NO981609L - Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak - Google Patents

Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak

Info

Publication number: NO981609L
Authority: NO; Norway
Prior art keywords: alkyl; alkynyl; alkenyl; aryl; arylalkyl
Prior art date: 1995-11-02

Application number

NO981609A

Other languages

English (en)

Other versions

NO981609D0 (no

NO309569B1 (no

Inventor

Jorgen Scheel-Krueger

Gunnar M Olsen

Bjarne Hugo Dahl

Leif Helth Jensen

Elsebeth Istergaard Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-02

Filing date

1998-04-07

Publication date

1998-06-26

1998-04-07 Application filed by Neurosearch As filed Critical Neurosearch As

1998-04-07 Publication of NO981609D0 publication Critical patent/NO981609D0/no

1998-06-26 Publication of NO981609L publication Critical patent/NO981609L/no

2001-02-19 Publication of NO309569B1 publication Critical patent/NO309569B1/no

Links

230000019818 neurotransmitter uptake Effects 0.000 title 1
150000003813 tropane derivatives Chemical class 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 6
125000000304 alkynyl group Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Exhaust Gas After Treatment (AREA)

NO981609A 1995-11-02 1998-04-07 Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak NO309569B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK122395		1995-11-02
DK14696		1996-02-13
PCT/EP1996/004793 WO1997016451A1 (en)	1995-11-02	1996-11-04	Fused tropane-derivatives as neurotransmitter reuptake inhibitors

Publications (3)

Publication Number	Publication Date
NO981609D0 NO981609D0 (no)	1998-04-07
NO981609L true NO981609L (no)	1998-06-26
NO309569B1 NO309569B1 (no)	2001-02-19

Family

ID=26063395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO981609A NO309569B1 (no)	1995-11-02	1998-04-07	Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak

Country Status (24)

Country	Link
US (1)	US5998405A (no)
EP (1)	EP0858461B1 (no)
JP (1)	JP3157839B2 (no)
KR (1)	KR100277482B1 (no)
CN (1)	CN1060775C (no)
AT (1)	ATE224392T1 (no)
AU (1)	AU702720B2 (no)
BR (1)	BR9611300A (no)
CA (1)	CA2236707C (no)
CZ (1)	CZ285571B6 (no)
DE (1)	DE69623799T2 (no)
DK (1)	DK0858461T3 (no)
EE (1)	EE03566B1 (no)
HU (1)	HUP9802534A3 (no)
IL (1)	IL123898A (no)
IS (1)	IS4708A (no)
NO (1)	NO309569B1 (no)
NZ (1)	NZ321970A (no)
PL (1)	PL184843B1 (no)
RU (1)	RU2162469C2 (no)
SK (1)	SK282944B6 (no)
TR (1)	TR199800780T2 (no)
UA (1)	UA47442C2 (no)
WO (1)	WO1997016451A1 (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6329520B1 (en) *	1990-08-09	2001-12-11	Research Triangle Institute	Cocaine receptor binding ligands
US6706880B2 (en)	1990-08-09	2004-03-16	Research Triangle Institute	Cocaine receptor binding ligands
US6150376A (en) *	1998-08-05	2000-11-21	Georgetown University	Bi- and tri-cyclic aza compounds and their uses
TR200100462T2 (tr) *	1998-08-18	2001-09-21	Ucb, S.A.	Muskarinik agonistleri ve antagonistleri
CA2384692A1 (en)	1999-09-27	2001-04-05	Alan P. Kozikowski	Novel tropane analogs
US6479509B1 (en)	2000-05-22	2002-11-12	Research Triangle Institute	Method of promoting smoking cessation
WO2002002559A1 (en) *	2000-07-04	2002-01-10	Neurosearch A/S	Steric isomers of fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
MXPA03009185A (es)	2001-04-09	2004-02-17	Neurosearch As	Antagonistas de receptor a2a de adenosina combinados con compuestos de actividad neurotrofica en el tratamiento de la enfermedad de parkinson.
WO2002094827A1 (en) *	2001-05-23	2002-11-28	Neurosearch A/S	Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW589312B (en)	2001-05-25	2004-06-01	Wyeth Corp	Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
WO2003045388A1 (en) *	2001-11-30	2003-06-05	Neurosearch A/S	Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
JP2006517567A (ja)	2003-02-12	2006-07-27	ニューロサーチ、アクティーゼルスカブ	新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
JP2006517568A (ja)	2003-02-12	2006-07-27	ニューロサーチ、アクティーゼルスカブ	８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
CN100356940C (zh) *	2004-12-01	2007-12-26	蒋毅	制备大叶蒟提取物的方法、提取物及其应用
US20090137625A1 (en)	2005-04-08	2009-05-28	Dan Peters	Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
EP1917264B1 (en)	2005-06-28	2010-11-17	NeuroSearch A/S	Novel 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US8093388B2 (en)	2005-06-28	2012-01-10	Neurosearch A/S	3-aza spiro[5,5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
BRPI0614944A2 (pt) *	2005-08-19	2011-04-26	Elan Pharm Inc	inibidores sulfonamido n-bicìclicos ponte de gama-secretase
TW200800980A (en)	2006-02-17	2008-01-01	Neurosearch As	Novel compounds
US8697721B2 (en)	2009-05-15	2014-04-15	Aniona Aps	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
PE20121066A1 (es) *	2009-06-19	2012-09-13	Abbvie Inc	Derivados de diazahomoadamantano y metodos para usarlos
WO2011032903A1 (en)	2009-09-21	2011-03-24	Neurosearch A/S	Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011092061A1 (en)	2010-01-29	2011-08-04	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en)	2010-03-25	2011-09-29	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
WO2012000881A1 (en)	2010-07-02	2012-01-05	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP6052524B1 (ja) *	2015-07-30	2016-12-27	秋夫湯田	持ち運び設置が容易な手提げハンドルの付いた薪ストーブ。
AU2023303077A1 (en)	2022-07-08	2025-02-06	Initiator Pharma A/S	Compound for treatment of female sexual dysfunction
JP2026512649A (ja)	2022-10-28	2026-04-20	イニシエーターファーマエー／エス	疼痛の治療用化合物
TW202440106A (zh)	2023-01-03	2024-10-16	丹麥商創始人製藥股份有限公司	用於治療勃起障礙之化合物
WO2025051846A1 (en)	2023-09-05	2025-03-13	Initiator Pharma A/S	Compound for treatment of female sexual dysfunction
KR20250050681A (ko)	2023-10-08	2025-04-15	임종완	이중관형멀티커넥터

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU672644B2 (en) *	1992-12-23	1996-10-10	Neurosearch A/S	Aryl substituted heterocyclic compounds
BR9507489A (pt) *	1994-04-19	1997-08-12	Neurosearch As	Derivados tropano sua preparacão e uso

1996
- 1996-11-04 EE EE9800100A patent/EE03566B1/xx not_active IP Right Cessation
- 1996-11-04 AU AU75631/96A patent/AU702720B2/en not_active Ceased
- 1996-11-04 RU RU98110007/04A patent/RU2162469C2/ru not_active IP Right Cessation
- 1996-11-04 EP EP96938064A patent/EP0858461B1/en not_active Expired - Lifetime
- 1996-11-04 CA CA002236707A patent/CA2236707C/en not_active Expired - Fee Related
- 1996-11-04 JP JP51708397A patent/JP3157839B2/ja not_active Expired - Fee Related
- 1996-11-04 SK SK422-98A patent/SK282944B6/sk unknown
- 1996-11-04 BR BR9611300A patent/BR9611300A/pt not_active Application Discontinuation
- 1996-11-04 AT AT96938064T patent/ATE224392T1/de not_active IP Right Cessation
- 1996-11-04 KR KR1019980702592A patent/KR100277482B1/ko not_active Expired - Fee Related
- 1996-11-04 CN CN96198012A patent/CN1060775C/zh not_active Expired - Fee Related
- 1996-11-04 UA UA98041933A patent/UA47442C2/uk unknown
- 1996-11-04 HU HU9802534A patent/HUP9802534A3/hu unknown
- 1996-11-04 NZ NZ321970A patent/NZ321970A/en unknown
- 1996-11-04 IL IL12389896A patent/IL123898A/en not_active IP Right Cessation
- 1996-11-04 CZ CZ981138A patent/CZ285571B6/cs not_active IP Right Cessation
- 1996-11-04 WO PCT/EP1996/004793 patent/WO1997016451A1/en not_active Ceased
- 1996-11-04 US US09/051,107 patent/US5998405A/en not_active Expired - Lifetime
- 1996-11-04 DK DK96938064T patent/DK0858461T3/da active
- 1996-11-04 TR TR1998/00780T patent/TR199800780T2/xx unknown
- 1996-11-04 PL PL96326448A patent/PL184843B1/pl unknown
- 1996-11-04 DE DE69623799T patent/DE69623799T2/de not_active Expired - Lifetime
1998
- 1998-03-31 IS IS4708A patent/IS4708A/is unknown
- 1998-04-07 NO NO981609A patent/NO309569B1/no unknown

Also Published As

Publication number	Publication date
EE9800100A (et)	1998-10-15
HUP9802534A3 (en)	1999-06-28
AU7563196A (en)	1997-05-22
AU702720B2 (en)	1999-03-04
US5998405A (en)	1999-12-07
RU2162469C2 (ru)	2001-01-27
NZ321970A (en)	2000-02-28
JPH11514638A (ja)	1999-12-14
IL123898A (en)	2001-08-08
CN1060775C (zh)	2001-01-17
PL326448A1 (en)	1998-09-28
CZ285571B6 (cs)	1999-09-15
IS4708A (is)	1998-03-31
CA2236707A1 (en)	1997-05-09
DE69623799T2 (de)	2003-01-30
WO1997016451A1 (en)	1997-05-09
IL123898A0 (en)	1998-10-30
PL184843B1 (pl)	2002-12-31
NO981609D0 (no)	1998-04-07
KR19990064111A (ko)	1999-07-26
SK42298A3 (en)	1998-10-07
EP0858461B1 (en)	2002-09-18
KR100277482B1 (ko)	2001-01-15
EP0858461A1 (en)	1998-08-19
ATE224392T1 (de)	2002-10-15
HK1016984A1 (en)	1999-11-12
NO309569B1 (no)	2001-02-19
JP3157839B2 (ja)	2001-04-16
CA2236707C (en)	2002-08-06
DE69623799D1 (de)	2002-10-24
CN1201461A (zh)	1998-12-09
BR9611300A (pt)	1999-06-15
TR199800780T2 (xx)	1998-07-21
UA47442C2 (uk)	2002-07-15
EE03566B1 (et)	2001-12-17
MX9803554A (es)	1998-09-30
HUP9802534A2 (hu)	1999-04-28
SK282944B6 (sk)	2003-01-09
DK0858461T3 (da)	2003-01-27
CZ113898A3 (cs)	1998-07-15

Publication	Publication Date	Title
NO981609D0 (no)	1998-04-07	Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak
UA49872C2 (uk)	2002-10-15	Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікування
IS4681A (is)	1998-03-04	8-azabísýkló(3.2.1)okt-2-en afleiður, framleiðslaþeirra og notkun
CA2187309A1 (en)	1995-10-26	Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors
BG102715A (bg)	1999-08-31	Нови производни на арилглицинамид, метод за получаването им и фармацевтични състави съдържащи, ги
PE20011212A1 (es)	2001-11-21	Compuestos para el tratamiento de la fibromialgia y el sindrome de fatiga cronica
DE69817557D1 (de)	2003-10-02	Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme
JO2235B1 (en)	2004-10-07	Derivatives of phenyl
AU3327399A (en)	1999-08-23	Benzisoxazole derivatives having d4-antagonistic activity