NO980955L - 2-Acylaminobenzamidderivater og et middel for forebyggelse og behandling av sykdommer forÕrsaket av eksessiv proliferasjon av vaskulµre intimalceller - Google Patents

2-Acylaminobenzamidderivater og et middel for forebyggelse og behandling av sykdommer forÕrsaket av eksessiv proliferasjon av vaskulµre intimalceller

Info

Publication number
NO980955L
NO980955L NO980955A NO980955A NO980955L NO 980955 L NO980955 L NO 980955L NO 980955 A NO980955 A NO 980955A NO 980955 A NO980955 A NO 980955A NO 980955 L NO980955 L NO 980955L
Authority
NO
Norway
Prior art keywords
diseases caused
preventing
excessive proliferation
treating diseases
group
Prior art date
Application number
NO980955A
Other languages
English (en)
Other versions
NO980955D0 (no
Inventor
Hiroshi Kusama
Hiromu Harada
Fumiyasu Satoh
Akira Iyobe
Yoshinori Nonaka
Hideki Fujikura
Koji Kamata
Yukihiko Hotei
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of NO980955D0 publication Critical patent/NO980955D0/no
Publication of NO980955L publication Critical patent/NO980955L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Foreliggende oppfinnelse vedrører 2-acylaminobenzamid- derivater representert ved den generelle formel: [hvor R1, R2, R3, R4 og R5 hver representerer et hydro- genatom etc.; X representerer en vinylengruppe etc.; B representerer en gruppe representert ved den generelle formel: -N(R6) (R7) (hvor R6 og R1 hver representerer et hydrogenatom etc.)/ en gruppe representert ved den generelle formel: -NH-(CH2)n-A-R8 (hvor A representerer en enkeltbinding etc.; Rfc representerer en hydroksygruppe etc.) eller en hydroksyaminogruppe] som er nyttige som midler for forebyggelse og behandling av sykdommer forårsaket av eksessiv proliferasjon av vaskulære intimaceller.
NO980955A 1995-09-07 1998-03-05 2-Acylaminobenzamidderivater og et middel for forebyggelse og behandling av sykdommer forÕrsaket av eksessiv proliferasjon av vaskulµre intimalceller NO980955L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP26762995 1995-09-07
JP35495295 1995-12-27
JP3703596 1996-01-18
PCT/JP1996/002415 WO1997009301A1 (en) 1995-09-07 1996-08-29 2-acylaminobenzamide derivatives and preventive and remedy for diseases caused by the supermultiplication of vascular intimal cells

Publications (2)

Publication Number Publication Date
NO980955D0 NO980955D0 (no) 1998-03-05
NO980955L true NO980955L (no) 1998-05-06

Family

ID=27289309

Family Applications (1)

Application Number Title Priority Date Filing Date
NO980955A NO980955L (no) 1995-09-07 1998-03-05 2-Acylaminobenzamidderivater og et middel for forebyggelse og behandling av sykdommer forÕrsaket av eksessiv proliferasjon av vaskulµre intimalceller

Country Status (6)

Country Link
EP (1) EP0855387A4 (no)
KR (1) KR19990044478A (no)
AU (1) AU6837096A (no)
CA (1) CA2231465A1 (no)
NO (1) NO980955L (no)
WO (1) WO1997009301A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127392A (en) * 1997-08-05 2000-10-03 American Home Products Corporation Anthranilic acid analogs
BR0007901A (pt) * 1999-02-03 2001-10-30 Smithkline Beecham Corp Método para a preservação ou redução deeventos cardiovasculares associados comintervenção coronária
TR200102245T2 (tr) * 1999-02-03 2002-05-21 Smithkline Beecham Corporation Koroner müdahale ile ilgili kardiovasküler olayların önlenmesi veya azaltılması için yöntem.
JP2002535989A (ja) 1999-02-04 2002-10-29 アナディーズ・ファーマスーティカルズ，インコーポレイテッド カンジダ・アルビカンスｓｒｂ‐７
AU7446600A (en) * 1999-10-01 2001-05-10 Japan Energy Corporation Novel diarylamide derivatives and use thereof as medicines
GB0103240D0 (en) * 2001-02-09 2001-03-28 Clariant Int Ltd Organic compounds
JP4781546B2 (ja) * 2001-03-13 2011-09-28 日産化学工業株式会社 アントラニル酸アミド化合物の製造方法並びにｐＨ官能性蛍光色素材料とその利用法
JP2006512306A (ja) * 2002-08-29 2006-04-13 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション アリール及びヘテロアリールプロペンアミド、それらの誘導体並びにそれらの治療用途
GB2499666A (en) * 2012-02-27 2013-08-28 Nanyang Polytechnic Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders
CN116730977B (zh) * 2022-03-04 2026-06-19 华东理工大学 新型芳基杂环类化合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136273A (ja) * 1984-07-26 1986-02-20 Mitsubishi Yuka Yakuhin Kk ２−フエニルアルキル−４（３ｈ）−キナゾリノン誘導体
JPS6426543A (en) * 1987-07-21 1989-01-27 Maruko Pharmaceutical Co Novel aminobenzoic acid amide derivative and production thereof

Also Published As

Publication number Publication date
KR19990044478A (ko) 1999-06-25
AU6837096A (en) 1997-03-27
EP0855387A4 (en) 1999-09-15
WO1997009301A1 (en) 1997-03-13
EP0855387A1 (en) 1998-07-29
NO980955D0 (no) 1998-03-05
CA2231465A1 (en) 1997-03-13

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