NO980145L - Polyucykliske alkaloid-derivater som NMDA-reseptor-antagonister - Google Patents
Polyucykliske alkaloid-derivater som NMDA-reseptor-antagonisterInfo
- Publication number
- NO980145L NO980145L NO980145A NO980145A NO980145L NO 980145 L NO980145 L NO 980145L NO 980145 A NO980145 A NO 980145A NO 980145 A NO980145 A NO 980145A NO 980145 L NO980145 L NO 980145L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- pct
- independently
- polyucyclic
- receptor antagonists
- Prior art date
Links
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 title 1
- 150000003797 alkaloid derivatives Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000001057 ionotropic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/16—Eight-membered rings
- C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/16—Eight-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Polycykliske alkaloider med formel (I) formel l hvor R, er H, C,^ alkyl eller C^2 aryl eventuelt substituert med polare grupper; R2 og R3 er uavhengig H, OH, C,^ alkyl, -C(NH)-NH2, en positivt ladet gruppe eller C7.13 aralkyl eventuelt substituert med NH2, OH, C,.6 alkyl eller halogen; eller R2 og R3 danner tilsammen en 5 til 6-leddet ring eventuelt inneholdende et heteroatom; R4er H, C,^ alkyl, OR6, SR6 eller N(R6)2, hvor hver F^ er uavhengig H, C,.3 alkyl; X er O, S, SO, SO2, N-R5 eller C-(R5)2, hvor hver R5 er uavhengig H, C,^ alkyl eller C7.13 aralkyl eventuelt avbrutt med ett eller flere heteroatomer; n er et helt tall fra O til 2; m er et helt tall fra O til 3; med det forbehold at når X er CH2, er R, ikke CH3, R2 og R3 er ikke begge H, R4 er ikke OH, m er ikke 3 og n er ikke 0. Disse virker som antagonister på den ionotrope NMDA (N-metyl-(D)- aspartinsyre) reseptor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514448.1A GB9514448D0 (en) | 1995-07-14 | 1995-07-14 | Novel heterocyclic NMDA-receptor antagonists |
| PCT/CA1996/000468 WO1997003979A1 (en) | 1995-07-14 | 1996-07-12 | Polycyclic alcaloid-derivatives as nmda-receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO980145L true NO980145L (no) | 1998-01-13 |
| NO980145D0 NO980145D0 (no) | 1998-01-13 |
Family
ID=10777682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO980145A NO980145D0 (no) | 1995-07-14 | 1998-01-13 | Polyucykliske alkaloid-derivater som NMDA-reseptor-antagonister |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5990104A (no) |
| EP (1) | EP0840731B1 (no) |
| JP (1) | JPH11509533A (no) |
| CN (1) | CN1195344A (no) |
| AT (1) | ATE206616T1 (no) |
| AU (1) | AU696502B2 (no) |
| CA (1) | CA2223644A1 (no) |
| DE (1) | DE69615845T2 (no) |
| ES (1) | ES2164901T3 (no) |
| GB (1) | GB9514448D0 (no) |
| NO (1) | NO980145D0 (no) |
| WO (1) | WO1997003979A1 (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001247762A1 (en) * | 2000-03-28 | 2001-10-08 | Delorenzo, Robert, J | Inhibition of a novel calcium injury current that forms in neurons during injury prevents neuronal cell death |
| AUPR215700A0 (en) * | 2000-12-19 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Carboxylic acid compound having cyclopropane ring |
| WO2006071274A2 (en) * | 2004-12-23 | 2006-07-06 | Voyager Pharmaceutical Corporation | Leuprolide acetate and acetylcholinesterase inhibitors or nmda receptor antagonists for the treatment of alzheimer’s disease |
| WO2020156522A1 (zh) * | 2019-02-02 | 2020-08-06 | 扬子江药业集团有限公司 | 地佐辛衍生物及其医药用途 |
| CN112137996B (zh) * | 2020-10-23 | 2023-08-25 | 湖南农业大学 | 一种预防钩吻中毒的药物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3836670A (en) * | 1971-11-19 | 1974-09-17 | American Home Prod | Benzobicycloalkane amines for inducing analgesia |
| US4957909A (en) * | 1989-05-04 | 1990-09-18 | American Home Products Corporation | Benzobicycloalkane derivatives as anticonvulsant neuroprotective agents |
-
1995
- 1995-07-14 GB GBGB9514448.1A patent/GB9514448D0/en active Pending
-
1996
- 1996-07-12 AT AT96922703T patent/ATE206616T1/de not_active IP Right Cessation
- 1996-07-12 WO PCT/CA1996/000468 patent/WO1997003979A1/en not_active Ceased
- 1996-07-12 DE DE69615845T patent/DE69615845T2/de not_active Expired - Fee Related
- 1996-07-12 US US08/981,935 patent/US5990104A/en not_active Expired - Fee Related
- 1996-07-12 CA CA002223644A patent/CA2223644A1/en not_active Abandoned
- 1996-07-12 ES ES96922703T patent/ES2164901T3/es not_active Expired - Lifetime
- 1996-07-12 EP EP96922703A patent/EP0840731B1/en not_active Expired - Lifetime
- 1996-07-12 CN CN96196727A patent/CN1195344A/zh active Pending
- 1996-07-12 JP JP9506032A patent/JPH11509533A/ja not_active Ceased
- 1996-07-12 AU AU63502/96A patent/AU696502B2/en not_active Ceased
-
1998
- 1998-01-13 NO NO980145A patent/NO980145D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU696502B2 (en) | 1998-09-10 |
| CN1195344A (zh) | 1998-10-07 |
| ES2164901T3 (es) | 2002-03-01 |
| AU6350296A (en) | 1997-02-18 |
| EP0840731B1 (en) | 2001-10-10 |
| US5990104A (en) | 1999-11-23 |
| DE69615845D1 (de) | 2001-11-15 |
| DE69615845T2 (de) | 2002-06-20 |
| JPH11509533A (ja) | 1999-08-24 |
| ATE206616T1 (de) | 2001-10-15 |
| WO1997003979A1 (en) | 1997-02-06 |
| CA2223644A1 (en) | 1997-02-06 |
| GB9514448D0 (en) | 1995-09-13 |
| NO980145D0 (no) | 1998-01-13 |
| EP0840731A1 (en) | 1998-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |