NO975585L - C-4' modifiserte adenosin-kinase inhibitorer - Google Patents

C-4' modifiserte adenosin-kinase inhibitorer

Info

Publication number
NO975585L
NO975585L NO975585A NO975585A NO975585L NO 975585 L NO975585 L NO 975585L NO 975585 A NO975585 A NO 975585A NO 975585 A NO975585 A NO 975585A NO 975585 L NO975585 L NO 975585L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
adenosine kinase
modified adenosine
adenosine
substituents
Prior art date
Application number
NO975585A
Other languages
English (en)
Other versions
NO975585D0 (no
Inventor
Serge H Boyer
Mark D Erion
Bheemarao G Ugarkar
Original Assignee
Gensia Sicor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gensia Sicor filed Critical Gensia Sicor
Publication of NO975585D0 publication Critical patent/NO975585D0/no
Publication of NO975585L publication Critical patent/NO975585L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det er beskrevet adenosinkinase inhibitorer og nukleosidanaloger, C-4' modifiserte pyrroio [2,3-d]pyrimidin og pyrasolo [3,4-d]pyrimidin nukleosid analoger som har aktivitet som adenosinkinanse inhibitorer. Det er beskrevet nukleosidanaloger av denne typen som har O substituenter eller 2 substituenter ved C-4'-stillingen av furanose (sukker)-enheten. Det er videre beskrevet fremstilling og anvendelse av disse adenosinkinase inhibitorene ved behandlingen av kardiovaskulære og cerebrovaskulære sykdommer, inflammasjon og andre sykdommer som kan reguleres ved økning av den lokale konsentrasjonen av adenosin.
NO975585A 1995-06-07 1997-12-03 C-4' modifiserte adenosin-kinase inhibitorer NO975585L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/486,161 US5674998A (en) 1989-09-15 1995-06-07 C-4' modified adenosine kinase inhibitors
PCT/US1996/010404 WO1996040705A1 (en) 1995-06-07 1996-06-07 C-4' modified adenosine kinase inhibitors

Publications (2)

Publication Number Publication Date
NO975585D0 NO975585D0 (no) 1997-12-03
NO975585L true NO975585L (no) 1998-02-05

Family

ID=23930844

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975585A NO975585L (no) 1995-06-07 1997-12-03 C-4' modifiserte adenosin-kinase inhibitorer

Country Status (24)

Country Link
US (1) US5674998A (no)
EP (1) EP0832091B1 (no)
JP (1) JPH11507387A (no)
KR (1) KR19990022740A (no)
CN (1) CN1190401A (no)
AP (1) AP9701165A0 (no)
AT (1) ATE257841T1 (no)
AU (1) AU6178396A (no)
BG (1) BG102163A (no)
BR (1) BR9609013A (no)
CA (1) CA2220642A1 (no)
CZ (1) CZ392797A3 (no)
DE (1) DE69631330T2 (no)
EA (1) EA199800009A1 (no)
HU (1) HUP9802193A3 (no)
IL (1) IL122335A0 (no)
IS (1) IS4621A (no)
MX (1) MX9709859A (no)
NO (1) NO975585L (no)
OA (1) OA10639A (no)
PL (1) PL323904A1 (no)
SK (1) SK166097A3 (no)
TR (1) TR199701539T1 (no)
WO (1) WO1996040705A1 (no)

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Also Published As

Publication number Publication date
EP0832091A1 (en) 1998-04-01
CZ392797A3 (cs) 1999-04-14
HUP9802193A3 (en) 1999-10-28
MX9709859A (es) 1998-08-30
AP9701165A0 (en) 1998-01-31
DE69631330D1 (de) 2004-02-19
CN1190401A (zh) 1998-08-12
EA199800009A1 (ru) 1998-06-25
NO975585D0 (no) 1997-12-03
HUP9802193A2 (hu) 1999-05-28
US5674998A (en) 1997-10-07
WO1996040705A1 (en) 1996-12-19
TR199701539T1 (xx) 1998-04-21
IS4621A (is) 1997-11-26
AU6178396A (en) 1996-12-30
PL323904A1 (en) 1998-04-27
CA2220642A1 (en) 1996-12-19
BG102163A (en) 1998-10-30
BR9609013A (pt) 1999-12-14
DE69631330T2 (de) 2004-10-28
ATE257841T1 (de) 2004-01-15
EP0832091B1 (en) 2004-01-14
JPH11507387A (ja) 1999-06-29
OA10639A (en) 2002-09-17
SK166097A3 (en) 1999-06-11
KR19990022740A (ko) 1999-03-25
IL122335A0 (en) 1998-04-05

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