IT1261213B - Procedimento per la preparazione di sali dell'acido clavulanico. - Google Patents

Procedimento per la preparazione di sali dell'acido clavulanico.

Info

Publication number
IT1261213B
IT1261213B ITRM930147A ITRM930147A IT1261213B IT 1261213 B IT1261213 B IT 1261213B IT RM930147 A ITRM930147 A IT RM930147A IT RM930147 A ITRM930147 A IT RM930147A IT 1261213 B IT1261213 B IT 1261213B
Authority
IT
Italy
Prior art keywords
clavulanic acid
preparation
salts
procedure
clavulanic
Prior art date
Application number
ITRM930147A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITRM930147A0 publication Critical patent/ITRM930147A0/it
Publication of ITRM930147A1 publication Critical patent/ITRM930147A1/it
Application granted granted Critical
Publication of IT1261213B publication Critical patent/IT1261213B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

L'invenzione riguarda l'impiego del sale di 2-ammino-2,4,4-trimetilpentano dell'acido clavulanico come prodotto intermedio nella preparazione di sali farmaceuticamente accettabili dell'acido clavulanico.
ITRM930147A 1992-03-10 1993-03-10 Procedimento per la preparazione di sali dell'acido clavulanico. IT1261213B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0047292A AT400033B (de) 1992-03-10 1992-03-10 Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben

Publications (3)

Publication Number Publication Date
ITRM930147A0 ITRM930147A0 (it) 1993-03-10
ITRM930147A1 ITRM930147A1 (it) 1994-09-10
IT1261213B true IT1261213B (it) 1996-05-09

Family

ID=3491521

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM930147A IT1261213B (it) 1992-03-10 1993-03-10 Procedimento per la preparazione di sali dell'acido clavulanico.

Country Status (21)

Country Link
US (4) US20010036940A1 (it)
JP (2) JP2817563B2 (it)
CN (3) CN1045604C (it)
AT (1) AT400033B (it)
AU (1) AU659282B2 (it)
CH (1) CH685054A5 (it)
CY (1) CY1995A (it)
DE (1) DE4307422B4 (it)
DK (1) DK26093A (it)
ES (1) ES2058029B1 (it)
FI (1) FI101965B (it)
FR (1) FR2688506B1 (it)
GB (1) GB2264944B (it)
GR (1) GR1002329B (it)
HK (1) HK42696A (it)
IE (1) IE70926B1 (it)
IT (1) IT1261213B (it)
NL (1) NL9300430A (it)
NO (1) NO301372B1 (it)
SE (1) SE508043C2 (it)
TW (1) TW364907B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
DE69427312T2 (de) 1993-11-17 2001-08-23 Biochemie Ges.M.B.H., Kundl Trennung von Cephalosporinisomeren
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
DE69618045D1 (de) * 1995-02-25 2002-01-31 Spurcourt Ltd Clavulansäure Salz
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
CN1312814A (zh) * 1998-07-16 2001-09-12 Dsm公司 制备棒酸盐类及其酯类的改进方法
MXPA01009808A (es) * 1999-04-01 2002-04-24 Dsm Nv Aglomerados por cristalizacion.
IL152643A0 (en) * 2000-05-13 2003-06-24 Smithkline Beecham Plc Process for the purification of a salt of clavulanic acid
KR101772375B1 (ko) * 2005-09-07 2017-08-29 신라젠(주) Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법
JP7028064B2 (ja) 2018-05-30 2022-03-02 横河電機株式会社 機器保全装置、機器保全方法、機器保全プログラム及び記録媒体
JP2023533544A (ja) 2020-07-10 2023-08-03 カーボン クリーン ソリューションズ リミテッド 低位熱を使用して溶媒から二酸化炭素を除去するための方法およびシステム

Family Cites Families (34)

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Publication number Priority date Publication date Assignee Title
US3288800A (en) 1962-05-29 1966-11-29 Squibb & Sons Inc Schiff's bases of 6-amino-penicillanic acid and purification of 6-aminopenicillanic acid by the use thereof
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
NZ177159A (en) 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1543563A (en) 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1561395A (en) 1976-02-26 1980-02-20 Beecham Group Ltd -lactam antibiotic
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB2003863B (en) 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
EP0002312B1 (en) 1977-11-26 1982-02-03 Beecham Group Plc Derivatives of clavulanic acid and pharmaceutical compositions containing them
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
MX7417E (es) 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
GB8618888D0 (en) 1986-08-01 1986-09-10 Davy Mckee Ltd Process
US5679789A (en) 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
ES2008418A6 (es) 1987-01-29 1989-07-16 Beecham Group Plc Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo.
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT399155B (de) 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
DE69618045D1 (de) 1995-02-25 2002-01-31 Spurcourt Ltd Clavulansäure Salz
GB2298201B (en) 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ZA975198B (en) 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
PL333247A1 (en) 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid

Also Published As

Publication number Publication date
USH2158H1 (en) 2006-06-06
GB9304704D0 (en) 1993-04-28
US20010036940A1 (en) 2001-11-01
JPH0641143A (ja) 1994-02-15
IE70926B1 (en) 1997-01-15
DK26093D0 (da) 1993-03-09
ITRM930147A1 (it) 1994-09-10
CN1079743A (zh) 1993-12-22
NL9300430A (nl) 1993-10-01
ES2058029A1 (es) 1994-10-16
DE4307422A1 (de) 1993-09-30
SE9300758D0 (sv) 1993-03-08
DK26093A (da) 1993-09-11
DE4307422B4 (de) 2004-11-25
HK42696A (en) 1996-03-22
ES2058029B1 (es) 1995-05-01
AU659282B2 (en) 1995-05-11
CN1145906A (zh) 1997-03-26
GR1002329B (el) 1996-05-15
JPH1067785A (ja) 1998-03-10
US20030203886A1 (en) 2003-10-30
CN1150153A (zh) 1997-05-21
GR930100090A (el) 1993-11-30
US20030022882A1 (en) 2003-01-30
CN1045604C (zh) 1999-10-13
FI931032A0 (fi) 1993-03-09
NO301372B1 (no) 1997-10-20
FR2688506B1 (fr) 1995-06-23
SE508043C2 (sv) 1998-08-17
CH685054A5 (de) 1995-03-15
AT400033B (de) 1995-09-25
GB2264944B (en) 1995-09-06
IE930172A1 (en) 1993-09-22
ITRM930147A0 (it) 1993-03-10
NO930829D0 (no) 1993-03-08
FI931032L (fi) 1993-09-11
ATA47292A (de) 1995-01-15
NO930829L (no) 1993-09-13
CY1995A (en) 1997-09-05
AU3407093A (en) 1993-09-16
FI101965B1 (fi) 1998-09-30
GB2264944A (en) 1993-09-15
FR2688506A1 (fr) 1993-09-17
TW364907B (en) 1999-07-21
JP2817563B2 (ja) 1998-10-30
US20020072513A1 (en) 2002-06-13
SE9300758L (sv) 1993-09-11
FI101965B (fi) 1998-09-30

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