ES2171717T3 - Tripeptidos de polifluoroalquiltriptofano inhibidores de la trombina. - Google Patents

Tripeptidos de polifluoroalquiltriptofano inhibidores de la trombina.

Info

Publication number
ES2171717T3
ES2171717T3 ES96931485T ES96931485T ES2171717T3 ES 2171717 T3 ES2171717 T3 ES 2171717T3 ES 96931485 T ES96931485 T ES 96931485T ES 96931485 T ES96931485 T ES 96931485T ES 2171717 T3 ES2171717 T3 ES 2171717T3
Authority
ES
Spain
Prior art keywords
thrombin
inhibitors
tripeptidos
polifluoroalquiltriptofano
polifluoroalquil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96931485T
Other languages
English (en)
Inventor
Joy Antony Malikayl
Joseph Paul Burkhart
Robert James Broersma
Norton Paul Peet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2171717T3 publication Critical patent/ES2171717T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A TRIPEPTIDOS POLIFLUOROALQUIL TRIPTOFANO Y A COMPOSICIONES QUE LOS CONTIENEN. LOS COMPUESTOS SON INHIBIDORES ALTAMENTE SELECTIVOS DE LA TROMBINA QUE TIENEN EFECTOS ANTICOAGULANTES UTILES EN EL TRATAMIENTO DE CONDICIONES RELACIONADAS CON LA TROMBINA Y EN LA PREVENCION DE LA COAGULACION DE SANGRE ENTERA ALMACENADA Y PRODUCTOS SANGUINEOS.
ES96931485T 1995-10-02 1996-09-06 Tripeptidos de polifluoroalquiltriptofano inhibidores de la trombina. Expired - Lifetime ES2171717T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US475595P 1995-10-02 1995-10-02
US56661595A 1995-12-04 1995-12-04
US08/698,931 US6069232A (en) 1995-10-02 1996-08-26 Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors

Publications (1)

Publication Number Publication Date
ES2171717T3 true ES2171717T3 (es) 2002-09-16

Family

ID=27357700

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96931485T Expired - Lifetime ES2171717T3 (es) 1995-10-02 1996-09-06 Tripeptidos de polifluoroalquiltriptofano inhibidores de la trombina.

Country Status (18)

Country Link
US (1) US6069232A (es)
EP (1) EP0863916B1 (es)
KR (1) KR19990063942A (es)
CN (1) CN1137134C (es)
AR (1) AR003756A1 (es)
AT (1) ATE215963T1 (es)
AU (1) AU700312B2 (es)
CA (1) CA2233698C (es)
DE (1) DE69620627T2 (es)
DK (1) DK0863916T3 (es)
ES (1) ES2171717T3 (es)
HU (1) HUP9901290A3 (es)
IL (1) IL123597A (es)
NO (1) NO981468L (es)
NZ (1) NZ318627A (es)
PT (1) PT863916E (es)
TW (1) TW339335B (es)
WO (1) WO1997012904A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525823A (ja) 1997-05-15 2001-12-11 イーライ・リリー・アンド・カンパニー 抗血栓化合物
JP2002501081A (ja) 1998-01-26 2002-01-15 ビーエーエスエフ アクチェンゲゼルシャフト トロンビンインヒビター
YU42401A (sh) * 1998-12-14 2003-12-31 Ortho-Mcneil Pharmaceuticals Inc. Supstituisani heterociklični acil-tripeptidi korisni kao modulatori receptora trombina
GB0408164D0 (en) * 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
GB0716992D0 (en) 2007-08-31 2007-10-10 Immune Targeting Systems Its L Influenza antigen delivery vectors and constructs
US9522892B2 (en) * 2011-11-29 2016-12-20 Perosphere Inc. Anticoagulant reversal agents
CN103450067B (zh) * 2012-05-29 2015-01-07 首都医科大学 乙基连接的双吲哚-3-基-乙酰氨基酸、其制备、抗血栓作用和应用
WO2019058374A1 (en) 2017-09-19 2019-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. N-METHYLATED CYCLIC PEPTIDES AND PRODRUGS THEREOF
US20200323962A1 (en) * 2017-09-19 2020-10-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipophilic peptide prodrugs
US11261215B2 (en) 2017-09-19 2022-03-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Somatostatin prodrugs

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247454A (en) * 1975-07-11 1981-01-27 Ab Kabi Novel chromogenic thrombin substrates
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4216142A (en) * 1978-12-18 1980-08-05 Abbott Laboratories Chromogenic substrates for the proteolytic enzymes
US4217269A (en) * 1979-03-23 1980-08-12 Abbott Laboratories Dipeptide chromogenic substrates
US4221706A (en) * 1979-06-14 1980-09-09 Abbott Laboratories Chromogenic substrates
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
FR2550447B1 (fr) * 1983-08-10 1986-01-17 Ile De France Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
FR2575753B1 (fr) * 1985-01-07 1987-02-20 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
US4762821A (en) * 1985-03-22 1988-08-09 Syntex (U.S.A.) Inc. N',N"-dialkylguanidino dipeptides
ATE71934T1 (de) * 1985-06-07 1992-02-15 Ici America Inc Selektionierte difluorverbindungen.
JPS62126197A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規な血漿キニノゲナーゼ測定用化合物
FR2598412B1 (fr) * 1986-03-12 1988-10-21 Sanofi Sa Nouveaux derives de diarylcetones et leurs procedes de preparation et les compositions pharmaceutiques les contenant
NZ220173A (en) * 1986-05-09 1990-01-29 Dainippon Pharmaceutical Co Tripeptide derivatives as antihypertensive agents;processes for their preparation and pharmaceutical compositions thereof
EP0253190B1 (en) * 1986-07-16 1992-12-30 ENIRICERCHE S.p.A. Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
US4929602A (en) * 1987-11-25 1990-05-29 Scripps Clinic And Research Foundation Method of inhibiting platelet dependent arterial thrombosis
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
DE69227895D1 (de) * 1991-02-04 1999-01-28 Akzo Nobel Nv FAKTOR IIa INHIBITOREN
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
CA2159834A1 (en) * 1993-04-30 1994-11-10 Daniel F. Veber Thrombin inhibitors
GB2287027A (en) * 1994-03-04 1995-09-06 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
EP0863916A1 (en) 1998-09-16
PT863916E (pt) 2002-07-31
CA2233698A1 (en) 1997-04-10
NO981468D0 (no) 1998-04-01
WO1997012904A1 (en) 1997-04-10
HUP9901290A3 (en) 1999-11-29
IL123597A (en) 2003-01-12
EP0863916B1 (en) 2002-04-10
DE69620627T2 (de) 2002-10-17
US6069232A (en) 2000-05-30
CA2233698C (en) 2002-04-09
DE69620627D1 (en) 2002-05-16
HK1015797A1 (en) 1999-10-22
TW339335B (en) 1998-09-01
ATE215963T1 (de) 2002-04-15
AU700312B2 (en) 1998-12-24
AU7015496A (en) 1997-04-28
CN1137134C (zh) 2004-02-04
DK0863916T3 (da) 2002-07-29
NZ318627A (en) 1999-11-29
AR003756A1 (es) 1998-09-09
KR19990063942A (ko) 1999-07-26
IL123597A0 (en) 1998-10-30
NO981468L (no) 1998-04-01
CN1198748A (zh) 1998-11-11
HUP9901290A2 (hu) 1999-08-30

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