrogen, hydroksy, lavere alkyl, sykloalkyl, lavere alkoksy, lavere alkenyl, lavere alkynyl, aryl, aryloksy, aryl-lavere alkyl, aryl-lavere alkoksy eller heterosyklyl, eller heterosyklyl-lavere alkyl, den lavere alkyl, sykloalkyl, lavere alkoksy, lavere alkenyl, sykloalkenyl, lavere alkynyl, aryl-lavere alkyl, aryl, aryloksy, aryl-lavere alkoksy, heterosyklyl bindinger usubstituert eller substituert med i det minste en gruppe valgt fra kar-boksy, amino, nitro, cyano, lavere alkyl, lavere alkoksy, hydroksy, halogen, -CONR22, -(2)COO23,CO-, ROCO- eller2COO-, hfor Rer hydrogen, lavere alkyl, eller sykloalkyl;er lavere alkyl, lavere alkenyl eller en karboksylsyre beskyttende gruppe: Y er -S- og Z er -CH- eller Y er -CH- og Z er -0-, ved å acylere en forbindelse med formelmed et aktivert karboksylsyrederivat med formel1x 1 x hvor RJ er lavere alkyl, R , R',X,Y og Z har betydningene angitt ovenfor: og den vedrorer videre forbindelser med formel III.
NO972461A 1996-06-10 1997-05-29 Fremstilling av cefem- og isooxacefemderivater NO972461L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96109239 1996-06-10

Publications (2)

Publication Number Publication Date
NO972461D0 NO972461D0 (no) 1997-05-29
NO972461L true NO972461L (no) 1997-12-11

Family

ID=8222876

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972461A NO972461L (no) 1996-06-10 1997-05-29 Fremstilling av cefem- og isooxacefemderivater

Country Status (21)

Country Link
US (2) US5883247A (no)
EP (1) EP0812846B1 (no)
JP (1) JP2950795B2 (no)
KR (1) KR100258652B1 (no)
CN (1) CN1167766A (no)
AT (1) ATE204282T1 (no)
AU (1) AU697970B2 (no)
BR (1) BR9703517A (no)
CA (1) CA2206199A1 (no)
CZ (1) CZ176997A3 (no)
DE (1) DE69706099T2 (no)
DK (1) DK0812846T3 (no)
ES (1) ES2162158T3 (no)
HU (1) HUP9701013A3 (no)
IL (1) IL120991A (no)
NO (1) NO972461L (no)
NZ (1) NZ314991A (no)
PL (1) PL320452A1 (no)
TR (1) TR199700481A2 (no)
TW (1) TW434244B (no)
ZA (1) ZA974885B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403049B (de) 1995-08-14 1997-10-27 Biochemie Gmbh Abreicherung von 7-adca in 3-vinyl-aca
ES2281090T3 (es) 1996-11-06 2007-09-16 Basilea Pharmaceutica Ag Derivados de vinilpirrolidona-cefalosporina.
WO2000032605A1 (en) * 1998-12-03 2000-06-08 F. Hoffmann-La Roche Ag Bi-pyrrolidinylvinl (carba) cephalosporins
KR100320671B1 (ko) * 1999-11-04 2002-01-17 이균철 방폭 방탄 안전 전투화
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
KR101058135B1 (ko) 2008-04-04 2011-08-24 대웅바이오 주식회사 세프디니르 합성에 유용한 중간체 및 이를 이용하여세프디니르를 제조하는 방법
WO2011029596A1 (en) 2009-09-11 2011-03-17 Lonza Ltd Process for preparing 2-aminothiazol-4-yl-acetic acid derivates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2824559C2 (de) * 1977-06-10 1985-01-10 Yamanouchi Pharmaceutical Co., Ltd., Tokio / Tokyo 7α-Methoxy-7β-(4-substituierte-methylen-1,3-dithietan-2-yl)-carboxamido-3-Δ↑3↑-cephem-4-carbonsäuren, Verfahren zu deren Herstellung sowie ihre Verwendung
FR2439785A1 (fr) * 1978-10-23 1980-05-23 Roussel Uclaf Nouveau procede de preparation des produits derives de l'acide 7-amino-thiazolyl acetamido cephalosporanique
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4576749A (en) * 1983-10-03 1986-03-18 E. R. Squibb & Sons, Inc. 3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones
TW212181B (no) * 1992-02-14 1993-09-01 Hoechst Ag
KR950013578B1 (ko) * 1993-04-10 1995-11-09 주식회사럭키 신규 티아(디아)졸 초산의 반응성 티오포스페이트 유도체 및 그의 제조방법
PT620225E (pt) * 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag Derivados de cefalosporina
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
WO1996012712A1 (en) * 1994-10-24 1996-05-02 Miwon Co., Ltd. Reactive phosphate derivatives of thiazolylacetic acid and process for preparing cephalosporin antibiotics using the same
WO1996026943A1 (en) * 1995-02-27 1996-09-06 F.Hoffmann-La Roche Ag Derivatives of 3-pyrrolidylidene-2-one-cephalosporines
ATE218572T1 (de) * 1995-12-27 2002-06-15 Hanmi Pharmaceutical Co Ltd Verfahren zur herstellung von cefdinir

Also Published As

Publication number Publication date
HUP9701013A1 (hu) 1998-08-28
IL120991A0 (en) 1997-11-20
US5919939A (en) 1999-07-06
ATE204282T1 (de) 2001-09-15
KR100258652B1 (ko) 2000-07-01
AU697970B2 (en) 1998-10-22
US5883247A (en) 1999-03-16
MX9704258A (es) 1998-07-31
DE69706099T2 (de) 2002-05-02
PL320452A1 (en) 1997-12-22
CA2206199A1 (en) 1997-12-10
DE69706099D1 (de) 2001-09-20
NO972461D0 (no) 1997-05-29
KR980002053A (ko) 1998-03-30
BR9703517A (pt) 1998-12-29
IL120991A (en) 2000-07-26
EP0812846A1 (en) 1997-12-17
JP2950795B2 (ja) 1999-09-20
EP0812846B1 (en) 2001-08-16
CN1167766A (zh) 1997-12-17
HU9701013D0 (en) 1997-07-28
HUP9701013A3 (en) 2001-04-28
ZA974885B (en) 1998-08-26
DK0812846T3 (da) 2001-11-12
CZ176997A3 (en) 1997-12-17
TR199700481A2 (xx) 1997-12-21
JPH1059978A (ja) 1998-03-03
NZ314991A (en) 2000-01-28
ES2162158T3 (es) 2001-12-16
AU2474697A (en) 1997-12-18
TW434244B (en) 2001-05-16

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application