NO975089L - Piperidinderivater - Google Patents

Piperidinderivater

Info

Publication number: NO975089L
Authority: NO; Norway
Prior art keywords: alkyl; phenyl; substd; opt; alkoxy
Prior art date: 1994-03-18

Application number

NO975089A

Other languages

English (en)

Other versions

NO303823B1 (no

NO975089D0 (no

Inventor

Daniel Bichon

Patrick Gueule

Didier Van Broeck

Xavier Emonds-Alt

Vincenzo Proietto

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-18

Filing date

1997-11-04

Publication date

1995-09-19

1994-03-18 Priority claimed from FR9403193A external-priority patent/FR2717477B1/fr

1994-07-29 Priority claimed from FR9409478A external-priority patent/FR2717478B1/fr

1995-09-19 Publication of NO975089L publication Critical patent/NO975089L/no

1997-11-04 Application filed by Sanofi Sa filed Critical Sanofi Sa

1997-11-04 Publication of NO975089D0 publication Critical patent/NO975089D0/no

1998-09-07 Publication of NO303823B1 publication Critical patent/NO303823B1/no

Links

NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 14
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 9
-1 acryloxy Chemical group 0.000 abstract 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
UZJOADBKLQJCBI-UHFFFAOYSA-N 1-[3-(3,4-dichlorophenyl)propyl]piperidine Chemical compound C1=C(Cl)C(Cl)=CC=C1CCCN1CCCCC1 UZJOADBKLQJCBI-UHFFFAOYSA-N 0.000 abstract 1
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000006497 3-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])* 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000005042 acyloxymethyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
125000002393 azetidinyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
230000001681 protective effect Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical group C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO975089A 1994-03-18 1997-11-04 Piperidinderivater NO303823B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9403193A FR2717477B1 (fr)	1994-03-18	1994-03-18	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR9409478A FR2717478B1 (fr)	1994-03-18	1994-07-29	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR9500571A FR2719311B1 (fr)	1994-03-18	1995-01-19	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.

Publications (3)

Publication Number	Publication Date
NO975089L true NO975089L (no)	1995-09-19
NO975089D0 NO975089D0 (no)	1997-11-04
NO303823B1 NO303823B1 (no)	1998-09-07

Family

ID=27252886

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO951044A NO302944B1 (no)	1994-03-18	1995-03-17	Selektive antagonist-forbindelser for menneske-NK3-reseptor, farmasöytiske preparater inneholdende dem, og deres anvendelse til fremstilling av medikamenter
NO975089A NO303823B1 (no)	1994-03-18	1997-11-04	Piperidinderivater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO951044A NO302944B1 (no)	1994-03-18	1995-03-17	Selektive antagonist-forbindelser for menneske-NK3-reseptor, farmasöytiske preparater inneholdende dem, og deres anvendelse til fremstilling av medikamenter

Country Status (22)

Country	Link
US (3)	US5741910A (no)
EP (1)	EP0673928B1 (no)
JP (1)	JP2922816B2 (no)
KR (1)	KR100238343B1 (no)
CN (1)	CN1056605C (no)
AT (1)	ATE204863T1 (no)
AU (1)	AU693845B2 (no)
CA (1)	CA2145000C (no)
CY (1)	CY2278B1 (no)
DE (1)	DE69522355T2 (no)
DK (1)	DK0673928T3 (no)
ES (1)	ES2164746T3 (no)
FI (1)	FI116621B (no)
FR (1)	FR2719311B1 (no)
HU (1)	HUT72065A (no)
IL (1)	IL113026A (no)
NO (2)	NO302944B1 (no)
NZ (1)	NZ270727A (no)
PL (1)	PL185075B1 (no)
PT (1)	PT673928E (no)
RU (1)	RU2143425C1 (no)
TW (1)	TW380138B (no)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5824690A (en) *	1993-05-06	1998-10-20	Hoechst Marion Roussel Inc.	Substituted pyrrolidin-3-yl-alkyl-piperidines
US5998444A (en) *	1995-10-24	1999-12-07	Zeneca Ltd.	Piperidinyl compounds as NK1 or NK2 antagonists
CA2162786A1 (en) *	1994-11-22	1996-05-23	Philip Arthur Hipskind	Heterocyclic tachykinin receptor antagonists
FR2738245B1 (fr) *	1995-08-28	1997-11-21	Sanofi Sa	Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
FR2738819B1 (fr) *	1995-09-14	1997-12-05	Sanofi Sa	Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
GB9521781D0 (en) *	1995-10-24	1996-01-03	Merck Sharp & Dohme	Therapeutic agents
US6211199B1 (en)	1995-11-17	2001-04-03	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
WO1997019074A1 (en) *	1995-11-17	1997-05-29	Hoechst Marion Roussel, Inc.	Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
RU2135494C1 (ru)	1995-12-01	1999-08-27	Санкио Компани Лимитед	Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
US6194406B1 (en)	1995-12-20	2001-02-27	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en)	1995-12-20	2002-07-23	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
GB9600235D0 (en) *	1996-01-05	1996-03-06	Pfizer Ltd	Therapeutic agents
GB9601697D0 (en) *	1996-01-27	1996-03-27	Pfizer Ltd	Therapeutic agents
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
FR2745811B1 (fr) *	1996-03-07	1998-05-22	Sanofi Sa	Glutarimide disubstitue procede pour sa preparation, et son utilisation
EP0915849A2 (en) *	1996-08-05	1999-05-19	Smithkline Beecham S.p.A.	Process for the preparation of 3,3-disubstituted piperidines
WO1998011090A2 (en) *	1996-09-16	1998-03-19	Warner-Lambert Company	3-alkyl-3-phenyl-piperidines
US6040316A (en) *	1996-09-16	2000-03-21	Warner-Lambert Company	3-alkyl-3-phenyl-piperidines
US5789422A (en) *	1996-10-28	1998-08-04	Schering Corporation	Substituted arylalkylamines as neurokinin antagonists
US5977139A (en) *	1996-12-15	1999-11-02	Hoechst Marion Roussel, Inc.	Carboxysubstituted cyclic carboxamide derivatives
US5861417A (en) *	1996-12-19	1999-01-19	Hoechst Marion Roussel, Inc.	Heterocyclic substituted pyrrolidine amide derivatives
AU6133098A (en) *	1997-01-21	1998-08-07	Merck & Co., Inc.	3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6124319A (en) *	1997-01-21	2000-09-26	Merck & Co., Inc.	3,3-disubstituted piperidines as modulators of chemokine receptor activity
EP1003514A4 (en) *	1997-07-25	2000-10-11	Merck & Co Inc	CYCLIC AMINE MODULATORS OF CHEMOKIN RECEPTORS
US6136827A (en) *	1997-07-25	2000-10-24	Merck & Co., Inc.	Cyclic amine modulations of chemokine receptor activity
US6140349A (en) *	1998-02-02	2000-10-31	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
EP1052992A1 (en) *	1998-02-02	2000-11-22	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
US6316445B1 (en)	1998-05-15	2001-11-13	Aventis Pharmaceuticals Inc.	Carboxy substituted acylic carboxamide derivatives
FR2782082B3 (fr) *	1998-08-05	2000-09-22	Sanofi Sa	Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose
FR2784377B3 (fr) *	1998-10-09	2000-11-17	Sanofi Sa	Nouveaux composes derives d'ureidopiperidine, antagonistes selectifs des recepteurs nk3 humains, procede pour leur obtention et compositions pharmaceutiques les contenant
FR2787449B3 (fr)	1998-12-15	2001-01-12	Sanofi Sa	Derives de 3-phenyl-2,6-dioxopiperidin-3-yl propionamide et leur procede de preparation
FR2787448B3 (fr)	1998-12-18	2001-01-12	Sanofi Sa	Ester d'alkyle inferieur de l'acide 3-(3,4-dihalogenophenyl) -2,6-dioxopiperidine3-propionique et son mode de preparation
FR2787790A1 (fr)	1998-12-23	2000-06-30	Sanofi Sa	Procede de preparation du (r)-(+)-3-{1[2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates
FR2792199B3 (fr)	1999-04-13	2001-05-18	Sanofi Sa	Utilisation de l'osanetant pour la preparation de medicaments utiles dans le traitement des troubles de l'humeur
GB9927125D0 (en) *	1999-11-16	2000-01-12	Univ Reading The	Placental human neurokinin B precursor
WO2002040023A1 (en) *	2000-11-16	2002-05-23	Smithkline Beecham Corporation	Novel use
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1995
- 1995-01-19 FR FR9500571A patent/FR2719311B1/fr not_active Expired - Fee Related
- 1995-03-16 PL PL95307723A patent/PL185075B1/pl not_active IP Right Cessation
- 1995-03-16 NZ NZ270727A patent/NZ270727A/en not_active IP Right Cessation
- 1995-03-17 FI FI951265A patent/FI116621B/fi active IP Right Grant
- 1995-03-17 NO NO951044A patent/NO302944B1/no not_active IP Right Cessation
- 1995-03-17 HU HU9500806A patent/HUT72065A/hu unknown
- 1995-03-17 DE DE69522355T patent/DE69522355T2/de not_active Expired - Lifetime
- 1995-03-17 AU AU14909/95A patent/AU693845B2/en not_active Ceased
- 1995-03-17 PT PT95400590T patent/PT673928E/pt unknown
- 1995-03-17 AT AT95400590T patent/ATE204863T1/de not_active IP Right Cessation
- 1995-03-17 IL IL11302695A patent/IL113026A/xx not_active IP Right Cessation
- 1995-03-17 EP EP95400590A patent/EP0673928B1/fr not_active Expired - Lifetime
- 1995-03-17 ES ES95400590T patent/ES2164746T3/es not_active Expired - Lifetime
- 1995-03-17 DK DK95400590T patent/DK0673928T3/da active
- 1995-03-17 CN CN95103542A patent/CN1056605C/zh not_active Expired - Fee Related
- 1995-03-17 RU RU95103737/04A patent/RU2143425C1/ru active
- 1995-03-18 TW TW084102614A patent/TW380138B/zh not_active IP Right Cessation
- 1995-03-18 KR KR1019950005722A patent/KR100238343B1/ko not_active Expired - Fee Related
- 1995-03-20 JP JP7061419A patent/JP2922816B2/ja not_active Expired - Fee Related
- 1995-03-20 CA CA002145000A patent/CA2145000C/en not_active Expired - Fee Related
1996
- 1996-02-29 US US08/607,976 patent/US5741910A/en not_active Expired - Lifetime
- 1996-02-29 US US08/608,718 patent/US5942523A/en not_active Expired - Lifetime
1997
- 1997-11-04 NO NO975089A patent/NO303823B1/no not_active IP Right Cessation
1999
- 1999-05-07 US US09/306,825 patent/US6124316A/en not_active Expired - Fee Related
2002
- 2002-05-15 CY CY0200032A patent/CY2278B1/xx unknown

Also Published As

Publication number	Publication date
RU95103737A (ru)	1997-04-27
HUT72065A (en)	1996-03-28
PT673928E (pt)	2002-02-28
FI951265A0 (fi)	1995-03-17
CN1128756A (zh)	1996-08-14
DK0673928T3 (da)	2001-11-12
IL113026A0 (en)	1995-06-29
KR100238343B1 (ko)	2000-03-02
PL307723A1 (en)	1995-10-02
FR2719311B1 (fr)	1998-06-26
HU9500806D0 (en)	1995-05-29
EP0673928B1 (fr)	2001-08-29
KR950032120A (ko)	1995-12-20
DE69522355T2 (de)	2002-05-23
CA2145000C (en)	2002-05-07
CA2145000A1 (en)	1995-09-19
TW380138B (en)	2000-01-21
FI116621B (fi)	2006-01-13
NO951044D0 (no)	1995-03-17
IL113026A (en)	1999-06-20
US5741910A (en)	1998-04-21
JP2922816B2 (ja)	1999-07-26
FR2719311A1 (fr)	1995-11-03
NZ270727A (en)	1997-05-26
ATE204863T1 (de)	2001-09-15
JPH0848669A (ja)	1996-02-20
EP0673928A1 (fr)	1995-09-27
CY2278B1 (en)	2003-07-04
HK1005137A1 (en)	1998-12-24
CN1056605C (zh)	2000-09-20
ES2164746T3 (es)	2002-03-01
FI951265A7 (fi)	1995-09-19
AU693845B2 (en)	1998-07-09
US5942523A (en)	1999-08-24
NO303823B1 (no)	1998-09-07
NO302944B1 (no)	1998-05-11
AU1490995A (en)	1995-09-28
US6124316A (en)	2000-09-26
NO975089D0 (no)	1997-11-04
DE69522355D1 (de)	2001-10-04
PL185075B1 (pl)	2003-02-28
RU2143425C1 (ru)	1999-12-27
NO951044L (no)	1995-09-19

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Date	Code	Title	Description
2010-11-01	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO975089D0 (no)	1997-11-04	Piperidinderivater
AU636012B2 (en)	1993-04-08	N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran )carboxamide derivatives
EA200000110A1 (ru)	2000-08-28	Бициклические бензамиды производных 3- или 4-замещенного 4-(аминометил) пиперидина с гастрокинетическими свойствами
IL91460A0 (en)	1990-04-29	Cycloalkyl-substituted glutaramide antihypertensive agents
NO962811L (no)	1996-09-04	Nye heterosykliske forbindelser
ATE159249T1 (de)	1997-11-15	2-piperazinonverbindungen, deren herstellung und verwendung
RO117913B1 (ro)	2002-09-30	Derivaţi de n-[(amino-(imino)metil)fenil]propil amide substituite, compoziţie farmaceutică care îi conţine şi metodă de tratament
AR050261A2 (es)	2006-10-11	Aminoacidos con afinidad por la proteina alfa-2-delta y composiciones farmaceuticas que los contienen y su uso para preparar un medicamento
FR2677019B1 (fr)	1994-11-25	Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.
IT1261213B (it)	1996-05-09	Procedimento per la preparazione di sali dell'acido clavulanico.
FR2340947A1 (fr)	1977-09-09	Nouveaux derives de la tetrahydro-equinocandine b, leur preparation et leur application comme medicaments
CA2174034A1 (fr)	1996-10-15	Nouveaux amides tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
NZ318627A (en)	1999-11-29	Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
GR3026428T3 (en)	1998-06-30	Optical isomers of 7- 3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
ES8602012A1 (es)	1985-11-16	Un procedimiento para la preparacion de nuevos derivados de 2-azaciclos alquiltiopenen.
FI810103L (fi)	1981-07-17	Nya 2,3-dihydro-imidazo /1,2-b/ pyridazinderivat foerfarande foer deras framstaellning och deras terapeutiska anvaendning
NZ271766A (en)	1999-01-28	4-[2-(2-amino-4-oxo-4,5,7,8-tetrahydro-3h-pyrimido[5,4-6]-[1,4]heter ocycl-6-yl)-hydrocarbyl]-2,5-heterocycloylamino-l-glutamic acid)diethyl ester derivatives; intermediates
FR2760235B1 (fr)	1999-04-09	Nouveaux derives de benzenesulfonylamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2253518A1 (en)	1975-07-04	4-Hydrazino pyrazolo (3,4-b)pyridine-6-carboxylates and derivs - CNS depressants and cyclic AMP increasing agents
HUP9701383A2 (hu)	1999-06-28	Új 8-metil-7H-1,3-dioxolo[4,5h][2,3]-benzodiazepin-származékok, ilyen hatóanyagot tartalmazó gyógyászati készítmény, és eljárás a hatóanyag előállítására
HUP9701382A2 (hu)	1999-06-28	Új 7,8-dihidro-8-metil-9H-1,3-dioxolo-[4,5-h][2,3]-benzodiazepin-származékok, ilyen hatóanyagot tartalmazó gyógyászati készítmény, és eljárás a hatóanyag előállítására
FR2191897A1 (en)	1974-02-08	Pyrido (2,3-d) pyrimidine-(2,4) (1H, 3-H)-diones - antiinflammatories, analgesics and CNS depressants
ES8307813A1 (es)	1983-08-16	"procedimiento de preparar nuevos compuestos beta-lactamicos y similares".