NO983919L - 7-fenyl-1,4-diazepanderivater, fremgangsmÕter for fremstilling av disse samt legemidler inneholdende slike forbindelser - Google Patents

7-fenyl-1,4-diazepanderivater, fremgangsmÕter for fremstilling av disse samt legemidler inneholdende slike forbindelser

Info

Publication number
NO983919L
NO983919L NO983919A NO983919A NO983919L NO 983919 L NO983919 L NO 983919L NO 983919 A NO983919 A NO 983919A NO 983919 A NO983919 A NO 983919A NO 983919 L NO983919 L NO 983919L
Authority
NO
Norway
Prior art keywords
lower alkyl
trifluoromethyl
halogen
represents hydrogen
compounds
Prior art date
Application number
NO983919A
Other languages
English (en)
Other versions
NO983919D0 (no
Inventor
Samuel David
Jochen Antel
Reinhard Brueckner
Dieter Ziegler
Christian Eeckhout
Gerhard-Wilhelm Bielenberg
Michael Peck
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of NO983919D0 publication Critical patent/NO983919D0/no
Publication of NO983919L publication Critical patent/NO983919L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Neurokinin-antagonistisk aktive forbindelser generell formel I, hvori R1 betegner hydrogen eller lavere alkyl, R2 betegner hydrogen, lavere alkyl, lavere alkoksy, halogen eller trifluormetyl, og R3 betegner hydrogen, lavere alkyl, lavere alkoksy, halogen eller trifluormetyl, eller R2 og R3 betegner sammen alkylendioksy med l til 2 karbonatomer bundet til nabokarbonatomer på fenyl- ringen, R' betegner hydrogen, lavere alkyl, lavere alkoksy, halogen eller trifluormetyl, og R5 betegner hydrogen, lavere alkyl, lavere alkoksy, halogen eller trifluormetyl, eller R4 og R5 betegner sammen alkylendioksy med l til 2 karbonatomer bundet til nabokarbonatomet på fenyl- ringen, K6 betegner lavere alkyl, halogen eller trifluormetyl, R7 betegner lavere alkyl, halogen eller trifluormetyl, A betegner en -(CH2)n-gruppe, hvori n betegner et helt tall fra l til 3, eller en -NH-(CH2)B- gruppe, hvori m betegner et helt tall fra 2 til 3, og B betegner en alkylenkjede med l til 3 karbonatomer som eventuelt er substituert med lavere alkyl, så vel som deres fysiologisk forenlige salter samt fremgangsmåter for frem- stilling av disse forbindelser.
NO983919A 1997-08-27 1998-08-26 7-fenyl-1,4-diazepanderivater, fremgangsmÕter for fremstilling av disse samt legemidler inneholdende slike forbindelser NO983919L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19737334A DE19737334A1 (de) 1997-08-27 1997-08-27 7-Phenyl-1,4-diazepan-Derivate, sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
NO983919D0 NO983919D0 (no) 1998-08-26
NO983919L true NO983919L (no) 1999-03-01

Family

ID=7840336

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983919A NO983919L (no) 1997-08-27 1998-08-26 7-fenyl-1,4-diazepanderivater, fremgangsmÕter for fremstilling av disse samt legemidler inneholdende slike forbindelser

Country Status (21)

Country Link
US (1) US6040303A (no)
EP (1) EP0899264B1 (no)
JP (1) JP4380814B2 (no)
KR (1) KR19990023606A (no)
CN (1) CN1220262A (no)
AR (1) AR009899A1 (no)
AT (1) ATE310732T1 (no)
AU (1) AU8190098A (no)
BR (1) BR9803250A (no)
CA (1) CA2245926C (no)
CZ (1) CZ267298A3 (no)
DE (2) DE19737334A1 (no)
HU (1) HUP9801888A3 (no)
ID (1) ID20786A (no)
IL (1) IL125886A0 (no)
NO (1) NO983919L (no)
NZ (1) NZ331523A (no)
PL (1) PL328222A1 (no)
SK (1) SK111798A3 (no)
TR (1) TR199801681A2 (no)
ZA (1) ZA986719B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0108595D0 (en) 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
KR100699886B1 (ko) * 2005-12-21 2007-03-28 삼성전자주식회사 하드디스크 드라이브의 스핀들 모터-디스크 조립체 및 이의조립방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2328870C2 (de) * 1973-06-06 1982-04-08 Vsesojuznyj naučno-issledovatel'skij chimiko-farmacevtičeskij institut imeni Sergo Ordžonikidze, Moskva N,N'-Di-(β-brompropionyl)-hexahydro-1,4-diazepin und Verfahren zu seiner Herstellung
DE3702755A1 (de) * 1987-01-30 1988-08-11 Hoechst Ag 3,5-di-tert.-butyl-4-hydroxybenzoesaeureamid, verschiedene von dessen derivaten, verfahren zur herstellung dieser verbindungen, die sie enthaltenden arzneimittel und ihre verwendung
JP2732003B2 (ja) * 1992-11-17 1998-03-25 富士写真フイルム株式会社 ２，６−ジアルコキシ−４−カルバモイルフェノ−ル誘導体及び抗酸化剤組成物
JPH07145060A (ja) * 1993-11-25 1995-06-06 Teijin Ltd 細胞遊走阻害剤
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5795894A (en) * 1995-05-02 1998-08-18 Schering Corporation Piperazino derivatives as neurokinn antagonists
WO1996034864A1 (en) * 1995-05-02 1996-11-07 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists

Also Published As

Publication number Publication date
KR19990023606A (ko) 1999-03-25
DE19737334A1 (de) 1999-03-04
DE59813212D1 (de) 2005-12-29
JPH11116557A (ja) 1999-04-27
CA2245926C (en) 2006-12-12
HU9801888D0 (en) 1998-10-28
EP0899264A1 (de) 1999-03-03
NZ331523A (en) 2000-02-28
TR199801681A3 (tr) 1999-03-22
NO983919D0 (no) 1998-08-26
IL125886A0 (en) 1999-04-11
TR199801681A2 (xx) 1999-03-22
CA2245926A1 (en) 1999-02-27
US6040303A (en) 2000-03-21
HUP9801888A2 (hu) 1999-05-28
ID20786A (id) 1999-03-04
HUP9801888A3 (en) 1999-06-28
AU8190098A (en) 1999-03-11
CZ267298A3 (cs) 1999-03-17
SK111798A3 (en) 1999-05-07
AR009899A1 (es) 2000-05-03
PL328222A1 (en) 1999-03-01
CN1220262A (zh) 1999-06-23
JP4380814B2 (ja) 2009-12-09
ZA986719B (en) 1999-02-02
EP0899264B1 (de) 2005-11-23
BR9803250A (pt) 2000-02-08
ATE310732T1 (de) 2005-12-15

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