NO975295L - 6-Karbamido-dihydropyran-derivater - Google Patents
6-Karbamido-dihydropyran-derivaterInfo
- Publication number
- NO975295L NO975295L NO975295A NO975295A NO975295L NO 975295 L NO975295 L NO 975295L NO 975295 A NO975295 A NO 975295A NO 975295 A NO975295 A NO 975295A NO 975295 L NO975295 L NO 975295L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- substituted aryl
- aryl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003107 substituted aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
- 150000008575 L-amino acids Chemical class 0.000 abstract 1
- 101150020251 NR13 gene Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- -1 amino, hydroxy Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000002911 sialidase inhibitor Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Forbindelser med formel (I): hvor R1 representerer OR5, SR5, NR5R6, N(OR5)R6 eller N(NR5R6)R6; X representerer OH, N3, NR3R4 eller NR*CO;R1S; Y representerer H eller NHRJ; R2 representerer en gruppe S02R7'eller COR7; R3 representerer H, C^alkyl eller C(=NR8)NR9R10; R4 representerer H eller C^alkyl; R5 representerer H, C^oalkyl, C^cykloalkyl, C2.2oalkenyl, Cj.walkynyl, CHR11COR12 eller C,.20alkyl substituert med en eller flere grupper valgt fra NR13R1<. NR13COR14, C02R13, OR13, CMcykloalkyl og eventuelt substituert aryl; hver R6 uavhengig representerer H. C^alkyl, C^cykloalkyl, C^alkenyl, Cj.» alkynyl, aryl eller C^alkyl substituert med en eller nere grupper valgt fra NR13R14, COR'3, Cwcykloalkyl, CN, N3. OR13 og eventuelt substituert aryl; eller R5 og R6 sammen danner en C2^ hydrokarbon-kjede som eventuelt kan inneholde en gruppe NR13, hvilken kjede er eventuelt substituert med 1, 2, 3 eller 4 grupper valgt fra okso og C^alkyl grupper, hvilke grupper eventuelt kan være substituert med hydroksy eller eventuelt substituert aryl; R7 representerer C^alkyl eventuelt substituert med ett eller flere halogen- atomer, CMcykloalkyl eller eventuelt substituert aryl; R8, R9 og R10 hver uavhengig representerer H, C^alkyl, amino, hydroksy, cyano eller nitro; R11 representerer sidekjede i en D- elter L- aminosyre; R12 representerer NR13R14, OR13 eller R13; hver R13 og hver R14 uavhengig representerer H, C^alkyl eller eventuelt substituert arylC1ualkyl; R15 representerer Ci^alkyl; og deres farmasøytisk godtagbare derivater er neuraminidase-inhibitorer nyttige for behandling av virale infeksjoner.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9510141.6A GB9510141D0 (en) | 1995-05-19 | 1995-05-19 | Chemical compounds |
| GBGB9525389.4A GB9525389D0 (en) | 1995-12-12 | 1995-12-12 | Chemical compounds |
| PCT/AU1996/000289 WO1996036628A1 (en) | 1995-05-19 | 1996-05-13 | 6-carboxamido dihydropyran derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO975295L true NO975295L (no) | 1997-11-18 |
| NO975295D0 NO975295D0 (no) | 1997-11-18 |
Family
ID=26307051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO975295A NO975295D0 (no) | 1995-05-19 | 1997-11-18 | 6-Karbamido-dihydropyran-derivater |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5990156A (no) |
| EP (1) | EP0833825B1 (no) |
| JP (1) | JP4162712B2 (no) |
| KR (1) | KR19990014910A (no) |
| CN (1) | CN1184473A (no) |
| AT (1) | ATE206116T1 (no) |
| AU (1) | AU709127B2 (no) |
| CA (1) | CA2220754A1 (no) |
| CZ (1) | CZ366697A3 (no) |
| DE (1) | DE69615555T2 (no) |
| ES (1) | ES2164881T3 (no) |
| HU (1) | HUP9801766A3 (no) |
| NO (1) | NO975295D0 (no) |
| PL (1) | PL323471A1 (no) |
| WO (1) | WO1996036628A1 (no) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866601A (en) * | 1995-02-27 | 1999-02-02 | Gilead Sciences, Inc. | Carbocyclic compounds |
| CN100409844C (zh) | 1995-02-27 | 2008-08-13 | 吉里德科学公司 | 神经氨酸苷酶抑制剂 |
| US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
| US5859284A (en) * | 1996-08-23 | 1999-01-12 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
| US6518438B2 (en) | 1996-08-23 | 2003-02-11 | Gilead Sciences, Inc. | Preparation of cyclohexene carboxylate derivatives |
| US5994377A (en) * | 1996-10-21 | 1999-11-30 | Gilead Sciences, Inc. | Piperidine compounds |
| US5886213A (en) * | 1997-08-22 | 1999-03-23 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
| US20040053999A1 (en) * | 1997-09-17 | 2004-03-18 | Bischofberger Norbert W. | Novel compounds and methods for synthesis and therapy |
| TW477783B (en) * | 1997-12-12 | 2002-03-01 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
| PT1040094E (pt) * | 1997-12-17 | 2009-06-03 | Biocryst Pharm Inc | Compostos de ciclopentano e de ciclopenteno substituídos úteis como inibidores da neuraminidase |
| US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
| US6455571B1 (en) | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
| US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
| US7045535B2 (en) * | 2001-03-08 | 2006-05-16 | Biocryst Pharmaceuticals, Inc. | Compounds useful for inhibiting paramyxovirus neuraminidase |
| WO2002092555A1 (en) * | 2001-05-11 | 2002-11-21 | Sankyo Company, Limited | Sialic acid derivatives |
| EP2427446B1 (en) * | 2009-05-04 | 2016-03-30 | National Research Council of Canada | Inhibitors of sialidase or sialidase-like enzymes |
| CN115991702B (zh) * | 2021-12-09 | 2024-02-02 | 珠海市藤栢医药有限公司 | 芳基c-葡萄糖苷衍生物、其制备方法及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK282950B6 (sk) * | 1990-04-24 | 2003-01-09 | Biota Scientific Management Pty Ltd | Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze |
| DE4131311A1 (de) * | 1991-09-20 | 1993-04-01 | Basf Ag | Dihydropyranderivate und diese enthaltende pflanzenschutzmittel |
| AU659501B2 (en) * | 1991-10-23 | 1995-05-18 | Biota Scientific Management Pty Ltd | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid |
| FR2687674B1 (fr) * | 1992-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
-
1996
- 1996-05-13 AT AT96911872T patent/ATE206116T1/de not_active IP Right Cessation
- 1996-05-13 CN CN96194026A patent/CN1184473A/zh active Pending
- 1996-05-13 EP EP96911872A patent/EP0833825B1/en not_active Expired - Lifetime
- 1996-05-13 HU HU9801766A patent/HUP9801766A3/hu unknown
- 1996-05-13 WO PCT/AU1996/000289 patent/WO1996036628A1/en not_active Ceased
- 1996-05-13 PL PL96323471A patent/PL323471A1/xx unknown
- 1996-05-13 US US08/945,676 patent/US5990156A/en not_active Expired - Lifetime
- 1996-05-13 AU AU54932/96A patent/AU709127B2/en not_active Ceased
- 1996-05-13 CA CA002220754A patent/CA2220754A1/en not_active Abandoned
- 1996-05-13 ES ES96911872T patent/ES2164881T3/es not_active Expired - Lifetime
- 1996-05-13 JP JP53439196A patent/JP4162712B2/ja not_active Expired - Fee Related
- 1996-05-13 KR KR1019970708256A patent/KR19990014910A/ko not_active Withdrawn
- 1996-05-13 CZ CZ973666A patent/CZ366697A3/cs unknown
- 1996-05-13 DE DE69615555T patent/DE69615555T2/de not_active Expired - Fee Related
-
1997
- 1997-11-18 NO NO975295A patent/NO975295D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2220754A1 (en) | 1996-11-21 |
| CN1184473A (zh) | 1998-06-10 |
| JP4162712B2 (ja) | 2008-10-08 |
| AU709127B2 (en) | 1999-08-19 |
| JPH11505227A (ja) | 1999-05-18 |
| HUP9801766A2 (hu) | 2000-06-28 |
| EP0833825A4 (en) | 1998-10-07 |
| DE69615555T2 (de) | 2002-05-29 |
| NO975295D0 (no) | 1997-11-18 |
| DE69615555D1 (de) | 2001-10-31 |
| EP0833825B1 (en) | 2001-09-26 |
| ES2164881T3 (es) | 2002-03-01 |
| AU5493296A (en) | 1996-11-29 |
| EP0833825A1 (en) | 1998-04-08 |
| PL323471A1 (en) | 1998-03-30 |
| CZ366697A3 (cs) | 1998-04-15 |
| KR19990014910A (ko) | 1999-02-25 |
| US5990156A (en) | 1999-11-23 |
| HUP9801766A3 (en) | 2000-09-28 |
| ATE206116T1 (de) | 2001-10-15 |
| WO1996036628A1 (en) | 1996-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |