ATE204282T1 - Herstellung von cephem- und isooxacephemderivaten - Google Patents

Herstellung von cephem- und isooxacephemderivaten

Info

Publication number: ATE204282T1
Authority: AT; Austria
Prior art keywords: lower alkyl; aryl; formula; alkoxy; cycloalkyl
Prior art date: 1996-06-10

Application number

AT97109069T

Other languages

English (en)

Inventor

Thomas Oberhauser

Original Assignee

Basilea Pharmaceutica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-10

Filing date

1997-06-05

Publication date

2001-09-15

1997-06-05 Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE204282T1 publication Critical patent/ATE204282T1/de

Links

150000001782 cephems Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 10
125000003545 alkoxy group Chemical group 0.000 abstract 5
125000003342 alkenyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
-1 carboxy, amino Chemical group 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT97109069T 1996-06-10 1997-06-05 Herstellung von cephem- und isooxacephemderivaten ATE204282T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96109239		1996-06-10

Publications (1)

Publication Number	Publication Date
ATE204282T1 true ATE204282T1 (de)	2001-09-15

Family

ID=8222876

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97109069T ATE204282T1 (de)	1996-06-10	1997-06-05	Herstellung von cephem- und isooxacephemderivaten

Country Status (21)

Country	Link
US (2)	US5883247A (de)
EP (1)	EP0812846B1 (de)
JP (1)	JP2950795B2 (de)
KR (1)	KR100258652B1 (de)
CN (1)	CN1167766A (de)
AT (1)	ATE204282T1 (de)
AU (1)	AU697970B2 (de)
BR (1)	BR9703517A (de)
CA (1)	CA2206199A1 (de)
CZ (1)	CZ176997A3 (de)
DE (1)	DE69706099T2 (de)
DK (1)	DK0812846T3 (de)
ES (1)	ES2162158T3 (de)
HU (1)	HUP9701013A3 (de)
IL (1)	IL120991A (de)
NO (1)	NO972461L (de)
NZ (1)	NZ314991A (de)
PL (1)	PL320452A1 (de)
TR (1)	TR199700481A2 (de)
TW (1)	TW434244B (de)
ZA (1)	ZA974885B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT403049B (de)	1995-08-14	1997-10-27	Biochemie Gmbh	Abreicherung von 7-adca in 3-vinyl-aca
ES2281090T3 (es)	1996-11-06	2007-09-16	Basilea Pharmaceutica Ag	Derivados de vinilpirrolidona-cefalosporina.
WO2000032605A1 (en) *	1998-12-03	2000-06-08	F. Hoffmann-La Roche Ag	Bi-pyrrolidinylvinl (carba) cephalosporins
KR100320671B1 (ko) *	1999-11-04	2002-01-17	이균철	방폭 방탄 안전 전투화
US6504025B2 (en) *	2000-05-24	2003-01-07	Basilea Pharmaceutica Ag	Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
KR101058135B1 (ko)	2008-04-04	2011-08-24	대웅바이오 주식회사	세프디니르 합성에 유용한 중간체 및 이를 이용하여세프디니르를 제조하는 방법
WO2011029596A1 (en)	2009-09-11	2011-03-17	Lonza Ltd	Process for preparing 2-aminothiazol-4-yl-acetic acid derivates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3971778A (en) *	1972-05-12	1976-07-27	Glaxo Laboratories Limited	Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
DE2716677C2 (de) *	1977-04-15	1985-10-10	Hoechst Ag, 6230 Frankfurt	Cephemderivate und Verfahren zu ihrer Herstellung
DE2824559C2 (de) *	1977-06-10	1985-01-10	Yamanouchi Pharmaceutical Co., Ltd., Tokio / Tokyo	7α-Methoxy-7β-(4-substituierte-methylen-1,3-dithietan-2-yl)-carboxamido-3-Δ↑3↑-cephem-4-carbonsäuren, Verfahren zu deren Herstellung sowie ihre Verwendung
FR2439785A1 (fr) *	1978-10-23	1980-05-23	Roussel Uclaf	Nouveau procede de preparation des produits derives de l'acide 7-amino-thiazolyl acetamido cephalosporanique
US4409214A (en) *	1979-11-19	1983-10-11	Fujisawa Pharmaceutical, Co., Ltd.	7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4576749A (en) *	1983-10-03	1986-03-18	E. R. Squibb & Sons, Inc.	3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones
TW212181B (de) *	1992-02-14	1993-09-01	Hoechst Ag
KR950013578B1 (ko) *	1993-04-10	1995-11-09	주식회사럭키	신규 티아(디아)졸 초산의 반응성 티오포스페이트 유도체 및 그의 제조방법
PT620225E (pt) *	1993-04-16	2003-03-31	Basilea Pharmaceutica Ag	Derivados de cefalosporina
US5523400A (en) *	1993-04-16	1996-06-04	Hoffmann-La Roche Inc.	Cephalosporin antibiotics
WO1996012712A1 (en) *	1994-10-24	1996-05-02	Miwon Co., Ltd.	Reactive phosphate derivatives of thiazolylacetic acid and process for preparing cephalosporin antibiotics using the same
WO1996026943A1 (en) *	1995-02-27	1996-09-06	F.Hoffmann-La Roche Ag	Derivatives of 3-pyrrolidylidene-2-one-cephalosporines
ATE218572T1 (de) *	1995-12-27	2002-06-15	Hanmi Pharmaceutical Co Ltd	Verfahren zur herstellung von cefdinir

1997
- 1997-05-14 US US08/856,070 patent/US5883247A/en not_active Expired - Fee Related
- 1997-05-23 TW TW086106970A patent/TW434244B/zh active
- 1997-05-27 CA CA002206199A patent/CA2206199A1/en not_active Abandoned
- 1997-05-29 NO NO972461A patent/NO972461L/no not_active Application Discontinuation
- 1997-06-03 ZA ZA974885A patent/ZA974885B/xx unknown
- 1997-06-03 NZ NZ314991A patent/NZ314991A/xx unknown
- 1997-06-04 IL IL12099197A patent/IL120991A/xx not_active IP Right Cessation
- 1997-06-05 EP EP97109069A patent/EP0812846B1/de not_active Expired - Lifetime
- 1997-06-05 AT AT97109069T patent/ATE204282T1/de not_active IP Right Cessation
- 1997-06-05 ES ES97109069T patent/ES2162158T3/es not_active Expired - Lifetime
- 1997-06-05 DE DE69706099T patent/DE69706099T2/de not_active Expired - Fee Related
- 1997-06-05 DK DK97109069T patent/DK0812846T3/da active
- 1997-06-06 AU AU24746/97A patent/AU697970B2/en not_active Ceased
- 1997-06-06 HU HU9701013A patent/HUP9701013A3/hu unknown
- 1997-06-09 JP JP9151131A patent/JP2950795B2/ja not_active Expired - Fee Related
- 1997-06-09 TR TR97/00481A patent/TR199700481A2/xx unknown
- 1997-06-09 PL PL97320452A patent/PL320452A1/xx unknown
- 1997-06-09 CN CN97105447A patent/CN1167766A/zh active Pending
- 1997-06-09 CZ CZ971769A patent/CZ176997A3/cs unknown
- 1997-06-09 KR KR1019970023548A patent/KR100258652B1/ko not_active Expired - Fee Related
- 1997-06-10 BR BR9703517A patent/BR9703517A/pt active Search and Examination
1998
- 1998-05-20 US US09/081,759 patent/US5919939A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUP9701013A1 (hu)	1998-08-28
IL120991A0 (en)	1997-11-20
US5919939A (en)	1999-07-06
NO972461L (no)	1997-12-11
KR100258652B1 (ko)	2000-07-01
AU697970B2 (en)	1998-10-22
US5883247A (en)	1999-03-16
MX9704258A (es)	1998-07-31
DE69706099T2 (de)	2002-05-02
PL320452A1 (en)	1997-12-22
CA2206199A1 (en)	1997-12-10
DE69706099D1 (de)	2001-09-20
NO972461D0 (no)	1997-05-29
KR980002053A (ko)	1998-03-30
BR9703517A (pt)	1998-12-29
IL120991A (en)	2000-07-26
EP0812846A1 (de)	1997-12-17
JP2950795B2 (ja)	1999-09-20
EP0812846B1 (de)	2001-08-16
CN1167766A (zh)	1997-12-17
HU9701013D0 (en)	1997-07-28
HUP9701013A3 (en)	2001-04-28
ZA974885B (en)	1998-08-26
DK0812846T3 (da)	2001-11-12
CZ176997A3 (en)	1997-12-17
TR199700481A2 (xx)	1997-12-21
JPH1059978A (ja)	1998-03-03
NZ314991A (en)	2000-01-28
ES2162158T3 (es)	2001-12-16
AU2474697A (en)	1997-12-18
TW434244B (en)	2001-05-16

Legal Events

Date	Code	Title	Description
2006-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NO994582D0 (no)	1999-09-21	Fremgangsmaate for fremstilling av piperidinderivater
ATE131470T1 (de)	1995-12-15	Neue arylethenylenderivate und verfahren zu ihrer herstellung
EP0775702A4 (de)	1997-11-05	Neue chinolon- oder naphthyridoncarbonsäurederivate oder deren salze
DK0994108T3 (da)	2003-08-18	Fremgangsmåde til fremstilling af 2-hydroxybenzamidderivater
ATE204282T1 (de)	2001-09-15	Herstellung von cephem- und isooxacephemderivaten
DK0806413T3 (da)	2002-01-28	2-substituerede viatmin D3-derivater
DE60037766D1 (de)	2008-02-21	Verfahren zur Herstellung von 2-Alkyl-3-aminothiophen Derivate und 3-Aminothiophen Derivate
ES2185599T3 (es)	2003-05-01	Preparacion de intermediarios de la imidazodiacepina.
CA2336380A1 (en)	2000-01-13	Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
KR940019681A (ko)	1994-09-14	베타-락탐 화합물의 제조방법 및 그의 중간체
DE69330658D1 (de)	2001-10-04	Verfahren zur Herstellung von 4-substituierten Azetidinonderivaten
DE69803618D1 (de)	2002-03-14	Verfahren zur Herstellung von 1,7-Diaryl- oder 1,7-Diheteroarylheptan-4-olen und Synthesezwischenprodukte
DE69815906D1 (de)	2003-08-07	Verfahren zur Herstellung von Chloroacetylaminothiazoleaceticsäure Derivate
ATE189813T1 (de)	2000-03-15	Prostaglandin-i-analoga
ECSP982576A (es)	1999-02-11	Derivados de epotilona