NO981468L - Polyfluoralkyltryptofantripeptid-trombininhibitorer - Google Patents

Polyfluoralkyltryptofantripeptid-trombininhibitorer

Info

Publication number
NO981468L
NO981468L NO981468A NO981468A NO981468L NO 981468 L NO981468 L NO 981468L NO 981468 A NO981468 A NO 981468A NO 981468 A NO981468 A NO 981468A NO 981468 L NO981468 L NO 981468L
Authority
NO
Norway
Prior art keywords
polyfluoralkyltryptofantripeptid
thrombin
Prior art date
Application number
NO981468A
Other languages
English (en)
Other versions
NO981468D0 (no
Inventor
Joy Antony Malikayl
Joseph Paul Burkhart
Robert James Broersma
Norton Paul Peet
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO981468L publication Critical patent/NO981468L/no
Publication of NO981468D0 publication Critical patent/NO981468D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
NO981468A 1995-10-02 1998-04-01 Polyfluoralkyltryptofantripeptid-trombininhibitorer NO981468D0 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US475595P 1995-10-02 1995-10-02
US56661595A 1995-12-04 1995-12-04
US08/698,931 US6069232A (en) 1995-10-02 1996-08-26 Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
PCT/US1996/014363 WO1997012904A1 (en) 1995-10-02 1996-09-06 Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors

Publications (2)

Publication Number Publication Date
NO981468L true NO981468L (no) 1998-04-01
NO981468D0 NO981468D0 (no) 1998-04-01

Family

ID=27357700

Family Applications (1)

Application Number Title Priority Date Filing Date
NO981468A NO981468D0 (no) 1995-10-02 1998-04-01 Polyfluoralkyltryptofantripeptid-trombininhibitorer

Country Status (18)

Country Link
US (1) US6069232A (no)
EP (1) EP0863916B1 (no)
KR (1) KR19990063942A (no)
CN (1) CN1137134C (no)
AR (1) AR003756A1 (no)
AT (1) ATE215963T1 (no)
AU (1) AU700312B2 (no)
CA (1) CA2233698C (no)
DE (1) DE69620627T2 (no)
DK (1) DK0863916T3 (no)
ES (1) ES2171717T3 (no)
HU (1) HUP9901290A3 (no)
IL (1) IL123597A (no)
NO (1) NO981468D0 (no)
NZ (1) NZ318627A (no)
PT (1) PT863916E (no)
TW (1) TW339335B (no)
WO (1) WO1997012904A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525823A (ja) 1997-05-15 2001-12-11 イーライ・リリー・アンド・カンパニー 抗血栓化合物
HUP0100082A3 (en) 1998-01-26 2001-12-28 Abbott Gmbh & Co Kg Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use
YU42401A (sh) * 1998-12-14 2003-12-31 Ortho-Mcneil Pharmaceuticals Inc. Supstituisani heterociklični acil-tripeptidi korisni kao modulatori receptora trombina
GB0408164D0 (en) 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
GB0716992D0 (en) 2007-08-31 2007-10-10 Immune Targeting Systems Its L Influenza antigen delivery vectors and constructs
WO2013082210A1 (en) * 2011-11-29 2013-06-06 Perosphere Inc. Anticoagulant reversal agents
CN103450067B (zh) * 2012-05-29 2015-01-07 首都医科大学 乙基连接的双吲哚-3-基-乙酰氨基酸、其制备、抗血栓作用和应用
EP3684417A1 (en) * 2017-09-19 2020-07-29 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Lipophilic peptide prodrugs
WO2019058365A1 (en) 2017-09-19 2019-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. SOMATOSTATIN PRODUCTS
EP3684785B1 (en) 2017-09-19 2024-10-02 Technische Universität München N-methylated cyclic peptides and their prodrugs

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247454A (en) * 1975-07-11 1981-01-27 Ab Kabi Novel chromogenic thrombin substrates
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4216142A (en) * 1978-12-18 1980-08-05 Abbott Laboratories Chromogenic substrates for the proteolytic enzymes
US4217269A (en) * 1979-03-23 1980-08-12 Abbott Laboratories Dipeptide chromogenic substrates
US4221706A (en) * 1979-06-14 1980-09-09 Abbott Laboratories Chromogenic substrates
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
FR2550447B1 (fr) * 1983-08-10 1986-01-17 Ile De France Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
FR2575753B1 (fr) * 1985-01-07 1987-02-20 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
US4762821A (en) * 1985-03-22 1988-08-09 Syntex (U.S.A.) Inc. N',N"-dialkylguanidino dipeptides
EP0204571B1 (en) * 1985-06-07 1992-01-22 Ici Americas Inc. Selected difluoro derivatives
JPS62126197A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規な血漿キニノゲナーゼ測定用化合物
FR2598412B1 (fr) * 1986-03-12 1988-10-21 Sanofi Sa Nouveaux derives de diarylcetones et leurs procedes de preparation et les compositions pharmaceutiques les contenant
NZ220173A (en) * 1986-05-09 1990-01-29 Dainippon Pharmaceutical Co Tripeptide derivatives as antihypertensive agents;processes for their preparation and pharmaceutical compositions thereof
EP0253190B1 (en) * 1986-07-16 1992-12-30 ENIRICERCHE S.p.A. Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
US4929602A (en) * 1987-11-25 1990-05-29 Scripps Clinic And Research Foundation Method of inhibiting platelet dependent arterial thrombosis
CA2021660A1 (en) * 1989-07-26 1991-01-27 Philippe Bey Peptidase inhibitors
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
DE69227895D1 (de) * 1991-02-04 1999-01-28 Akzo Nobel Nv FAKTOR IIa INHIBITOREN
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
WO1994025051A1 (en) * 1993-04-30 1994-11-10 Merck & Co., Inc. Thrombin inhibitors
GB2287027A (en) * 1994-03-04 1995-09-06 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
DE69620627T2 (de) 2002-10-17
EP0863916B1 (en) 2002-04-10
KR19990063942A (ko) 1999-07-26
CN1137134C (zh) 2004-02-04
TW339335B (en) 1998-09-01
EP0863916A1 (en) 1998-09-16
AU700312B2 (en) 1998-12-24
HUP9901290A3 (en) 1999-11-29
CA2233698A1 (en) 1997-04-10
NO981468D0 (no) 1998-04-01
NZ318627A (en) 1999-11-29
AU7015496A (en) 1997-04-28
WO1997012904A1 (en) 1997-04-10
IL123597A0 (en) 1998-10-30
CA2233698C (en) 2002-04-09
DK0863916T3 (da) 2002-07-29
HUP9901290A2 (hu) 1999-08-30
IL123597A (en) 2003-01-12
CN1198748A (zh) 1998-11-11
ES2171717T3 (es) 2002-09-16
DE69620627D1 (en) 2002-05-16
AR003756A1 (es) 1998-09-09
PT863916E (pt) 2002-07-31
US6069232A (en) 2000-05-30
HK1015797A1 (en) 1999-10-22
ATE215963T1 (de) 2002-04-15

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application