NO975679L - Fremgangsmåte for fremstilling av N-monosubstituerte og N,N'-disubstituerte, usymmetriske, cykliske ureaer - Google Patents

Fremgangsmåte for fremstilling av N-monosubstituerte og N,N'-disubstituerte, usymmetriske, cykliske ureaer

Info

Publication number
NO975679L
NO975679L NO975679A NO975679A NO975679L NO 975679 L NO975679 L NO 975679L NO 975679 A NO975679 A NO 975679A NO 975679 A NO975679 A NO 975679A NO 975679 L NO975679 L NO 975679L
Authority
NO
Norway
Prior art keywords
preparation
monosubstituted
cyclic urea
disubstituted
unsymmetrical cyclic
Prior art date
Application number
NO975679A
Other languages
English (en)
Other versions
NO975679D0 (no
Inventor
James David Rodgers
Jung-Hui Sun
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of NO975679D0 publication Critical patent/NO975679D0/no
Publication of NO975679L publication Critical patent/NO975679L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Foreliggende oppfinnelse angår generelt fremgangsmåte for fremstilling av usymmetrisk substituerte, sykliske ureaer av formel (Via) og (VIb), som er anvendbare som HIV-proteaseinhibitorer. De tilveiebrakte fremgangsmåter går gjennom et isoureamellomprodukt.
NO975679A 1995-06-07 1997-12-05 Fremgangsmåte for fremstilling av N-monosubstituerte og N,N'-disubstituerte, usymmetriske, cykliske ureaer NO975679L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/481,683 US5532357A (en) 1995-06-07 1995-06-07 Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas
PCT/US1996/009021 WO1996040652A1 (en) 1995-06-07 1996-06-06 Method for preparing n-monosubstituted and n,n'-disubstituted unsymmetrical cyclic ureas

Publications (2)

Publication Number Publication Date
NO975679D0 NO975679D0 (no) 1997-12-05
NO975679L true NO975679L (no) 1998-02-02

Family

ID=23912954

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975679A NO975679L (no) 1995-06-07 1997-12-05 Fremgangsmåte for fremstilling av N-monosubstituerte og N,N'-disubstituerte, usymmetriske, cykliske ureaer

Country Status (26)

Country Link
US (1) US5532357A (no)
EP (2) EP0837855A4 (no)
JP (1) JPH11506779A (no)
KR (1) KR19990022467A (no)
CN (1) CN1192209A (no)
AR (1) AR002384A1 (no)
AU (1) AU704535B2 (no)
BR (1) BR9609493A (no)
CA (1) CA2223391A1 (no)
CZ (1) CZ381997A3 (no)
EA (1) EA000363B1 (no)
EE (1) EE9700330A (no)
HR (1) HRP960259A2 (no)
HU (1) HUP9900913A2 (no)
IL (1) IL122424A0 (no)
LT (1) LT4381B (no)
LV (1) LV12045B (no)
MX (1) MX9709652A (no)
NO (1) NO975679L (no)
NZ (1) NZ309648A (no)
PL (1) PL323993A1 (no)
SI (1) SI9620077A (no)
SK (1) SK164397A3 (no)
TW (1) TW358091B (no)
WO (1) WO1996040652A1 (no)
ZA (1) ZA964847B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US6054597A (en) * 1995-11-14 2000-04-25 Dupont Pharmaceuticals Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
US6218386B1 (en) 1996-11-08 2001-04-17 Dupont Pharmaceuticals A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
EE9900188A (et) * 1996-11-08 1999-12-15 Dupont Pharmaceuticals Company HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread
JP2001518094A (ja) * 1997-03-31 2001-10-09 デュポン ファーマシューティカルズ カンパニー Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素
US6218534B1 (en) 1997-10-06 2001-04-17 Dupont Pharmaceuticals Company Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate
AU4698399A (en) * 1998-06-30 2000-01-17 Du Pont Pharmaceuticals Company 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones useful as hiv reverse transcriptase inhibitors
WO2000073284A2 (en) 1999-05-26 2000-12-07 Du Pont Pharmaceuticals Company 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
US6313110B1 (en) * 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
FR2810039B1 (fr) * 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation
WO2002078628A2 (en) * 2001-03-28 2002-10-10 Bristol-Myers Squibb Company Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazapines as hiv reverse transcriptase inhibitors
US7777030B2 (en) 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100268694B1 (ko) * 1991-10-11 2000-10-16 미리암 디. 메코너헤이, 블레어큐. 퍼거슨 레트로바이러스 프로테아제 억제제로 유용한 시클릭 우레아 및 유사체
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US5430043A (en) * 1993-08-24 1995-07-04 G. D. Searle & Co. Platelet aggregation inhibitors
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
US5532356A (en) * 1995-06-06 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N,N'-disubstituted cyclic ureas
US7344671B2 (en) 2003-11-26 2008-03-18 Glopak Inc. Optical sealing clamp and a method for sealing and cutting polymeric sheets with a laser
US7369013B2 (en) 2005-04-06 2008-05-06 Avago Technologies Wireless Ip Pte Ltd Acoustic resonator performance enhancement using filled recessed region

Also Published As

Publication number Publication date
TW358091B (en) 1999-05-11
EA000363B1 (ru) 1999-06-24
US5532357A (en) 1996-07-02
IL122424A0 (en) 1998-06-15
HUP9900913A2 (hu) 1999-09-28
JPH11506779A (ja) 1999-06-15
LT97188A (en) 1998-04-27
MX9709652A (es) 1998-03-29
SK164397A3 (en) 2000-04-10
AU704535B2 (en) 1999-04-29
SI9620077A (sl) 1998-08-31
NZ309648A (en) 1998-09-24
CN1192209A (zh) 1998-09-02
HRP960259A2 (en) 1997-10-31
NO975679D0 (no) 1997-12-05
EP0837855A4 (en) 1998-09-02
EP0837855A1 (en) 1998-04-29
BR9609493A (pt) 1999-03-02
CA2223391A1 (en) 1996-12-19
WO1996040652A1 (en) 1996-12-19
LV12045A (lv) 1998-05-20
CZ381997A3 (cs) 1999-01-13
LV12045B (en) 1998-09-20
AU5986896A (en) 1996-12-30
ZA964847B (en) 1997-12-08
LT4381B (lt) 1998-09-25
KR19990022467A (ko) 1999-03-25
PL323993A1 (en) 1998-04-27
EE9700330A (et) 1998-06-15
EA199800034A1 (ru) 1998-08-27
AR002384A1 (es) 1998-03-11
EP1029859A1 (en) 2000-08-23

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application