NO975738D0 - Modulering av kalsiumkanaler - Google Patents

Modulering av kalsiumkanaler

Info

Publication number: NO975738D0
Authority: NO; Norway
Prior art keywords: calcium channels; modulation; pharmaceutically; alkyl; phenyl
Prior art date: 1995-06-07

Application number

NO975738A

Other languages

English (en)

Norwegian (no)

Other versions

NO975738L (no

Inventor

Nancy L Bowling

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1997-12-05

Publication date

1997-12-05

1997-12-05 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1997-12-05 Publication of NO975738L publication Critical patent/NO975738L/no

1997-12-05 Publication of NO975738D0 publication Critical patent/NO975738D0/no

Links

108090000312 Calcium Channels Proteins 0.000 title abstract 3
102000003922 Calcium Channels Human genes 0.000 title abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
210000005003 heart tissue Anatomy 0.000 abstract 1
-1 hexamethylenemino Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
230000000297 inotrophic effect Effects 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
230000036584 pressor response Effects 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/56—Preparation of melamine
- C07D251/58—Preparation of melamine from cyanamide, dicyanamide or calcium cyanamide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Liquid Crystal Substances (AREA)
Hydrogenated Pyridines (AREA)
Soft Magnetic Materials (AREA)

NO975738A 1995-06-07 1997-12-05 Modulering av kalsiumkanaler NO975738D0 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/485,317 US5532254A (en)	1995-06-07	1995-06-07	Modulation of calcium channels using benzothiophenes
PCT/US1996/009161 WO1996039833A1 (en)	1995-06-07	1996-06-04	Modulation of calcium channels

Publications (2)

Publication Number	Publication Date
NO975738L NO975738L (no)	1997-12-05
NO975738D0 true NO975738D0 (no)	1997-12-05

Family

ID=23927688

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO975738A NO975738D0 (no)	1995-06-07	1997-12-05	Modulering av kalsiumkanaler

Country Status (19)

Country	Link
US (1)	US5532254A (cs)
EP (1)	EP0873051B1 (cs)
JP (1)	JPH11506787A (cs)
KR (1)	KR19990022365A (cs)
CN (1)	CN1094758C (cs)
AT (1)	ATE272315T1 (cs)
AU (1)	AU692400B2 (cs)
CA (1)	CA2222739A1 (cs)
CZ (1)	CZ288547B6 (cs)
DE (1)	DE69633070D1 (cs)
EA (1)	EA000873B1 (cs)
HU (1)	HUP9900860A3 (cs)
IL (1)	IL122282A (cs)
NO (1)	NO975738D0 (cs)
NZ (1)	NZ310177A (cs)
PL (1)	PL323930A1 (cs)
RO (1)	RO117892B1 (cs)
UA (1)	UA42837C2 (cs)
WO (1)	WO1996039833A1 (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5840747A (en) *	1995-06-07	1998-11-24	Eli Lilly And Company	Calcium channel antagonists
US5846983A (en) †	1996-02-09	1998-12-08	Mayo Foundation For Medical Education And Research	Colonic delivery of nicotine to treat inflammatory bowel disease
US6458811B1 (en)	1996-03-26	2002-10-01	Eli Lilly And Company	Benzothiophenes formulations containing same and methods
EA001257B1 (ru) *	1996-03-26	2000-12-25	Эли Лилли Энд Компани	Бензотиофены, содержащие их фармацевтические композиции и способы лечения патологических состояний с их использованием
EP0980366B1 (en)	1997-04-30	2004-06-09	Eli Lilly And Company	Antithrombotic agents
CA2288224A1 (en)	1997-04-30	1998-11-05	Mary George Johnson	Antithrombotic agents
EP0973517A4 (en)	1997-04-30	2002-07-24	Lilly Co Eli	ANTITHROMBOTIC AGENTS
EP0980367A4 (en) *	1997-04-30	2003-03-19	Lilly Co Eli	ANTITHROMBOTIC AGENTS
US5760030A (en) *	1997-06-30	1998-06-02	Eli Lilly And Company	Benzothiophene compounds and methods of use
US6284756B1 (en)	1998-04-30	2001-09-04	Eli Lilly And Company	Antithrombotic agents
PT997460E (pt) *	1998-10-28	2003-03-31	Lilly Co Eli	Compostos benzotiofenos como agentes antitromboticos e seus intermediarios
EP1533295A1 (en) *	2003-11-24	2005-05-25	Newron Pharmaceuticals S.p.A.	Cyclopentyl Derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) *	1981-04-03	1983-04-19	Eli Lilly And Company	Synthesis of acylated benzothiophenes
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
CN1058390C (zh) *	1993-10-15	2000-11-15	伊莱利利公司	苯并噻吩类化合物的用途
US6562862B1 (en) *	1994-10-20	2003-05-13	Eli Lilly And Company	Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y

1995
- 1995-06-07 US US08/485,317 patent/US5532254A/en not_active Expired - Fee Related
1996
- 1996-06-04 WO PCT/US1996/009161 patent/WO1996039833A1/en not_active Ceased
- 1996-06-04 AU AU60918/96A patent/AU692400B2/en not_active Ceased
- 1996-06-04 EA EA199800019A patent/EA000873B1/ru not_active IP Right Cessation
- 1996-06-04 EP EP96918209A patent/EP0873051B1/en not_active Expired - Lifetime
- 1996-06-04 CA CA002222739A patent/CA2222739A1/en not_active Abandoned
- 1996-06-04 JP JP9501550A patent/JPH11506787A/ja active Pending
- 1996-06-04 IL IL12228296A patent/IL122282A/en not_active IP Right Cessation
- 1996-06-04 UA UA97125828A patent/UA42837C2/uk unknown
- 1996-06-04 KR KR1019970708845A patent/KR19990022365A/ko not_active Abandoned
- 1996-06-04 DE DE69633070T patent/DE69633070D1/de not_active Expired - Lifetime
- 1996-06-04 NZ NZ310177A patent/NZ310177A/en unknown
- 1996-06-04 AT AT96918209T patent/ATE272315T1/de not_active IP Right Cessation
- 1996-06-04 CZ CZ19973880A patent/CZ288547B6/cs not_active IP Right Cessation
- 1996-06-04 RO RO97-02223A patent/RO117892B1/ro unknown
- 1996-06-04 CN CN96195873A patent/CN1094758C/zh not_active Expired - Fee Related
- 1996-06-04 HU HU9900860A patent/HUP9900860A3/hu unknown
- 1996-06-04 PL PL96323930A patent/PL323930A1/xx unknown
1997
- 1997-12-05 NO NO975738A patent/NO975738D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
RO117892B1 (ro)	2002-09-30
EP0873051B1 (en)	2004-08-04
CZ288547B6 (cs)	2001-07-11
IL122282A (en)	2001-08-08
CN1094758C (zh)	2002-11-27
AU6091896A (en)	1996-12-30
EA000873B1 (ru)	2000-06-26
EA199800019A1 (ru)	1998-06-25
HUP9900860A3 (en)	1999-11-29
NO975738L (no)	1997-12-05
KR19990022365A (ko)	1999-03-25
HUP9900860A2 (hu)	1999-09-28
NZ310177A (en)	2000-06-23
AU692400B2 (en)	1998-06-04
EP0873051A1 (en)	1998-10-28
CN1192121A (zh)	1998-09-02
US5532254A (en)	1996-07-02
PL323930A1 (en)	1998-04-27
CZ388097A3 (cs)	1998-06-17
JPH11506787A (ja)	1999-06-15
EP0873051A4 (en)	1999-01-07
ATE272315T1 (de)	2004-08-15
DE69633070D1 (de)	2004-09-09
IL122282A0 (en)	1998-04-05
WO1996039833A1 (en)	1996-12-19
CA2222739A1 (en)	1996-12-19
UA42837C2 (uk)	2001-11-15

Legal Events

Date	Code	Title	Description
2004-02-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO975738D0 (no)	1997-12-05	Modulering av kalsiumkanaler
DE69505651D1 (de)	1998-12-03	Hemmen von haarwuchs
YU32196A (sh)	1999-06-15	Upotreba jedinjenja za pripremanje leka korisnog za inhibiranje migracije vaskularnih ćelija glatkog mišića
MX9706069A (es)	1997-10-31	Nuevos inhibidores de la trombina.
DE69415316D1 (de)	1999-01-28	Sulfonamide und derivate zur modulierung der endothelin aktivitat
EP0982988A4 (en)	2000-04-05	IN KEY PURE ZONULIN AS A PHYSIOLOGICAL MODULATOR OF "TIGHT JUNCTIONS" IN MAMMALS
NO944919L (no)	1995-06-22	Fremgangsmåte for å inhibere atrofi av huden eller vagina
DE69412049D1 (de)	1998-09-03	Hemmung von dysfunctionalen Uterusblutungen
DK0528922T3 (da)	1999-11-22	Hidtil ukendte sulfonylforbindelser
IL116231A (en)	2001-01-28	Dipeptide p-amidinobenzylamides with n-terminal sulfonyl or aminosulfonyl radicals as thrombin inhibitors
SE9302431D0 (sv)	1993-07-16	Use of indenoindole compounds
DE69726716T2 (de)	2004-10-07	Antikachektische zusammensetzung
TW342389B (en)	1998-10-11	Arylalkyl-thiadiazinones
EA199700136A1 (ru)	1997-12-30	Способы ингибирования экзогенных эстрогенов
DK0458950T3 (da)	1993-12-27	Stabilisering af K2P pro
EA199800015A1 (ru)	1998-06-25	Способ ингибирования меланомы
MX9709542A (es)	1998-03-31	Modulacion de los canales de calcio.
PL324086A1 (en)	1998-05-11	Antagonists of calcium passages
EA199800366A1 (ru)	1998-10-29	Способы ингибирования ингибитора 1 активатора плазминогена
UA26459C2 (uk)	1999-08-30	Іhгібітор впливу амілоїдhих білків
ATE158796T1 (de)	1997-10-15	Pharmazeutisch wirksame enantiomere
ATE200623T1 (de)	2001-05-15	Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung der primären endometriumhyperplasie
MX9705697A (es)	1997-10-31	Metodos para reducir los niveles de calcio del suero.
AU4965593A (en)	1994-04-12	Ureido-acetamide derivatives, preparation thereof and drugs containing same